| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ye Xu, Jinsong Kang, Zhaoxin Yuan, Hongyan Li, Jing Su, Yang Li, Xiaoxia Kong, Hongyu Zhang, Weiwei Wang, Liankun Su. Suppression of CLIC4/mtCLIC enhances hydrogen peroxide-induced apoptosis in C6 glioma cells. Oncology reports. vol 29. issue 4. 2013-09-12. PMID:23380911. |
the upregulation of clic4 protein expression was paralleled with an increased bax/bcl-2 ratio, cytochrome c and cleaved caspase-3 protein expression upon h2o2-induced c6 cell apoptosis. |
2013-09-12 |
2023-08-12 |
Not clear |
| Shuken Boku, Shin Nakagawa, Naoki Takamura, Akiko Kato, Minoru Takebayashi, Kazue Hisaoka-Nakashima, Yuki Omiya, Takeshi Inoue, Ichiro Kusum. GDNF facilitates differentiation of the adult dentate gyrus-derived neural precursor cells into astrocytes via STAT3. Biochemical and biophysical research communications. vol 434. issue 4. 2013-08-27. PMID:23603362. |
because previous studies showed that antidepressants increase the expression and secretion of glial cell line-derived neurotrophic factor (gdnf) in c6 glioma cells derived from rat astrocytes and gdnf increases neurogenesis in adult dg in vivo, we investigated the effects of gdnf on the proliferation, differentiation and apoptosis of cultured neural precursor cells derived from the adult dg. |
2013-08-27 |
2023-08-12 |
rat |
| Dong-Chun Wang, Yan Zhang, Hai-Yan Chen, Xiao-Li Li, Li-Juan Qin, Ya-Juan Li, Hong-Yi Zhang, Shuo Wan. Hyperthermia promotes apoptosis and suppresses invasion in C6 rat glioma cells. Asian Pacific journal of cancer prevention : APJCP. vol 13. issue 7. 2013-06-03. PMID:22994741. |
hyperthermia promotes apoptosis and suppresses invasion in c6 rat glioma cells. |
2013-06-03 |
2023-08-12 |
rat |
| Dong-Chun Wang, Yan Zhang, Hai-Yan Chen, Xiao-Li Li, Li-Juan Qin, Ya-Juan Li, Hong-Yi Zhang, Shuo Wan. Hyperthermia promotes apoptosis and suppresses invasion in C6 rat glioma cells. Asian Pacific journal of cancer prevention : APJCP. vol 13. issue 7. 2013-06-03. PMID:22994741. |
here our data show hyperthermia stimulated the release of tumor necrosis factor-alpha (tnf-α) and decreased c6 glioma cell migration and invasive capability at 30, 60, 120 and 180 min; with increased spontaneous apoptosis in c6 glioma cells at 120 min. |
2013-06-03 |
2023-08-12 |
rat |
| Dong-Chun Wang, Yan Zhang, Hai-Yan Chen, Xiao-Li Li, Li-Juan Qin, Ya-Juan Li, Hong-Yi Zhang, Shuo Wan. Hyperthermia promotes apoptosis and suppresses invasion in C6 rat glioma cells. Asian Pacific journal of cancer prevention : APJCP. vol 13. issue 7. 2013-06-03. PMID:22994741. |
based on the results, we conclude that hyperthermia alone reduced invasion of c6 glioma cells through stimulating tnf-α signaling to activate apoptosis, enhancing p38 mapk expression and inhibiting the nf-κb pathway, a first report in c6 rat glioma cells. |
2013-06-03 |
2023-08-12 |
rat |
| Yongwoo Jung, Young-Su Yi, Dae Sung Yoo, Ji Hye Kim, Woo Seok Yang, Jongsung Lee, Kye Won Park, Dae-Hyuk Kweon, Sungyoul Hong, Jae Youl Ch. 8-(Tosylamino)quinoline inhibits tumour progression through targeting phosphoinositide-3-kinase/Akt pathway. Die Pharmazie. vol 68. issue 2. 2013-04-08. PMID:23469688. |
according to the analysis of level of active caspase-3, and morphologies of c6, hela and mda-mb-231 cells, it was revealed that 8-tq is able to induce apoptosis. |
2013-04-08 |
2023-08-12 |
Not clear |
| Yu Duan, Xin Zhao, Wei Ren, Xin Wang, Ke-Fu Yu, Dan Li, Xuan Zhang, Qiang Zhan. Antitumor activity of dichloroacetate on C6 glioma cell: in vitro and in vivo evaluation. OncoTargets and therapy. vol 6. 2013-03-22. PMID:23515860. |
dca inhibited c6 glioma cell proliferation, induced c6 cell apoptosis, and arrested c6 cells in s phase. |
2013-03-22 |
2023-08-12 |
mouse |
| Yang-guang Han, Jing Xu, Zhi-gui Li, Guo-gang Ren, Zhuo Yan. In vitro toxicity of multi-walled carbon nanotubes in C6 rat glioma cells. Neurotoxicology. vol 33. issue 5. 2013-03-21. PMID:22728153. |
the exposure of c6 rat glioma cells to mwcnt (200-400 μg/ml) resulted in a concentration dependent cell apoptosis and g1 cell cycle arrest, and increased the level of oxidative stress. |
2013-03-21 |
2023-08-12 |
rat |
| Bo Yin, Hansong Sheng, Jian Lin, Hui Zhou, Nu Zhan. The cell death of C6 astrocytoma cells induced by oridonin and its mechanism. International journal of clinical and experimental pathology. vol 5. issue 6. 2013-01-31. PMID:22949939. |
hochest 33258 staining and flow cytometry revealed that oridonin induced apoptosis and arrested the entry into g2/m phase of c6 cells. |
2013-01-31 |
2023-08-12 |
rat |
| Bo Yin, Hansong Sheng, Jian Lin, Hui Zhou, Nu Zhan. The cell death of C6 astrocytoma cells induced by oridonin and its mechanism. International journal of clinical and experimental pathology. vol 5. issue 6. 2013-01-31. PMID:22949939. |
all together, our results suggested that oridonin can cause the suppression of proliferation in c6 astrocytoma cells and the cell death induced by oridonin might be associated with mitochondria- mediated apoptosis by activating caspase-3. |
2013-01-31 |
2023-08-12 |
rat |
| E Ö Uçar, N Arda, A Aitke. Extract from mistletoe, Viscum album L., reduces Hsp27 and 14-3-3 protein expression and induces apoptosis in C6 rat glioma cells. Genetics and molecular research : GMR. vol 11. issue 3. 2013-01-08. PMID:23007975. |
extract from mistletoe, viscum album l., reduces hsp27 and 14-3-3 protein expression and induces apoptosis in c6 rat glioma cells. |
2013-01-08 |
2023-08-12 |
rat |
| E Ö Uçar, N Arda, A Aitke. Extract from mistletoe, Viscum album L., reduces Hsp27 and 14-3-3 protein expression and induces apoptosis in C6 rat glioma cells. Genetics and molecular research : GMR. vol 11. issue 3. 2013-01-08. PMID:23007975. |
pretreatment with the extract before heat shock increased apoptosis via caspase-3 activation (60%) in c6 glioma cells. |
2013-01-08 |
2023-08-12 |
rat |
| Takayuki Sassa, Shota Suto, Yuriko Okayasu, Akio Kihar. A shift in sphingolipid composition from C24 to C16 increases susceptibility to apoptosis in HeLa cells. Biochimica et biophysica acta. vol 1821. issue 7. 2012-11-02. PMID:22579584. |
apoptosis induced by uv radiation or c6 ceramides also increased in elovl1 or cers2 knockdown cells. |
2012-11-02 |
2023-08-12 |
Not clear |
| Jiefang Bian, Xiling Wang, Jun Yun, Ruifeng Cao, Yunxin Cao, Jingwen Liang, B Fucheng M. Single-fraction γ-60Co radiation induces apoptosis in cultured rat C6 cells. Annals of Saudi medicine. vol 32. issue 3. 2012-10-18. PMID:22588438. |
single-fraction γ-60co radiation induces apoptosis in cultured rat c6 cells. |
2012-10-18 |
2023-08-12 |
rat |
| M A Vogelbaum, J X Tong, R Higashikubo, D H Gutmann, K M Ric. Transfection of C6 glioma cells with the bax gene and increased sensitivity to treatment with cytosine arabinoside. Neurosurgical focus. vol 3. issue 5. 2012-10-02. PMID:17206779. |
overexpression of the bax gene resulted in a decreased growth rate (average doubling time of 32.96 hours compared with 22.49 hours for untransfected c6, and 23.11 hours for clones transfected with pcdna3 only), which may be caused, in part, by an increased rate of spontaneous apoptosis (0.77 +/- 0.15% compared with 0.42 +/- 0.08% for the vector-only transfected c6 cell line; p = 0.038, two-tailed student's t-test). |
2012-10-02 |
2023-08-12 |
rat |
| M S Yang, W K F Tse, L C Yu, K M Li, N K Mak, R C Gupt. Energy and redox States in the c6 glioma cells following acute exposure to zn, se(+4), and se(+6) and the correlation with apoptosis. Toxicology mechanisms and methods. vol 16. issue 1. 2012-10-02. PMID:20021036. |
energy and redox states in the c6 glioma cells following acute exposure to zn, se(+4), and se(+6) and the correlation with apoptosis. |
2012-10-02 |
2023-08-12 |
Not clear |
| Mildred S Yang, Ramesh C Gupt. Modulation of energy metabolism in c6 glioma cells as possible mechanism contributing to zinc neurotoxicity. Toxicology mechanisms and methods. vol 13. issue 4. 2012-10-02. PMID:20021152. |
however, the ultimate toxic action of zn on the c6 glioma cells appears to be due to a gradual inhibition of energy utilization, leading to cell shrinkage and apoptosis. |
2012-10-02 |
2023-08-12 |
Not clear |
| M V Vettori, R Gatti, G Orlandini, S Belletti, R Alinovi, A Smargiassi, A Mutt. An in vitro model for the assessment of manganese neurotoxicity. Toxicology in vitro : an international journal published in association with BIBRA. vol 13. issue 6. 2012-10-02. PMID:20654569. |
exposure to both mncl(2) and mn-tf was followed by time- and dose-dependent morphological changes characteristic of apoptosis, which was never observed in mn-exposed c6 glial cells. |
2012-10-02 |
2023-08-12 |
monkey |
| Alfeu Zanotto-Filho, Elizandra Braganhol, Maria Isabel Edelweiss, Guilherme A Behr, Rafael Zanin, Rafael Schröder, André Simões-Pires, Ana Maria Oliveira Battastini, José Cláudio Fonseca Moreir. The curry spice curcumin selectively inhibits cancer cells growth in vitro and in preclinical model of glioblastoma. The Journal of nutritional biochemistry. vol 23. issue 6. 2012-09-25. PMID:21775121. |
in this work, we examined the mechanisms underlying apoptosis, selectivity, efficacy and safety of curcumin from in vitro (u138mg, u87, u373 and c6 cell lines) and in vivo (c6 implants) models of gbm. |
2012-09-25 |
2023-08-12 |
rat |
| Alfeu Zanotto-Filho, Elizandra Braganhol, Maria Isabel Edelweiss, Guilherme A Behr, Rafael Zanin, Rafael Schröder, André Simões-Pires, Ana Maria Oliveira Battastini, José Cláudio Fonseca Moreir. The curry spice curcumin selectively inhibits cancer cells growth in vitro and in preclinical model of glioblastoma. The Journal of nutritional biochemistry. vol 23. issue 6. 2012-09-25. PMID:21775121. |
in u138mg and c6 cells, curcumin decreased the constitutive activation of pi3k/akt and nfkappab survival pathways, down-regulated the antiapoptotic nfkappab-regulated protein bcl-xl and induced mitochondrial dysfunction as a prelude to apoptosis. |
2012-09-25 |
2023-08-12 |
rat |