| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Itzhak Fische. Big tau: What, how, where and why. Cytoskeleton (Hoboken, N.J.). 2023-08-14. PMID:37578198. |
over the last 50 years the different isoforms of tau proteins (45-60 kda) have been a focus of research because of their roles in modulating the dynamic properties of microtubules shaping the structure and function of neurons but also becoming a center of attention in the pathology of neurodegeneration associated with tauopathies. |
2023-08-14 |
2023-08-16 |
Not clear |
| Itzhak Fische. Big tau: What, how, where and why. Cytoskeleton (Hoboken, N.J.). 2023-08-14. PMID:37578198. |
this perspective summarizes the progress so far in defining the structure and expression of big tau within and outside the nervous system, proposes a role for big tau in improving axonal transport in projecting axons, considers its potential in averting tau aggregation in tauopathies and highlights the need for further progress. |
2023-08-14 |
2023-08-16 |
Not clear |
| Nahuel N Foressi, Leandro Cruz Rodríguez, M Soledad Cele. Heterotypic liquid-liquid phase separation of tau and α-synuclein: Implications for overlapping neuropathologies. Biochimica et biophysica acta. Proteins and proteomics. 2023-08-13. PMID:37574035. |
tauopathies and synucleinopathies are characterized by the aggregation of tau and α-synuclein (as) into amyloid structures, respectively. |
2023-08-13 |
2023-08-16 |
Not clear |
| Eliot J Davidowitz, Patricia Lopez, Heidy Jimenez, Leslie Adrien, Peter Davies, James G Mo. Small molecule inhibitor of tau self-association in a mouse model of tauopathy: A preventive study in P301L tau JNPL3 mice. PloS one. vol 18. issue 8. 2023-08-09. PMID:37556474. |
this study was performed in jnpl3 mice, which are representative of inherited forms of 4-repeat tauopathies with the p301l tau mutation (e.g., progressive supranuclear palsy and frontotemporal dementia). |
2023-08-09 |
2023-08-16 |
mouse |
| Kimberly L Fiock, Jordan Hook, Marco M Heft. Determinants of Astrocytic Pathology in Stem Cell Models of Primary Tauopathies. bioRxiv : the preprint server for biology. 2023-08-07. PMID:37546981. |
astrocytic tau aggregates are seen in several primary and secondary tauopathies, including progressive supranuclear palsy (psp), corticobasal degeneration (cbd), and chronic traumatic encephalopathy (cte). |
2023-08-07 |
2023-08-14 |
Not clear |
| Qiuxuan Xia, Zhiming Wang, Wang Wan, Huan Feng, Rui Sun, Biao Jing, Yusong Ge, Yu Li. Fluorene-based tau fibrillation sensor and inhibitor with fluorogenic and photo-crosslinking properties. Chemical communications (Cambridge, England). 2023-07-31. PMID:37522834. |
tau protein aggregation into neurofibrillary tangles often causes tauopathies. |
2023-07-31 |
2023-08-14 |
Not clear |
| Sanghyun Ahn, Jung-Soo Suh, Yoon-Kwan Jang, Heonsu Kim, Kiseok Han, Yerim Lee, Gyuho Choi, Tae-Jin Ki. TAUCON and TAUCOM: A novel biosensor based on fluorescence resonance energy transfer for detecting tau hyperphosphorylation-associated cellular pathologies. Biosensors & bioelectronics. vol 237. 2023-07-30. PMID:37517333. |
tauopathies are neurodegenerative diseases characterized by abnormal conformational changes in tau protein. |
2023-07-30 |
2023-08-14 |
Not clear |
| Zhikai Zeng, Vishnu Vijayan, Karen Tsay, Matthew P Frost, Athena Quddus, Alexa Albert, Michael Vigers, Amanda L Woerman, Songi Ha. CBD and PSP cell-passaged Tau Seeds Generate Heterogeneous Fibrils with A sub-population Adopting Disease Folds. bioRxiv : the preprint server for biology. 2023-07-28. PMID:37502998. |
the recent discovery by cryo-electron microscopy that the neuropatho-logical hallmarks of different tauopathies, including alzheimer's disease, corticobasal degeneration (cbd), and progressive supranuclear palsy (psp), are caused by unique misfolded conformations of the protein tau is among the most profound developments in neurodegenerative disease research. |
2023-07-28 |
2023-08-14 |
Not clear |
| Zi-Yang Zhang, Dilshan S Harischandra, Ruifang Wang, Shivani Ghaisas, Janet Y Zhao, Thomas P McMonagle, Guixin Zhu, Kenzo D Lacuarta, Jianing Song, John Q Trojanowski, Hong Xu, Virginia M-Y Lee, Xiaolu Yan. TRIM11 protects against tauopathies and is down-regulated in Alzheimer's disease. Science (New York, N.Y.). vol 381. issue 6656. 2023-07-27. PMID:37499037. |
aggregation of tau into filamentous inclusions underlies alzheimer's disease (ad) and numerous other neurodegenerative tauopathies. |
2023-07-27 |
2023-08-14 |
human |
| Aditi Halder, Eleanor Drummon. Strategies for translating proteomics discoveries into drug discovery for dementia. Neural regeneration research. vol 19. issue 1. 2023-07-25. PMID:37488854. |
tauopathies, diseases characterized by neuropathological aggregates of tau including alzheimer's disease and subtypes of frontotemporal dementia, make up the vast majority of dementia cases. |
2023-07-25 |
2023-08-14 |
Not clear |
| Alisa Cario, Christopher L Berge. Tau, microtubule dynamics, and axonal transport: New paradigms for neurodegenerative disease. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 45. issue 8. 2023-07-25. PMID:37489532. |
the etiology of tauopathies, a diverse class of neurodegenerative diseases associated with the microtubule associated protein (map) tau, is usually described by a common mechanism in which tau dysfunction results in the loss of axonal microtubule stability. |
2023-07-25 |
2023-08-14 |
Not clear |
| Hiroki Umeda, Taka Sawazaki, Masahiro Furuta, Takanobu Suzuki, Shigehiro A Kawashima, Harunobu Mitsunuma, Yukiko Hori, Taisuke Tomita, Youhei Sohma, Motomu Kana. Quantitative Assays for Catalytic Photo-Oxygenation of Alzheimer Disease-Related Tau Proteins. ACS chemical neuroscience. 2023-07-20. PMID:37470225. |
catalytic photo-oxygenation of tau amyloid is a potential therapeutic approach to tauopathies, including alzheimer disease (ad). |
2023-07-20 |
2023-08-14 |
Not clear |
| Roberto Tira, Giovanna Viola, Carlo Giorgio Barracchia, Francesca Parolini, Francesca Munari, Stefano Capaldi, Michael Assfalg, Mariapina D'Onofri. Espresso Coffee Mitigates the Aggregation and Condensation of Alzheimer's Associated Tau Protein. Journal of agricultural and food chemistry. 2023-07-19. PMID:37466260. |
alzheimer's disease belongs to a group of disorders, called tauopathies, which are characterized by the intraneuronal accumulation of the microtubule-associated protein tau in fibrillar aggregates. |
2023-07-19 |
2023-08-14 |
Not clear |
| S B Wharton, J E Simpson, P G Ince, C D Richardson, R Merrick, F E Matthews, C Brayn. Insights into the Pathological Basis of Dementia from Population Based Neuropathology Studies. Neuropathology and applied neurobiology. 2023-07-18. PMID:37462105. |
furthermore, additional pathologies such as limbic-predominant age related tdp-43 encephalopathy, ageing related tau astrogliopathy and primary age-related tauopathies contribute to late-life dementia. |
2023-07-18 |
2023-08-14 |
Not clear |
| Gabrielle Zuniga, Bess Fros. Selective neuronal vulnerability to deficits in RNA processing. Progress in neurobiology. 2023-07-16. PMID:37454791. |
additionally, we explore how tau, a microtubule-associated protein implicated in alzheimer's disease and related tauopathies, contributes to deficits in rna processing and clearance. |
2023-07-16 |
2023-08-14 |
Not clear |
| Marta Jorge-Oliva, Jan R T van Weering, Wiep Schepe. Structurally and Morphologically Distinct Pathological Tau Assemblies Differentially Affect GVB Accumulation. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446051. |
tau aggregation is central to the pathogenesis of a large group of neurodegenerative diseases termed tauopathies, but it is still unclear in which way neurons respond to tau pathology and how tau accumulation leads to neurodegeneration. |
2023-07-14 |
2023-08-14 |
Not clear |
| Yijun Chen, Yang Y. Tau and neuroinflammation in Alzheimer's disease: interplay mechanisms and clinical translation. Journal of neuroinflammation. vol 20. issue 1. 2023-07-14. PMID:37452321. |
unraveling the precise mechanisms underlying the relationship between tau pathology and neuroinflammation will provide new insights into the discovery and clinical translation of therapeutic targets for ad and other tau-related diseases (tauopathies). |
2023-07-14 |
2023-08-14 |
Not clear |
| Runyao Zhu, Kamlesh M Makwana, Youwen Zhang, Benjamin H Rajewski, Juan R Del Valle, Yichun Wan. Blocking tau transmission by biomimetic graphene nanoparticles. Journal of materials chemistry. B. 2023-07-11. PMID:37431684. |
the primary pathological feature of tauopathies is the presence of neurofibrillary tangles in the brain composed of tau protein aggregates. |
2023-07-11 |
2023-08-14 |
Not clear |
| Runyao Zhu, Kamlesh M Makwana, Youwen Zhang, Benjamin H Rajewski, Juan R Del Valle, Yichun Wan. Blocking tau transmission by biomimetic graphene nanoparticles. Journal of materials chemistry. B. 2023-07-11. PMID:37431684. |
overall, our studies indicate that gqds with biomimetic properties can efficiently inhibit and disassemble pathological tau aggregates, and thus block tau transmission, which supports their future developments as a potential treatment for tauopathies. |
2023-07-11 |
2023-08-14 |
Not clear |
| Marta Leńska-Mieciek, Natalia Madetko-Alster, Piotr Alster, Leszek Królicki, Urszula Fiszer, Dariusz Koziorowsk. Inflammation in multiple system atrophy. Frontiers in immunology. vol 14. 2023-07-10. PMID:37426656. |
among proteinopathies are neurodegenerative diseases with atypical parkinsonism and an accumulation of insoluble fibrillary alpha-synuclein (synucleinopathies) or hyperphosphorylated tau protein fragments (tauopathies). |
2023-07-10 |
2023-08-14 |
Not clear |