| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Noemí Esteras, Carolina Alquézar, Félix Bermejo-Pareja, Emilia Bialopiotrowicz, Urszula Wojda, Angeles Martín-Requer. Downregulation of extracellular signal-regulated kinase 1/2 activity by calmodulin KII modulates p21Cip1 levels and survival of immortalized lymphocytes from Alzheimer's disease patients. Neurobiology of aging. vol 34. issue 4. 2013-08-01. PMID:23153928. |
previously, we reported a ca(2+)/calmodulin (cam)-dependent impairment of apoptosis induced by serum deprivation in alzheimer's disease (ad) lymphoblasts. |
2013-08-01 |
2023-08-12 |
Not clear |
| Juan Xiao, Jun Song, Vida Hodara, Allen Ford, Xing Li Wang, Qiang Shi, Li Chen, John L Vandeber. Protective Effects of Resveratrol on TNF-α-Induced Endothelial Cytotoxicity in Baboon Femoral Arterial Endothelial Cells. Journal of diabetes research. vol 2013. 2013-05-15. PMID:23671856. |
endothelial cell (ec) apoptosis, proliferation, migration, and cellular adhesion molecule (cam) expression contribute to the development of atherosclerosis. |
2013-05-15 |
2023-08-12 |
Not clear |
| Masashi Ohe, Satoshi Hashino, Atsuo Hattor. Successful treatment of diffuse large B-cell lymphoma with clarithromycin and prednisolone. The Korean journal of hematology. vol 47. issue 4. 2013-01-16. PMID:23320009. |
she did not receive conventional chemotherapy because of the risk of recurrent non-tuberculous mycobacteria infection; therefore, she was treated with 20 mg/day psl and 800 mg/day cam to induce apoptosis in lymphoma cells. |
2013-01-16 |
2023-08-12 |
Not clear |
| B B Chen, J R Glasser, T A Coon, R K Mallampall. F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest. Oncogene. vol 31. issue 20. 2012-08-31. PMID:22020328. |
the chemotherapeutic agent vinorelbine increased apoptosis of human lung carcinoma cells by inducing fbxl2 expression and cyclin d3 degradation, an effect accentuated by cam knockdown. |
2012-08-31 |
2023-08-12 |
mouse |
| Seiichiro Komatsu, Keisuke Miyazawa, Shota Moriya, Akiko Takase, Munekazu Naito, Masato Inazu, Norio Kohno, Masahiro Itoh, Akio Tomod. Clarithromycin enhances bortezomib-induced cytotoxicity via endoplasmic reticulum stress-mediated CHOP (GADD153) induction and autophagy in breast cancer cells. International journal of oncology. vol 40. issue 4. 2012-08-31. PMID:22200786. |
simultaneously targeting two major intracellular protein degradation pathways such as the ubiquitin-proteasome system by bz and the autophagy-lysosome pathway by cam may improve the therapeutic outcome in breast cancer patients via er-stress mediated apoptosis. |
2012-08-31 |
2023-08-12 |
Not clear |
| Huixiang Yin, Zhenwang Liu, Ailian Zhang, Tianyuan Zhang, Jinxian Luo, Jincheng Shen, Liping Chen, Bing Zhou, Xian Fu, Ceyi Fu, Zehua Zhan. Intracellular expression and purification of the Canstatin-N protein in Pichia pastoris. Gene. vol 504. issue 1. 2012-08-28. PMID:22575729. |
the purified recombinant canstatin-n inhibited cam angiogenesis and induced significant apoptosis of the human umbilical vein endothelial cell (evc340). |
2012-08-28 |
2023-08-12 |
human |
| Kanwardeep S Kaleka, Amber N Petersen, Matthew A Florence, Nashaat Z Gerge. Pull-down of calmodulin-binding proteins. Journal of visualized experiments : JoVE. issue 59. 2012-05-25. PMID:22297704. |
cam is involved at multiple levels in almost all cellular processes, including apoptosis, metabolism, smooth muscle contraction, synaptic plasticity, nerve growth, inflammation and the immune response. |
2012-05-25 |
2023-08-12 |
Not clear |
| D X Su, A L Zhang, G H Yi, Z W Liu, J X Luo, L Y Rao, T Y Zhang, Z J Zho. Inducible expression of calreticulin-N58 in Pichia pastoris by high density cell culture. Molecular biology reports. vol 38. issue 8. 2012-02-17. PMID:21181274. |
the recombinant calreticulin-n58 induced endothelial cell apoptosis and inhibited the angiogenesis on the cam. |
2012-02-17 |
2023-08-12 |
Not clear |
| Gu Jing, Kaiyu Yuan, Qiuli Liang, Yong Sun, Xia Mao, Jay M McDonald, Yabing Che. Reduced CaM/FLIP binding by a single point mutation in c-FLIP(L) modulates Fas-mediated apoptosis and decreases tumorigenesis. Laboratory investigation; a journal of technical methods and pathology. vol 92. issue 1. 2012-02-15. PMID:21912376. |
deletion of the cam-binding region (amino acid 197-213) results in reduced cam binding, and increased fas-mediated apoptosis and decreased tumorigenesis of cholangiocarcinoma cells. |
2012-02-15 |
2023-08-12 |
mouse |
| Gu Jing, Kaiyu Yuan, Qiuli Liang, Yong Sun, Xia Mao, Jay M McDonald, Yabing Che. Reduced CaM/FLIP binding by a single point mutation in c-FLIP(L) modulates Fas-mediated apoptosis and decreases tumorigenesis. Laboratory investigation; a journal of technical methods and pathology. vol 92. issue 1. 2012-02-15. PMID:21912376. |
reduced cam binding by the h204 mutant resulted in increased sensitivity to fas-mediated apoptosis and inhibited tumor growth in mice compared with wild-type c-flip(l). |
2012-02-15 |
2023-08-12 |
mouse |
| Tatsuya Usui, Muneyoshi Okada, Yukio Hara, Hideyuki Yamawak. Exploring calmodulin-related proteins, which mediate development of hypertension, in vascular tissues of spontaneous hypertensive rats. Biochemical and biophysical research communications. vol 405. issue 1. 2011-03-14. PMID:21195054. |
calmodulin (cam) is associated with a variety of cell functions including inflammation, apoptosis, and muscular contraction. |
2011-03-14 |
2023-08-12 |
rat |
| Ping Mu, Qing Liu, Rongliang Zhen. Biphasic regulation of H2O2 on angiogenesis implicated NADPH oxidase. Cell biology international. vol 34. issue 10. 2011-01-10. PMID:20575760. |
in the present work, we examined the effects of h2o2 on angiogenesis including proliferation and migration in huvecs (human umbilical vein endothelial cells), new vessel formation in chicken embryo cam (chorioallantoic membrane) and endothelial cell apoptosis, which is closely related to anti-angiogenesis. |
2011-01-10 |
2023-08-12 |
human |
| Giuliana Papoff, Nadia Trivieri, Roberta Crielesi, Francesca Ruberti, Sonia Marsilio, Giovina Rubert. FADD-calmodulin interaction: a novel player in cell cycle regulation. Biochimica et biophysica acta. vol 1803. issue 8. 2010-09-23. PMID:20420860. |
moreover, complementation experiments in jurkat fadd-/- t cells indicated that: a) cells expressing fadd mutants in the cam binding sites are protected from taxol-induced g2/m cell cycle arrest; b) fadd/cam interaction is not required for fas receptor-mediated apoptosis although fas and cam might compete for binding to fadd. |
2010-09-23 |
2023-08-12 |
mouse |
| Zhicheng Wang, Suping Li, Quanwei Shi, Rong Yan, Guanglei Liu, Kesheng Da. Calmodulin antagonists induce platelet apoptosis. Thrombosis research. vol 125. issue 4. 2010-07-02. PMID:20172594. |
calmodulin (cam) antagonists induce apoptosis in various tumor models and inhibit tumor cell invasion and metastasis, thus some of which have been extensively used as anti-cancer agents. |
2010-07-02 |
2023-08-12 |
human |
| Zhicheng Wang, Suping Li, Quanwei Shi, Rong Yan, Guanglei Liu, Kesheng Da. Calmodulin antagonists induce platelet apoptosis. Thrombosis research. vol 125. issue 4. 2010-07-02. PMID:20172594. |
however, it is still unknown whether cam antagonists induce platelet apoptosis. |
2010-07-02 |
2023-08-12 |
human |
| Zhicheng Wang, Suping Li, Quanwei Shi, Rong Yan, Guanglei Liu, Kesheng Da. Calmodulin antagonists induce platelet apoptosis. Thrombosis research. vol 125. issue 4. 2010-07-02. PMID:20172594. |
therefore, these findings indicate that cam antagonists induce platelet apoptosis. |
2010-07-02 |
2023-08-12 |
human |
| Zhicheng Wang, Suping Li, Quanwei Shi, Rong Yan, Guanglei Liu, Kesheng Da. Calmodulin antagonists induce platelet apoptosis. Thrombosis research. vol 125. issue 4. 2010-07-02. PMID:20172594. |
the elevation of the cytosolic ca(2+) levels may be involved in the regulation of cam antagonists-induced platelet apoptosis. |
2010-07-02 |
2023-08-12 |
human |
| Mi-kyung Hwang, Yong Ki Min, Seong Hwan Ki. Calmodulin inhibition contributes to sensitize TRAIL-induced apoptosis in human lung cancer H1299 cells. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 87. issue 6. 2010-03-04. PMID:19935877. |
we evaluated the effect of 180 enzyme inhibitors on trail-induced apoptosis in human lung cancer h1299 cells, and found fluphenazine-n-2-chloroethane (a calmodulin (cam) antagonist) sensitized trail-induced apoptosis. |
2010-03-04 |
2023-08-12 |
human |
| Mi-kyung Hwang, Yong Ki Min, Seong Hwan Ki. Calmodulin inhibition contributes to sensitize TRAIL-induced apoptosis in human lung cancer H1299 cells. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 87. issue 6. 2010-03-04. PMID:19935877. |
we suggested the blockade of cam could sensitize lung cancer cells to trail-induced apoptosis in at least 2 ways: (i) it can activate death-inducing signaling complex mediated apoptosis by inhibiting trail-induced binding of flip and trail-enhanced binding of caspase-8 to fadd; (ii) it can inhibit akt phosphorylation, consequently leading to decreased expression of anti-apoptotic molecules such as flip and members of the inhibitor of apoptosis protein family. |
2010-03-04 |
2023-08-12 |
human |
| Mi-kyung Hwang, Yong Ki Min, Seong Hwan Ki. Calmodulin inhibition contributes to sensitize TRAIL-induced apoptosis in human lung cancer H1299 cells. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 87. issue 6. 2010-03-04. PMID:19935877. |
this study suggests the combination of cam antagonists with trail may have the therapeutic potential to overcome the resistance of lung cancers to apoptosis. |
2010-03-04 |
2023-08-12 |
human |