| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ahmed A Abd-Rabou, Dhruba J Bharali, Shaker A Mous. Viramidine-Loaded Galactosylated Nanoparticles Induce Hepatic Cancer Cell Apoptosis and Inhibit Angiogenesis. Applied biochemistry and biotechnology. vol 190. issue 1. 2020-02-17. PMID:31346920. |
to test the mechanistic pathway, we investigated in vitro apoptosis using flow cytometry and in ovo angiogenesis using the cam assay. |
2020-02-17 |
2023-08-13 |
Not clear |
| Zhipeng Cai, Fuli Zheng, Yan Ding, Yanting Zhan, Ruijie Gong, Jing Li, Michael Aschner, Qunwei Zhang, Siying Wu, Huangyuan L. Nrf2-regulated miR-380-3p blocks the translation of Sp3 protein and its mediation of paraquat-induced toxicity in mouse neuroblastoma N2a cells. Toxicological sciences : an official journal of the Society of Toxicology. 2019-10-23. PMID:31368498. |
two mediators of apoptosis and cell cycle identified in previous studies as sp3-regulated, namely cyclin-dependent kinase inhibitor 1 (p21) and calmodulin (cam), were dysregulated by pq, but not sp3 deficiency. |
2019-10-23 |
2023-08-13 |
mouse |
| Xuan Zhao, WenLiang Dong, YuanDi Gao, Dong-Shoo Shin, Qing Ye, Le Su, Fan Jiang, BaoXiang Zhao, JunYing Mia. Novel indolyl-chalcone derivatives inhibit A549 lung cancer cell growth through activating Nrf-2/HO-1 and inducing apoptosis in vitro and in vivo. Scientific reports. vol 7. issue 1. 2019-01-11. PMID:28634389. |
in vivo, we proved that compound 3d inhibited the tumor growth effectively through inducing cell apoptosis without affecting cam normal angiogenesis. |
2019-01-11 |
2023-08-13 |
human |
| Guang Wang, Jia-Hui Nie, Yongping Bao, Xuesong Yan. Sulforaphane Rescues Ethanol-Suppressed Angiogenesis through Oxidative and Endoplasmic Reticulum Stress in Chick Embryos. Journal of agricultural and food chemistry. vol 66. issue 36. 2018-09-21. PMID:30125492. |
ethanol exposure caused cell apoptosis in chick cam, and the cell apoptosis could be remitted by administration of sfn. |
2018-09-21 |
2023-08-13 |
chicken |
| Shibin Yuan, Bangyuan Wu, Zhengqiang Yu, Jing Fang, Na Liang, Mingqiang Zhou, Cheng Huang, Xi Pen. The mitochondrial and endoplasmic reticulum pathways involved in the apoptosis of bursa of Fabricius cells in broilers exposed to dietary aflatoxin B1. Oncotarget. vol 7. issue 40. 2018-02-23. PMID:27542244. |
(3) afb1-induced apoptosis of bursal cells involved mitochondrial pathway (increase of bax, bak, cytc, caspase-9, apaf-1, caspase-3 and decrease of bcl-2 and bcl-xl) and er pathway (increase of grp78/bip, grp94 and cam). |
2018-02-23 |
2023-08-13 |
chicken |
| Uttara Saran, Krishna Priya Mani, Uma Maheswari Balaguru, Akila Swaminathan, Shunmugam Nagarajan, Arun M Dharmarajan, Suvro Chatterje. sFRP4 signalling of apoptosis and angiostasis uses nitric oxide-cGMP-permeability axis of endothelium. Nitric oxide : biology and chemistry. vol 66. 2018-01-16. PMID:28267592. |
the imbalance between no and ros levels results in apoptosis and subsequent leakiness of endothelium as confirmed in vivo (texas red/annxin - cam assay) and in vitro (monolayer permeability assay) conditions. |
2018-01-16 |
2023-08-13 |
Not clear |
| Romone M Fancy, Harrison Kim, Tong Zhou, Kurt R Zinn, Donald J Buchsbaum, Yuhua Son. Calmodulin Binding to Death Receptor 5-mediated Death-Inducing Signaling Complex in Breast Cancer Cells. Journal of cellular biochemistry. vol 118. issue 8. 2017-12-27. PMID:28092099. |
calmodulin (cam) that is overexpressed in breast cancer plays a critical role in regulating dr5-mediated apoptosis. |
2017-12-27 |
2023-08-13 |
Not clear |
| Romone M Fancy, Harrison Kim, Tong Zhou, Kurt R Zinn, Donald J Buchsbaum, Yuhua Son. Calmodulin Binding to Death Receptor 5-mediated Death-Inducing Signaling Complex in Breast Cancer Cells. Journal of cellular biochemistry. vol 118. issue 8. 2017-12-27. PMID:28092099. |
in this study, we characterized cam binding to dr5-mediated disc for apoptosis in tra-8 sensitive breast cancer cell lines using co-immunoprecipitation, fluorescence microscopic imaging, caspase signaling analysis, and cell viability assay. |
2017-12-27 |
2023-08-13 |
Not clear |
| Oluwatosin Adaramoye, Bettina Erguen, Bianca Nitzsche, Michael Höpfner, Klaus Jung, Anja Rabie. Punicalagin, a polyphenol from pomegranate fruit, induces growth inhibition and apoptosis in human PC-3 and LNCaP cells. Chemico-biological interactions. vol 274. 2017-09-05. PMID:28709945. |
this study evaluated anti-proliferative effects of pn and its effects on extrinsic pathway of apoptosis in pca cells, and angiogenesis in chicken chorioallantoic membrane (cam). |
2017-09-05 |
2023-08-13 |
human |
| Oluwatosin Adaramoye, Bettina Erguen, Bianca Nitzsche, Michael Höpfner, Klaus Jung, Anja Rabie. Punicalagin, a polyphenol from pomegranate fruit, induces growth inhibition and apoptosis in human PC-3 and LNCaP cells. Chemico-biological interactions. vol 274. 2017-09-05. PMID:28709945. |
antiangiogenic effects were measured using cam assay, while apoptosis was assessed by dna fragmentation, enrichment factor by cell death detection elisa kit and expressions of caspases-3 and -8. |
2017-09-05 |
2023-08-13 |
human |
| Ali Aydın, Sengul Aslan Korkmaz, Veysel Demir, Saban Teki. Anticancer and Cytotoxic Activities of [Cu(C6H16N2O2)2][Ni(CN)4] and [Cu(C6H16N2O2)Pd(CN)4] Cyanidometallate Compounds on HT29, HeLa, C6 and Vero Cell Lines. Anti-cancer agents in medicinal chemistry. vol 17. issue 6. 2017-08-10. PMID:28044934. |
in cancer, apoptosis relevant proteins-such as cam kinase, bcl-2 or p53, topoisomerase i, cell migration feature and dna/bsa-macromolecules represent significant targets for current chemotherapeutics. |
2017-08-10 |
2023-08-13 |
Not clear |
| Jina Lee, Min Seong Kim, Min Aeh Kim, Yeun Kyu Jan. Calmidazolium chloride inhibits growth of murine embryonal carcinoma cells, a model of cancer stem-like cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 35. 2017-04-04. PMID:27247146. |
calmidazolium chloride (cmz) is widely used as a calmodulin (cam) antagonist, but is also known to induce apoptosis in certain cancer cell lines. |
2017-04-04 |
2023-08-13 |
Not clear |
| Ji Hye Park, Sung Hyun Choi, Hyungtae Kim, Seung Taek Ji, Woong Bi Jang, Jae Ho Kim, Sang Hong Baek, Sang Mo Kwo. Doxorubicin Regulates Autophagy Signals via Accumulation of Cytosolic Ca International journal of molecular sciences. vol 17. issue 10. 2017-03-31. PMID:27735842. |
doxo induced hcpc apoptosis with reduction of smp30 (regucalcin) and autophagosome marker lc3, as well as remarkable induction of the autophagy-related markers, beclin-1, apg7, and p62/sqstm1 and induction of calcium-related molecules, cam (calmodulin) and camkii (calmodulin kinase ii). |
2017-03-31 |
2023-08-13 |
human |
| Qin Ma, Wei Chen, Wen Che. Anti-tumor angiogenesis effect of a new compound: B-9-3 through interference with VEGFR2 signaling. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 5. 2017-03-10. PMID:26611645. |
moreover, b-9-3 could significantly increase the apoptosis rate (80.95 %) of vascular endothelial cells, while inhibiting migration of endothelial cells, capillary tube formation of endothelial cells, neovascularization of the rat thoracic aorta ring, and the angiogenesis of chick chorioallantoic membrane (cam) predominantly through blocking vegfr2 signaling pathway. |
2017-03-10 |
2023-08-13 |
mouse |
| Q Lu, Z G Li, N Zhou, Z G Gong, J Q Jiang, Z N Chen, Q J Jiang, Y Peng, S F Din. Impact of citrate pretreatment on ventricular arrhythmia and myocardial capase-3 expression in ischemia/reperfusion injury. Genetics and molecular research : GMR. vol 15. issue 4. 2017-02-27. PMID:27813585. |
citrate can reduce myocardial cell apoptosis, alleviating ventricular arrhythmia and protecting the myocardium by reducing serum calcium ion concentration and downregulating caspase-3 and cam expression. |
2017-02-27 |
2023-08-13 |
rat |
| Yihao Zhu, Shu Li, Xiaohua Ten. The involvement of the mitochondrial pathway in manganese-induced apoptosis of chicken splenic lymphocytes. Chemosphere. vol 153. 2016-12-23. PMID:27035383. |
our research indicated that excess mn induced ros and mda content, inhibited mn-sod and gsh-px activities, induced bax and p53 mrna expression, inhibited bcl-2 and cam mrna expression, induced caspase-3 mrna and protein expression, upregulated [ca(2+)]i, inhibited ΔΨm, and induced apoptosis in a dose effect. |
2016-12-23 |
2023-08-13 |
chicken |
| Zheng Cao, Dawei Liu, Qiuyue Zhang, Xudong Sun, Yanfei L. Aluminum Chloride Induces Osteoblasts Apoptosis via Disrupting Calcium Homeostasis and Activating Ca(2+)/CaMKII Signal Pathway. Biological trace element research. vol 169. issue 2. 2016-10-25. PMID:26138010. |
then ob apoptosis rate, intracellular calcium ions concentration ([ca(2+)]i), mrna expression level of calmodulin (cam), and protein expression levels of cam and p-camkii in obs were examined. |
2016-10-25 |
2023-08-13 |
rat |
| Zheng Cao, Dawei Liu, Qiuyue Zhang, Xudong Sun, Yanfei L. Aluminum Chloride Induces Osteoblasts Apoptosis via Disrupting Calcium Homeostasis and Activating Ca(2+)/CaMKII Signal Pathway. Biological trace element research. vol 169. issue 2. 2016-10-25. PMID:26138010. |
the result showed that alcl3 increased ob apoptosis rate, and [ca(2+)]i and p-camkii expression levels and decreased cam expression levels, whereas bapta-am relieved the effects. |
2016-10-25 |
2023-08-13 |
rat |
| Chethana Kulkarni, Megan Lo, Julia G Fraseur, David A Tirrell, Tamara L Kinzer-Urse. Bioorthogonal Chemoenzymatic Functionalization of Calmodulin for Bioconjugation Applications. Bioconjugate chemistry. vol 26. issue 10. 2016-08-17. PMID:26431265. |
calmodulin (cam) is a widely studied ca(2+)-binding protein that is highly conserved across species and involved in many biological processes, including vesicle release, cell proliferation, and apoptosis. |
2016-08-17 |
2023-08-13 |
Not clear |
| Imen Jridi, Ivana Catacchio, Hafed Majdoub, Delavar Shahbazeddah, Mohamed El Ayeb, Maria Antonia Frassanito, Domenico Ribatti, Angelo Vacca, Lamia Borchan. Hemilipin, a novel Hemiscorpius lepturus venom heterodimeric phospholipase A2, which inhibits angiogenesis in vitro and in vivo. Toxicon : official journal of the International Society on Toxinology. vol 105. 2016-08-03. PMID:26335363. |
its antiangiogenic activity was studied in vitro by evaluating effects on apoptosis, matrigel angiogenesis, migration and adhesion of human umbilical vein endothelial cells (huvecs) and human pulmonary artery endothelial cells (hpaecs) and in vivo by the chorioallantoic membrane (cam) assay. |
2016-08-03 |
2023-08-13 |
human |