| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X-P Cui, J-X Ye, H Lin, H Zhou, S Ye, J-S M. Effects of edaravone combined with Oxiracetam on neuronal apoptosis in rats with cerebral infarction through targeting SIRT1/NF-κB inflammatory pathway. European review for medical and pharmacological sciences. vol 26. issue 1. 2022-01-20. PMID:35048998. |
the objective of this study was to investigate the effects of edaravone combined with oxiracetam on neuronal apoptosis in rats with cerebral infarction (ci) and to explore the potential molecular mechanism. |
2022-01-20 |
2023-08-13 |
rat |
| Elisabete Lima, Jorge Medeiro. Marine Organisms as Alkaloid Biosynthesizers of Potential Anti-Alzheimer Agents. Marine drugs. vol 20. issue 1. 2022-01-20. PMID:35049930. |
as the major clinical indications (ci) of ad are extracellular plaques formed by β-amyloid (aβ) protein, intracellular neurofibrillary tangles (nfts) formed by hyper phosphorylated τ-protein, uncommon inflammatory response and neuron apoptosis and death caused by oxidative stress, alkaloids that may decrease ci, might be used against ad. |
2022-01-20 |
2023-08-13 |
Not clear |
| David F Fiorentino, Christopher A Mecoli, Matthew C Rosen, Lorinda S Chung, Lisa Christopher-Stine, Antony Rosen, Livia Casciola-Rose. Immune responses to CCAR1 and other dermatomyositis autoantigens are associated with attenuated cancer emergence. The Journal of clinical investigation. vol 132. issue 2. 2022-01-18. PMID:35040440. |
autoantibodies recognizing cell division cycle and apoptosis regulator protein 1 (ccar1) were the most frequent, and were significantly negatively associated with contemporaneous cancer (discovery cohort or 0.27 [95% ci 0.7-1.00], p = 0.050; validation cohort or 0.13 [95% ci 0.03-0.59], p = 0.008). |
2022-01-18 |
2023-08-13 |
Not clear |
| Atousa Janzadeh, Michael R Hamblin, Narges Janzadeh, Hossein Arzani, MahsaTashakori-Miyanroudi, Mahmoud Yousefifard, Fatemeh Ramezan. The Toxic Effect of Silver Nanoparticles on Nerve Cells: A Systematic Review and Meta-Analysis. Reviews of environmental contamination and toxicology. vol 257. 2021-11-19. PMID:34622369. |
measurement of apoptosis (smd = 2.21; 95% ci: 1.62 to 2.80; p=0.001) and lactate dehydrogenase release rate (smd = 0.9; 95% ci: 0.33 to 1.47; p < 0.0001) also confirmed the destructive effect of silver nanoparticles on nerve cells. |
2021-11-19 |
2023-08-13 |
Not clear |
| Yu-Ning Teng, Bo-Hau Huang, Shih-Ya Huang, I-Ting Wu, Tian-Shung Wu, Tsui-Er Lee, Chin-Chuan Hun. Cinnamophilin overcomes cancer multi-drug resistance via allosterically modulating human P-glycoprotein on both drug binding sites and ATPase binding sites. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 144. 2021-11-19. PMID:34794239. |
the cancer mdr-reversing ability and mechanisms were analyzed through cytotoxicity and combination index (ci), cell cycle, and apoptosis experiments. |
2021-11-19 |
2023-08-13 |
human |
| Ying Shangguan, Jianghong Han, Haisheng S. GAS5 knockdown ameliorates apoptosis and inflammatory response by modulating miR-26b-5p/Smad1 axis in cerebral ischaemia/reperfusion injury. Behavioural brain research. vol 379. 2021-05-03. PMID:31751592. |
besides, knockdown of gas5 by sirna (si-gas5) reversed ci / r-induced apoptosis and inflammatory responses. |
2021-05-03 |
2023-08-13 |
rat |
| Ying Shangguan, Jianghong Han, Haisheng S. GAS5 knockdown ameliorates apoptosis and inflammatory response by modulating miR-26b-5p/Smad1 axis in cerebral ischaemia/reperfusion injury. Behavioural brain research. vol 379. 2021-05-03. PMID:31751592. |
in addition, mir-26b-5p overexpression reversed ci / r-induced apoptosis and inflammatory responses, whereas low expression of mir-26b-5p had the opposite effect. |
2021-05-03 |
2023-08-13 |
rat |
| Ying Shangguan, Jianghong Han, Haisheng S. GAS5 knockdown ameliorates apoptosis and inflammatory response by modulating miR-26b-5p/Smad1 axis in cerebral ischaemia/reperfusion injury. Behavioural brain research. vol 379. 2021-05-03. PMID:31751592. |
conversely, smad1 overexpression reversed the inhibitory effect of mir-26b-5p on ci / r-induced apoptosis and inflammatory responses in rats. |
2021-05-03 |
2023-08-13 |
rat |
| Ying Shangguan, Jianghong Han, Haisheng S. GAS5 knockdown ameliorates apoptosis and inflammatory response by modulating miR-26b-5p/Smad1 axis in cerebral ischaemia/reperfusion injury. Behavioural brain research. vol 379. 2021-05-03. PMID:31751592. |
collectively, these results indicate that gas5 knockdown can improve apoptosis and inflammatory responses by modulating the mir-26b-5p / smad1 axis in ci / r rats. |
2021-05-03 |
2023-08-13 |
rat |
| Gongshen Jin, Kangwei Wang, Yonghong Liu, Xianhu Liu, Xiaojing Zhang, Hao Zhan. Proteomic Level Changes on Treatment in MCF-7/DDP Breast Cancer Drug- Resistant Cells. Anti-cancer agents in medicinal chemistry. vol 20. issue 6. 2021-05-03. PMID:32053082. |
however, when lcl161 is used in combination with caspase inhibitors (ci), its capacity to induce apoptosis of breast cancer cells is enhanced. |
2021-05-03 |
2023-08-13 |
Not clear |
| Jana Koch, Dina Mönch, Annika Maaß, Christian Gromoll, Thomas Hehr, Tobias Leibold, Hans J Schlitt, Marc-H Dahlke, Philipp Renne. Three dimensional cultivation increases chemo- and radioresistance of colorectal cancer cell lines. PloS one. vol 16. issue 1. 2021-04-23. PMID:33395433. |
after irradiation with 10 gy, annexin v/pi staining revealed a 1.8- to 4-fold increase in the apoptosis rate in the 2d cell cultures (95% ci 3.24±0.96), and a 1.5- to 2.4-fold increase in the 3d spheroids (95% ci 1.56±0.41). |
2021-04-23 |
2023-08-13 |
human |
| Anna Dietz, Nahide Dalda, Svenja Zielke, Jessica Dittmann, Sjoerd J L van Wijk, Meike Vogler, Simone Fuld. Proteasome inhibitors and Smac mimetics cooperate to induce cell death in diffuse large B-cell lymphoma by stabilizing NOXA and triggering mitochondrial apoptosis. International journal of cancer. vol 147. issue 5. 2021-04-02. PMID:32170726. |
we show a synergistic decrease in cell viability and induction of apoptosis by bv6/carfilzomib (cfz) treatment, which was confirmed by calculation of combination index (ci) and bliss score. |
2021-04-02 |
2023-08-13 |
Not clear |
| Jiacheng Wang, Wenshu Qiao, Xu Li, Haitian Zhao, Hua Zhang, Aijun Dong, Xin Yan. A directed co-assembly of herbal small molecules into carrier-free nanodrugs for enhanced synergistic antitumor efficacy. Journal of materials chemistry. B. vol 9. issue 4. 2021-04-01. PMID:33392615. |
not only do co-assembled nps have rapid cellular uptake ability and passive targeting tumor ability based on the epr effect, but also their constituent units could arrest the cell cycle at different stages of tumor cells and induce apoptosis, showing synergistic anti-tumor effects (ci < 0.7). |
2021-04-01 |
2023-08-13 |
Not clear |
| Y-L Jiang, W-W Liu, Y Wang, W-Y Yan. MiR-210 suppresses neuronal apoptosis in rats with cerebral infarction through regulating VEGF-notch signaling pathway. European review for medical and pharmacological sciences. vol 24. issue 9. 2021-03-31. PMID:32432760. |
the aim of this study was to explore the effect of micro ribonucleic acid (mir)-210 on neuronal apoptosis in rats with cerebral infarction (ci) by regulating the vascular endothelial growth factor (vegf)-notch signaling pathway. |
2021-03-31 |
2023-08-13 |
rat |
| Yu Wang, Yajun Shi, Junbo Zou, Xiaofei Zhang, Mei Wang, Dongyan Guo, Guiyuan Lv, Jie Su, Ting Wan. The intranasal administration of Carthamus tinctorius L. extract/phospholipid complex in the treatment of cerebral infarction via the TNF-α/MAPK pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 130. 2021-02-15. PMID:32745908. |
the therapeutic effect of es and espc on ci acts by improving the circulation of blood in the central nervous system, reducing the inflammatory reaction, inhibiting apoptosis, and by protecting brain nerve cells from injury. |
2021-02-15 |
2023-08-13 |
rat |
| Y-X Xie, M Zhang, C-R Zhang, F Che. Relationship between NogoA/NgR1/RhoA signaling pathway and the apoptosis of cerebral neurons after cerebral infarction in rats. European review for medical and pharmacological sciences. vol 24. issue 1. 2021-01-01. PMID:31957843. |
the aim of this study was to investigate the effect and the mechanism of the nogoa/ngr1/rhoa signaling pathway on the apoptosis of neurons in cerebral infarction (ci) rats. |
2021-01-01 |
2023-08-13 |
rat |
| Wei Guo, Yuanyuan Song, Wantong Song, Yingmin Liu, Zhihe Liu, Dawei Zhang, Zhaohui Tang, Ou Ba. Co-delivery of Doxorubicin and Curcumin with Polypeptide Nanocarrier for Synergistic Lymphoma Therapy. Scientific reports. vol 10. issue 1. 2020-11-30. PMID:32398729. |
l-dox + cur increased cytotoxicity, induced higher rates of apoptosis, and had synergistic effect, especially in bjab cells (min ci 0.019). |
2020-11-30 |
2023-08-13 |
mouse |
| T N Zhao, L D Yuan, L X Chen, Y Yuan, D L Ca. PI3K/Akt and ERK1/2 pathways are responsible for sodium butyrateinduced inhibition of neuronal apoptosis in rats with cerebral infarction. Journal of biological regulators and homeostatic agents. vol 34. issue 3. 2020-11-04. PMID:32752588. |
the aim of this study was to elucidate the neuronal protection effect of sodium butyrate (nab) on neuronal apoptosis in rats with cerebral infarction (ci), and the involvement of the phosphatidilinositol 3-kinase/protein kinase b (pi3k/akt) and extracellular-signal-regulated kinase 1/2 (erk1/2) pathways. |
2020-11-04 |
2023-08-13 |
rat |
| T N Zhao, L D Yuan, L X Chen, Y Yuan, D L Ca. PI3K/Akt and ERK1/2 pathways are responsible for sodium butyrateinduced inhibition of neuronal apoptosis in rats with cerebral infarction. Journal of biological regulators and homeostatic agents. vol 34. issue 3. 2020-11-04. PMID:32752588. |
nab treatment alleviates neuronal apoptosis via the pi3k/akt and erk1/2 pathways in ci rats, thus protecting the deterioration of ci. |
2020-11-04 |
2023-08-13 |
rat |
| Q-Q Che, T Huang, Y-D Zhang, X-J Qia. Effect of miR-124 on neuronal apoptosis in rats with cerebral infarction through Wnt/β-catenin signaling pathway. European review for medical and pharmacological sciences. vol 23. issue 15. 2020-10-15. PMID:31378908. |
the aim of this study was to observe the influence of micro ribonucleic acid (mir)-124 on neuronal apoptosis in rats with cerebral infarction (ci), and to further investigate the underlying mechanism of mir-124 in ci occurrence and development. |
2020-10-15 |
2023-08-13 |
rat |