| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura Vidal-Palencia, Cristina Font, Agustín Rebollada-Merino, Gabriel Santpere, Pol Andrés-Benito, Isidro Ferrer, Martí Pumarol. Primary Feline Tauopathy: Clinical, Morphological, Immunohistochemical, and Genetic Studies. Animals : an open access journal from MDPI. vol 13. issue 18. 2023-09-28. PMID:37760385. |
tauopathies are a group of neurodegenerative diseases characterized by the pathological aggregation of hyperphosphorylated tau in neurons and glia. |
2023-09-28 |
2023-10-07 |
cat |
| Giavanna Paterno, Jose Torrellas, Brach M Bell, Kimberly-Marie M Gorion, Stephan S Quintin, Gabriela P Hery, Stefan Prokop, Benoit I Giasso. Novel Conformation-Dependent Tau Antibodies Are Modulated by Adjacent Phosphorylation Sites. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37761979. |
tau proteins within the adult central nervous system (cns) are found to be abnormally aggregated into heterogeneous filaments in neurodegenerative diseases, termed tauopathies. |
2023-09-28 |
2023-10-07 |
Not clear |
| Peng Wang, D Eric Anderson, Yihong Y. PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis. Cell & bioscience. vol 13. issue 1. 2023-09-27. PMID:37759245. |
microtubule-binding protein tau is a misfolding-prone protein associated with tauopathies. |
2023-09-27 |
2023-10-07 |
Not clear |
| Naruhiko Sahara, Makoto Higuch. Diagnostic and therapeutic targeting of pathological tau proteins in neurodegenerative disorders. FEBS open bio. 2023-09-25. PMID:37746832. |
tauopathies, characterized by fibrillar tau accumulation in neurons and glial cells, constitute a major neuropathological category of neurodegenerative diseases. |
2023-09-25 |
2023-10-07 |
mouse |
| Naruhiko Sahara, Makoto Higuch. Diagnostic and therapeutic targeting of pathological tau proteins in neurodegenerative disorders. FEBS open bio. 2023-09-25. PMID:37746832. |
recent advances in cryo-em examination have revealed various core structures of tau filaments from different tauopathy patients, which can be used to classify tauopathies. |
2023-09-25 |
2023-10-07 |
mouse |
| Salvatore P Mangiafico, Qing-Zhang Tuo, Xiao-Lan Li, Yu Liu, Christian Haralambous, Xu-Long Ding, Scott Ayton, Qing Wang, D Ross Laybutt, Jeng Yie Chan, Xiang Zhang, Cameron Kos, Helen E Thomas, Thomas Loudovaris, Chieh-Hsin Yang, Christos N Joannides, Benjamin J Lamont, Lunzhi Dai, Hai-Huai He, Biao Dong, Sofianos Andrikopoulos, Ashley I Bush, Peng Le. Tau suppresses microtubule-regulated pancreatic insulin secretion. Molecular psychiatry. 2023-09-22. PMID:37735502. |
tau protein is implicated in the pathogenesis of alzheimer's disease (ad) and other tauopathies, but its physiological function is in debate. |
2023-09-22 |
2023-10-07 |
mouse |
| Wyatt C Powell, Ruiheng Jing, Maciej A Walcza. Chemical Synthesis of Microtubule-Associated Protein Tau. Journal of the American Chemical Society. 2023-09-22. PMID:37737824. |
deposits of the microtubule-associated protein tau (mapt) serve as a hallmark of neurodegenerative diseases known as tauopathies. |
2023-09-22 |
2023-10-07 |
Not clear |
| Wyatt C Powell, Ruiheng Jing, Maciej A Walcza. Chemical Synthesis of Microtubule-Associated Protein Tau. Journal of the American Chemical Society. 2023-09-22. PMID:37737824. |
in broader terms, the presented strategy can be applied to the preparation of other shorter isoforms of tau as well as to introduce all post-translational modifications that are characteristic of tauopathies such as ad. |
2023-09-22 |
2023-10-07 |
Not clear |
| Pijush Chakraborty, Gwladys Rivière, Alina Hebestreit, Alain Ibáñez de Opakua, Ina M Vorberg, Loren B Andreas, Markus Zweckstette. Acetylation discriminates disease-specific tau deposition. Nature communications. vol 14. issue 1. 2023-09-22. PMID:37739953. |
pathogenic aggregation of the protein tau is a hallmark of alzheimer's disease and several other tauopathies. |
2023-09-22 |
2023-10-07 |
Not clear |
| Pijush Chakraborty, Gwladys Rivière, Alina Hebestreit, Alain Ibáñez de Opakua, Ina M Vorberg, Loren B Andreas, Markus Zweckstette. Acetylation discriminates disease-specific tau deposition. Nature communications. vol 14. issue 1. 2023-09-22. PMID:37739953. |
tauopathies are characterized by the deposition of specific tau isoforms as disease-related tau filament structures. |
2023-09-22 |
2023-10-07 |
Not clear |
| Reshma Bhagat, Miguel A Minaya, Arun Renganathan, Muneshwar Mehra, Jacob Marsh, Rita Martinez, Abdallah M Eteleeb, Alissa L Nana, Salvatore Spina, William W Seeley, Lea T Grinberg, Celeste M Karc. Long non-coding RNA SNHG8 drives stress granule formation in tauopathies. Molecular psychiatry. 2023-09-21. PMID:37730840. |
tauopathies are a heterogenous group of neurodegenerative disorders characterized by tau aggregation in the brain. |
2023-09-21 |
2023-10-07 |
mouse |
| Reshma Bhagat, Miguel A Minaya, Arun Renganathan, Muneshwar Mehra, Jacob Marsh, Rita Martinez, Abdallah M Eteleeb, Alissa L Nana, Salvatore Spina, William W Seeley, Lea T Grinberg, Celeste M Karc. Long non-coding RNA SNHG8 drives stress granule formation in tauopathies. Molecular psychiatry. 2023-09-21. PMID:37730840. |
in a subset of tauopathies, rare mutations in the mapt gene, which encodes the tau protein, are sufficient to cause disease; however, the events downstream of mapt mutations are poorly understood. |
2023-09-21 |
2023-10-07 |
mouse |
| Cristina Di Primio, Paola Quaranta, Marianna Mignanelli, Giacomo Siano, Matteo Bimbati, Arianna Scarlatti, Carmen Rita Piazza, Piero Giorgio Spezia, Paola Perrera, Fulvio Basolo, Anello Marcello Poma, Mario Costa, Mauro Pistello, Antonino Cattane. Severe acute respiratory syndrome coronavirus 2 infection leads to Tau pathological signature in neurons. PNAS nexus. vol 2. issue 9. 2023-09-21. PMID:37731949. |
upon infection, tau is phosphorylated at several pathological epitopes associated with alzheimer's disease and other tauopathies. |
2023-09-21 |
2023-10-07 |
mouse |
| Nina Rostgaard, Pia Holm Jul, Mats Garmer, Christiane Volbrach. Increasing O-GlcNAcylation Attenuates tau Hyperphosphorylation and Behavioral Impairment in rTg4510 Tauopathy Mice. Journal of integrative neuroscience. vol 22. issue 5. 2023-09-21. PMID:37735138. |
tauopathies such as alzheimer's disease (ad) are characterized by abnormal hyperphosphorylation of the microtubule-associated protein tau (mapt) aggregating into neurofibrillary tangles (nfts). |
2023-09-21 |
2023-10-07 |
mouse |
| Lenka Hromadkova, Chae Kim, Tracy Haldiman, Lihua Peng, Xiongwei Zhu, Mark Cohen, Rohan de Silva, Jiri G Safa. Evolving prion-like tau conformers differentially alter postsynaptic proteins in neurons inoculated with distinct isolates of Alzheimer's disease tau. Cell & bioscience. vol 13. issue 1. 2023-09-18. PMID:37723591. |
although accumulation of misfolded tau species has been shown to predict cognitive decline in patients with alzheimer's disease (ad) and other tauopathies but with the remarkable diversity of clinical manifestations, neuropathology profiles, and time courses of disease progression remaining unexplained by current genetic data. |
2023-09-18 |
2023-10-07 |
Not clear |
| Brian D Hitt, Ankit Gupta, Ruhar Singh, Ting Yang, Joshua D Beaver, Ping Shang, Charles L White, Lukasz A Joachimiak, Marc I Diamon. Anti-tau antibodies targeting a conformation-dependent epitope selectively bind seeds. The Journal of biological chemistry. 2023-09-15. PMID:37714465. |
neurodegenerative tauopathies are caused by transition of tau protein from a monomer to a toxic aggregate. |
2023-09-15 |
2023-10-07 |
Not clear |
| Ana Ojeda, Valentina Cofré, Francisco Melo, Leonardo Caballero, Denis Fuentealba, Alberto Cornej. α-synuclein drives tau´s cytotoxic aggregates formation through hydrophobic interactions. ChemPlusChem. 2023-09-14. PMID:37708459. |
tau and α-synuclein are proteins involved in pathologies known as tauopathies and synucleinopathies, respectively. |
2023-09-14 |
2023-10-07 |
Not clear |
| Iain J Hartnell, Declan Woodhouse, William Jasper, Luke Mason, Pavan Marwaha, Manon Graffeuil, Laurie C Lau, Jeanette L Norman, David S Chatelet, Luc Buee, James A R Nicoll, David Blum, Guillaume Dorothee, Delphine Boch. Glial reactivity and T cell infiltration in frontotemporal lobar degeneration with tau pathology. Brain : a journal of neurology. 2023-09-13. PMID:37703311. |
frontotemporal lobar degeneration with tau (ftld-tau) is a group of tauopathies that underlie ∼50% of frontotemporal lobar degeneration (ftld) cases. |
2023-09-13 |
2023-10-07 |
mouse |
| Sushobhna Batra, Jaime Vaquer-Alicea, Victor A Manon, Omar M Kashmer, Andrew Lemoff, Nigel J Cairns, Charles L White, Marc I Diamon. VCP increases or decreases tau seeding using specific cofactors. bioRxiv : the preprint server for biology. 2023-09-11. PMID:37693404. |
neurodegenerative tauopathies may progress based on seeding by pathological tau assemblies, whereby an aggregate is released from one cell, gains entry to an adjacent or connected cell, and serves as a specific template for its own replication in the cytoplasm. |
2023-09-11 |
2023-10-07 |
Not clear |
| Andrew P Longhini, Austin Dubose, Samuel Lobo, Vishnu Vijayan, Yeran Bai, Erica Keane Rivera, Julia Salar-Jarque, Arina Nikitina, Daniel C Carrettiero, Matthew Unger, Olivia Sclafani, Valerie Fu, Michael Vigers, Luc Buee, Isabelle Landrieu, Scott Shell, Joan E Shea, Songi Han, Kenneth S Kosi. A Small Tau Fragment Specifically Templates Four Repeat Tau Aggregates Through Multiple Generations. bioRxiv : the preprint server for biology. 2023-09-11. PMID:37693456. |
prion-like spread of disease-specific tau conformers is a hallmark of all tauopathies. |
2023-09-11 |
2023-10-07 |
Not clear |