| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hidetomo Tanaka, Ivan Martinez-Valbuena, Shelley L Forrest, Blas Couto, Nikolai Gil Reyes, Alonso Morales-Rivero, Seojin Lee, Jun Li, Ali M Karakani, David F Tang-Wai, Charles Tator, Mozhgan Khadadadi, Nusrat Sadia, Maria Carmela Tartaglia, Anthony E Lang, Gabor G Kovac. Distinct involvement of the cranial and spinal nerves in progressive supranuclear palsy. Brain : a journal of neurology. 2023-11-16. PMID:37972275. |
to characterize the involvement of the pns in tauopathies, we investigated tau pathology in cranial and spinal nerves (pns-tau) in 54 tauopathy cases (progressive supranuclear palsy: psp, n = 15; alzheimer's disease: ad, n = 18; chronic traumatic encephalopathy: cte, n = 5; and corticobasal degeneration: cbd, n = 6; pick's disease, n = 9; limbic-predominant neuronal inclusion body 4-repeat tauopathy, lnt, n = 1) using immunohistochemistry, gallyas silver staining, biochemistry, and seeding assays. |
2023-11-16 |
2023-11-20 |
Not clear |
| Maria Laura Passaro, Francesco Matarazzo, Gianmarco Abbadessa, Antonio Pezone, Antonio Porcellini, Fausto Tranfa, Michele Rinaldi, Ciro Costagliol. Glaucoma as a Tauopathy-Is It the Missing Piece in the Glaucoma Puzzle? Journal of clinical medicine. vol 12. issue 21. 2023-11-14. PMID:37959365. |
tauopathies represent a subclass of neurodegenerative diseases characterized by the abnormal deposition of tau protein within the brain and consequent microtubule destabilization. |
2023-11-14 |
2023-11-20 |
Not clear |
| Maria Laura Passaro, Francesco Matarazzo, Gianmarco Abbadessa, Antonio Pezone, Antonio Porcellini, Fausto Tranfa, Michele Rinaldi, Ciro Costagliol. Glaucoma as a Tauopathy-Is It the Missing Piece in the Glaucoma Puzzle? Journal of clinical medicine. vol 12. issue 21. 2023-11-14. PMID:37959365. |
notably, recent decades have witnessed emerging documentation of tau inclusion among glaucoma patients, providing substantiation that this ocular disease may similarly manifest features of tauopathies. |
2023-11-14 |
2023-11-20 |
Not clear |
| Marc I Diamon. Travels with tau prions. Cytoskeleton (Hoboken, N.J.). 2023-11-11. PMID:37950616. |
tau was originally identified as a microtubule associated protein, and subsequently recognized to constitute the fibrillar assemblies found in alzheimer disease and related neurodegenerative tauopathies. |
2023-11-11 |
2023-11-20 |
mouse |
| Marc I Diamon. Travels with tau prions. Cytoskeleton (Hoboken, N.J.). 2023-11-11. PMID:37950616. |
point mutations in the microtubule associated protein tau (mapt) gene cause dominantly inherited tauopathies, and most predispose it to aggregate. |
2023-11-11 |
2023-11-20 |
mouse |
| Marc I Diamon. Travels with tau prions. Cytoskeleton (Hoboken, N.J.). 2023-11-11. PMID:37950616. |
this indicates tau aggregation underlies pathogenesis of tauopathies. |
2023-11-11 |
2023-11-20 |
mouse |
| Marc I Diamon. Travels with tau prions. Cytoskeleton (Hoboken, N.J.). 2023-11-11. PMID:37950616. |
the study of tau prions has raised important questions about basic cell biological processes that underlie their replication and propagation, with implications for therapy of tauopathies. |
2023-11-11 |
2023-11-20 |
mouse |
| Tanrada Pansuwan, Annelies Quaegebeur, Sanne S Kaalund, Eric Hidari, Mayen Briggs, James B Rowe, Timothy Rittma. Accurate digital quantification of tau pathology in progressive supranuclear palsy. Acta neuropathologica communications. vol 11. issue 1. 2023-11-10. PMID:37946288. |
overall, our data indicate the potential for highly accurate digital tau aggregate type-specific quantification for neurodegenerative tauopathies; and the importance of studying tau aggregate type-specific burden in different brain regions as opposed to overall tau, to gain insights into the pathogenesis and progression of tauopathies. |
2023-11-10 |
2023-11-20 |
human |
| Yoon A Kim, Marian Mellen, Caghan Kizil, Ismael Santa-Mari. Mechanisms linking cerebrovascular dysfunction and tauopathy: adding a layer of epiregulatory complexity. British journal of pharmacology. 2023-11-05. PMID:37926507. |
intracellular accumulation of hyperphosphorylated misfolded tau proteins is found in many neurodegenerative tauopathies, including alzheimer's disease (ad). |
2023-11-05 |
2023-11-08 |
Not clear |
| Zhenfeng Song, Kuang-Wei Wang, Hsiao-Tien Chien Hagar, Hong-Ru Chen, Chia-Yi Kuan, Kezhong Zhang, Min-Hao Ku. Hyperphosphorylated Tau Inflicts Intracellular Stress Responses that Are Mitigated by Apomorphine. Molecular neurobiology. 2023-11-03. PMID:37919601. |
abnormal phosphorylation of the microtubule-binding protein tau in the brain is a key pathological marker for alzheimer's disease and additional neurodegenerative tauopathies. |
2023-11-03 |
2023-11-08 |
Not clear |
| Fabio Moda, Arianna Ciullini, Ilaria Linda Dellarole, Annalisa Lombardo, Nicole Campanella, Giuseppe Bufano, Federico Angelo Cazzaniga, Giorgio Giaccon. Secondary Protein Aggregates in Neurodegenerative Diseases: Almost the Rule Rather than the Exception. Frontiers in bioscience (Landmark edition). vol 28. issue 10. 2023-11-02. PMID:37919089. |
tau aggregates, in addition to being present in primary tauopathies, have been identified in prion diseases, α-synucleinopathies, and cognitively healthy aged subjects. |
2023-11-02 |
2023-11-08 |
human |
| Airi Tarutani, Fuyuki Kametani, Marina Tahira, Yuko Saito, Mari Yoshida, Andrew C Robinson, David M A Mann, Shigeo Murayama, Taisuke Tomita, Masato Hasegaw. Distinct tau folds initiate templated seeding and alter the post-translational modification profile. Brain : a journal of neurology. 2023-10-31. PMID:37904205. |
pathological tau accumulates in the brain in tauopathies such as alzheimer's disease, pick's disease, progressive supranuclear palsy and corticobasal degeneration, and forms amyloid-like filaments incorporating various post-translational modifications (ptms). |
2023-10-31 |
2023-11-08 |
Not clear |
| Ethan D Smith, Quan Vo, Benoit I Giasson, David R Borchelt, Stefan Prokop, Paramita Chakrabart. Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau. Acta neuropathologica communications. vol 11. issue 1. 2023-10-30. PMID:37891635. |
our results highlight the existence of a phospho-ptm code in tau seeding and further demonstrate the distinctive nature of this code in 4r tauopathies. |
2023-10-30 |
2023-11-08 |
human |
| Mihika Gangolli, Sinisa Pajevic, Joong Hee Kim, Elizabeth B Hutchinson, Dan Benjamini, Peter J Basse. Correspondence of mean apparent propagator MRI metrics with phosphorylated tau and astrogliosis in chronic traumatic encephalopathy. Brain communications. vol 5. issue 5. 2023-10-30. PMID:37901038. |
although its identification remains the primary diagnostic criteria to distinguish chronic traumatic encephalopathy from other tauopathies, the hyperphosphorylated tau that accumulates in neurofibrillary tangles in cortical grey matter and perivascular regions is often accompanied by concomitant pathology such as astrogliosis. |
2023-10-30 |
2023-11-08 |
Not clear |
| Francesca Parolini, Elham Ataie Kachoie, Giulia Leo, Laura Civiero, Luigi Bubacco, Giorgio Arrigoni, Francesca Munari, Michael Assfalg, Mariapina D'Onofrio, Stefano Capald. Site-Specific Ubiquitination of Tau Amyloids Promoted by the E3 Ligase CHIP. Angewandte Chemie (International ed. in English). 2023-10-25. PMID:37878393. |
post-translational modifications of tau are emerging as key players in determining the onset and progression of different tauopathies such as alzheimer's disease, and are recognized to mediate the structural diversity of the disease-specific tau amyloids. |
2023-10-25 |
2023-11-08 |
Not clear |
| Himanshi Singh, Asmita Das, Mohammad Moshahid Khan, Tayebeh Pourmotabbe. New insights into the therapeutic approaches for the treatment of tauopathies. Neural regeneration research. vol 19. issue 5. 2023-10-20. PMID:37862204. |
tauopathies are a group of neurological disorders, including alzheimer's disease and frontotemporal dementia, which involve progressive neurodegeneration, cognitive deficits, and aberrant tau protein accumulation. |
2023-10-20 |
2023-11-08 |
Not clear |
| Himanshi Singh, Asmita Das, Mohammad Moshahid Khan, Tayebeh Pourmotabbe. New insights into the therapeutic approaches for the treatment of tauopathies. Neural regeneration research. vol 19. issue 5. 2023-10-20. PMID:37862204. |
given the significant contribution of tau burden in primary tauopathies and the strong association between pathogenic tau accumulation and cognitive deficits, there has been a lot of interest in creating therapies that can alleviate tau pathology and render neuroprotective effects. |
2023-10-20 |
2023-11-08 |
Not clear |
| Himanshi Singh, Asmita Das, Mohammad Moshahid Khan, Tayebeh Pourmotabbe. New insights into the therapeutic approaches for the treatment of tauopathies. Neural regeneration research. vol 19. issue 5. 2023-10-20. PMID:37862204. |
recently, small molecules, immunotherapies, and gene therapy have been used to reduce the pathological tau burden and prevent neurodegeneration in animal models of tauopathies. |
2023-10-20 |
2023-11-08 |
Not clear |
| Mingyue Jin, Shengming Wang, Xiaodie Gao, Zhenyou Zou, Shinji Hirotsune, Liyuan Su. Pathological and physiological functional cross-talks of α-synuclein and tau in the central nervous system. Neural regeneration research. vol 19. issue 4. 2023-10-16. PMID:37843221. |
interestingly, the co-occurrence of α-synuclein and tau aggregates was found in post-mortem brains with synucleinopathies and tauopathies, some of which share similarities in clinical manifestations. |
2023-10-16 |
2023-11-08 |
mouse |
| Benjamin H Rajewski, Kamlesh M Makwana, Isaac J Angera, Danielle K Geremia, Anna R Zepeda, Grace I Hallinan, Ruben Vidal, Bernardino Ghetti, Arnaldo L Serrano, Juan R Del Vall. β-Bracelets: Macrocyclic Cross-β Epitope Mimics Based on a Tau Conformational Strain. Journal of the American Chemical Society. 2023-10-16. PMID:37844142. |
the aggregation of misfolded tau into neurotoxic fibrils is linked to the progression of alzheimer's disease (ad) and related tauopathies. |
2023-10-16 |
2023-11-08 |
Not clear |