| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Salvatore Benvenga, Antonio Micali, Antonio Ieni, Alessandro Antonelli, Poupak Fallahi, Giovanni Pallio, Natasha Irrera, Francesco Squadrito, Giacomo Picciolo, Domenico Puzzolo, Letteria Minutol. The Association of Myo-Inositol and Selenium Contrasts Cadmium-Induced Thyroid C Cell Hyperplasia and Hypertrophy in Mice. Frontiers in endocrinology. vol 12. 2021-06-15. PMID:33716965. |
compared to vehicle, cd significantly decreased follicle mean diameter, increased ct-positive cells number, area and cytoplasmic density, and caused the disappearance of tunel-positive c cells, namely, the disappearance of c cells undergoing apoptosis. |
2021-06-15 |
2023-08-13 |
mouse |
| Suprabha Suresh Nayak, Mamatha Vishwanatha Shetty, Cannanore Ganesh Pai, Kanive Parashiva Guruprasad, Kapaettu Satyamoorth. Apoptosis in peripheral blood lymphocytes in intestinal tuberculosis and Crohn's disease: Implications to diagnostic differentiation. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology. vol 39. issue 4. 2021-06-14. PMID:32803718. |
we evaluated the difference between itb and cd using the extent of apoptosis in peripheral blood lymphocytes. |
2021-06-14 |
2023-08-13 |
Not clear |
| Hao Jia, Kathy Qian Lu. Fluorescence resonance energy transfer-based sensor zebrafish for detecting toxic agents with single-cell sensitivity. Journal of hazardous materials. vol 408. 2021-05-31. PMID:33421851. |
using the sensor zebrafish, we found that, at 100 nm, heavy metal cadmium (cd) induced apoptosis of zebrafish cells, while no obvious morphological or behavioral changes were observed from the sensor zebrafish. |
2021-05-31 |
2023-08-13 |
zebrafish |
| Hao Jia, Kathy Qian Lu. Fluorescence resonance energy transfer-based sensor zebrafish for detecting toxic agents with single-cell sensitivity. Journal of hazardous materials. vol 408. 2021-05-31. PMID:33421851. |
even at 44.5 nm (the maximum allowable concentration in drinking water), cd induced a significant increase of apoptosis in sensor zebrafish. |
2021-05-31 |
2023-08-13 |
zebrafish |
| Yonggang Ma, Di Ran, Ying Cao, Hongyan Zhao, Ruilong Song, Hui Zou, Jianhong Gu, Yan Yuan, Jianchun Bian, Jiaqiao Zhu, Zongping Li. The effect of P2X7 on cadmium-induced osteoporosis in mice. Journal of hazardous materials. vol 405. 2021-05-26. PMID:33168313. |
our results demonstrate that short-term cd exposure does not affect osteoblast and osteoclast apoptosis in vivo and in vitro, but long-term cd exposure significantly increases bone tissue apoptosis. |
2021-05-26 |
2023-08-13 |
mouse |
| Zahra Azarmehr, Najmeh Ranji, Zeinab Khazaei Koohpar, Hadi Habibollah. The effect of N-Acetyl cysteine on the expression of Fxr (Nr1h4), LXRα (Nr1h3) and Sirt1 genes, oxidative stress, and apoptosis in the liver of rats exposed to different doses of cadmium. Molecular biology reports. vol 48. issue 3. 2021-05-19. PMID:33772418. |
the aim of this study was to consider the expression of farnesoid x receptor (fxr), liver x receptor (lxrα) and sirtuin 1 (sirt1), oxidative stress, inflammation, apoptosis, and the protective role of n-acetylcysteine (nac) in the liver of rats treated with cadmium (cd). |
2021-05-19 |
2023-08-13 |
rat |
| Zahra Azarmehr, Najmeh Ranji, Zeinab Khazaei Koohpar, Hadi Habibollah. The effect of N-Acetyl cysteine on the expression of Fxr (Nr1h4), LXRα (Nr1h3) and Sirt1 genes, oxidative stress, and apoptosis in the liver of rats exposed to different doses of cadmium. Molecular biology reports. vol 48. issue 3. 2021-05-19. PMID:33772418. |
our results suggested that nac protects liver tissue against cd toxicity by elevating antioxidant capacity, mitigating oxidative stress, inflammation, apoptosis and up-regulation of fxr, lxr, and sirt1 genes. |
2021-05-19 |
2023-08-13 |
rat |
| Lu Yiming, Han Yanfei, Yin Hang, Cong Yimei, Shi Guangliang, Li Sh. Cadmium induces apoptosis of pig lymph nodes by regulating the PI3K/AKT/HIF-1α pathway. Toxicology. vol 451. 2021-05-12. PMID:33493553. |
this study was aimed to explore the possible mechanism of environmental metal cadmium (cd) inducing apoptosis of pig lymph nodes. |
2021-05-12 |
2023-08-13 |
Not clear |
| Yue Zhang, Yulong Li, Jinxi Zhang, Xue Qi, Yuan Cui, Kai Yin, Hongjin Li. Cadmium induced inflammation and apoptosis of porcine epididymis via activating RAF1/MEK/ERK and NF-κB pathways. Toxicology and applied pharmacology. vol 415. 2021-05-11. PMID:33577919. |
it was largely unknown whether cd exposure caused inflammation and apoptosis in epididymis. |
2021-05-11 |
2023-08-13 |
Not clear |
| Yue Zhang, Yulong Li, Jinxi Zhang, Xue Qi, Yuan Cui, Kai Yin, Hongjin Li. Cadmium induced inflammation and apoptosis of porcine epididymis via activating RAF1/MEK/ERK and NF-κB pathways. Toxicology and applied pharmacology. vol 415. 2021-05-11. PMID:33577919. |
in summary, we believed that the raf1/mek/erk pathway came into play in the apoptosis of epididymal tissues exposed to cd by activating the nf-κb inflammation pathway, followed by activation of the mitochondrial apoptotic pathway. |
2021-05-11 |
2023-08-13 |
Not clear |
| Hye-Ji Shin, Kyung-A Hwang, Ryeo-Eun Go, Seung U Kim, Kyung-Chul Cho. Antithyroid cancer effects of human neural stem cells expressing therapeutic genes on anaplastic thyroid cancer cells. Journal of cellular biochemistry. vol 121. issue 2. 2021-04-29. PMID:31512776. |
taken together, engineered hnscs were revealed to selectively migrate to atc cells and to inhibit growth as well as to induce apoptosis of atc cells via ros production through the actions of transgenes such as cd and ifn-β. |
2021-04-29 |
2023-08-13 |
human |
| Gang Liu, Kanglei Zhang, Wenxuan Dong, Yun Tan, Mengfei Long, Hui Zou, Zongping Li. Puerarin restores the autophagic flux to alleviate cadmium‑induced endoplasmic reticulum stress in NRK‑52E cells. Molecular medicine reports. vol 22. issue 3. 2021-04-26. PMID:32705200. |
the present study employed a rat nrk‑52e cell model, where alterations in cell morphology, density and viability, the accumulation of reactive oxygen species, an increase in malondialdehyde generation and a decrease in antioxidant enzyme activity and apoptosis were induced by cd treatment. |
2021-04-26 |
2023-08-13 |
rat |
| Ying Liao, Hong Zheng, Langbo Wu, Lei He, Yu Wang, Yangsong Ou, Hongjun Yang, Shiqin Peng, Fengwang Chen, Xiaoyan Wang, Jiayuan Zha. Cadmium cytotoxicity and possible mechanisms in human trophoblast HTR-8/SVneo cells. Environmental toxicology. vol 36. issue 6. 2021-04-23. PMID:33559965. |
in addition, cd dose-dependently inducedcell apoptosis and decreased cell migration and invasion capacities. |
2021-04-23 |
2023-08-13 |
human |
| Ying Liao, Hong Zheng, Langbo Wu, Lei He, Yu Wang, Yangsong Ou, Hongjun Yang, Shiqin Peng, Fengwang Chen, Xiaoyan Wang, Jiayuan Zha. Cadmium cytotoxicity and possible mechanisms in human trophoblast HTR-8/SVneo cells. Environmental toxicology. vol 36. issue 6. 2021-04-23. PMID:33559965. |
finally, cd significantly upregulated all the genes related to oxidative stress (sod1, ros1, and hspa6), inflammatory response, cell cycle, apoptosis, and migration and invasion. |
2021-04-23 |
2023-08-13 |
human |
| Hyun-Young Lee, Seon-Hee O. Autophagy-mediated cytoplasmic accumulation of p53 leads to apoptosis through DRAM-BAX in cadmium-exposed human proximal tubular cells. Biochemical and biophysical research communications. vol 534. 2021-04-13. PMID:33321290. |
the tumor suppressor p53 is involved in cadmium (cd)-induced apoptosis and autophagy. |
2021-04-13 |
2023-08-13 |
human |
| Hyun-Young Lee, Seon-Hee O. Autophagy-mediated cytoplasmic accumulation of p53 leads to apoptosis through DRAM-BAX in cadmium-exposed human proximal tubular cells. Biochemical and biophysical research communications. vol 534. 2021-04-13. PMID:33321290. |
collectively, cd induces apoptosis through p53-mediated dram-bax signaling, which can be regulated by autophagy. |
2021-04-13 |
2023-08-13 |
human |
| Mingkun Zhu, Sasa Miao, Wenting Zhou, Shaaban Saad Elnesr, Xinyang Dong, Xiaoting Zo. MAPK, AKT/FoxO3a and mTOR pathways are involved in cadmium regulating the cell cycle, proliferation and apoptosis of chicken follicular granulosa cells. Ecotoxicology and environmental safety. vol 214. 2021-03-31. PMID:33706141. |
this study aimed to assess the toxic impacts of cd on the ovarian tissue, and to examine the mechanism of cd-induced granulosa cell proliferation and apoptosis. |
2021-03-31 |
2023-08-13 |
chicken |
| Mingkun Zhu, Sasa Miao, Wenting Zhou, Shaaban Saad Elnesr, Xinyang Dong, Xiaoting Zo. MAPK, AKT/FoxO3a and mTOR pathways are involved in cadmium regulating the cell cycle, proliferation and apoptosis of chicken follicular granulosa cells. Ecotoxicology and environmental safety. vol 214. 2021-03-31. PMID:33706141. |
results from the nitric oxide (no) and malondialdehyde (mda) content, total superoxide dismutase (t-sod), glutathione peroxide (gsh-px), total nitric oxide synthase (t-nos) and adenosine triphosphatase (atpase) activities, terminal deoxynucleotidyl transferase-mediated dutp-biotin nick end labeling (tunel) assay, and hematoxylin-eosin (h & e) staining indicated that excess cd induced oxidative stress, granulosa cell apoptosis and follicular atresia in the layer ovary. |
2021-03-31 |
2023-08-13 |
chicken |
| Mingkun Zhu, Sasa Miao, Wenting Zhou, Shaaban Saad Elnesr, Xinyang Dong, Xiaoting Zo. MAPK, AKT/FoxO3a and mTOR pathways are involved in cadmium regulating the cell cycle, proliferation and apoptosis of chicken follicular granulosa cells. Ecotoxicology and environmental safety. vol 214. 2021-03-31. PMID:33706141. |
low-dose cd exposure (1 μm) induced the granulosa cell proliferation, upregulated the mrna levels of rsk1 and rheb, activated foxo3a, akt, erk1/2, mtor and p70s6k1 phosphorylation, and promoted cell cycle progression from phase g1 to s. however, high-dose cd exposure (15 μm) induced reactive oxygen species (ros) generation and cell apoptosis, upregulated the mrna levels of the inflammatory factors, ask1, jnk, p38 and tak1, downregulated the expressions of rsk1 and rheb genes, and inhibited the phosphorylation of erk1/2, mtor and p70s6k1 proteins, and the cell cycle progression. |
2021-03-31 |
2023-08-13 |
chicken |
| Mingkun Zhu, Sasa Miao, Wenting Zhou, Shaaban Saad Elnesr, Xinyang Dong, Xiaoting Zo. MAPK, AKT/FoxO3a and mTOR pathways are involved in cadmium regulating the cell cycle, proliferation and apoptosis of chicken follicular granulosa cells. Ecotoxicology and environmental safety. vol 214. 2021-03-31. PMID:33706141. |
conclusively, these results indicated that cd can cause the ovarian damage and follicular atresia, and regulate cell cycle, cell proliferation or apoptosis of granulosa cells through mapk, akt/foxo3a and mtor pathways in laying hens. |
2021-03-31 |
2023-08-13 |
chicken |