| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dhanush Danes, Pooja Raval, Anjali Singh, Lakshmi Pillai, Suresh Balakrishna. Exposure to a sublethal dose of technical grade flubendiamide hampers angiogenesis in the chicken chorioallantoic membrane. Toxicological research. vol 40. issue 4. 2024-09-30. PMID:39345746. |
caspase-3 reaffirmed heightened apoptosis in the cam of day 2 embryos. |
2024-09-30 |
2024-10-02 |
chicken |
| Shota Moriya, Hiromi Kazama, Hirotsugu Hino, Naoharu Takano, Masaki Hiramoto, Shin Aizawa, Keisuke Miyazaw. Clarithromycin overcomes stromal cell-mediated drug resistance against proteasome inhibitors in myeloma cells via autophagy flux blockage leading to high NOXA expression. PloS one. vol 18. issue 12. 2023-12-01. PMID:38039297. |
we previously reported that macrolide antibiotics, such as clarithromycin (cam), blocked autophagy flux, and simultaneous proteasome and autophagy inhibition by bortezomib (btz) plus cam resulted in enhanced apoptosis induction in multiple myeloma (mm) cells via increased endoplasmic reticulum (er) stress loading. |
2023-12-01 |
2023-12-10 |
Not clear |
| Fang-Fang Ren, Lin Zhao, Xian-Yun Jiang, Jing-Jing Zhang, Jia-Min Gou, Xiao-Yu Yu, Shu-Jin Wu, Lei L. Sphingosylphosphorylcholine alleviates pressure overload-induced myocardial remodeling in mice via inhibiting CaM-JNK/p38 signaling pathway. Acta pharmacologica Sinica. 2023-10-13. PMID:37833535. |
in this study we investigated the role of cam in cardiomyocyte apoptosis in heart failure and the associated signaling pathways. |
2023-10-13 |
2023-10-15 |
mouse |
| Seyed Isaac Hashemy, Hamed Amiri, Hossein Hosseini, Farzaneh Sadeghzadeh, Muslem Mohammed Mosa Jaseem, Masoud Homayouni Tabriz. PEGylated Lecithin-Chitosan-Folic Acid Nanoparticles as Nanocarriers of Allicin for In Vitro Controlled Release and Anticancer Effects. Applied biochemistry and biotechnology. 2023-01-18. PMID:36652093. |
increased expression of caspase 3 and 9 genes showed activation of the intrinsic apoptosis pathway in treated cells, and on the other hand, reduction of vascular and embryonic growth factors in cam model confirmed the anti-angiogenesis effects of ac-plcf-nps. |
2023-01-18 |
2023-08-14 |
Not clear |
| Pei Pei Che, Ana Katrina Mapanao, Alessandro Gregori, Maria Laura Ermini, Agata Zamborlin, Mjriam Capula, Danitsja Ngadimin, Ben J Slotman, Valerio Voliani, Peter Sminia, Elisa Giovannett. Biodegradable Ultrasmall-in-Nano Architectures Loaded with Cisplatin Prodrug in Combination with Ionizing Radiation Induces DNA Damage and Apoptosis in Pancreatic Ductal Adenocarcinoma. Cancers. vol 14. issue 12. 2022-06-24. PMID:35740699. |
similarly, combined treatment of nas-cispt + ir in pdac3 and suit2-028 cam models showed enhanced dna damage and apoptosis leading to tumor growth delay. |
2022-06-24 |
2023-08-14 |
Not clear |
| Anna Wawruszak, Jarogniew Luszczki, Estera Okon, Arkadiusz Czerwonka, Andrzej Stepula. Antagonistic Pharmacological Interaction between Sirtuin Inhibitor Cambinol and Paclitaxel in Triple-Negative Breast Cancer Cell Lines: An Isobolographic Analysis. International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35742901. |
induction of apoptosis in tnbc cell lines after pax and cam treatment applied individually or in combination was determined by flow cytometry (facs) as a number of cells with active caspase-3. |
2022-06-24 |
2023-08-14 |
human |
| Maryam Mohammadlou, Shima Salehi, Rasoul Baharlo. Development of anti DLL4 nanobody fused to truncated form of Pseudomonas exotoxin: As a novel immunotoxin to inhibit of cell proliferation and neovascularization. Analytical biochemistry. 2022-06-09. PMID:35679954. |
the functional assessment was carried out via mtt, apoptosis and cam assays. |
2022-06-09 |
2023-08-14 |
chicken |
| Ganesh Babu Manoharan, Sunday Okutachi, Daniel Abankw. Potential of phenothiazines to synergistically block calmodulin and reactivate PP2A in cancer cells. PloS one. vol 17. issue 5. 2022-05-26. PMID:35617282. |
consistently, we show that the combination of a cam inhibitor and the pp2a activator dt-061 synergistically inhibited the 3d-spheroid formation of mda-mb-231 (k-ras-g13d), nci-h358 (k-ras-g12c) and a375 (b-raf-v600e) cancer cells, and increased apoptosis in mda-mb-231. |
2022-05-26 |
2023-08-13 |
Not clear |
| Ning Li, Dong Gao, Chen Li, Baiqi Wang, Boying Li, Benkai Bao, Manman Wu, Mengying Li, Chengfen Xin. Polymer Nanoparticles Overcome Drug Resistance by a Dual-Targeting Apoptotic Signaling Pathway in Breast Cancer. ACS applied materials & interfaces. 2022-05-11. PMID:35544735. |
simultaneously, the cpns locally release w-7, which targets calmodulin (cam) and further promotes caspase-8 cleavage and enhances cancer cell apoptosis. |
2022-05-11 |
2023-08-13 |
Not clear |
| Benkai Bao, Dong Gao, Ning Li, Manman Wu, Chengfen Xin. Near-Infrared Light Regulation of Tumor PI3K/Akt Signaling Pathway for Enhancing Cancer Cell Apoptosis through Conjugated Polymer Nanoparticles. ACS applied bio materials. vol 3. issue 4. 2022-01-13. PMID:35025292. |
calmodulin (cam), as a calcium binding protein involved in the signal pathways of many life activities such as cell proliferation and apoptosis, can be regulated with the near-infrared (nir) light-based photothermal conversion. |
2022-01-13 |
2023-08-13 |
Not clear |
| Gülsel Yurtdaş-Kırımlıoğlu, Kadri Güleç, Şennur Görgülü, Hülya Tuba Kıya. Oseltamivir phosphate loaded pegylated-Eudragit nanoparticles for lung cancer therapy: Characterization, prolonged release, cytotoxicity profile, apoptosis pathways and in vivo anti-angiogenic effect by using CAM assay. Microvascular research. vol 139. 2021-11-30. PMID:34520775. |
oseltamivir phosphate loaded pegylated-eudragit nanoparticles for lung cancer therapy: characterization, prolonged release, cytotoxicity profile, apoptosis pathways and in vivo anti-angiogenic effect by using cam assay. |
2021-11-30 |
2023-08-13 |
Not clear |
| Lian Liu, Ming Liu, Wei Zhao, Yuan-Ling Zhao, Yun Wan. Tetrahydropalmatine Regulates BDNF through TrkB/CAM Interaction to Alleviate the Neurotoxicity Induced by Methamphetamine. ACS chemical neuroscience. vol 12. issue 18. 2021-09-20. PMID:34448569. |
thp attenuated the ma-induced neurotoxicity by decreasing cam, increasing trkb, phosphorylating akt, up-regulating nf-κb and bdnf, and inhibiting cell apoptosis. |
2021-09-20 |
2023-08-13 |
rat |
| Ying Li, Qi Qi, Wan-Cheng Yang, Tian-Liang Zhang, Chen-Chen Lu, Yu-Juan Yao, Wei-Hua Kong, Jing Zha. Sphingosylphosphorylcholine alleviates hypoxia-caused apoptosis in cardiac myofibroblasts via CaM/p38/STAT3 pathway. Apoptosis : an international journal on programmed cell death. vol 25. issue 11-12. 2021-08-19. PMID:33068199. |
we clarified that spc inhibited myofibroblast apoptosis through cam as evidenced by decreased cleaved caspase 3, parp1 and condensed nucleus. |
2021-08-19 |
2023-08-13 |
Not clear |
| Ying Li, Qi Qi, Wan-Cheng Yang, Tian-Liang Zhang, Chen-Chen Lu, Yu-Juan Yao, Wei-Hua Kong, Jing Zha. Sphingosylphosphorylcholine alleviates hypoxia-caused apoptosis in cardiac myofibroblasts via CaM/p38/STAT3 pathway. Apoptosis : an international journal on programmed cell death. vol 25. issue 11-12. 2021-08-19. PMID:33068199. |
furthermore, the employment of inhibitor and agonist of p38 and stat3 suggests that spc inhibits myofibroblast apoptosis by regulating the phosphorylation of p38 and stat3, and they act as downstream of cam. |
2021-08-19 |
2023-08-13 |
Not clear |
| T S Anirudhan, V Manjusha, V Chithra Sekha. A new biodegradable nano cellulose-based drug delivery system for pH-controlled delivery of curcumin. International journal of biological macromolecules. vol 183. 2021-07-26. PMID:34097960. |
the prepared dds was also examined for apoptosis, hemocompatibility, and chorioallantoic membrane (cam) studies to assess its pharmaceutical field application and the investigation results recommended that it may serve as a potential device for targeted delivery and controlled release of cur for cancer treatment. |
2021-07-26 |
2023-08-13 |
Not clear |
| Justus Kähler, Susanne Hafner, Tanja Popp, Cornelius Hermann, Alexis Rump, Matthias Port, Konrad Steinestel, Stefan Ede. Heterogeneous nuclear ribonucleoprotein K is overexpressed and contributes to radioresistance irrespective of HPV status in head and neck squamous cell carcinoma. International journal of molecular medicine. vol 46. issue 5. 2021-06-30. PMID:32901844. |
sirna‑based knockdown of hnrnp k induced apoptosis and abolished tumor formation after xenotransplantation of hnscc cells onto the chick egg chorioallantoic membrane (cam). |
2021-06-30 |
2023-08-13 |
human |
| Dandan Shao, Jiayong Zhang, Le Tang, Qiuli Yu, Xiaoxiao Hu, Qin Ruan, Wei Ouyang, Zigui Zhan. Effects and Molecular Mechanism of L-Type Calcium Channel on Fluoride-Induced Kidney Injury. Biological trace element research. vol 197. issue 1. 2021-06-18. PMID:31792773. |
the apoptosis of kidney cell was observed by tunel, and the protein expression levels of cav1.2 and cam, camkii, bcl-2, and bax were detected by western blot. |
2021-06-18 |
2023-08-13 |
mouse |
| Soad Nasr, Mai Rady, Aya Sebak, Iman Gomaa, Walid Fayad, Menna El Gaafary, Mahmoud Abdel-Kader, Tatiana Syrovets, Thomas Simme. A Naturally Derived Carrier for Photodynamic Treatment of Squamous Cell Carcinoma: In Vitro and In Vivo Models. Pharmaceutics. vol 12. issue 6. 2020-09-28. PMID:32485800. |
in addition, pdt treatment of squamous cell carcinoma xenografts grown on chorioallantoic membranes of chick eggs (cam) exhibited reduced expression of ki-67 proliferation marker and increased terminal deoxynucleotidyl transferase dutp nick end labelling (tunel) staining, indicating reduced proliferation and activation of apoptosis, respectively. |
2020-09-28 |
2023-08-13 |
chicken |
| Anran Xu, Jianye Wang, Haiyu Wang, Yanqing Sun, Tianyu Ha. Protective effect of lycopene on testicular toxicity induced by Benzo[a]pyrene intake in rats. Toxicology. vol 427. 2020-05-19. PMID:31568845. |
besides, lyc ameliorated bap-mediated gap-junction dysfunction of sertoli cells, as shown by the inhibited sertoli cell death and apoptosis, the upregulation of bcl2 and cx43, the downregulation of cleaved caspase 3, bax and cam, and the decrease in ca |
2020-05-19 |
2023-08-13 |
rat |
| Zeinab Abd El-Samad Ibrahim, Amal Ahmad El-Ashmawy, Yomna Mazid El-Hamd Neinaa, Dareen Abd El-Aziz Mohamma. Immunohistochemical Expression of Calmodulin in Cutaneous Lichen Planus: A Case-Control Study. Indian journal of dermatology. vol 64. issue 4. 2020-02-25. PMID:31516153. |
calmodulin (cam) is a multifunctional intermediate messenger protein that plays important role in cell motility, proliferation, and apoptosis. |
2020-02-25 |
2023-08-13 |
Not clear |