| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Do Yeon Kim, Min Woo Park, Hai Dan Yuan, Hyo Jung Lee, Sung Hoon Kim, Sung Hyun Chun. Compound K induces apoptosis via CAMK-IV/AMPK pathways in HT-29 colon cancer cells. Journal of agricultural and food chemistry. vol 57. issue 22. 2010-02-18. PMID:19845353. |
although compound k (ck), an intestinal metabolite of ginseng protopanaxadiol saponins, has been known to induce apoptosis in various cancer cells, association of amp-activated protein kinase (ampk) with apoptosis in ht-29 colon cancer cells remains unclear. |
2010-02-18 |
2023-08-12 |
Not clear |
| Daniela Aparecida Sussai, Paulo de Tarso Camillo de Carvalho, Doroty Mesquita Dourado, Ana Carulina Guimarães Belchior, Filipe Abdalla dos Reis, Daniel Martins Pereir. Low-level laser therapy attenuates creatine kinase levels and apoptosis during forced swimming in rats. Lasers in medical science. vol 25. issue 1. 2010-02-05. PMID:19554361. |
the aim of this study was to investigate the effects of low-level laser therapy (lllt) on a decrease in creatine kinase (ck) levels and cell apoptosis. |
2010-02-05 |
2023-08-12 |
rat |
| Heike Serke, Constanze Vilser, Marcin Nowicki, Fayez A Hmeidan, Verona Blumenauer, Katja Hummitzsch, Andreas Lösche, Katharina Spanel-Borowsk. Granulosa cell subtypes respond by autophagy or cell death to oxLDL-dependent activation of the oxidized lipoprotein receptor 1 and toll-like 4 receptor. Autophagy. vol 5. issue 7. 2010-01-04. PMID:19730000. |
in ck(-) cells, the inhibition of tlr4 downregulated lox-1 and induced apoptosis. |
2010-01-04 |
2023-08-12 |
Not clear |
| Heike Serke, Constanze Vilser, Marcin Nowicki, Fayez A Hmeidan, Verona Blumenauer, Katja Hummitzsch, Andreas Lösche, Katharina Spanel-Borowsk. Granulosa cell subtypes respond by autophagy or cell death to oxLDL-dependent activation of the oxidized lipoprotein receptor 1 and toll-like 4 receptor. Autophagy. vol 5. issue 7. 2010-01-04. PMID:19730000. |
we concluded that ck(-) granulosa cells are protected against oxldl-dependent apoptosis by tlr4, whereas, in ck(+) cells, oxldl-induced tlr4 activation triggers nonapoptotic cell death. |
2010-01-04 |
2023-08-12 |
Not clear |
| You-En Zhang, Jia-Ning Wang, Jun-Ming Tang, Ling-Yun Guo, Jian-Ye Yang, Yong-Zhang Huang, Yan Tan, Shou-Zhi Fu, Xia Kong, Fei Zhen. In vivo protein transduction: delivery of PEP-1-SOD1 fusion protein into myocardium efficiently protects against ischemic insult. Molecules and cells. vol 27. issue 2. 2009-06-02. PMID:19277497. |
when injected into sprague-dawley rat tail veins, the pep-1- sod1 fusion protein significantly attenuated myocardial ischemia-reperfusion damage; characterized by improving cardiac function of the left ventricle, decreasing infarct size, reducing the level of malondialdehyde (mda), decreasing the release of creatine kinase (ck) and lactate dehydrogenase (ldh), and relieving cardiomyocyte apoptosis. |
2009-06-02 |
2023-08-12 |
rat |
| D G Kiebac. Adenovirus-mediated thymidine kinase gene therapy induces apoptosis in human epithelial ovarian cancer cells and damages PARP-1. In vivo (Athens, Greece). vol 23. issue 1. 2009-05-05. PMID:19368128. |
apoptosis induction was established in this investigation as the mechanism of the adv-rsv-tk gene therapy effect of acyclovir administration by caspase activity and subsequent ck 18 cleavage. |
2009-05-05 |
2023-08-12 |
human |
| Irmgard Riedmaier, Ales Tichopad, Martina Reiter, Michael W Pfaffl, Heinrich H D Meye. Identification of potential gene expression biomarkers for the surveillance of anabolic agents in bovine blood cells. Analytica chimica acta. vol 638. issue 1. 2009-04-24. PMID:19298887. |
it could be demonstrated that the combination of trenbolone acetate plus estradiol significantly influences mrna expression of the steroid receptors (er-alpha and gr-alpha), the apoptosis regulator fas, the proinflammatory interleukins il-1alpha, il-1beta and il-6 and of mhcii, ck, mtpn, rbm5 and actin-beta. |
2009-04-24 |
2023-08-12 |
cattle |
| Liu-Yi Dong, Zhi-Wu Chen, Yan Guo, Xin-Ping Cheng, Xu Sha. Mechanisms of vitexin preconditioning effects on cultured neonatal rat cardiomyocytes with anoxia and reoxygenation. The American journal of Chinese medicine. vol 36. issue 2. 2008-09-03. PMID:18457368. |
these results suggest that vitexin preconditioning has a protective effect on cardiomyocytes a/r injury through the improvement of cell viability, decrease of ldh and ck release, such that the protective mechanism may relate to its ability to inhibit the cardiomyocytes apoptosis, reduce the cardiomyocytes calcium overload and increase the abundance of phosphor-erk1/2 of the cardiomyocytes after anoxia and reoxygenation. |
2008-09-03 |
2023-08-12 |
rat |
| Tomoya Ishii, Shuji Bandoh, Jiro Fujita, Yuji Ohtsuki, Yasunori Tojo, Nobuhiro Kanaji, Yoko Fukunaga, Yutaka Ueda, Toshihiko Ishida, Akihito Kub. Full-length cytokeratin 8 is released and circulates in patients with non-small cell lung cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 29. issue 1. 2008-06-06. PMID:18497550. |
while apoptosis is a mechanism of ck release, the molecular nature of circulating cks is poorly understood. |
2008-06-06 |
2023-08-12 |
Not clear |
| Holger Lenz, Melanie Schmidt, Vivienne Welge, Thomas Kueper, Uwe Schlattner, Theo Wallimann, Hans-Peter Elsässer, Klaus-Peter Wittern, Horst Wenck, Franz Staeb, Thomas Blat. Inhibition of cytosolic and mitochondrial creatine kinase by siRNA in HaCaT- and HeLaS3-cells affects cell viability and mitochondrial morphology. Molecular and cellular biochemistry. vol 306. issue 1-2. 2008-01-29. PMID:17660950. |
only for the rate of apoptosis, it was the least expressed ck present in each of the cell lines whose inhibition led to the highest proportion of apoptotic cells, i.e., downregulation of umi-ck in case of helas3 and bb-ck in case of hacat cells. |
2008-01-29 |
2023-08-12 |
human |
| Jhy-Chong Liang, Hen-Rong Chen, Chaw-Chi Chiu, Shu-Fen Liou, Ing-Jun Chen, Jwu-Lai Ye. Protective effect of labedipinedilol-A, a novel dihydropyridine-type calcium channel blocker, on myocardial apoptosis in ischemia-reperfusion injury. Life sciences. vol 79. issue 13. 2006-09-28. PMID:16647091. |
in the vehicle group, myocardial ischemia-reperfusion induced creatine kinase (ck) release and caused cardiomyocyte apoptosis, as evidenced by dna ladder formation and terminal dutp deoxynucleotidyltransferase nick end-labeling (tunel) staining. |
2006-09-28 |
2023-08-12 |
rat |
| Haluk Ince, Eyup Kandemir, Cahit Bagci, Mukaddes Gulec, Omer Akyo. The effect of caffeic acid phenethyl ester on short-term acute myocardial ischemia. Medical science monitor : international medical journal of experimental and clinical research. vol 12. issue 5. 2006-09-08. PMID:16641873. |
we previously showed that caffeic acid phenethyl ester (cape) attenuated no production, reduced apoptosis, diminished serum ck and ast activities, and is cardio-protective in rat heart subjected to ischemia/reperfusion (i/r). |
2006-09-08 |
2023-08-12 |
rat |
| Xiaotian Chang, Jinxiang Ha. Expression of peptidylarginine deiminase type 4 (PAD4) in various tumors. Molecular carcinogenesis. vol 45. issue 3. 2006-06-06. PMID:16355400. |
the results further confirm the expression of pad4 in the tumors and support that pad4 may contribute to the disrupted apoptosis of tumors by caspase-mediated cleavage of ck. |
2006-06-06 |
2023-08-12 |
Not clear |
| Kerim Cagli, Cahit Bagci, Mukaddes Gulec, Beyhan Cengiz, Omer Akyol, Ibrahim Sari, Sevgi Cavdar, Sadrettin Pence, Hakan Dincka. In vivo effects of caffeic acid phenethyl ester on myocardial ischemia-reperfusion injury and apoptotic changes in rats. Annals of clinical and laboratory science. vol 35. issue 4. 2006-02-14. PMID:16254262. |
i/r resulted in myocardial apoptosis, alterations of antioxidant status, elevation of serum creatine kinase (ck) and aspartate aminotransferase (ast) activities, evidence of lipid peroxidation, and elevated nitric oxide levels, compared to the sham-operation group. |
2006-02-14 |
2023-08-12 |
rat |
| Kerim Cagli, Cahit Bagci, Mukaddes Gulec, Beyhan Cengiz, Omer Akyol, Ibrahim Sari, Sevgi Cavdar, Sadrettin Pence, Hakan Dincka. In vivo effects of caffeic acid phenethyl ester on myocardial ischemia-reperfusion injury and apoptotic changes in rats. Annals of clinical and laboratory science. vol 35. issue 4. 2006-02-14. PMID:16254262. |
the i/r+cape group showed reduced apoptosis, attenuated no production, elevated myocardial superoxide dismutase (sod) activity, and diminished serum ck and ast activities, compared to the i/r group. |
2006-02-14 |
2023-08-12 |
rat |
| Keiichi Iwaya, Kiyoshi Muka. Accumulation of ubiquitin-conjugated cytokeratin fragments in tumor cells. Seminars in cancer biology. vol 15. issue 4. 2005-10-13. PMID:15907383. |
modified ck also deregulates mechanisms of mitosis and apoptosis, and leads to immortalization. |
2005-10-13 |
2023-08-12 |
Not clear |
| Tomohiro Shiotani, Satoshi Yamanokuchi, Etsuro Hatano, Iwao Ika. Relocation of truncated bid plays an important role in suppression of tumor necrosis factor alpha induced apoptosis in hepatocytes isolated from transgenic mouse. The Journal of surgical research. vol 127. issue 2. 2005-09-22. PMID:15882876. |
this study sought to clarify the relationship between hepatic energy status and tnfalpha-induced hepatocyte apoptosis, using mice transgenic for creatine kinase (ck) expression. |
2005-09-22 |
2023-08-12 |
mouse |
| Sevil Cayli, Denny Sakkas, Lynne Vigue, Ramazan Demir, Gabor Husza. Cellular maturity and apoptosis in human sperm: creatine kinase, caspase-3 and Bcl-XL levels in mature and diminished maturity sperm. Molecular human reproduction. vol 10. issue 5. 2005-09-16. PMID:15044602. |
we hypothesize that during faulty sperm development, three alternatives may occur: (i) elimination of aberrant germ cells by apoptosis; (ii) in surviving immature cells, caspase-3 is activated, and in response the antiapoptotic bcl-(xl), and perhaps hspa2, provide protection; (iii) in a third type of immature sperm, in addition to the ck, caspase-3 and bcl-(xl) expression, there are related manifestations of increased head size and shorter tail length. |
2005-09-16 |
2023-08-12 |
human |
| Myung-Jin Kim, Koo-Young Lim, Jong-Won Kim, Il-Woo Nam, Jong-Ho Lee, Hoon Myoun. Stage and mRNA expression of survivin in lymph node as prognostic indicators in patients with oral squamous cell carcinoma. Cancer letters. vol 224. issue 2. 2005-07-19. PMID:15914276. |
furthermore, cytokeratin (ck), carcinoembryonic antigen (cea), and recently documented apoptosis related protein, survivin, were analyzed by rt-pcr. |
2005-07-19 |
2023-08-12 |
Not clear |
| José Palacios, Emiliano Honrado, Ana Osorio, Alicia Cazorla, David Sarrió, Alicia Barroso, Sandra Rodríguez, Juan C Cigudosa, Orland Diez, Carmen Alonso, Enrique Lerma, Joaquín Dopazo, Carmen Rivas, Javier Beníte. Phenotypic characterization of BRCA1 and BRCA2 tumors based in a tissue microarray study with 37 immunohistochemical markers. Breast cancer research and treatment. vol 90. issue 1. 2005-05-19. PMID:15770521. |
markers analyzed included, amog others, common markers in breast cancer, such as hormone receptors, p53 and her2, along with 15 molecules involved in cell cycle regulation, such as cyclins, cyclin dependent kinases (cdk) and cdk inhibitors (cdki), apoptosis markers, such as bcl2 and active caspase 3, and two basal/myoepithelial markers (ck 5/6 and p-cadherin). |
2005-05-19 |
2023-08-12 |
Not clear |