| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fen Tian, Huijiao Wu, Zhihua Li, Na Wang, Jintao Huang, Chaohong Li, Fukang Xi. Activated PKCalpha/ERK1/2 signaling inhibits tamoxifen-induced apoptosis in C6 cells. Cancer investigation. vol 27. issue 7. 2009-08-25. PMID:19544110. |
in this study, we provided the evidence that pkcalpha-erk1/2 signaling pathway plays a negative role in tam-induced c6 cell apoptosis, and a combined utilization of tam with inhibitors of pkcalpha or erk1/2 could enhance the effectiveness of tam on inhibiting tumor growth. |
2009-08-25 |
2023-08-12 |
human |
| Ting-Ching Chen, Kuang-Chi Lai, Jai-Sing Yang, Ching-Lung Liao, Te-Chun Hsia, Guang-Wei Chen, Jen-Jyh Lin, Hui-Ju Lin, Tsan-Hung Chiu, Yih-Jing Tang, Jing-Gung Chun. Involvement of reactive oxygen species and caspase-dependent pathway in berberine-induced cell cycle arrest and apoptosis in C6 rat glioma cells. International journal of oncology. vol 34. issue 6. 2009-08-18. PMID:19424587. |
involvement of reactive oxygen species and caspase-dependent pathway in berberine-induced cell cycle arrest and apoptosis in c6 rat glioma cells. |
2009-08-18 |
2023-08-12 |
rat |
| Ting-Ching Chen, Kuang-Chi Lai, Jai-Sing Yang, Ching-Lung Liao, Te-Chun Hsia, Guang-Wei Chen, Jen-Jyh Lin, Hui-Ju Lin, Tsan-Hung Chiu, Yih-Jing Tang, Jing-Gung Chun. Involvement of reactive oxygen species and caspase-dependent pathway in berberine-induced cell cycle arrest and apoptosis in C6 rat glioma cells. International journal of oncology. vol 34. issue 6. 2009-08-18. PMID:19424587. |
the cytotoxicity of berberine on c6 rat glioma cells indicated that berberine induced morphological changes and caused cell death through g2/m arrest and apoptosis. |
2009-08-18 |
2023-08-12 |
rat |
| Ting-Ching Chen, Kuang-Chi Lai, Jai-Sing Yang, Ching-Lung Liao, Te-Chun Hsia, Guang-Wei Chen, Jen-Jyh Lin, Hui-Ju Lin, Tsan-Hung Chiu, Yih-Jing Tang, Jing-Gung Chun. Involvement of reactive oxygen species and caspase-dependent pathway in berberine-induced cell cycle arrest and apoptosis in C6 rat glioma cells. International journal of oncology. vol 34. issue 6. 2009-08-18. PMID:19424587. |
these results demonstrate that the cytotoxicity of berberine in c6 rat glioma cells is attributable to apoptosis mainly through induced g2/m-arrested cells, in an er-dependent manner, via a mitochondria-dependent caspase pathway regulated by bax and bcl-2. |
2009-08-18 |
2023-08-12 |
rat |
| Ju Du, Wan-Liang Lu, Xue Ying, Yang Liu, Ping Du, Wei Tian, Ying Men, Jia Guo, Yan Zhang, Ruo-Jing Li, Jia Zhou, Jin-Ning Lou, Jian-Cheng Wang, Xuan Zhang, Qiang Zhan. Dual-targeting topotecan liposomes modified with tamoxifen and wheat germ agglutinin significantly improve drug transport across the blood-brain barrier and survival of brain tumor-bearing animals. Molecular pharmaceutics. vol 6. issue 3. 2009-08-06. PMID:19344115. |
similar strong activity was found in the reduction of c6 glioma tumor spheroid volume and in the apoptosis of the spheroids. |
2009-08-06 |
2023-08-12 |
rat |
| Benjamin Y S Ong, Sudhir H Ranganath, Lai Yeng Lee, Fan Lu, How-Sung Lee, Nikolaos V Sahinidis, Chi-Hwa Wan. Paclitaxel delivery from PLGA foams for controlled release in post-surgical chemotherapy against glioblastoma multiforme. Biomaterials. vol 30. issue 18. 2009-07-23. PMID:19285718. |
furthermore, apoptosis of c6 glioma cells in vitro demonstrated the benefits of sustained paclitaxel release by the foams in comparison to acute taxol exposure. |
2009-07-23 |
2023-08-12 |
rat |
| Rajiv Janardhanan, Jonathan T Butler, Naren L Banik, Swapan K Ra. N-(4-Hydroxyphenyl) retinamide potentiated paclitaxel for cell cycle arrest and apoptosis in glioblastoma C6 and RG2 cells. Brain research. vol 1268. 2009-06-24. PMID:19285047. |
n-(4-hydroxyphenyl) retinamide potentiated paclitaxel for cell cycle arrest and apoptosis in glioblastoma c6 and rg2 cells. |
2009-06-24 |
2023-08-12 |
rat |
| Shujun Zhang, Jiping Qi, Libo Sun, Binglin Cheng, Shangha Pan, Min Zhou, Xueying Su. Matrine induces programmed cell death and regulates expression of relevant genes based on PCR array analysis in C6 glioma cells. Molecular biology reports. vol 36. issue 4. 2009-06-01. PMID:18392946. |
exposure of c6 cells to matrine resulted in inhibition of proliferation and induction of apoptosis in a dose-dependent manner, as measured by the mtt assay and flow cytometry. |
2009-06-01 |
2023-08-12 |
rat |
| Shujun Zhang, Jiping Qi, Libo Sun, Binglin Cheng, Shangha Pan, Min Zhou, Xueying Su. Matrine induces programmed cell death and regulates expression of relevant genes based on PCR array analysis in C6 glioma cells. Molecular biology reports. vol 36. issue 4. 2009-06-01. PMID:18392946. |
we used ao/eb staining to examine the programmed cell death of matrine-treated c6 cells, and showed that the death rate detected by ao/eb staining was higher than the apoptosis rate measured by annexin v/pi staining, suggesting that autophagy, the type ii programmed cell death, may be involved in matrine-induced cell death, which was further confirmed by electronic microscopy. |
2009-06-01 |
2023-08-12 |
rat |
| Shujun Zhang, Jiping Qi, Libo Sun, Binglin Cheng, Shangha Pan, Min Zhou, Xueying Su. Matrine induces programmed cell death and regulates expression of relevant genes based on PCR array analysis in C6 glioma cells. Molecular biology reports. vol 36. issue 4. 2009-06-01. PMID:18392946. |
to explore the molecular mechanism, an apoptosis real-time pcr array was performed, which has demonstrated that 57 genes were at least 2-fold upregulated, and 11 genes were at least 2-fold downregulated in matrine-treated c6 cells, compared with untreated cells. |
2009-06-01 |
2023-08-12 |
rat |
| Shujun Zhang, Jiping Qi, Libo Sun, Binglin Cheng, Shangha Pan, Min Zhou, Xueying Su. Matrine induces programmed cell death and regulates expression of relevant genes based on PCR array analysis in C6 glioma cells. Molecular biology reports. vol 36. issue 4. 2009-06-01. PMID:18392946. |
however, the gene expression profiles could only partly and roughly explain molecular mechanisms of apoptosis and autophagy in matrine-treated c6 cells, thus further investigations are required to confirm the specific molecular pathways and related molecules responsible for the programmed cell death. |
2009-06-01 |
2023-08-12 |
rat |
| Zhen-quan Jiao, Yun-chang Guo, Yong X. [The effects of acrylonitrile on cell apoptosis, proliferation and related genes expression of rat normal and tumor glial cells]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. vol 42. issue 6. 2009-05-26. PMID:19035041. |
to study the effect of acrylonitrile (acn) to cell growth, apoptosis, proliferation and related gene expression of rat normal glial cells (di tnc1) and tumor glial cells (c6). |
2009-05-26 |
2023-08-12 |
rat |
| Cheng-Fa Cai, Lei Feng, Lei Wang, Qing-Zhong Kong, Yun-Feng Zha. Tetrazolium violet induces apoptosis via caspases-8, -9 activation and Fas/FasL up-regulation in rat C6 glioma cells. Archives of pharmacal research. vol 32. issue 4. 2009-05-14. PMID:19407976. |
tetrazolium violet induces apoptosis via caspases-8, -9 activation and fas/fasl up-regulation in rat c6 glioma cells. |
2009-05-14 |
2023-08-12 |
rat |
| Cheng-Fa Cai, Lei Feng, Lei Wang, Qing-Zhong Kong, Yun-Feng Zha. Tetrazolium violet induces apoptosis via caspases-8, -9 activation and Fas/FasL up-regulation in rat C6 glioma cells. Archives of pharmacal research. vol 32. issue 4. 2009-05-14. PMID:19407976. |
a previous study showed that tetrazolium violet inhibited cell growth, and induced cell cycle arrest and apoptosis in c6 rat glioma cells. |
2009-05-14 |
2023-08-12 |
rat |
| Marion Poenisch, Nils Burger, Peter Staeheli, Georg Bauer, Urs Schneide. Protein X of Borna disease virus inhibits apoptosis and promotes viral persistence in the central nervous systems of newborn-infected rats. Journal of virology. vol 83. issue 9. 2009-05-06. PMID:19211764. |
rat c6 astroglioma cells persistently infected with wild-type bdv were significantly more resistant to death receptor-dependent and -independent apoptotic stimuli than uninfected cells or cells infected with a bdv mutant expressing reduced amounts of x. confocal microscopy demonstrated that x colocalizes with mitochondria and expression of x from plasmid dna rendered human 293t and mouse l929 cells resistant to apoptosis induction. |
2009-05-06 |
2023-08-12 |
mouse |
| Marion Poenisch, Nils Burger, Peter Staeheli, Georg Bauer, Urs Schneide. Protein X of Borna disease virus inhibits apoptosis and promotes viral persistence in the central nervous systems of newborn-infected rats. Journal of virology. vol 83. issue 9. 2009-05-06. PMID:19211764. |
a recombinant virus encoding a mutant x protein unable to associate with mitochondria (bdv-x(a6a7)) failed to block apoptosis in c6 cells. |
2009-05-06 |
2023-08-12 |
mouse |
| E Decrock, E De Vuyst, M Vinken, M Van Moorhem, K Vranckx, N Wang, L Van Laeken, M De Bock, K D'Herde, C P Lai, V Rogiers, W H Evans, C C Naus, L Leybaer. Connexin 43 hemichannels contribute to the propagation of apoptotic cell death in a rat C6 glioma cell model. Cell death and differentiation. vol 16. issue 1. 2009-01-22. PMID:18820645. |
we induced apoptosis in c6 glioma cells stably transfected with connexin (cx)43, with cytochrome c (cytc) using in situ electroporation and found that healthy surrounding cells underwent apoptotic transformation. |
2009-01-22 |
2023-08-12 |
rat |
| Arabinda Das, Amogh Belagodu, Russel J Reiter, Swapan K Ray, Naren L Bani. Cytoprotective effects of melatonin on C6 astroglial cells exposed to glutamate excitotoxicity and oxidative stress. Journal of pineal research. vol 45. issue 2. 2009-01-14. PMID:18373557. |
exposure of c6 cells to 500 microm l-glutamic acid (lga) and 100 microm hydrogen peroxide (h(2)o(2)) for 24 hr caused significant increases in apoptosis. |
2009-01-14 |
2023-08-12 |
rat |
| Arabinda Das, Amogh Belagodu, Russel J Reiter, Swapan K Ray, Naren L Bani. Cytoprotective effects of melatonin on C6 astroglial cells exposed to glutamate excitotoxicity and oxidative stress. Journal of pineal research. vol 45. issue 2. 2009-01-14. PMID:18373557. |
however, 15-min post-treatment of c6 cells with melatonin dramatically reduced bax:bcl-2 ratio and proteolytic activities, decreasing lga or h(2)o(2)-induced apoptosis. |
2009-01-14 |
2023-08-12 |
rat |
| Arabinda Das, Amogh Belagodu, Russel J Reiter, Swapan K Ray, Naren L Bani. Cytoprotective effects of melatonin on C6 astroglial cells exposed to glutamate excitotoxicity and oxidative stress. Journal of pineal research. vol 45. issue 2. 2009-01-14. PMID:18373557. |
our data showed that melatonin prevented proteolysis and apoptosis in c6 astroglial cells. |
2009-01-14 |
2023-08-12 |
rat |