| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kaiyu Yuan, Sun Yong, Fei Xu, Tong Zhou, Jay M McDonald, Yabing Che. Calmodulin antagonists promote TRA-8 therapy of resistant pancreatic cancer. Oncotarget. vol 6. issue 28. 2016-07-25. PMID:26320171. |
we investigated the effects of calmodulin(cam) antagonists, trifluoperazine(tfp) and tamoxifen(tmx), on tra-8-induced apoptosis and tumorigenesis of tra-8-resistant pancreatic cancer cells, and underlying mechanisms. |
2016-07-25 |
2023-08-13 |
Not clear |
| Kaiyu Yuan, Sun Yong, Fei Xu, Tong Zhou, Jay M McDonald, Yabing Che. Calmodulin antagonists promote TRA-8 therapy of resistant pancreatic cancer. Oncotarget. vol 6. issue 28. 2016-07-25. PMID:26320171. |
altogether, we have demonstrated that cam antagonists enhance tra-8-induced apoptosis of tra-8-resistant pancreatic cancer cells by increasing dr5 expression and enhancing recruitment of apoptotic signal while decreasing survival signals in dr5-associated disc. |
2016-07-25 |
2023-08-13 |
Not clear |
| Bliss J Chang, Alexandra B Samal, Jiri Vlach, Timothy F Fernandez, Dewey Brooke, Peter E Prevelige, Jamil S Saa. Identification of the Calmodulin-Binding Domains of Fas Death Receptor. PloS one. vol 11. issue 1. 2016-07-06. PMID:26735300. |
inhibition of cam activity in disc stimulates apoptosis significantly. |
2016-07-06 |
2023-08-13 |
Not clear |
| Bliss J Chang, Alexandra B Samal, Jiri Vlach, Timothy F Fernandez, Dewey Brooke, Peter E Prevelige, Jamil S Saa. Identification of the Calmodulin-Binding Domains of Fas Death Receptor. PloS one. vol 11. issue 1. 2016-07-06. PMID:26735300. |
here, we employed mass spectrometry, nuclear magnetic resonance (nmr), biophysical, and biochemical methods to identify the binding regions of fasdd and provide a molecular basis for the role of cam in fas-mediated apoptosis. |
2016-07-06 |
2023-08-13 |
Not clear |
| Emilia Păunescu, Patrycja Nowak-Sliwinska, Catherine M Clavel, Rosario Scopelliti, Arjan W Griffioen, Paul J Dyso. Anticancer Organometallic Osmium(II)-p-cymene Complexes. ChemMedChem. vol 10. issue 9. 2016-06-21. PMID:26190176. |
two of these three cancer-cell-selective compounds induce cell death largely via apoptosis and were also found to disrupt vascularization in the chicken embryo chorioallantoic membrane (cam) model. |
2016-06-21 |
2023-08-13 |
human |
| Zhihong Chen, Walid Jalabi, Weiwei Hu, Hyun-Joo Park, John T Gale, Grahame J Kidd, Rodica Bernatowicz, Zachary C Gossman, Jacqueline T Chen, Ranjan Dutta, Bruce D Trap. Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain. Nature communications. vol 5. 2016-04-26. PMID:25047355. |
increased neuronal activity results in the calcium-mediated activation of cam kinase iv, phosphorylation of creb, increased expression of antiapoptotic and neurotrophic molecules and reduced apoptosis of cortical neurons following injury. |
2016-04-26 |
2023-08-13 |
mouse |
| Maike Busch, Claudia Philippeit, Andreas Weise, Nicole Dünke. Re-characterization of established human retinoblastoma cell lines. Histochemistry and cell biology. vol 143. issue 3. 2015-10-01. PMID:25326674. |
forty years after their first description, in the present study, we re-characterized seven established retinoblastoma cell lines with regard to their rb1 mutation status, morphology, growth pattern, endogenous apoptosis levels, colony formation efficiency in soft agar and invasiveness and dissemination capacity in chick chorioallantoic membrane (cam) assays. |
2015-10-01 |
2023-08-13 |
human |
| Shuang Liu, Feng-ping Xu, Zi-jiang Yang, Ming Li, Ya-hong Min, Shu L. Cadmium-induced injury and the ameliorative effects of selenium on chicken splenic lymphocytes: mechanisms of oxidative stress and apoptosis. Biological trace element research. vol 160. issue 3. 2015-08-28. PMID:25035189. |
the population of apoptosis cells demonstrated that cd induces the apoptosis of chicken splenic lymphocytes; in addition, increased mrna level of bak, p53, caspase-3, caspase-9, and cytochrome c (cyt c) and decreased bcl-2, bcl-xl, and cam were observed in cd treatment group. |
2015-08-28 |
2023-08-13 |
cat |
| Shota Moriya, Seiichiro Komatsu, Kaho Yamasaki, Yusuke Kawai, Hiroko Kokuba, Ayako Hirota, Xiao-Fang Che, Masato Inazu, Akihiko Gotoh, Masaki Hiramoto, Keisuke Miyazaw. Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress‑mediated cell death in multiple myeloma cells. International journal of oncology. vol 46. issue 2. 2015-08-21. PMID:25422130. |
pronounced apoptosis was induced by the combination of vorinostat [suberoylanilide hydroxamic acid (saha); potently inhibits hdac6] with cam and bz compared with each reagent or a 2‑reagent combination. |
2015-08-21 |
2023-08-13 |
Not clear |
| Shigeyuki Yokokura, Saki Yurimoto, Akihito Matsuoka, Osamu Imataki, Hiroaki Dobashi, Shuji Bandoh, Takuya Matsunag. Calmodulin antagonists induce cell cycle arrest and apoptosis in vitro and inhibit tumor growth in vivo in human multiple myeloma. BMC cancer. vol 14. 2015-08-20. PMID:25424011. |
calmodulin (cam) antagonists have been reported to induce apoptosis and inhibit tumor cell invasion and metastasis in various tumor models. |
2015-08-20 |
2023-08-13 |
human |
| Peng Cao, Wenting Zhang, Wenjun Gui, Yuhui Dong, Tao Jiang, Yong Gon. Structural insights into the mechanism of calmodulin binding to death receptors. Acta crystallographica. Section D, Biological crystallography. vol 70. issue Pt 6. 2015-01-30. PMID:24914971. |
calmodulin (cam), a major calcium sensor, has previously been reported to be one of the fas adaptors that modulate apoptosis. |
2015-01-30 |
2023-08-13 |
Not clear |
| Chaitali Banerjee, Preeti Khatri, Rajagopal Raman, Himanshi Bhatia, Malabika Datta, Shibnath Mazumde. Role of calmodulin-calmodulin kinase II, cAMP/protein kinase A and ERK 1/2 on Aeromonas hydrophila-induced apoptosis of head kidney macrophages. PLoS pathogens. vol 10. issue 4. 2014-12-10. PMID:24763432. |
camk kinase (camkk), the other cam dependent kinase exhibited no role in a. hydrophila-induced hkm apoptosis. |
2014-12-10 |
2023-08-13 |
Not clear |
| Chaitali Banerjee, Preeti Khatri, Rajagopal Raman, Himanshi Bhatia, Malabika Datta, Shibnath Mazumde. Role of calmodulin-calmodulin kinase II, cAMP/protein kinase A and ERK 1/2 on Aeromonas hydrophila-induced apoptosis of head kidney macrophages. PLoS pathogens. vol 10. issue 4. 2014-12-10. PMID:24763432. |
we conclude that the alteration in intracellular ca2+ levels initiated by a. hydrophila activates cam and calpain-2; both pathways converge on camkiig which in turn induces camp/pka mediated erk 1/2 phosphorylation leading to caspase-3 mediated apoptosis of infected hkm. |
2014-12-10 |
2023-08-13 |
Not clear |
| Hyo-Eun Yoon, Seone-Hee Oh, Soo-A Kim, Jung-Hoon Yoon, Sang-Gun Ah. Pheophorbide a-mediated photodynamic therapy induces autophagy and apoptosis via the activation of MAPKs in human skin cancer cells. Oncology reports. vol 31. issue 1. 2014-09-05. PMID:24253565. |
an in vivo study using the cam xenograft model demonstrated that pa-pdt strongly induced autophagy and apoptosis in a431-transplanted tumors and/or apoptosis in g361-transplanted tumors. |
2014-09-05 |
2023-08-12 |
human |
| Romone M Fancy, Lingyun Wang, Tiara Napier, Jiabei Lin, Gu Jing, Aaron L Lucius, Jay M McDonald, Tong Zhou, Yuhua Son. Characterization of calmodulin-Fas death domain interaction: an integrated experimental and computational study. Biochemistry. vol 53. issue 16. 2014-08-20. PMID:24702583. |
a quantitative understanding of the interaction between cam and fas is important for the optimal design of antagonists for cam or fas to regulate the cam-fas interaction, thus modulating fas-mediated disc formation and apoptosis. |
2014-08-20 |
2023-08-13 |
mouse |
| C Sticozzi, G Belmonte, A Meini, P Carbotti, G Grasso, M Palm. IL-1β induces GFAP expression in vitro and in vivo and protects neurons from traumatic injury-associated apoptosis in rat brain striatum via NFκB/Ca²⁺-calmodulin/ERK mitogen-activated protein kinase signaling pathway. Neuroscience. vol 252. 2014-06-11. PMID:23928073. |
we investigated in human astrocytoma cells and the rat brain striatum, the role of the nuclear factor-kb (nf-kb) intracellular ca(2+) concentration ([ca(2+)]i) calmodulin (cam) and extracellular regulated mitogen-activated protein kinases (erk1/2) in il-1β-induced expression of glial fibrillary acidic protein (gfap) and neuronal apoptosis associated to a brain trauma. |
2014-06-11 |
2023-08-12 |
human |
| Henning Tidow, Poul Nisse. Structural diversity of calmodulin binding to its target sites. The FEBS journal. vol 280. issue 21. 2013-12-05. PMID:23601118. |
calmodulin (cam) is a ubiquitous, highly conserved, eukaryotic protein that binds to and regulates a number of diverse target proteins involved in different functions such as metabolism, muscle contraction, apoptosis, memory, inflammation and the immune response. |
2013-12-05 |
2023-08-12 |
Not clear |
| Timothy F Fernandez, Alexandra B Samal, Gregory J Bedwell, Yabing Chen, Jamil S Saa. Structural and biophysical characterization of the interactions between the death domain of Fas receptor and calmodulin. The Journal of biological chemistry. vol 288. issue 30. 2013-11-04. PMID:23760276. |
cam antagonists induce apoptosis through a fas-related mechanism in cholangiocarcinoma and other cancer cell lines possibly by inhibiting fas-cam interactions. |
2013-11-04 |
2023-08-12 |
Not clear |
| Timothy F Fernandez, Alexandra B Samal, Gregory J Bedwell, Yabing Chen, Jamil S Saa. Structural and biophysical characterization of the interactions between the death domain of Fas receptor and calmodulin. The Journal of biological chemistry. vol 288. issue 30. 2013-11-04. PMID:23760276. |
our findings provide the first structural evidence for fas-cam interactions and mechanism of inhibition and provide new insight into the molecular basis for a novel role of cam in regulating fas-mediated apoptosis. |
2013-11-04 |
2023-08-12 |
Not clear |
| Seiichiro Komatsu, Shota Moriya, Xiao-Fang Che, Tomohisa Yokoyama, Norio Kohno, Keisuke Miyazaw. Combined treatment with SAHA, bortezomib, and clarithromycin for concomitant targeting of aggresome formation and intracellular proteolytic pathways enhances ER stress-mediated cell death in breast cancer cells. Biochemical and biophysical research communications. vol 437. issue 1. 2013-10-01. PMID:23792097. |
we previously reported that clarithromycin (cam) blocks autophagy flux, and that combined treatment with cam and proteasome inhibitor bortezomib (bz) enhances er-stress-mediated apoptosis in breast cancer cells, whereas treatment with cam alone results in almost no cytotoxicity. |
2013-10-01 |
2023-08-12 |
Not clear |