| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Neeraj Kumar Rai, Harikrishnan Venugopal, Rithika Rajesh, Pranavi Ancha, Sundararajan Venkates. Mitochondrial complex-1 as a therapeutic target for cardiac diseases. Molecular and cellular biochemistry. 2024-07-20. PMID:39033212. |
several studies demonstrated that impaired ci function contributes to increased oxidative stress, altered calcium homeostasis, and mitochondrial dna damage in cardiac cells, leading to cardiomyocyte dysfunction and apoptosis. |
2024-07-20 |
2024-07-24 |
Not clear |
| Pingqing Lin, Chengshi Lin, Liangbiao Dia. RBM3 ameliorates acute brain injury-induced inflammation and oxidative stress by stabilizing GAS6 mRNA through Nrf2 signaling pathway. Neuroscience. 2024-03-30. PMID:38555015. |
additionally, rbm3 reversed the increased oxidative stress, inflammatory level, and apoptosis induced by ci and ogd. |
2024-03-30 |
2024-04-02 |
rat |
| Ren Yang, Chen Zen. Protective effects of MiR-146b in cerebral infarction via targeting SIRT1/FOXO1 signaling pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 12. 2023-12-08. PMID:38063102. |
mir-146b can play a protective role in ci rats by activating the sirt1/foxo1 signaling pathway, lowering the oxidative stress level and reducing brain tissue apoptosis. |
2023-12-08 |
2023-12-17 |
rat |
| Mikahela A López-Morales, María Castelló-Ruiz, María C Burguete, David Hervás, Miguel A Pérez-Pinzón, Juan B Salo. Effect and mechanisms of resveratrol in animal models of ischemic stroke: A systematic review and Bayesian meta-analysis. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2023-10-06. PMID:37802493. |
bayesian meta-analysis showed smd estimates (95% ci) favoring rsv: infarct size (-1.72 [-2.03; -1.41]), edema size (-1.61 [-2.24; -0.98]), bbb impairment (-1.85 [-2.54; -1.19]), neurofunctional impairment (-1.60 [-1.92; -1.29]), and motor performance (1.39 [0.64; 2.08]); and less probably neuronal survival (0.63 [-1.40; 2.48]) and apoptosis (-0.96 [-2.87; 1.02]). |
2023-10-06 |
2023-10-15 |
mouse |
| Yajuan Xing, Jianhui Guo, Wen Gu. Butylphthalide regulation of nerve cells in rats with cerebral infarction through jnk/p38mapk signaling pathway. Pakistan journal of pharmaceutical sciences. vol 36. issue 4(Special). 2023-08-22. PMID:37606030. |
the comparison of the neurological function score between the model group and the nbp group, as well as the integrated locomotor ability score, slit2 expression level, blood-brain barrier permeability, micro vessel density (mvd), ci volume, neuronal apoptosis rate of the brain tissue and expression levels of brain tissue p-jnk and p-p38mapk protein among three groups was conducted. |
2023-08-22 |
2023-09-07 |
rat |
| Yajuan Xing, Jianhui Guo, Wen Gu. Butylphthalide regulation of nerve cells in rats with cerebral infarction through jnk/p38mapk signaling pathway. Pakistan journal of pharmaceutical sciences. vol 36. issue 4(Special). 2023-08-22. PMID:37606030. |
nbp inhibits the expression of jnk/p38mapk signaling pathway, promotes the expression of slit2 in ci rats, improves the neurological function and locomotor ability of ci rats, while promoting micro vascularization of the brain tissue, protecting the blood-brain barrier, reducing the volume of ci and the apoptosis of nerve cells. |
2023-08-22 |
2023-09-07 |
rat |
| Yajuan Xing, Jianhui Guo, Wen Gu. Butylphthalide regulation of nerve cells in rats with cerebral infarction through jnk/p38mapk signaling pathway15. Pakistan journal of pharmaceutical sciences. vol 36. issue 2(Special). 2023-08-07. PMID:37548207. |
the comparison of the neurological function score between the model group and the nbp group, as well as the integrated locomotor ability score, slit2 expression level, blood-brain barrier permeability, micro vessel density (mvd), ci volume, neuronal apoptosis rate of the brain tissue and expression levels of brain tissue p-jnk and p-p38mapk protein among three groups was conducted. |
2023-08-07 |
2023-08-14 |
rat |
| Yajuan Xing, Jianhui Guo, Wen Gu. Butylphthalide regulation of nerve cells in rats with cerebral infarction through jnk/p38mapk signaling pathway15. Pakistan journal of pharmaceutical sciences. vol 36. issue 2(Special). 2023-08-07. PMID:37548207. |
nbp inhibits the expression of jnk/p38mapk signaling pathway, promotes the expression of slit2 in ci rats, improves the neurological function and locomotor ability of ci rats, while promoting micro vascularization of the brain tissue, protecting the blood-brain barrier, reducing the volume of ci and the apoptosis of nerve cells. |
2023-08-07 |
2023-08-14 |
rat |
| Ning Li, Xinyue Wang, Yuru Wang, Pengtao Wang, Na Sun, Jiale Chen, Lu Han, Zizheng Li, Haojun Fan, Yanhua Gon. Delayed step-by-step decompression with DSF alleviates skeletal muscle crush injury by inhibiting NLRP3/CASP-1/GSDMD pathway. Cell death discovery. vol 9. issue 1. 2023-08-01. PMID:37528068. |
however, the function and mechanism of pyroptosis and apoptosis in the pathogenesis of skeletal muscle injury in ci remain elusive. |
2023-08-01 |
2023-08-14 |
mouse |
| Ning Li, Xinyue Wang, Yuru Wang, Pengtao Wang, Na Sun, Jiale Chen, Lu Han, Zizheng Li, Haojun Fan, Yanhua Gon. Delayed step-by-step decompression with DSF alleviates skeletal muscle crush injury by inhibiting NLRP3/CASP-1/GSDMD pathway. Cell death discovery. vol 9. issue 1. 2023-08-01. PMID:37528068. |
here, we identified that pyroptosis and apoptosis occur independently of each other and are regulated differently in the injured mice's skeletal muscle of ci. |
2023-08-01 |
2023-08-14 |
mouse |
| Ning Li, Xinyue Wang, Yuru Wang, Pengtao Wang, Na Sun, Jiale Chen, Lu Han, Zizheng Li, Haojun Fan, Yanhua Gon. Delayed step-by-step decompression with DSF alleviates skeletal muscle crush injury by inhibiting NLRP3/CASP-1/GSDMD pathway. Cell death discovery. vol 9. issue 1. 2023-08-01. PMID:37528068. |
then, we confirmed that delayed step-by-step decompression of ci mice could significantly reduce skeletal muscle injury by substantially inhibiting nlrp3/casp-1/gsdmd pyroptosis pathway but not altering the casp-3/parp apoptosis pathway. |
2023-08-01 |
2023-08-14 |
mouse |
| Ruike Wang, Xi Yang, Tiancai Wang, Ruirui Kou, Panpan Liu, Yueqing Huang, Chen Che. Synergistic effects on oxidative stress, apoptosis and necrosis resulting from combined toxicity of three commonly used pesticides on HepG2 cells. Ecotoxicology and environmental safety. vol 263. 2023-07-14. PMID:37451096. |
to assess the toxic effects caused by exposures to individual pesticides (chlorpyrifos, carbofuran and acetamiprid), binary combinations and ternary combinations, individual and combined exposure models were developed using hepg2 cells and the types of combined effects of pesticide mixtures were assessed using concentration addition (ca), independent action (ia) and combination index (ci) models, respectively, and the expression of biomarkers related to oxidative stress, apoptosis and cell necrosis was further examined. |
2023-07-14 |
2023-08-14 |
human |
| Le-le Zhang, Ai-Hong Yuan, Jun Yang, Bi-Xiang Zha, Guang Gu, Yin-Qiu Fan, Yu-Song Yang, Wen-Jing Ka. [Moxibustion improves learning-memory ability by regulating apoptosis related proteins of hippocampus in diabetic rats with cognitive impairment]. Zhen ci yan jiu = Acupuncture research. vol 48. issue 2. 2023-03-01. PMID:36858415. |
to investigate the effect of moxibustion on the proteins related with apoptosis and nuclear transcription factor kappa b (nf-κb) in hippocampus of diabetic rats with cognitive impairment (ci), so as to explore its mechanism underlying improvement of learning-memory ability. |
2023-03-01 |
2023-08-14 |
rat |
| Yueli Zhang, Zhilan Ye, Ruixuan He, Yuyang Li, Bei Xiong, Mengqi Yi, Yuqi Chen, Jia Liu, Bo L. Bovine serum albumin-based and dual-responsive targeted hollow mesoporous silica nanoparticles for breast cancer therapy. Colloids and surfaces. B, Biointerfaces. vol 224. 2023-02-23. PMID:36822117. |
additionally, a series of biological evaluations, such as cell uptake experiments, toxicity experiments, and in vivo therapeutic assays indicated that md@hbf possesses the features of accurately targeting fr-expressing 4t1 cells to induce cells apoptosis in vitro, exhibits outstanding tumor cell synergistic killing efficiency of chemo-photodynamic therapy (combination index ci = 0.325), and inhibits tumors growth. |
2023-02-23 |
2023-08-14 |
cattle |
| Hai Duc Nguye. Resveratrol, Endocrine Disrupting Chemicals, Neurodegenerative Diseases and Depression: Genes, Transcription Factors, microRNAs, and Sponges Involved. Neurochemical research. 2022-10-16. PMID:36245065. |
detoxification was noted as the most important for als, dopamine metabolism for pd, apoptosis for ci, and the selenium micronutrient network for depression. |
2022-10-16 |
2023-08-14 |
Not clear |
| Zhen Liu, Xinran Li, Junling Gao, Panpan Yin, Yuou Teng, Peng Y. The therapeutic inhibition of topoisomerase inhibitor and crizotinib combination in EGFR wild and mutant lung cancer cells. Biochemical pharmacology. 2022-10-14. PMID:36241099. |
the combination group significantly inhibited the lung cancer growth with combination index (ci) < 1, and they synergistically induced the cell apoptosis by disrupting the balance of bax and bcl-xl, loss of mitochondrial membrane potential (mmp), and accumulation of reactive oxygen species (ros). |
2022-10-14 |
2023-08-14 |
Not clear |
| Hai Duc Nguyen, Min-Sun Ki. Roles of Curcumin on Cognitive Impairment Induced by a Mixture of Heavy Metals. Neurotoxicity research. 2022-10-05. PMID:36197595. |
these mirnas were found to be related to the important pathways related to ci and involved in curcumin's protective activity against mixed heavy metals such as "apoptosis multiple species", "apoptosis", and "alzheimer's disease". |
2022-10-05 |
2023-08-14 |
Not clear |
| Shisi Ma, Jiayang Yin, Lili Hao, Xiao Liu, Qi Shi, Yuyao Diao, Guocheng Yu, Lian Liu, Jiansu Chen, Jingxiang Zhon. Exosomes From Human Umbilical Cord Mesenchymal Stem Cells Treat Corneal Injury via Autophagy Activation. Frontiers in bioengineering and biotechnology. vol 10. 2022-05-06. PMID:35519619. |
the effects of hucmsc-exos combined with autophagy regulators on hcecs and ci mice were assessed using cell viability assays, scratch assay, cell cycle assay, apoptosis assay, corneal fluorescein staining, haze grades, pathological examinations, western blotting, and quantitative polymerase chain reaction (qpcr). |
2022-05-06 |
2023-08-13 |
mouse |
| Y-X Xie, M Zhang, C-R Zhang, F Che. Relationship between NogoA/NgR1/RhoA signaling pathway and the apoptosis of cerebral neurons after cerebral infarction in rats. European review for medical and pharmacological sciences. vol 26. issue 6. 2022-04-01. PMID:35363321. |
the authors state that they recently conducted animal experiments again to verify the state of apoptosis in the brain tissue of the ci + nogoa ko group. |
2022-04-01 |
2023-08-13 |
rat |
| Nur Şebnem Ersöz, Aysun Ada. Resveratrol triggers anti-proliferative and apoptotic effects in FLT3-ITD-positive acute myeloid leukemia cells via inhibiting ceramide catabolism enzymes. Medical oncology (Northwood, London, England). vol 39. issue 3. 2022-01-21. PMID:35059910. |
co-administrations intensified resveratrol's effect by inhibiting cell proliferation synergistically (a ci of < 1) or additively (a ci 1.0-1.1) and inducing apoptosis via ps relocalization and parp cleavage. |
2022-01-21 |
2023-08-13 |
Not clear |