| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chun Hu, Gang Song, Bing Zhang, Zhongchen Liu, Rong Chen, Hong Zhang, Tianhui H. Intestinal metabolite compound K of panaxoside inhibits the growth of gastric carcinoma by augmenting apoptosis via Bid-mediated mitochondrial pathway. Journal of cellular and molecular medicine. vol 16. issue 1. 2012-06-08. PMID:21323864. |
further studies show that ck induces apoptosis in bgc823 and sgc7901 cells mainly through mitochondria-mediated internal pathway, and that ck induces the translocation of nuclear bid to mitochondria. |
2012-06-08 |
2023-08-12 |
mouse |
| Chun Hu, Gang Song, Bing Zhang, Zhongchen Liu, Rong Chen, Hong Zhang, Tianhui H. Intestinal metabolite compound K of panaxoside inhibits the growth of gastric carcinoma by augmenting apoptosis via Bid-mediated mitochondrial pathway. Journal of cellular and molecular medicine. vol 16. issue 1. 2012-06-08. PMID:21323864. |
our studies show that ck can inhibit the viabilities and induce apoptosis of human gastric carcinoma cells via bid-mediated mitochondrial pathway. |
2012-06-08 |
2023-08-12 |
mouse |
| Shuang Zhang, Hong Li, Hui Xu, Shi-Jie Yan. [Effect of gross saponins of Tribulus terrestris on cardiocytes impaired by adriamycin]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 45. issue 1. 2012-02-23. PMID:21351446. |
mtt colorimetric method was deployed to detect cardiocyte survival rate, activities of ck, ldh, ast, sod, mda and no were detected, and apoptosis was detected with flow cytometry. |
2012-02-23 |
2023-08-12 |
rat |
| Yusuf Yilma. Cytokeratins in hepatitis. Clinica chimica acta; international journal of clinical chemistry. vol 412. issue 23-24. 2012-02-03. PMID:21925155. |
interest in ck in viral and nonviral hepatitis has been rapidly increasing during the last years, especially as they have been proposed as circulating biomarkers of hepatocyte necrosis and apoptosis. |
2012-02-03 |
2023-08-12 |
Not clear |
| Sora Park, Hyo-Jung Lee, Soo-Jin Jeong, Hyo Sook Song, Minseok Kim, Hyo-Jeong Lee, Eun-Ok Lee, Dong-Hyun Kim, Kyoo Seok Ahn, Sung-Hoon Ki. Inhibition of JAK1/STAT3 signaling mediates compound K-induced apoptosis in human multiple myeloma U266 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 49. issue 6. 2011-08-30. PMID:21420464. |
overall, our findings demonstrate that jak1/stat3 signaling mediates ck-induced apoptosis in u266 cells and also suggest the chemopreventive potential of ck for treatment of multiple myeloma. |
2011-08-30 |
2023-08-12 |
human |
| Ting-Ting Li, Yi-Shuai Zhang, Lan He, Nian-Sheng Li, Jun Peng, Yuan-Jian L. Protective effect of phloroglucinol against myocardial ischaemia-reperfusion injury is related to inhibition of myeloperoxidase activity and inflammatory cell infiltration. Clinical and experimental pharmacology & physiology. vol 38. issue 1. 2011-05-04. PMID:21039756. |
infarct size, the release of creatine kinase (ck), inflammatory cell infiltration, mpo activity and protein content, catalase in the blood and myocardium, and myocardial apoptosis were measured. |
2011-05-04 |
2023-08-12 |
rat |
| Yang Wu, Zhong-yuan Xia, Qing-tao Meng, Jie Zhu, Shaoqing Lei, Jinjin Xu, Juan Do. Shen-Fu injection preconditioning inhibits myocardial ischemia-reperfusion injury in diabetic rats: activation of eNOS via the PI3K/Akt pathway. Journal of biomedicine & biotechnology. vol 2011. 2011-04-04. PMID:21151615. |
sfi preconditioning significantly decreased infarct size, apoptosis, caspase-3 protein expression, mda level in myocardial tissues, and plasma level of ck and ldh but increased p-akt, p-enos, bcl-2 protein expression, and sod activity compared to i/r group. |
2011-04-04 |
2023-08-12 |
rat |
| Gang Song, Shiguang Guo, Weiwei Wang, Chun Hu, Yubing Mao, Bing Zhang, Hong Zhang, Tianhui H. Intestinal metabolite compound K of ginseng saponin potently attenuates metastatic growth of hepatocellular carcinoma by augmenting apoptosis via a Bid-mediated mitochondrial pathway. Journal of agricultural and food chemistry. vol 58. issue 24. 2011-03-23. PMID:21121651. |
further study shows that translocation of full-length bid to the mitochondria from nuclei during cytotoxic apoptosis was associated with the release of cytochrome c from mitochondria, indicating that full-length bid is sufficient for the activation of mitochondrial cell death pathways in response to ck treatment in hcc cells. |
2011-03-23 |
2023-08-12 |
Not clear |
| Richard W Smith, Jiaxi Wang, Carmel E Mothersill, Thomas G Hinton, Kouichi Aizawa, Colin B Seymou. Proteomic changes in the gills of wild-type and transgenic radiosensitive medaka following exposure to direct irradiation and to X-ray induced bystander signals. Biochimica et biophysica acta. vol 1814. issue 2. 2011-03-15. PMID:21081182. |
annexin a4, ck and ldh are associated with apoptosis and mirror the increase in apoptotic bodies previously reported in irradiated and bystander medaka, whereas increased wap65 and ldh suggest a protective response. |
2011-03-15 |
2023-08-12 |
Not clear |
| Tatsuya Tada, Koutaro Suzuki, Yu Sakurai, Masanori Kubo, Hironao Okada, Toshihiro Itoh, Kenji Tsukamot. NP body domain and PB2 contribute to increased virulence of H5N1 highly pathogenic avian influenza viruses in chickens. Journal of virology. vol 85. issue 4. 2011-03-07. PMID:21123376. |
inversely, reassortants possessing the np or pb2 gene of ckym7 in the dkyk10 background (rgdkyk-pb2(ck), rgdkyk-np(ck)) replicated quickly and reached higher titers than dkyk10, accompanied by more rapid and frequent apoptosis of macrophages. |
2011-03-07 |
2023-08-12 |
chicken |
| Arong Jeong, Hyo-Jung Lee, Soo-Jin Jeong, Hyo-Jeong Lee, Eun-Ok Lee, Hyunsu Bae, Sung-Hoon Ki. Compound K inhibits basic fibroblast growth factor-induced angiogenesis via regulation of p38 mitogen activated protein kinase and AKT in human umbilical vein endothelial cells. Biological & pharmaceutical bulletin. vol 33. issue 6. 2011-01-10. PMID:20522957. |
compound k (ck; 20-o-beta-d-glucopyranosyl-20(s)-protopanaxadiol), an active ginseng saponin metabolite, exerts anticancer activity via apoptosis induction in various cancers. |
2011-01-10 |
2023-08-12 |
mouse |
| Kaiwei Si, Juntian Liu, Langchong He, Xikuan Li, Wei Gou, Chuanhao Liu, Xiaoqi L. Caulophine protects cardiomyocytes from oxidative and ischemic injury. Journal of pharmacological sciences. vol 113. issue 4. 2010-12-14. PMID:20724803. |
the results showed that pretreatment with caulophine increased the viability of h(2)o(2)- and adriamycin-injured cardiomyocytes; decreased ck, ldh, and mda; increased sod; and inhibited h(2)o(2)-induced cellular apoptosis. |
2010-12-14 |
2023-08-12 |
rat |
| José Linares-Palomino, Muhammad A Husainy, Vien K Lai, John M Dickenson, Manuel Galiñane. Selective blockade of protein kinase B protects the rat and human myocardium against ischaemic injury. The Journal of physiology. vol 588. issue Pt 12. 2010-10-04. PMID:20403980. |
myocardial slices from rat left ventricle and from the right atrial appendage of patients undergoing elective cardiac surgery were subjected to 90 min ischaemia/120 min reoxygenation at 37 degrees c. tissue injury was assessed by creatine kinase (ck) released and determination of cell necrosis and apoptosis. |
2010-10-04 |
2023-08-12 |
human |
| Xiaorong Hu, Xiaoya Zhou, Bo He, Changwu Xu, Liu Wu, Bo Cui, Huazhi Wen, Zhibing Lu, Hong Jian. Minocycline protects against myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats. European journal of pharmacology. vol 638. issue 1-3. 2010-09-27. PMID:20406632. |
the lactate dehydrogenase (ldh), creatine kinase (ck) and infarct size were measured and the myocardial tissue apoptosis was assessed by tunnel assay. |
2010-09-27 |
2023-08-12 |
rat |
| Xiaorong Hu, Xiaoya Zhou, Bo He, Changwu Xu, Liu Wu, Bo Cui, Huazhi Wen, Zhibing Lu, Hong Jian. Minocycline protects against myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats. European journal of pharmacology. vol 638. issue 1-3. 2010-09-27. PMID:20406632. |
after 4h of reperfusion, minocycline could significantly decrease the infarct size, myocardium apoptosis and the levels of ldh and ck (all p<0.05). |
2010-09-27 |
2023-08-12 |
rat |
| Doreen Brandt, Xandra Volkmann, Matthias Anstätt, Florian Länger, Michael P Manns, Klaus Schulze-Osthoff, Heike Bante. Serum biomarkers of cell death for monitoring therapy response of gastrointestinal carcinomas. European journal of cancer (Oxford, England : 1990). vol 46. issue 8. 2010-09-22. PMID:20202824. |
in epithelial cells, caspases, the key enzymes of apoptosis, cleave the intermediate filament protein cytokeratin (ck)-18 into specific fragments that are released into circulating blood and can be detected by a specific elisa. |
2010-09-22 |
2023-08-12 |
Not clear |
| Chang-Suk Kong, Young-Eun Bahn, Boh-Kyung Kim, Kang-Yoon Lee, Kun-Young Par. Antiproliferative effect of chitosan-added kimchi in HT-29 human colon carcinoma cells. Journal of medicinal food. vol 13. issue 1. 2010-08-05. PMID:20136430. |
treatment with sk and nk induced apoptosis, as determined by 4,6-diamidino-2-phenylindole staining, and resulted in the up-regulation of bax expression and down-regulation of bcl-2, ciap-1, cellular inhibitor of apoptosis-2, cyclooxygenase-2, inhibitory nitric oxide synthase, and nuclear factor kappab (nf-kappab) expressions when compared to ck. |
2010-08-05 |
2023-08-12 |
human |
| Jin-Zhi Wang, Cong-Yi Cai, Yan-Mei Zhang, Jin-Hong Zheng, Yi-Cun Chen, Wei-Qiu Li, Gang-Gang Sh. N-n-Butyl haloperidol iodide protects against hypoxia/reoxygenation-induced cardiomyocyte injury by modulating protein kinase C activity. Biochemical pharmacology. vol 79. issue 10. 2010-04-08. PMID:20105432. |
measurements included cell damage evaluated by creatine kinase (ck) release, and apoptosis measured by annexin v-fitc assay. |
2010-04-08 |
2023-08-12 |
Not clear |
| Jin-Zhi Wang, Cong-Yi Cai, Yan-Mei Zhang, Jin-Hong Zheng, Yi-Cun Chen, Wei-Qiu Li, Gang-Gang Sh. N-n-Butyl haloperidol iodide protects against hypoxia/reoxygenation-induced cardiomyocyte injury by modulating protein kinase C activity. Biochemical pharmacology. vol 79. issue 10. 2010-04-08. PMID:20105432. |
total pkc activity, ck release and apoptosis were increased after h/r. |
2010-04-08 |
2023-08-12 |
Not clear |
| Jin-Zhi Wang, Cong-Yi Cai, Yan-Mei Zhang, Jin-Hong Zheng, Yi-Cun Chen, Wei-Qiu Li, Gang-Gang Sh. N-n-Butyl haloperidol iodide protects against hypoxia/reoxygenation-induced cardiomyocyte injury by modulating protein kinase C activity. Biochemical pharmacology. vol 79. issue 10. 2010-04-08. PMID:20105432. |
pretreatment with f2 inhibited translocation of pkcalpha, increased translocation of pkcepsilon, and relieved the ck release and apoptosis. |
2010-04-08 |
2023-08-12 |
Not clear |