| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J-H Zhao, B Wang, X-H Wang, J-R Wang, C-W X. Influence of lncRNA ANRIL on neuronal apoptosis in rats with cerebral infarction by regulating the NF-κB signaling pathway. European review for medical and pharmacological sciences. vol 23. issue 22. 2020-10-15. PMID:31799680. |
the aim of this study was to evaluate the influence of long non-coding ribonucleic acid (lncrna) antisense non-coding rna in the ink4 locus (anril) on neuronal apoptosis in rats with cerebral infarction (ci), and to further explore the underlying mechanism of lncrna anril in the occurrence and development of ci. |
2020-10-15 |
2023-08-13 |
rat |
| J-H Zhao, B Wang, X-H Wang, C-W X. Effect of lncRNA GAS5 on the apoptosis of neurons via the notch1 signaling pathway in rats with cerebral infarction. European review for medical and pharmacological sciences. vol 23. issue 22. 2020-10-15. PMID:31799679. |
to observe the effect of long non-coding ribonucleic acid (lncrna) growth arrest specific 5 (gas5) knockdown on the apoptosis of neurons in rats with cerebral infarction (ci), and to explore the potential mechanism of lncrna gas5 in the pathogenesis of ci. |
2020-10-15 |
2023-08-13 |
rat |
| Jianchang Wei, Ping Yang, Wanglin Li, Feng He, Shanqi Zeng, Tong Zhang, Junbin Zhong, Di Huang, Zhuanpeng Chen, Chengxing Wang, Huacui Chen, He Hu, Jie Ca. Gambogic acid potentiates the chemosensitivity of colorectal cancer cells to 5-fluorouracil by inhibiting proliferation and inducing apoptosis. Experimental and therapeutic medicine. vol 13. issue 2. 2020-10-01. PMID:28352348. |
the combination index (ci) was calculated and the median-effect principle was applied to analyze the interaction between 5-fu and ga. flow cytometry was used to determine the percentage of cells undergoing apoptosis. |
2020-10-01 |
2023-08-13 |
human |
| Yinming Wang, Junquan Gu, Linlin Hu, Liang Kong, Tinggang Wang, Meiqi Di, Chaosheng Li, Shuhua Gu. miR-130a alleviates neuronal apoptosis and changes in expression of Bcl-2/Bax and caspase-3 in cerebral infarction rats through PTEN/PI3K/Akt signaling pathway. Experimental and therapeutic medicine. vol 19. issue 3. 2020-09-28. PMID:32104274. |
effect of micro ribonucleic acid (mir)-130a on neuronal apoptosis in rats with cerebral infarction (ci) was studied to explore whether phosphatase and tensin homolog deleted on chromosome ten (pten)/phosphatidylinositol 3-hydroxy kinase (pi3k)/protein kinase b (akt) is involved in the regulation of neuronal apoptosis. |
2020-09-28 |
2023-08-13 |
rat |
| Nasim Manouchehri, Fariba Khodagholi, Leila Dargahi, Abolhassan Ahmadian. Mitochondrial Complex I Is an Essential Player in LPS-Induced Preconditioning in Differentiated PC12 Cells. Iranian journal of pharmaceutical research : IJPR. vol 18. issue 3. 2020-09-28. PMID:32641953. |
taken together, cell survival and reduction of apoptosis followed by pc can be at least partially attributed to the preservation of mitochondrial ci function. |
2020-09-28 |
2023-08-13 |
Not clear |
| W Liao, Y Zhong, W Cheng, L-F Don. 3-N-butylphthalide inhibits neuronal apoptosis in rats with cerebral infarction via targeting P38/MAPK. European review for medical and pharmacological sciences. vol 23. issue 3 Suppl. 2020-09-04. PMID:31389585. |
to study the effect of 3-n-butylphthalide (nbp) on neuronal apoptosis in rats with cerebral infarction (ci) through the p38/mitogen-activated protein kinase (mapk) pathway. |
2020-09-04 |
2023-08-13 |
rat |
| X-D Pan, X-L Chen, S-F Ding, D Kou, H-L Hu, L L. Promethazine inhibits neuronal apoptosis via PI3K/Akt signaling pathway in rats with cerebral infarction. European review for medical and pharmacological sciences. vol 23. issue 3 Suppl. 2020-09-04. PMID:31389591. |
to study the effect of promethazine on neuronal apoptosis in rats with cerebral infarction (ci) through the phosphatidylinositol 3-hydroxy kinase/protein kinase b (pi3k/akt) signaling pathway. |
2020-09-04 |
2023-08-13 |
rat |
| Xingan Wang, Michael Emmet O'Brien, Junyi Yu, Che Xu, Qiang Zhang, Songjian Lu, Lifan Liang, Xiaojing An, John F McDyer, Rama K Mallampall. Prolonged Cold Ischemia Induces Necroptotic Cell Death in Ischemia-Reperfusion Injury and Contributes to Primary Graft Dysfunction after Lung Transplantation. American journal of respiratory cell and molecular biology. vol 61. issue 2. 2020-04-06. PMID:30742487. |
extension of ci time to 96 hours led to increased cellular infiltration and necroptotic pathway activation, without evidence of apoptosis, after 24-hour reperfusion. |
2020-04-06 |
2023-08-13 |
mouse |
| Myrto Denaxa, Guilherme Neves, Adam Rabinowitz, Sarah Kemlo, Petros Liodis, Juan Burrone, Vassilis Pachni. Modulation of Apoptosis Controls Inhibitory Interneuron Number in the Cortex. Cell reports. vol 22. issue 7. 2019-06-04. PMID:29444425. |
here, we provide evidence that the extent of ci apoptosis during this critical period is plastic and cell-type specific and can be reduced in a cell-autonomous manner by acute increases in neuronal activity. |
2019-06-04 |
2023-08-13 |
Not clear |
| Wen-Ying Shi, Jie Yan, Xiao-Rong Chang, Bi-Dan Lou, Jin-Xiang Li, Jie Huang, Hua Lin, Chao Wang, Wei Zhan. [Observation of electroacupuncture intervention on cell apoptosis and Bax and Bcl-2 expression in cerebral and myocardial tissues in cerebral ischemia rats based on "heart-brain correlation" theory]. Zhen ci yan jiu = Acupuncture research. vol 44. issue 2. 2019-04-25. PMID:30945486. |
to compare the effect of electroacupuncture (ea) of "neiguan" (pc6) of the pericardium meridian, "shenmen" (ht7) of the heart meridian，"shuigou" (gv26) of the governor vessel and "zhaohai" (ki6) of the kidney meridian on myocardial and cerebral cell apoptosis in cerebral ischemia (ci) rats, so as to explore its mechanism underlying improvement of ci based on the theory of "heart-brain correlation". |
2019-04-25 |
2023-08-13 |
rat |
| Ting Song, Minhang Zhang, Peng Liu, Zhenyu Xue, Yudan Fan, Zhichao Zhan. Identification of JNK1 as a predicting biomarker for ABT-199 and paclitaxel combination treatment. Biochemical pharmacology. vol 155. 2019-04-04. PMID:29953843. |
combination index (ci) assay showed that four of nine call lines exhibited synergistic respond to abt-199/paclitaxel combination due to enhanced intrinsic apoptosis. |
2019-04-04 |
2023-08-13 |
Not clear |
| Manuel Soliño, Ignacio M Larrayoz, Ester M López, Marina Vacotto, Noelí Martignone, Manuel Rey-Funes, Alfredo Martínez, Elena Girardi, Juan J López-Cost. The expression of adenosine receptors changes throughout light induced retinal degeneration in the rat. Neuroscience letters. vol 687. 2019-03-07. PMID:30291879. |
the observed up-regulation of a1r after 1 day of ci, corresponds with the peak of oxidative stress; while the rise of a2ar at day 2 of ci, coincides with the massive apoptosis of photoreceptors. |
2019-03-07 |
2023-08-13 |
rat |
| Mei-Rong Lv, Bin Li, Ming-Guang Wang, Fan-Guo Meng, Jian-Jun Yu, Feng Guo, Ye L. Activation of the PI3K-Akt pathway promotes neuroprotection of the δ-opioid receptor agonist against cerebral ischemia-reperfusion injury in rat models. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 93. 2018-04-24. PMID:28645007. |
the cerebral infarction (ci) volume and nerve cell apoptosis was determined using ttc and tunel staining. |
2018-04-24 |
2023-08-13 |
rat |
| Mei-Rong Lv, Bin Li, Ming-Guang Wang, Fan-Guo Meng, Jian-Jun Yu, Feng Guo, Ye L. Activation of the PI3K-Akt pathway promotes neuroprotection of the δ-opioid receptor agonist against cerebral ischemia-reperfusion injury in rat models. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 93. 2018-04-24. PMID:28645007. |
the mcao group showed higher ci volume, nerve cell apoptosis and cleaved caspase-3 expressions than the dadle and dmso groups, which were also higher in the ly294002 group than the dadle group. |
2018-04-24 |
2023-08-13 |
rat |
| Cristina Florean, Michael Schnekenburger, Jin-Young Lee, Kyung Rok Kim, Aloran Mazumder, Sungmi Song, Jae-Myun Kim, Cindy Grandjenette, Jeoung-Gyun Kim, Ah-Young Yoon, Mario Dicato, Kyu-Won Kim, Christo Christov, Byung-Woo Han, Peter Proksch, Marc Diederic. Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells. Oncotarget. vol 7. issue 17. 2018-02-23. PMID:27006469. |
furthermore, iso-3 strongly synergized with tumor-necrosis-factor related apoptosis inducing ligand (trail) in raji [combination index (ci) = 0.22] and u-937 cells (ci = 0.21) and increased trail-induced apoptosis via a mechanism involving reduction of survivin expression but not of bcl-2 family proteins nor x-linked inhibitor of apoptosis protein (xiap). |
2018-02-23 |
2023-08-13 |
zebrafish |
| Xiaogang Zheng, Xiaodong Jin, Feifei Li, Xiongxiong Liu, Yan Liu, Fei Ye, Ping Li, Ting Zhao, Qiang L. Inhibiting autophagy with chloroquine enhances the anti-tumor effect of high-LET carbon ions via ER stress-related apoptosis. Medical oncology (Northwood, London, England). vol 34. issue 2. 2017-03-08. PMID:28070729. |
in this work, we studied the impact of autophagy and apoptosis induced by er stress following high-let ci radiation on the radiosensitivity of s180 cells both in vitro and in vivo. |
2017-03-08 |
2023-08-13 |
Not clear |
| Xiaogang Zheng, Xiaodong Jin, Feifei Li, Xiongxiong Liu, Yan Liu, Fei Ye, Ping Li, Ting Zhao, Qiang L. Inhibiting autophagy with chloroquine enhances the anti-tumor effect of high-LET carbon ions via ER stress-related apoptosis. Medical oncology (Northwood, London, England). vol 34. issue 2. 2017-03-08. PMID:28070729. |
thus, our study indicates that inhibiting autophagy might be a promising therapeutic strategy in ci radiotherapy via aggravating the er stress-related apoptosis. |
2017-03-08 |
2023-08-13 |
Not clear |
| Mrinmay Chakrabarti, Swapan K Ra. Experimental Procedures for Demonstration of MicroRNA Mediated Enhancement of Functional Neuroprotective Effects of Estrogen Receptor Agonists. Methods in molecular biology (Clifton, N.J.). vol 1366. 2016-08-29. PMID:26585150. |
the protocols described herein demonstrate that mir-7-1, a neuroprotective mir, can enhance the functional neuroprotective effects of estrogen receptor agonists such as 1,3,5-tris(4-hydroxyphenyl)-4-propyl-1h-pyrazole (ppt), way 200070 (way), and estrogen (e2) in preventing apoptosis in a23187 calcium ionophore (ci) exposed vsc4.1 motoneurons. |
2016-08-29 |
2023-08-13 |
Not clear |
| Concetta Paola Ilisso, Maria Castellano, Silvia Zappavigna, Angela Lombardi, Giovanni Vitale, Alessandra Dicitore, Giovanna Cacciapuoti, Michele Caraglia, Marina Porcell. The methyl donor S-adenosylmethionine potentiates doxorubicin effects on apoptosis of hormone-dependent breast cancer cell lines. Endocrine. vol 50. issue 1. 2016-06-20. PMID:25577236. |
for the evaluation of synergism, we have calculated the combination index (ci) by the calcusyn software and we have evaluated the effects of the combination on apoptosis occurrence at facs analysis in hormone-dependent cg5 cell line. |
2016-06-20 |
2023-08-13 |
human |
| Khairunnisa' Md Yusof, Suzana Makpol, Rahman Jamal, Roslan Harun, Norfilza Mokhtar, Wan Zurinah Wan Nga. γ-Tocotrienol and 6-Gingerol in Combination Synergistically Induce Cytotoxicity and Apoptosis in HT-29 and SW837 Human Colorectal Cancer Cells. Molecules (Basel, Switzerland). vol 20. issue 6. 2016-02-19. PMID:26046324. |
these bioactives in combination showed synergistic effect on ht-29 (ci: 0.89 ± 0.02,) and sw837 (ci: 0.79 ± 0.10) apoptosis was increased by 21.2% in ht-29 and 55.4% in sw837 (p < 0.05) after 24 h treatment, while normal hepatic wrl-68 cells were unaffected. |
2016-02-19 |
2023-08-13 |
human |