| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Xu, Pengjuan Xu, Zhigui Li, Jie Huang, Zhuo Yan. Oxidative stress and apoptosis induced by hydroxyapatite nanoparticles in C6 cells. Journal of biomedical materials research. Part A. vol 100. issue 3. 2012-05-21. PMID:22213249. |
results from hoechst 33342 staining and flow cytometry assay showed that ha induced c6 cell apoptosis significantly. |
2012-05-21 |
2023-08-12 |
human |
| Jing Xu, Pengjuan Xu, Zhigui Li, Jie Huang, Zhuo Yan. Oxidative stress and apoptosis induced by hydroxyapatite nanoparticles in C6 cells. Journal of biomedical materials research. Part A. vol 100. issue 3. 2012-05-21. PMID:22213249. |
interestingly, pretreatment of n-(mercaptopropionyl)-glycine (n-mpg), known as a type of ros scavenger formulations, could somehow inhibit c6 cell apoptosis induced by ha. |
2012-05-21 |
2023-08-12 |
human |
| Qing-you Zheng, Feng-suo Jin, Chen Yao, Tong Zhang, Guo-hui Zhang, Xing A. Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells. Biochemical and biophysical research communications. vol 419. issue 4. 2012-05-11. PMID:22387548. |
we found the ceramide level was increased after ua treatment in t24 cells, and ua-induced ampk activation and t24 cell apoptosis were inhibited by ceramide synthase inhibitor fumonisin b1, and was enhanced by exogenously adding cell permeable short-chain ceramide (c6), suggesting that ceramide might serve as an upstream signal for ampk activation. |
2012-05-11 |
2023-08-12 |
human |
| Yuesheng Xia, Yongqi Li, Jianhua Wang, Huan Wang, Jing Kang, Baoying Wang, Zengxia Ho. Bidirectional function of shenghe powder on repair of radiation-induced DNA damage in glioma and astrocyte. African journal of traditional, complementary, and alternative medicines : AJTCAM. vol 8. issue 2. 2012-05-02. PMID:22238502. |
it significant effect on inhibition of c6 cell proliferation and induced c6 cells apoptosis in a time-depdendent manner than radiation alone (p<0.001). |
2012-05-02 |
2023-08-12 |
human |
| Caixia Yuan, Miaoli Zhu, Qingming Wang, Liping Lu, Shu Xing, Xueqi Fu, Zheng Jiang, Shuo Zhang, Zongwei Li, Zhuoyu Li, Ruiting Zhu, Ling Ma, Liqing X. Potent and selective inhibition of T-cell protein tyrosine phosphatase (TCPTP) by a dinuclear copper(II) complex. Chemical communications (Cambridge, England). vol 48. issue 8. 2012-04-30. PMID:22159501. |
a dinuclear cu(ii) complex, [cu(2)(μ-ida)(phen)(3)(no(3))]no(3)·4h(2)o (phen = 1,10-phenanthroline, h(2)ida = iminodiacetic acid), was found to potently and selectively inhibit t-cell protein tyrosine phosphatase, and lead to the anti-proliferation and apoptosis of c6 glioma cells. |
2012-04-30 |
2023-08-12 |
Not clear |
| Cuixian Li, Chun Zhou, Shaogui Wang, Ying Feng, Wei Lin, Sisi Lin, Ying Wang, Heqing Huang, Peiqing Liu, Yong-Gao Mu, Xiaoyan She. Sensitization of glioma cells to tamoxifen-induced apoptosis by Pl3-kinase inhibitor through the GSK-3β/β-catenin signaling pathway. PloS one. vol 6. issue 10. 2012-03-26. PMID:22046442. |
herein, we show by colony formation, hochest 33342 and tunel staining, as well as by flow cytometric analysis, that ly294002, a specific phosphatidylinositide-3-kinase (pi3k) inhibitor, enhanced significantly the sensitization of a traditional cytotoxic chemotherapeutic agent, tamoxifen-induced apoptosis in c6 glioma cells. |
2012-03-26 |
2023-08-12 |
Not clear |
| Xin He, Hui Nie, Yunyi Hong, Caibin Sheng, Weiliang Xia, Weihai Yin. SIRT2 activity is required for the survival of C6 glioma cells. Biochemical and biophysical research communications. vol 417. issue 1. 2012-03-22. PMID:22166219. |
our studies, by conducting such assays as flow cytometry-based annexin v assay and caspase-3 immunostaining, have indicated that decreased sirt2 activity leads to apoptosis of c6 glioma cells by caspase-3-dependent pathway. |
2012-03-22 |
2023-08-12 |
human |
| Xin He, Hui Nie, Yunyi Hong, Caibin Sheng, Weiliang Xia, Weihai Yin. SIRT2 activity is required for the survival of C6 glioma cells. Biochemical and biophysical research communications. vol 417. issue 1. 2012-03-22. PMID:22166219. |
collectively, our study has provided novel evidence indicating that sirt2 activity plays a key role in maintaining the survival of glioma cells, and that reduced sirt2 activity can induce both necrosis and caspase-3-dependent apoptosis of c6 glioma cells. |
2012-03-22 |
2023-08-12 |
human |
| Hongliang Jiao, Fangxia Guan, Bo Yang, Jianbin Li, Laijun Song, Xiang Hu, Ying D. Human amniotic membrane derived-mesenchymal stem cells induce C6 glioma apoptosis in vivo through the Bcl-2/caspase pathways. Molecular biology reports. vol 39. issue 1. 2012-03-21. PMID:21556762. |
human amniotic membrane derived-mesenchymal stem cells induce c6 glioma apoptosis in vivo through the bcl-2/caspase pathways. |
2012-03-21 |
2023-08-12 |
mouse |
| Hongliang Jiao, Fangxia Guan, Bo Yang, Jianbin Li, Laijun Song, Xiang Hu, Ying D. Human amniotic membrane derived-mesenchymal stem cells induce C6 glioma apoptosis in vivo through the Bcl-2/caspase pathways. Molecular biology reports. vol 39. issue 1. 2012-03-21. PMID:21556762. |
the data collected herein confirms for the first time that hamcs can inhibit c6 glioma growth and induce apoptosis of c6 gliomas in vivo. |
2012-03-21 |
2023-08-12 |
mouse |
| Du Cheng, Nuo Cao, Jifeng Chen, Xingsu Yu, Xintao Shua. Multifunctional nanocarrier mediated co-delivery of doxorubicin and siRNA for synergistic enhancement of glioma apoptosis in rat. Biomaterials. vol 33. issue 4. 2012-03-07. PMID:22061491. |
although cell apoptosis was initiated even at low dox doses such as 0.5 μg/ml in the dox-alone treatment mediated by the folate-targeted nanocarrier, anti-apoptotic response in c6 cells was activated as well, as revealed by molecular biological investigations. |
2012-03-07 |
2023-08-12 |
rat |
| Du Cheng, Nuo Cao, Jifeng Chen, Xingsu Yu, Xintao Shua. Multifunctional nanocarrier mediated co-delivery of doxorubicin and siRNA for synergistic enhancement of glioma apoptosis in rat. Biomaterials. vol 33. issue 4. 2012-03-07. PMID:22061491. |
in particular, animal studies using the in situ rat c6 glioma model showed that the folate-targeted co-delivery of bcl-2 sirna and dox caused not only an obvious down-regulation of the anti-apoptotic bcl-2 gene but also a remarkable up-regulation of the pro-apoptotic bax gene, resulting in the significantly elevated level of caspase-3 activation and remarkable cell apoptosis in tumor tissues. |
2012-03-07 |
2023-08-12 |
rat |
| Du Cheng, Nuo Cao, Jifeng Chen, Xingsu Yu, Xintao Shua. Multifunctional nanocarrier mediated co-delivery of doxorubicin and siRNA for synergistic enhancement of glioma apoptosis in rat. Biomaterials. vol 33. issue 4. 2012-03-07. PMID:22061491. |
our results strongly demonstrated the synergistic effect of sirna and dox in inducing glioma c6 cell apoptosis, upon which an excellent therapeutic effect was achieved using the folate-targeted co-delivery strategy as indicated by the effective tumor growth inhibition and prolonged rat survival time in the animal test. |
2012-03-07 |
2023-08-12 |
rat |
| Michael Wilhelm, Nickolay V Kukekov, Travis L Schmit, Katherine V Biagas, Andrew A Sproul, Stephen Gire, Margaret E Maes, Zhiheng Xu, Lloyd A Green. Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein. The Journal of biological chemistry. vol 287. issue 3. 2012-03-05. PMID:22128169. |
sirna-mediated knockdown of sh3rf2 promotes apoptosis of neuronal pc12 cells, cultured cortical neurons, and c6 glioma cells. |
2012-03-05 |
2023-08-12 |
Not clear |
| Jiaqing Zhou, Yan Li, Guangyan Yan, Qian Bu, Lei Lv, Yanzhu Yang, Jinxuan Zhao, Xue Shao, Yi Deng, Ruimin Zhu, Yinglan Zhao, Xiaobo Ce. Protective role of taurine against morphine-induced neurotoxicity in C6 cells via inhibition of oxidative stress. Neurotoxicity research. vol 20. issue 4. 2012-01-25. PMID:21611853. |
collectively, the results show that taurine possesses the capability to ameliorate morphine-induced oxidative insult and apoptosis in c6 cells, probably due to its antioxidant activity rather than activation of gaba receptors. |
2012-01-25 |
2023-08-12 |
cat |
| Yu-Hui Zhang, He Zhang, Jian-min Liu, Zhi-Jian Yu. Temozolomide/PLGA microparticles: a new protocol for treatment of glioma in rats. Medical oncology (Northwood, London, England). vol 28. issue 3. 2012-01-18. PMID:20396980. |
the apoptosis of c6 cells in interstitial tm/plga group significantly increased when compared with that in oral tm group. |
2012-01-18 |
2023-08-12 |
human |
| Masashi Yanae, Masanobu Tsubaki, Takao Satou, Tatsuki Itoh, Motohiro Imano, Yuzuru Yamazoe, Shozo Nishid. Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma. Journal of experimental & clinical cancer research : CR. vol 30. 2011-12-28. PMID:21831290. |
in the present study, we attempted to elucidate the mechanism by which statins induce apoptosis in c6 glioma cells. |
2011-12-28 |
2023-08-12 |
Not clear |
| Jian-Hua Li, Wu Yue, Zheng Huang, Zhi-Qiang Chen, Qi Zhan, Fu-Bin Ren, Jing-Ye Liu, Song-Bin F. Calcium overload induces C6 rat glioma cell apoptosis in sonodynamic therapy. International journal of radiation biology. vol 87. issue 10. 2011-11-18. PMID:21961969. |
calcium overload induces c6 rat glioma cell apoptosis in sonodynamic therapy. |
2011-11-18 |
2023-08-12 |
rat |
| Jian-Hua Li, Wu Yue, Zheng Huang, Zhi-Qiang Chen, Qi Zhan, Fu-Bin Ren, Jing-Ye Liu, Song-Bin F. Calcium overload induces C6 rat glioma cell apoptosis in sonodynamic therapy. International journal of radiation biology. vol 87. issue 10. 2011-11-18. PMID:21961969. |
our aim was to study calcium overload-induced apoptosis and its relation to reactive oxygen species (ros) in rat c6 glioma cells after sonodynamic treatment (sdt). |
2011-11-18 |
2023-08-12 |
rat |
| Ling Yang, Zhong-yuan Xu, Xiao-hua Chen, Ke-wan Wang, Guo-feng Li, Zhi-liang Che. [Effect of imatinib at different concentrations on rat C6 glioma cell apoptosis and cell cycle]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 30. issue 5. 2011-10-13. PMID:20501402. |
[effect of imatinib at different concentrations on rat c6 glioma cell apoptosis and cell cycle]. |
2011-10-13 |
2023-08-12 |
rat |