| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W Gorczyca, M R Melamed, Z Darzynkiewic. Apoptosis of S-phase HL-60 cells induced by DNA topoisomerase inhibitors: detection of DNA strand breaks by flow cytometry using the in situ nick translation assay. Toxicology letters. vol 67. issue 1-3. 1993-04-12. PMID:8383887. |
dna topoisomerase i inhibitor camptothecin (cam), topoisomerase ii inhibitors teniposide (tn) and amsacrine (m-amsa) induce apoptosis of hl-60 cells. |
1993-04-12 |
2023-08-12 |
Not clear |
| W Gorczyca, M R Melamed, Z Darzynkiewic. Apoptosis of S-phase HL-60 cells induced by DNA topoisomerase inhibitors: detection of DNA strand breaks by flow cytometry using the in situ nick translation assay. Toxicology letters. vol 67. issue 1-3. 1993-04-12. PMID:8383887. |
at that early stage of apoptosis dna was not yet extractable from the cells; the loss of dna from s-phase cells could not be seen, by flow cytometry, during the initial 2 h of incubation with cam. |
1993-04-12 |
2023-08-12 |
Not clear |
| S Bruno, P Lassota, W Giaretti, Z Darzynkiewic. Apoptosis of rat thymocytes triggered by prednisolone, camptothecin, or teniposide is selective to G0 cells and is prevented by inhibitors of proteases. Oncology research. vol 4. issue 1. 1992-06-16. PMID:1374671. |
rat thymocytes were treated in culture with prednisolone or the dna topoisomerase i or ii inhibitors, camptothecin (cam) or teniposide (tn), and proportions of cells in different phases of the cell cycle were estimated by flow cytometry using a staining methodology which makes it possible to discriminate between g0 and g1 cells, as well as to recognize the cells which undergo apoptosis. |
1992-06-16 |
2023-08-11 |
rat |
| S Bruno, P Lassota, W Giaretti, Z Darzynkiewic. Apoptosis of rat thymocytes triggered by prednisolone, camptothecin, or teniposide is selective to G0 cells and is prevented by inhibitors of proteases. Oncology research. vol 4. issue 1. 1992-06-16. PMID:1374671. |
together with our earlier studies on the effects of cam and tn on molt-4 and hl-60 leukemic cell lines, these data indicate that both, phenotypic- and and cell cycle phase specific- factors modify the ability of cells to respond to toxic agents, including chemotherapeutics by apoptosis. |
1992-06-16 |
2023-08-11 |
rat |
| D R Dowd, P N MacDonald, B S Komm, M R Haussler, R Miesfel. Evidence for early induction of calmodulin gene expression in lymphocytes undergoing glucocorticoid-mediated apoptosis. The Journal of biological chemistry. vol 266. issue 28. 1991-11-08. PMID:1917967. |
in the present study, expression of the cam gene was examined during glucocorticoid-induced apoptosis in wehi7.2 lymphocytes. |
1991-11-08 |
2023-08-11 |
Not clear |
| D R Dowd, P N MacDonald, B S Komm, M R Haussler, R Miesfel. Evidence for early induction of calmodulin gene expression in lymphocytes undergoing glucocorticoid-mediated apoptosis. The Journal of biological chemistry. vol 266. issue 28. 1991-11-08. PMID:1917967. |
these results indicate that cam mrna levels were hormonally controlled in wehi7.2 lymphocytes and support the putative involvement of cam in glucocorticoid-induced apoptosis. |
1991-11-08 |
2023-08-11 |
Not clear |