| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H C Drexler, W Risau, M A Konerdin. Inhibition of proteasome function induces programmed cell death in proliferating endothelial cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 1. 2000-02-17. PMID:10627281. |
psi treatment of the cam led to the formation of areas devoid of blood flow due to the induction of apoptosis in endothelial and other cells and to the collapse of capillaries and first order vessels. |
2000-02-17 |
2023-08-12 |
chicken |
| H Baisch, H Bollmann, S Bornkesse. Degradation of apoptotic cells and fragments in HL-60 suspension cultures after induction of apoptosis by camptothecin and ethanol. Cell proliferation. vol 32. issue 5. 2000-01-20. PMID:10619491. |
hl-60 cells were induced to apoptosis by 3% ethanol and 1.5 microm camptothecin (cam) and the kinetics of the apoptotic cells were measured. |
2000-01-20 |
2023-08-12 |
Not clear |
| F H Meng, Q Y He, H Q Zhang, S B Xu. Inhibition of harringtonine-induced apoptosis by tetradecanoylphorbol acetate in human leukemia HL-60 cells. Zhongguo yao li xue bao = Acta pharmacologica Sinica. vol 18. issue 5. 1999-06-25. PMID:10322942. |
to study the changes of the apoptosis induced by camptothecin (cam) or harringtonine (har) in human leukemia hl-60 cells after the cells were preincubated with tetradecanoylphorbol acetate (ta). |
1999-06-25 |
2023-08-12 |
human |
| b' P Rauko, J Sedl\\xc3\\xa1k, J Duraj, M F Szekeres, L Novotn\\xc3\\xb. Pentoxifylline stimulates drug-induced apoptosis in leukemic cells. Neoplasma. vol 45. issue 5. 1999-02-10. PMID:9921918.' |
camptothecin (cam) and cisplatin (cis-diamminedichloroplatinum(ii), cis-pt) were used as inducers of apoptosis in the mouse leukemic l1210 cells. |
1999-02-10 |
2023-08-12 |
mouse |
| H Ishikawa, M Sasaki, S Noda, Y Kog. Apoptosis induction by the binding of the carboxyl terminus of human immunodeficiency virus type 1 gp160 to calmodulin. Journal of virology. vol 72. issue 8. 1998-08-05. PMID:9658102. |
the role of calmodulin (cam) in apoptosis induced by gp160 of human immunodeficiency virus type 1 was investigated with cells undergoing single-cell killing. |
1998-08-05 |
2023-08-12 |
human |
| H Ishikawa, M Sasaki, S Noda, Y Kog. Apoptosis induction by the binding of the carboxyl terminus of human immunodeficiency virus type 1 gp160 to calmodulin. Journal of virology. vol 72. issue 8. 1998-08-05. PMID:9658102. |
these results thus indicated that cam plays a key role in gp160-induced apoptosis. |
1998-08-05 |
2023-08-12 |
human |
| E K Heist, H Schulma. The role of Ca2+/calmodulin-dependent protein kinases within the nucleus. Cell calcium. vol 23. issue 2-3. 1998-08-03. PMID:9601605. |
cam kinases may thus serve to decode ca2+ signals to the nucleus in order to produce a multitude of cellular responses including control of cell cycle, apoptosis and synaptic efficacy. |
1998-08-03 |
2023-08-12 |
Not clear |
| S Hara, Y Tagawa, H Ayabe, Z Darzynkiwic. [Analysis of drug-induced apoptosis in human leukemic cell line (HL-60)]. Gan to kagaku ryoho. Cancer & chemotherapy. vol 25 Suppl 3. 1998-05-20. PMID:9589041. |
cam induced apoptosis on s phase and aza on g1 phase. |
1998-05-20 |
2023-08-12 |
human |
| J M Cobo, R Garcia-Cañero, J G Valdez, A M Barrasso, B L Sailer, H A Crissma. Attenuation of apoptotic DNA fragmentation by amiloride. Journal of cellular physiology. vol 175. issue 1. 1998-03-12. PMID:9491781. |
we have examined the effects of amiloride on the progression of apoptosis in hl-60 cells induced by camptothecin (cam), cycloheximide (chx), and 20 gy gamma irradiation. |
1998-03-12 |
2023-08-12 |
Not clear |
| J P Vial, F Belloc, P Dumain, S Besnard, F Lacombe, M R Boisseau, J Reiffers, P Bernar. Study of the apoptosis induced in vitro by antitumoral drugs on leukaemic cells. Leukemia research. vol 21. issue 2. 1997-05-09. PMID:9112434. |
for two other drugs (cam and colc), apoptosis occurred for the same concentrations and in the same phase as the block (in s and g2m, respectively). |
1997-05-09 |
2023-08-12 |
Not clear |
| A Dolzhanskiy, R S Basc. Flow cytometric determination of apoptosis in heterogeneous cell populations. Journal of immunological methods. vol 180. issue 1. 1995-04-25. PMID:7897243. |
in model systems, apoptosis was detected in human pbmnc treated with the dna topoisomerase i inhibitor cam and in murine thymocytes treated with dex. |
1995-04-25 |
2023-08-12 |
human |
| G Del Bino, X Li, F Traganos, Z Darzynkiewic. Altered susceptibility of differentiating HL-60 cells to apoptosis induced by antitumor drugs. Leukemia. vol 8. issue 2. 1994-03-11. PMID:7508535. |
the cells were treated with: (i) the dna topoisomerase i inhibitor camptothecin (cam), which selectively triggers apoptosis or s phase cells; (ii) the nucleoside antimetabolite 5-azacytidine (azc) and hyperthermia, both of which preferentially affects g1 cells; and (iii) gamma radiation, which causes apoptosis predominantly of g2 + m cells. |
1994-03-11 |
2023-08-12 |
human |
| G Del Bino, X Li, F Traganos, Z Darzynkiewic. Altered susceptibility of differentiating HL-60 cells to apoptosis induced by antitumor drugs. Leukemia. vol 8. issue 2. 1994-03-11. PMID:7508535. |
on the other hand, when the cells were pretreated with low concentrations of cam or azc, washed free of drug, and then treated with dmso, the proportion of cells undergoing apoptosis was markedly increased, relative to drug-treated cells returned to dmso-free medium. |
1994-03-11 |
2023-08-12 |
human |
| J Gong, X Li, Z Darzynkiewic. Different patterns of apoptosis of HL-60 cells induced by cycloheximide and camptothecin. Journal of cellular physiology. vol 157. issue 2. 1993-12-01. PMID:8227159. |
we have studied apoptosis of hl-60 cells triggered by the dna topoisomerase i inhibitor camptothecin (cam) in the absence and presence of chx and apoptosis induced by chx alone. |
1993-12-01 |
2023-08-12 |
human |
| J Gong, X Li, Z Darzynkiewic. Different patterns of apoptosis of HL-60 cells induced by cycloheximide and camptothecin. Journal of cellular physiology. vol 157. issue 2. 1993-12-01. PMID:8227159. |
apoptosis induced by cam was limited to s phase cells, e.g., at a cam concentration of 0.15 microm, nearly 90% of the s phase cells underwent apoptosis after 4 h. in contrast, apoptosis triggered by chx was indiscriminate, affecting all phases of the cycle: approximately 40% of the cells from each phase the cycle underwent apoptosis at 5 microm chx concentration. |
1993-12-01 |
2023-08-12 |
human |
| J Gong, X Li, Z Darzynkiewic. Different patterns of apoptosis of HL-60 cells induced by cycloheximide and camptothecin. Journal of cellular physiology. vol 157. issue 2. 1993-12-01. PMID:8227159. |
when cam and chx were added together, the pattern of apoptosis resembled that of cycloheximide alone, namely, cells in all phases of the cycle in similar proportion were affected. |
1993-12-01 |
2023-08-12 |
human |
| J Gong, X Li, Z Darzynkiewic. Different patterns of apoptosis of HL-60 cells induced by cycloheximide and camptothecin. Journal of cellular physiology. vol 157. issue 2. 1993-12-01. PMID:8227159. |
thus, chx, while itself inducing apoptosis of a fraction of cells, protected the s phase cells against apoptosis triggered by cam. |
1993-12-01 |
2023-08-12 |
human |
| J Gong, X Li, Z Darzynkiewic. Different patterns of apoptosis of HL-60 cells induced by cycloheximide and camptothecin. Journal of cellular physiology. vol 157. issue 2. 1993-12-01. PMID:8227159. |
furthermore, whereas apoptosis (dna degradation) triggered by cam was prevented by the serine protease inhibitor n-tosyl-l-lysylchloromethyl ketone (tlck), this process was actually potentiated by this inhibitor when induced by chx. |
1993-12-01 |
2023-08-12 |
human |
| J Gong, X Li, Z Darzynkiewic. Different patterns of apoptosis of HL-60 cells induced by cycloheximide and camptothecin. Journal of cellular physiology. vol 157. issue 2. 1993-12-01. PMID:8227159. |
the present data indicate differences in mechanism of apoptosis triggered by cam (and perhaps other antitumor drugs) as compared with chx. |
1993-12-01 |
2023-08-12 |
human |
| F Traganos, J Kapuscinski, J Gong, B Ardelt, R J Darzynkiewicz, Z Darzynkiewic. Caffeine prevents apoptosis and cell cycle effects induced by camptothecin or topotecan in HL-60 cells. Cancer research. vol 53. issue 19. 1993-11-02. PMID:8402636. |
low (20 nm) concentrations of cam or tpt perturbed progression of hl-60 cells through s-phase, whereas higher concentrations (0.15 microm) of these drugs induced apoptosis; both effects were easily demonstrable after 4 h of treatment. |
1993-11-02 |
2023-08-12 |
human |