| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yabing Chen, Pritish Pawar, George Pan, Liping Ma, Hui Liu, Jay M McDonal. Calmodulin binding to the Fas-mediated death-inducing signaling complex in cholangiocarcinoma cells. Journal of cellular biochemistry. vol 103. issue 3. 2008-06-23. PMID:17654480. |
characterization of the role of cam in fas-mediated disc formation and apoptosis signaling may provide important insights in the development of novel therapeutic targets for cholangiocarcinoma. |
2008-06-23 |
2023-08-12 |
Not clear |
| Randal May, Terrence E Riehl, Clayton Hunt, Sripathi M Sureban, Shrikant Anant, Courtney W Houche. Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice. Stem cells (Dayton, Ohio). vol 26. issue 3. 2008-05-07. PMID:18055444. |
here, we used the putative stem cell marker doublecortin and cam kinase-like-1 (dcamkl-1) to examine radiation-induced stem cell apoptosis and adenomatous polyposis coli (apc)/multiple intestinal neoplasia (min) mice to determine the effects of apc mutation on dcamkl-1 expression. |
2008-05-07 |
2023-08-12 |
mouse |
| Shaker A Mous. Cell adhesion molecules: potential therapeutic & diagnostic implications. Molecular biotechnology. vol 38. issue 1. 2008-02-11. PMID:18095189. |
the role of cell adhesion molecules (cam) and extracellular matrix proteins (ecm) in various pathological processes including angiogenesis, thrombosis, apoptosis, cell migration & proliferation are well documented. |
2008-02-11 |
2023-08-12 |
Not clear |
| F Bartolomé, N de Las Cuevas, U Muñoz, F Bermejo, A Martín-Requer. Impaired apoptosis in lymphoblasts from Alzheimer's disease patients: cross-talk of Ca2+/calmodulin and ERK1/2 signaling pathways. Cellular and molecular life sciences : CMLS. vol 64. issue 11. 2007-08-06. PMID:17502994. |
the following observations suggested that modulation of erk1/2 activity by ca(2+)/calmodulin (cam) is involved in preventing apoptosis: (i) erk1/2 activity seems to support lethality in control cells, as pd98059, the inhibitor of the activating mek prevented cell death; (ii) control cells show a persistent and higher stimulation of erk1/2 than that of ad cells in the absence of serum; (iii) cam antagonists have no effects on control cells, but sensitize ad cells to death induced by serum withdrawal and increased erk1/2 phosphorylation, and (iv) no apoptotic effects of cam antagonists were observed in ad cells treated with pd98059. |
2007-08-06 |
2023-08-12 |
Not clear |
| Hui Yang, Sheng-di Chen, Guo-qiang Lu, Biao Li, Liang Liang, Jie-yi X. [Proteasomal inhibitor lactacystin induces cell apoptosis and caspase 3 activation in PC12 cells]. Zhonghua yi xue za zhi. vol 85. issue 29. 2007-05-29. PMID:16313802. |
to explore whether proteasome dysfunction cam induce dopaminergic cell apoptosis and investigate the probable molecular mechanism. |
2007-05-29 |
2023-08-12 |
Not clear |
| Cynthia M Simbulan-Rosenthal, Radharaman Ray, Betty Benton, Emiko Soeda, Ahmad Daher, Dana Anderson, William J Smith, Dean S Rosentha. Calmodulin mediates sulfur mustard toxicity in human keratinocytes. Toxicology. vol 227. issue 1-2. 2006-11-29. PMID:16935404. |
because of its importance in apoptosis in the skin, we tested whether calmodulin (cam) mediates the mitochondrial apoptotic pathway induced by sm. |
2006-11-29 |
2023-08-12 |
human |
| Cynthia M Simbulan-Rosenthal, Radharaman Ray, Betty Benton, Emiko Soeda, Ahmad Daher, Dana Anderson, William J Smith, Dean S Rosentha. Calmodulin mediates sulfur mustard toxicity in human keratinocytes. Toxicology. vol 227. issue 1-2. 2006-11-29. PMID:16935404. |
cam has been shown to activate the phosphatase calcineurin, which can induce apoptosis by bad dephosphorylation. |
2006-11-29 |
2023-08-12 |
human |
| Cynthia M Simbulan-Rosenthal, Radharaman Ray, Betty Benton, Emiko Soeda, Ahmad Daher, Dana Anderson, William J Smith, Dean S Rosentha. Calmodulin mediates sulfur mustard toxicity in human keratinocytes. Toxicology. vol 227. issue 1-2. 2006-11-29. PMID:16935404. |
to determine if pharmacological cam inhibitors could attenuate sm-induced apoptosis via bad dephosphorylation, kc were pretreated with the cam-specific antagonist w-13 or its less active structural analogue w-12. |
2006-11-29 |
2023-08-12 |
human |
| Cynthia M Simbulan-Rosenthal, Radharaman Ray, Betty Benton, Emiko Soeda, Ahmad Daher, Dana Anderson, William J Smith, Dean S Rosentha. Calmodulin mediates sulfur mustard toxicity in human keratinocytes. Toxicology. vol 227. issue 1-2. 2006-11-29. PMID:16935404. |
these results indicate that cam, calcineurin, and bad also play a role in sm-induced apoptosis, and may therefore be targets for therapeutic intervention to reduce sm injury. |
2006-11-29 |
2023-08-12 |
human |
| Shaun M Sheets, Jan Potempa, James Travis, Hansel M Fletcher, Carlos A Casian. Gingipains from Porphyromonas gingivalis W83 synergistically disrupt endothelial cell adhesion and can induce caspase-independent apoptosis. Infection and immunity. vol 74. issue 10. 2006-11-28. PMID:16988242. |
we have shown previously that gingipains from porphyromonas gingivalis w83 can induce cell detachment, cell adhesion molecule (cam) cleavage, and apoptosis in endothelial cells; however, the specific roles of the individual gingipains are unclear. |
2006-11-28 |
2023-08-12 |
Not clear |
| Thomas J Weber, Heather S Smallwood, Loel E Kathmann, Lye Meng Markillie, Thomas C Squier, Brian D Thral. Functional link between TNF biosynthesis and CaM-dependent activation of inducible nitric oxide synthase in RAW 264.7 macrophages. American journal of physiology. Cell physiology. vol 290. issue 6. 2006-07-14. PMID:16421203. |
increasing the level of cellular cam by stable transfection results in reductions in lps-induced expression of tnf and inos, along with reduced activation of their transcriptional regulators and concomitant protection against apoptosis. |
2006-07-14 |
2023-08-12 |
Not clear |
| Thomas J Weber, Heather S Smallwood, Loel E Kathmann, Lye Meng Markillie, Thomas C Squier, Brian D Thral. Functional link between TNF biosynthesis and CaM-dependent activation of inducible nitric oxide synthase in RAW 264.7 macrophages. American journal of physiology. Cell physiology. vol 290. issue 6. 2006-07-14. PMID:16421203. |
although cam and inos protein levels are coordinately increased as part of the oxidative burst, limiting cellular concentrations of cam due to association with inos (and other high-affinity binders) commit the cell to an unchecked inflammatory cascade leading to apoptosis. |
2006-07-14 |
2023-08-12 |
Not clear |
| Fang Tian, Xiongwen Zhang, Yunguang Tong, Yanghua Yi, Shilong Zhang, Ling Li, Peng Sun, Liping Lin, Jian Din. PE, a new sulfated saponin from sea cucumber, exhibits anti-angiogenic and anti-tumor activities in vitro and in vivo. Cancer biology & therapy. vol 4. issue 8. 2006-07-05. PMID:16082187. |
in vivo, cam assays were used to assess inhibition effect of pe on physiological angiogenesis, and immunofluorescent microscopy was used to examine tumor microvessel density and apoptosis in pe-treated mouse tumor models. |
2006-07-05 |
2023-08-12 |
mouse |
| Lei Huang, Yoshihiro Hotta, Kunihiro Miyazeki, Naohisa Ishikawa, Yasuyoshi Miki, Yumi Sugimoto, Jun Yamada, Akinobu Nakano, Kimitoshi Hishiwaki, Yasuhiro Shimad. Different effects of optical isomers of the 5-HT1A receptor antagonist pyrapyridolol against postischemic guinea-pig myocardial dysfunction and apoptosis through the mitochondrial permeability transition pore. European journal of pharmacology. vol 534. issue 1-3. 2006-06-07. PMID:16612842. |
therefore, these results suggest that (s)-(-)-pyrapyridolol likely inhibits the opening of the mptp by preventing the cam overload induced apoptosis related to endogenous 5-ht accumulation in ischemia-reperfusion hearts. |
2006-06-07 |
2023-08-12 |
Not clear |
| Rana Anjum, Philippe P Roux, Bryan A Ballif, Steven P Gygi, John Bleni. The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling. Current biology : CB. vol 15. issue 19. 2006-05-02. PMID:16213824. |
death-associated protein kinase (dapk) is a multidomain calcium/calmodulin (cam)-dependent ser/thr protein kinase with an important role in apoptosis regulation and tumor suppression. |
2006-05-02 |
2023-08-12 |
Not clear |
| Andrew M Schumacher, Anastasia V Velentza, D Martin Watterso. Death-associated protein kinase as a potential therapeutic target. Expert opinion on therapeutic targets. vol 6. issue 4. 2006-04-26. PMID:12223064. |
death associated protein kinase (dapk) is a calmodulin (cam)-regulated serine/threonine protein kinase implicated in diverse apoptosis pathways, including those involved in neuronal cell death and tumour suppression. |
2006-04-26 |
2023-08-12 |
human |
| Jeanna Jacobi, Batya Kristal, Judith Chezar, Shasha M Shaul, Shifra Sel. Exogenous superoxide mediates pro-oxidative, proinflammatory, and procoagulatory changes in primary endothelial cell cultures. Free radical biology & medicine. vol 39. issue 9. 2006-02-23. PMID:16214039. |
sublethal superoxide dose evoked: (1) proinflammatory state manifested by increased il-8 mrna expression and cam on the endothelial surface, (2) huvec apoptosis and activated endothelial nadph oxidase, (3) increase in intracellular tissue factor, and (4) decrease in enos mrna and protein and up-regulation of inos mrna. |
2006-02-23 |
2023-08-12 |
human |
| Raj Wadgaonkar, Steven M Dudek, Ari L Zaiman, Laura Linz-McGillem, Alexander D Verin, Saule Nurmukhambetova, Lewis H Romer, Joe G N Garci. Intracellular interaction of myosin light chain kinase with macrophage migration inhibition factor (MIF) in endothelium. Journal of cellular biochemistry. vol 95. issue 4. 2005-09-19. PMID:15838879. |
the endothelial cell ca2+/calmodulin (cam)-dependent myosin light chain kinase isoform (ec mlck) is a multifunctional contractile effector involved in vascular barrier regulation, leukocyte diapedesis, apoptosis, and angiogenesis. |
2005-09-19 |
2023-08-12 |
Not clear |
| Jing Zhao, Junying Miao, Baoxiang Zhao, Shangli Zhang, Deling Yi. Safrole oxide inhibits angiogenesis by inducing apoptosis. Vascular pharmacology. vol 43. issue 1. 2005-09-08. PMID:15936989. |
eggs treated with 2-11 micromol 100 microl(-1) per egg of the safrole oxide for 48 h exhibited a significant reduction in blood vessel area of the cam, a process likely mediated by apoptosis as demonstrated by dna fragmentation. |
2005-09-08 |
2023-08-12 |
rat |
| Shigetoshi Yano, Motohiro Morioka, Jun-Ichi Kuratsu, Kohji Fukunag. Functional proteins involved in regulation of intracellular Ca(2+) for drug development: role of calcium/calmodulin-dependent protein kinases in ischemic neuronal death. Journal of pharmacological sciences. vol 97. issue 3. 2005-08-29. PMID:15764842. |
calcium/calmodulin (cam)-dependent protein kinase kinase (cam-kk) is an upstream kinase for cam kinase iv (cam-kiv) that was reported to prevent apoptosis through phosphorylation of creb (cyclic amp responsive element-binding protein). |
2005-08-29 |
2023-08-12 |
Not clear |