| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyun-Young Lee, Seon-Hee O. Autophagy-mediated cytoplasmic accumulation of p53 leads to apoptosis through DRAM-BAX in cadmium-exposed human proximal tubular cells. Biochemical and biophysical research communications. vol 534. 2021-04-13. PMID:33321290. |
the tumor suppressor p53 is involved in cadmium (cd)-induced apoptosis and autophagy. |
2021-04-13 |
2023-08-13 |
human |
| Hyun-Young Lee, Seon-Hee O. Autophagy-mediated cytoplasmic accumulation of p53 leads to apoptosis through DRAM-BAX in cadmium-exposed human proximal tubular cells. Biochemical and biophysical research communications. vol 534. 2021-04-13. PMID:33321290. |
collectively, cd induces apoptosis through p53-mediated dram-bax signaling, which can be regulated by autophagy. |
2021-04-13 |
2023-08-13 |
human |
| Mingkun Zhu, Sasa Miao, Wenting Zhou, Shaaban Saad Elnesr, Xinyang Dong, Xiaoting Zo. MAPK, AKT/FoxO3a and mTOR pathways are involved in cadmium regulating the cell cycle, proliferation and apoptosis of chicken follicular granulosa cells. Ecotoxicology and environmental safety. vol 214. 2021-03-31. PMID:33706141. |
this study aimed to assess the toxic impacts of cd on the ovarian tissue, and to examine the mechanism of cd-induced granulosa cell proliferation and apoptosis. |
2021-03-31 |
2023-08-13 |
chicken |
| Mingkun Zhu, Sasa Miao, Wenting Zhou, Shaaban Saad Elnesr, Xinyang Dong, Xiaoting Zo. MAPK, AKT/FoxO3a and mTOR pathways are involved in cadmium regulating the cell cycle, proliferation and apoptosis of chicken follicular granulosa cells. Ecotoxicology and environmental safety. vol 214. 2021-03-31. PMID:33706141. |
results from the nitric oxide (no) and malondialdehyde (mda) content, total superoxide dismutase (t-sod), glutathione peroxide (gsh-px), total nitric oxide synthase (t-nos) and adenosine triphosphatase (atpase) activities, terminal deoxynucleotidyl transferase-mediated dutp-biotin nick end labeling (tunel) assay, and hematoxylin-eosin (h & e) staining indicated that excess cd induced oxidative stress, granulosa cell apoptosis and follicular atresia in the layer ovary. |
2021-03-31 |
2023-08-13 |
chicken |
| Mingkun Zhu, Sasa Miao, Wenting Zhou, Shaaban Saad Elnesr, Xinyang Dong, Xiaoting Zo. MAPK, AKT/FoxO3a and mTOR pathways are involved in cadmium regulating the cell cycle, proliferation and apoptosis of chicken follicular granulosa cells. Ecotoxicology and environmental safety. vol 214. 2021-03-31. PMID:33706141. |
low-dose cd exposure (1 μm) induced the granulosa cell proliferation, upregulated the mrna levels of rsk1 and rheb, activated foxo3a, akt, erk1/2, mtor and p70s6k1 phosphorylation, and promoted cell cycle progression from phase g1 to s. however, high-dose cd exposure (15 μm) induced reactive oxygen species (ros) generation and cell apoptosis, upregulated the mrna levels of the inflammatory factors, ask1, jnk, p38 and tak1, downregulated the expressions of rsk1 and rheb genes, and inhibited the phosphorylation of erk1/2, mtor and p70s6k1 proteins, and the cell cycle progression. |
2021-03-31 |
2023-08-13 |
chicken |
| Mingkun Zhu, Sasa Miao, Wenting Zhou, Shaaban Saad Elnesr, Xinyang Dong, Xiaoting Zo. MAPK, AKT/FoxO3a and mTOR pathways are involved in cadmium regulating the cell cycle, proliferation and apoptosis of chicken follicular granulosa cells. Ecotoxicology and environmental safety. vol 214. 2021-03-31. PMID:33706141. |
conclusively, these results indicated that cd can cause the ovarian damage and follicular atresia, and regulate cell cycle, cell proliferation or apoptosis of granulosa cells through mapk, akt/foxo3a and mtor pathways in laying hens. |
2021-03-31 |
2023-08-13 |
chicken |
| Jianqing Chen, Dechun Chen, Jingxin Li, Yuanlong Liu, Xianhong Gu, Xiaohua Ten. Cadmium-induced Oxidative Stress and Immunosuppression Mediated Mitochondrial Apoptosis via JNK-FoxO3a-PUMA pathway in Common Carp (Cyprinus carpio L.) Gills. Aquatic toxicology (Amsterdam, Netherlands). vol 233. 2021-03-24. PMID:33631492. |
hence, in this study, we established a cd poisoning model to explore whether excess cd can induce apoptosis through observing histomorphology and apoptotic cells; and determining mineral elements, oxidative stress-related factors, immune-related, and apoptosis-related genes in common carp gills. |
2021-03-24 |
2023-08-13 |
Not clear |
| Bentolhoda Alizadeh, Ali Salehzadeh, Najmeh Ranji, Amir Araste. Effects of N-Acetyl Cysteine on Genes Expression of c-myc, and Ask-1, Histopathological, Oxidative Stress, Inflammation, and Apoptosis in the Liver of Male Rats Exposed to Cadmium. Biological trace element research. 2021-03-19. PMID:33740178. |
this study aimed to consider the oxidative damage induced by cadmium (cd) and apoptosis and the role of n-acetylcysteine (nac) in preserving hepatic cells against cd toxicity. |
2021-03-19 |
2023-08-13 |
rat |
| Bentolhoda Alizadeh, Ali Salehzadeh, Najmeh Ranji, Amir Araste. Effects of N-Acetyl Cysteine on Genes Expression of c-myc, and Ask-1, Histopathological, Oxidative Stress, Inflammation, and Apoptosis in the Liver of Male Rats Exposed to Cadmium. Biological trace element research. 2021-03-19. PMID:33740178. |
cd exposure is strongly associated with oxidative stress, inflammation, antioxidant depletion, and liver cells apoptosis. |
2021-03-19 |
2023-08-13 |
rat |
| Yonggang Ma, Di Ran, Xueni Shi, Hongyan Zhao, Zongping Li. Cadmium toxicity: A role in bone cell function and teeth development. The Science of the total environment. vol 769. 2021-03-18. PMID:33485206. |
cd inhibits the differentiation of bone marrow mesenchymal stem cells (bmscs) into osteoblasts, and directly causes bmsc apoptosis. |
2021-03-18 |
2023-08-13 |
Not clear |
| Yu-Chi Chen, Po-Yu Wang, Bu-Miin Huang, Yu-Jen Chen, Wei-Chang Lee, Yung-Chia Che. 16-Hydroxycleroda-3,13-dien-15,16-olide Induces Apoptosis in Human Bladder Cancer Cells through Cell Cycle Arrest, Mitochondria ROS Overproduction, and Inactivation of EGFR-Related Signalling Pathways. Molecules (Basel, Switzerland). vol 25. issue 17. 2021-03-11. PMID:32872665. |
in summary, cd induces apoptosis in t24 bladder cancer cells through targeting multiple intracellular signaling pathways as a result of oxidative stress and cell cycle arrest. |
2021-03-11 |
2023-08-13 |
human |
| Ming-Yu Hsieh, Ming-Ju Hsieh, Yu-Sheng Lo, Chia-Chieh Lin, Yi-Ching Chuang, Mu-Kuan Chen, Ming-Chih Cho. Modulating effect of Coronarin D in 5-fluorouracil resistance human oral cancer cell lines induced apoptosis and cell cycle arrest through JNK1/2 signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 128. 2021-03-01. PMID:32502840. |
furthermore, western blotting was performed to assess the effect of cd on the expression levels of apoptosis related protein and mapk signaling pathway. |
2021-03-01 |
2023-08-13 |
human |
| Ming-Yu Hsieh, Ming-Ju Hsieh, Yu-Sheng Lo, Chia-Chieh Lin, Yi-Ching Chuang, Mu-Kuan Chen, Ming-Chih Cho. Modulating effect of Coronarin D in 5-fluorouracil resistance human oral cancer cell lines induced apoptosis and cell cycle arrest through JNK1/2 signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 128. 2021-03-01. PMID:32502840. |
the cytotoxic effect of cd lead to cell cycle arrest in the g2/m phase and induced apoptosis in both internal and external pathways. |
2021-03-01 |
2023-08-13 |
human |
| Ming-Yu Hsieh, Ming-Ju Hsieh, Yu-Sheng Lo, Chia-Chieh Lin, Yi-Ching Chuang, Mu-Kuan Chen, Ming-Chih Cho. Modulating effect of Coronarin D in 5-fluorouracil resistance human oral cancer cell lines induced apoptosis and cell cycle arrest through JNK1/2 signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 128. 2021-03-01. PMID:32502840. |
cd induces apoptosis by enhancing phosphorylation of jnk, further exploring the combination of cd and sp600125 reduced the overexpression of phosphate jnk levels. |
2021-03-01 |
2023-08-13 |
human |
| Deliang Yu, Zheng Peng, Huifeng Wu, Xiaoying Zhang, Chenglong Ji, Xiao Pen. Stress responses in expressions of microRNAs in mussel Mytilus galloprovincialis exposed to cadmium. Ecotoxicology and environmental safety. vol 212. 2021-02-26. PMID:33508712. |
target genes of these differentially expressions of mirnas related to immune defense, apoptosis, lipid and xenobiotic metabolism showed significant changes under cd stress. |
2021-02-26 |
2023-08-13 |
Not clear |
| Azadeh Aminzadeh, Ayda Salarineja. Effects of myricetin against cadmium-induced neurotoxicity in PC12 cells. Toxicology research. vol 10. issue 1. 2021-02-23. PMID:33613976. |
cd induces toxicity and apoptosis in various organs and cells. |
2021-02-23 |
2023-08-13 |
Not clear |
| Junfei Zhan, Shuang Wang, Fei Li, Chenglong Ji, Huifeng W. Global characterization of dose-dependent effects of cadmium in clam Ruditapes philippinarum. Environmental pollution (Barking, Essex : 1987). vol 273. 2021-02-15. PMID:33486241. |
bmd analysis on biological processes and pathways showed that peptide cross-linking was the most sensitive biological process to cd exposure, followed by focal adhesion, ubiquitin mediated proteolysis, and apoptosis. |
2021-02-15 |
2023-08-13 |
Not clear |
| Junfei Zhan, Shuang Wang, Fei Li, Chenglong Ji, Huifeng W. Global characterization of dose-dependent effects of cadmium in clam Ruditapes philippinarum. Environmental pollution (Barking, Essex : 1987). vol 273. 2021-02-15. PMID:33486241. |
occurrence of apoptosis was also confirmed by tuenl-positive staining in gills and hepatopancreas of clams treated with cd. |
2021-02-15 |
2023-08-13 |
Not clear |
| Zejing Wei, Gaohui Nie, Fan Yang, Shaoxing Pi, Chang Wang, Huabin Cao, Xiaoquan Guo, Ping Liu, Guyue Li, Guoliang Hu, Caiying Zhan. Inhibition of ROS/NLRP3/Caspase-1 mediated pyroptosis attenuates cadmium-induced apoptosis in duck renal tubular epithelial cells. Environmental pollution (Barking, Essex : 1987). vol 273. 2021-02-15. PMID:33497945. |
to evaluate the effects of cd on pyroptosis and the relationship between pyroptosis and apoptosis in duck renal tubular epithelial cells, the cells were cultured with 3cdso |
2021-02-15 |
2023-08-13 |
Not clear |
| Aline Ferain, Eva Delbecque, Ineke Neefs, Hélène Dailly, Nancy De Saeyer, Mélusine Van Larebeke, Valérie Cornet, Yvan Larondelle, Jean-François Rees, Patrick Kestemont, Karel A C De Schamphelaere, Cathy Debie. Interplay between dietary lipids and cadmium exposure in rainbow trout liver: Influence on fatty acid metabolism, metal accumulation and stress response. Aquatic toxicology (Amsterdam, Netherlands). vol 231. 2021-02-10. PMID:33341509. |
fish fed the ala-enriched diet seemed to be the least affected by the cd exposure, as they showed a higher detoxifying ability against cd with an early upregulation of protective metallothionein a (mta) and apoptosis regulator bcl2-like1 (bclx) genes, an increased long-term phospholipid synthesis and turnover and fatty acid bioconversion efficiency, as well as a lower long-term accumulation of cd in their liver. |
2021-02-10 |
2023-08-13 |
Not clear |