| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhiyun Yu, Guifang Xie, Guangtong Zhou, Ye Cheng, Guangtao Zhang, Guangming Yao, Yong Chen, Yunqian Li, Gang Zha. NVP-BEZ235, a novel dual PI3K-mTOR inhibitor displays anti-glioma activity and reduces chemoresistance to temozolomide in human glioma cells. Cancer letters. vol 367. issue 1. 2015-10-21. PMID:26188279. |
combination treatment with both tmz and nvp-bez235 resulted in synergistically inhibited glioma cell growth and induced apoptosis (combination index ci<1) in a subset of glioma cell lines, as shown in the increased levels of bax, and active caspase-3, and decreased level of bcl-2. |
2015-10-21 |
2023-08-13 |
mouse |
| Xu Chen, Jing-Xiang Wu, Xing-Ji You, Hong-Wei Zhu, Jiong-Lin Wei, Mei-Ying X. Cold ischemia-induced autophagy in rat lung tissue. Molecular medicine reports. vol 11. issue 4. 2015-09-16. PMID:25435100. |
in the present study, ci preservation‑induced autophagy and apoptosis was investigated in the lungs of sprague dawley rats. |
2015-09-16 |
2023-08-13 |
rat |
| Xu Chen, Jing-Xiang Wu, Xing-Ji You, Hong-Wei Zhu, Jiong-Lin Wei, Mei-Ying X. Cold ischemia-induced autophagy in rat lung tissue. Molecular medicine reports. vol 11. issue 4. 2015-09-16. PMID:25435100. |
the levels of autophagy, autophagic cell death and apoptosis were measured at each time point following ci. |
2015-09-16 |
2023-08-13 |
rat |
| Xu Chen, Jing-Xiang Wu, Xing-Ji You, Hong-Wei Zhu, Jiong-Lin Wei, Mei-Ying X. Cold ischemia-induced autophagy in rat lung tissue. Molecular medicine reports. vol 11. issue 4. 2015-09-16. PMID:25435100. |
additionally, a coexistence of autophagic cell death and apoptosis was observed in rat lung tissues following prolonged ci. |
2015-09-16 |
2023-08-13 |
rat |
| Xu Chen, Jing-Xiang Wu, Xing-Ji You, Hong-Wei Zhu, Jiong-Lin Wei, Mei-Ying X. Cold ischemia-induced autophagy in rat lung tissue. Molecular medicine reports. vol 11. issue 4. 2015-09-16. PMID:25435100. |
furthermore, autophagic cell death in addition to necrosis and apoptosis occurs following ci in the lung. |
2015-09-16 |
2023-08-13 |
rat |
| Brittany A Potz, Ashraf A Sabe, Nassrene Y Elmadhun, Jun Feng, Yuhong Liu, Hunter Mitchell, Peter Quesenberry, M Ruhul Abid, Frank W Sellk. Calpain inhibition decreases myocardial apoptosis in a swine model of chronic myocardial ischemia. Surgery. vol 158. issue 2. 2015-09-14. PMID:25991048. |
in this study, we hypothesized that ci (by mld28170) would decrease myocardial apoptosis in the same model. |
2015-09-14 |
2023-08-13 |
Not clear |
| Angelika Stehle, Manuela Hugle, Simone Fuld. Eribulin synergizes with Polo-like kinase 1 inhibitors to induce apoptosis in rhabdomyosarcoma. Cancer letters. vol 365. issue 1. 2015-08-24. PMID:25917079. |
eribulin and the plk1 inhibitor bi 2536 at subtoxic concentrations synergize to induce apoptosis in rms cells as confirmed by calculation of combination index (ci). |
2015-08-24 |
2023-08-13 |
Not clear |
| Manuela Hugle, Simone Fuld. Dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 synergizes with chloroquine to induce apoptosis in embryonal rhabdomyosarcoma. Cancer letters. vol 360. issue 1. 2015-07-10. PMID:25637161. |
bez235 and cq at subtoxic concentrations synergize to induce apoptosis in erms cells, as confirmed by calculation of combination index (ci). |
2015-07-10 |
2023-08-13 |
Not clear |
| Hui Zou, Liling Zhuo, Tao Han, Di Hu, Xiaokang Yang, Yi Wang, Yan Yuan, Jianhong Gu, Jianchun Bian, Xuezhong Liu, Zongping Li. Autophagy and gap junctional intercellular communication inhibition are involved in cadmium-induced apoptosis in rat liver cells. Biochemical and biophysical research communications. vol 459. issue 4. 2015-06-05. PMID:25778869. |
in this study, cd-induced apoptosis was demonstrated in rat liver cells (brl 3a) with apoptotic nuclear morphological changes and a decrease in cell index (ci) in a time- and concentration-dependent manner. |
2015-06-05 |
2023-08-13 |
rat |
| Allison S Betof, Christopher D Lascola, Douglas Weitzel, Chelsea Landon, Peter M Scarbrough, Gayathri R Devi, Gregory Palmer, Lee W Jones, Mark W Dewhirs. Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise. Journal of the National Cancer Institute. vol 107. issue 5. 2015-04-27. PMID:25780062. |
exercise statistically significantly reduced tumor growth and was associated with a 1.4-fold increase in apoptosis (sedentary vs exercise: 1544 cells/mm(2), 95% ci = 1223 to 1865 vs 2168 cells/mm(2), 95% ci = 1620 to 2717; p = .048), increased microvessel density (p = .004), vessel maturity (p = .006) and perfusion, and reduced intratumoral hypoxia (p = .012), compared with sedentary controls. |
2015-04-27 |
2023-08-13 |
mouse |
| M Chakrabarti, N L Banik, S K Ra. MiR-7-1 potentiated estrogen receptor agonists for functional neuroprotection in VSC4.1 motoneurons. Neuroscience. vol 256. 2014-08-27. PMID:24157932. |
we tested whether neuroprotective micrornas (mirs) like mir-206, mir-17, mir-21, mir-7-1, and mir-106a could enhance efficacy of estrogen receptor (er) agonists such as 1,3,5-tris (4-hydroxyphenyl)-4-propyl-1h-pyrazole (ppt, erα agonist), way200070 (way, erβ agonist), and estrogen (est, erα and erβ agonist) in preventing apoptosis in the calcium ionophore (ci)-insulted ventral spinal cord 4.1 (vsc4.1) motoneurons. |
2014-08-27 |
2023-08-12 |
Not clear |
| Uksha Saini, Richard J Gumina, Brian Wolfe, M Lakshmi Kuppusamy, Periannan Kuppusamy, Konstantinos Dean Boudoula. Preconditioning mesenchymal stem cells with caspase inhibition and hyperoxia prior to hypoxia exposure increases cell proliferation. Journal of cellular biochemistry. vol 114. issue 11. 2014-04-07. PMID:23794477. |
mscs preconditioned with hyperoxia or ci significantly decreased apoptosis as suggested by tunel assay and annexin v analysis using fluorescence assisted cell sorting. |
2014-04-07 |
2023-08-12 |
Not clear |
| Federica Valsecchi, Sander Grefte, Peggy Roestenberg, Jori Joosten-Wagenaars, Jan A M Smeitink, Peter H G M Willems, Werner J H Koopma. Primary fibroblasts of NDUFS4(-/-) mice display increased ROS levels and aberrant mitochondrial morphology. Mitochondrion. vol 13. issue 5. 2014-03-10. PMID:23234723. |
ndufs4(-/-) fibroblasts displayed an inactive ci subcomplex on native gels but proliferated normally and showed no obvious signs of apoptosis. |
2014-03-10 |
2023-08-12 |
mouse |
| Misun Park, Stephen F Vatner, Lin Yan, Shumin Gao, Seunghun Yoon, Grace Jung Ah Lee, Lai-Hua Xie, Richard N Kitsis, Dorothy E Vatne. Novel mechanisms for caspase inhibition protecting cardiac function with chronic pressure overload. Basic research in cardiology. vol 108. issue 1. 2013-08-05. PMID:23277091. |
tac increased apoptosis in non-myocytes more than in myocytes and these increases were blunted more in non-myocytes by ci. |
2013-08-05 |
2023-08-12 |
mouse |
| Misun Park, Stephen F Vatner, Lin Yan, Shumin Gao, Seunghun Yoon, Grace Jung Ah Lee, Lai-Hua Xie, Richard N Kitsis, Dorothy E Vatne. Novel mechanisms for caspase inhibition protecting cardiac function with chronic pressure overload. Basic research in cardiology. vol 108. issue 1. 2013-08-05. PMID:23277091. |
since changes in myocyte numbers did not account for protection from tac, several other ci-mediated mechanisms were identified including: (a) lessening of tac-induced fibrosis, (b) augmentation of isolated myocyte contractility, and (c) increased angiogenesis and ki67-positive myocytes, which were due almost entirely to the non-myocyte apoptosis, but not myocyte apoptosis, with ci. |
2013-08-05 |
2023-08-12 |
mouse |
| E Giovannetti, M Labots, H Dekker, E Galvani, J S W Lind, R Sciarrillo, R Honeywell, E F Smit, H M Verheul, G J Peter. Molecular mechanisms and modulation of key pathways underlying the synergistic interaction of sorafenib with erlotinib in non-small-cell-lung cancer (NSCLC) cells. Current pharmaceutical design. vol 19. issue 5. 2013-07-22. PMID:22973961. |
pharmacologic interaction was studied using mtt/srb assays and the combination index (ci) method, while effects on egfr, erk1/2 and akt phosphorylation, cell cycle and apoptosis were studied with western-blot, elisa, and flow cytometry. |
2013-07-22 |
2023-08-12 |
Not clear |
| Christian Seitz, Manuela Hugle, Silvia Cristofanon, Aurélie Tchoghandjian, Simone Fuld. The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosis via mitochondrial-lysosomal cross-talk. International journal of cancer. vol 132. issue 11. 2013-05-28. PMID:23151917. |
here, bez235 acts in concert with the lysosomotropic agent chloroquine (cq) to trigger apoptosis in neuroblastoma cells in a synergistic manner, as calculated by combination index (ci < 0.5). |
2013-05-28 |
2023-08-12 |
Not clear |
| Giovanni Musso, Maurizio Cassader, Simona Bo, Franco De Michieli, Roberto Gambin. Sterol regulatory element-binding factor 2 (SREBF-2) predicts 7-year NAFLD incidence and severity of liver disease and lipoprotein and glucose dysmetabolism. Diabetes. vol 62. issue 4. 2013-05-21. PMID:23274901. |
in biopsy-proven nafld patients, srebf-2 predicted nonalcoholic steatohepatitis (odds ratio 2.92 [95% ci 2.08-4.18], p = 0.002) and the severity of tissue insulin resistance, β-cell dysfunction, and oral fat intolerance (characterized by higher postprandial lipemia, cholesterol enrichment of triglyceride-rich lipoproteins and oxidized ldls, hdl cholesterol fall, adipokine imbalance, and postprandial apoptosis activation). |
2013-05-21 |
2023-08-12 |
human |
| Kristin Pietschmann, Hella Anna Bolck, Marc Buchwald, Steffi Spielberg, Harald Polzer, Karsten Spiekermann, Gesine Bug, Thorsten Heinzel, Frank-Dietmar Böhmer, Oliver H Kräme. Breakdown of the FLT3-ITD/STAT5 axis and synergistic apoptosis induction by the histone deacetylase inhibitor panobinostat and FLT3-specific inhibitors. Molecular cancer therapeutics. vol 11. issue 11. 2013-04-23. PMID:22942377. |
median dose-effect analyses of drug-induced apoptosis rates of aml cells (mv4-11 and molm-13) revealed combination index (ci) values indicating strong synergism. |
2013-04-23 |
2023-08-12 |
Not clear |
| Esperanza Bas, Chhavi Gupta, Thomas R Van De Wate. A novel organ of corti explant model for the study of cochlear implantation trauma. Anatomical record (Hoboken, N.J. : 2007). vol 295. issue 11. 2013-04-04. PMID:23044812. |
mechanical trauma from insertion of a ci electrode into the scala tympani can lead to inflammation and a high level of oxidative stress, which can initiate the apoptosis of auditory hcs and intracochlear fibrosis. |
2013-04-04 |
2023-08-12 |
rat |