| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tina Cascone, Maria Pia Morelli, Floriana Morgillo, Woo-Young Kim, Gabriella Rodolico, Stefano Pepe, Giampaolo Tortora, Liberato Berrino, Ho-Young Lee, John V Heymach, Fortunato Ciardiell. Synergistic anti-proliferative and pro-apoptotic activity of combined therapy with bortezomib, a proteasome inhibitor, with anti-epidermal growth factor receptor (EGFR) drugs in human cancer cells. Journal of cellular physiology. vol 216. issue 3. 2008-08-26. PMID:18381602. |
a significant synergistic growth inhibitory effect was observed with the combination of bortezomib and each egfr inhibitor in all cell lines (combination index, ci, range 0.10-0.55), which was accompanied by a significant induction in apoptosis by the combined treatment with bortezomib, cetuximab and vandetanib. |
2008-08-26 |
2023-08-12 |
human |
| Paul Finnon, Naomi Robertson, Sylwia Dziwura, Claudine Raffy, Wei Zhang, Liz Ainsbury, Jaakko Kaprio, Christophe Badie, Simon Bouffle. Evidence for significant heritability of apoptotic and cell cycle responses to ionising radiation. Human genetics. vol 123. issue 5. 2008-06-09. PMID:18437427. |
a model incorporating additive genetic factors and unique environmental factors yielded estimates of heritability for the two traits of 68% (95% ci 40-82%, cell cycle) and 59% (95% ci 22-79%, apoptosis). |
2008-06-09 |
2023-08-12 |
human |
| Temitope O Keku, Ahmad Amin, Joseph Galanko, Christopher Martin, Barbara Schliebe, Robert S Sandle. Apoptosis in normal rectal mucosa, baseline adenoma characteristics, and risk of future adenomas. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. vol 17. issue 2. 2008-05-13. PMID:18268113. |
compared with those in the lowest tertile, subjects with high apoptosis were less likely to have an adenoma at follow-up (crude or, 0.25; 95% ci, 0.09-0.65; adjusted or, 0.29; 95% ci, 0.08-1.06). |
2008-05-13 |
2023-08-12 |
human |
| Elisa Giovannetti, Clara Lemos, Christina Tekle, Kees Smid, Sara Nannizzi, José A Rodriguez, Simona Ricciardi, Romano Danesi, Giuseppe Giaccone, Godefridus J Peter. Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells. Molecular pharmacology. vol 73. issue 4. 2008-04-03. PMID:18187583. |
pharmacological interaction was studied using the combination index (ci) method, whereas cell cycle, apoptosis induction, and egfr, extracellular signal-regulated kinases 1 and 2, and akt phosphorylation were studied by flow cytometry, fluorescence microscopy, and enzyme-linked immunosorbent assays. |
2008-04-03 |
2023-08-12 |
Not clear |
| Elisa Giovannetti, Clara Lemos, Christina Tekle, Kees Smid, Sara Nannizzi, José A Rodriguez, Simona Ricciardi, Romano Danesi, Giuseppe Giaccone, Godefridus J Peter. Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells. Molecular pharmacology. vol 73. issue 4. 2008-04-03. PMID:18187583. |
synergistic cytotoxicity was found in all cells, most pronounced with pemetrexed + erlotinib (24 h) --> erlotinib (48 h) sequence (ci, 0.09-0.40), which was associated with a significant induction of apoptosis. |
2008-04-03 |
2023-08-12 |
Not clear |
| Johanna Annunen-Rasila, Steffen Ohlmeier, Hanna Tuokko, Johanna Veijola, Kari Majama. Proteome and cytoskeleton responses in osteosarcoma cells with reduced OXPHOS activity. Proteomics. vol 7. issue 13. 2007-09-04. PMID:17533645. |
analysis of the total proteome revealed that a lack of mitochondrial dna or inhibition of ci or civ led to changes in the expression of cytoskeletal and cytoskeleton-associated proteins and proteins involved in apoptosis, oxphos, glycolysis, the tricarboxylic acid cycle, and oxidative stress responses. |
2007-09-04 |
2023-08-12 |
Not clear |
| Gordon L Warren, Mukesh Summan, Xin Gao, Rebecca Chapman, Tracy Hulderman, Petia P Simeonov. Mechanisms of skeletal muscle injury and repair revealed by gene expression studies in mouse models. The Journal of physiology. vol 582. issue Pt 2. 2007-08-20. PMID:17478534. |
only ci activated a set of genes associated with the repair of impaired proteins and structures including genes related to apoptosis, whereas fi uniquely activated gene sets involved in extensive inflammatory responses, tissue remodelling, angiogenesis and myofibre/extracellular matrix synthesis. |
2007-08-20 |
2023-08-12 |
mouse |
| Joakim Glamann, Anker Jon Hanse. Dynamic detection of natural killer cell-mediated cytotoxicity and cell adhesion by electrical impedance measurements. Assay and drug development technologies. vol 4. issue 5. 2006-12-26. PMID:17115926. |
such a rapid fall of ci was due to changes in the adhesion and morphology of target cell undergoing apoptosis. |
2006-12-26 |
2023-08-12 |
human |
| Shu-Zhi Bai, Xiao-Bin Liu, Yu-Hui Xi, Tian-Ying Wang, Guo-Hui F. [Expression of band 3 protein on erythrocytes of malignant tumor patients and its impact on proliferation of K562 cells]. Ai zheng = Aizheng = Chinese journal of cancer. vol 24. issue 5. 2006-11-07. PMID:15890094. |
it has been found recently that abnormality of ci(-)/hco3(-) exchange, which mainly leads to change of intracellular ph, may be involved in cell proliferation and apoptosis. |
2006-11-07 |
2023-08-12 |
Not clear |
| A Kessel, D Yehudai, R Peri, E Pavlotzky, E Bamberger, N Tov, E Toub. Increased susceptibility of cord blood B lymphocytes to undergo spontaneous apoptosis. Clinical and experimental immunology. vol 145. issue 3. 2006-11-06. PMID:16907927. |
we found that spontaneous apoptosis of cultured b cells, as assessed by utilizing annexin-v binding, was significantly higher in cord blood than in healthy adult individuals (77.5; 95 ci, 73.5-81.5 versus 59.2; 95 ci, 54-64, respectively, p < 0.0001) and further confirmed by 4' 6-diamidino-2-phenylindole, dihydrochloride (dapi) staining. |
2006-11-06 |
2023-08-12 |
Not clear |
| Clayton D Knox, Janene M Pierce, Ian B Nicoud, Andrey E Belous, Christopher M Jones, Christopher D Anderson, Ravi S Char. Inhibition of phospholipase C attenuates liver mitochondrial calcium overload following cold ischemia. Transplantation. vol 81. issue 4. 2006-04-05. PMID:16495805. |
during ci, the consumption of atp and the increase in cellular ca concentration may result in mitochondrial ca (mca) overload through the mca uniporter, which can ultimately lead to apoptosis and graft nonfunction. |
2006-04-05 |
2023-08-12 |
Not clear |
| b' R\\xc3\\xa9my Pedeux, Fran\\xc3\\xa7ois Sales, Julie Pourchet, Mireille Kallassy, Caroline Fayolle, Mathieu Boniol, Gianluca Severi, Ghanem Ghanem, Hisayoshi Nym Nakazawa, Philippe Autier, Jean-Fran\\xc3\\xa7ois Dor\\xc3\\xa. Ultraviolet B sensitivity of peripheral lymphocytes as an independent risk factor for cutaneous melanoma. European journal of cancer (Oxford, England : 1990). vol 42. issue 2. 2006-03-07. PMID:16337788.' |
analysis of data (adjusted for age and phototype) shows that uvb-induced apoptosis is an important risk factor for melanoma (or 9.1, 95% ci [3-28], p=0.0001). |
2006-03-07 |
2023-08-12 |
Not clear |
| Yen-Chou Chen, Shing-Chuan Shen, Shu-Huei Tsa. Prostaglandin D(2) and J(2) induce apoptosis in human leukemia cells via activation of the caspase 3 cascade and production of reactive oxygen species. Biochimica et biophysica acta. vol 1743. issue 3. 2005-06-09. PMID:15843042. |
the proliferator-activated receptor-gamma (ppar-gamma) agonists, rosiglitazone (ro), troglitazone (tr), and ciglitazone (ci), induced apoptosis in cells which was blocked by the addition of the ppar-gamma antagonists, gw9662 and badge, via blocking of caspase 3 and parp cleavage. |
2005-06-09 |
2023-08-12 |
human |
| Karin Söderlund, Gizeh Pérez-Tenorio, Olle Stå. Activation of the phosphatidylinositol 3-kinase/Akt pathway prevents radiation-induced apoptosis in breast cancer cells. International journal of oncology. vol 26. issue 1. 2005-05-02. PMID:15586221. |
10 gy gamma-radiation increased apoptosis by on an average 76% (95% ci, 44-109%) in mcf-7. |
2005-05-02 |
2023-08-12 |
human |
| Karin Söderlund, Gizeh Pérez-Tenorio, Olle Stå. Activation of the phosphatidylinositol 3-kinase/Akt pathway prevents radiation-induced apoptosis in breast cancer cells. International journal of oncology. vol 26. issue 1. 2005-05-02. PMID:15586221. |
treatment of mcf-7 with heregulin-beta1 decreased apoptosis by 66% (95% ci, 48-84%) compared to the untreated controls. |
2005-05-02 |
2023-08-12 |
human |
| Karin Söderlund, Gizeh Pérez-Tenorio, Olle Stå. Activation of the phosphatidylinositol 3-kinase/Akt pathway prevents radiation-induced apoptosis in breast cancer cells. International journal of oncology. vol 26. issue 1. 2005-05-02. PMID:15586221. |
in bt-474 cells, wortmannin in combination with radiation resulted in 119% (95% ci, 76-161%) more apoptosis compared to wortmannin alone, whereas radiation alone resulted in 45% (95% ci, 15-75%) increased apoptosis. |
2005-05-02 |
2023-08-12 |
human |
| Leah E Mechanic, Aizen J Marrogi, Judith A Welsh, Elise D Bowman, Mohammed A Khan, Lindsey Enewold, Yun-Ling Zheng, Stephen Chanock, Peter G Shields, Curtis C Harri. Polymorphisms in XPD and TP53 and mutation in human lung cancer. Carcinogenesis. vol 26. issue 3. 2005-04-13. PMID:15564288. |
functional polymorphisms in xpd (asp312asn, rs1799793 and lys751gln, rs1052559), a protein required for nucleotide excision repair and with roles in p53-mediated apoptosis, were modestly associated with g:c-->t:a mutations in tp53 in lung tumors [asp/asn312 + asn/asn312 and/or lys/gln751 + gln/gln751 versus asp/asp312 + lys/lys751; odds ratio (or) 2.73, 95% confidence interval (ci) 0.98-7.61], consistent with the role of this protein in repair of bulky carcinogen-dna adducts. |
2005-04-13 |
2023-08-12 |
human |
| Leah E Mechanic, Aizen J Marrogi, Judith A Welsh, Elise D Bowman, Mohammed A Khan, Lindsey Enewold, Yun-Ling Zheng, Stephen Chanock, Peter G Shields, Curtis C Harri. Polymorphisms in XPD and TP53 and mutation in human lung cancer. Carcinogenesis. vol 26. issue 3. 2005-04-13. PMID:15564288. |
in addition, a tp53 polymorphism (arg72pro, rs1042522) with a known role in the efficiency of apoptosis was also associated with the presence of a tp53 mutation (pro/arg72 or pro/pro72 versus arg/arg72; or 2.25, 95% ci 1.21-4.17) or a g:c-->t:a mutation in tp53 (pro/arg72 or pro/pro72 versus arg/arg72; or 2.42, 95% ci 0.97-6.04). |
2005-04-13 |
2023-08-12 |
human |
| D Azria, S Gourgou, W J Sozzi, A Zouhair, R O Mirimanoff, A Kramar, C Lemanski, J B Dubois, G Romieu, A Pelegrin, M Ozsahi. Concomitant use of tamoxifen with radiotherapy enhances subcutaneous breast fibrosis in hypersensitive patients. British journal of cancer. vol 91. issue 7. 2004-11-02. PMID:15328527. |
in each of these groups, the crfs rates were significantly lower for patients with low levels of cd8 radiation-induced apoptosis, 20% (95% ci 10-31.9%), 66% (95% ci 51.1-77.6%), and 79% (95% ci 55-90.9%) for cd8 24%, respectively. |
2004-11-02 |
2023-08-12 |
Not clear |
| Stéphane Honore, Kathy Kamath, Diane Braguer, Susan Band Horwitz, Leslie Wilson, Claudette Briand, Mary Ann Jorda. Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells. Cancer research. vol 64. issue 14. 2004-09-09. PMID:15256469. |
discodermolide and paclitaxel also synergistically blocked cell cycle progression at g(2)-m (41, 9.6, and 16% for both drugs together, for discodermolide alone, and for paclitaxel alone, respectively; ci = 0.59), and they synergistically enhanced apoptosis (ci = 0.85). |
2004-09-09 |
2023-08-12 |
human |