| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abigail Alexander, Victor E Alvarez, Bertrand R Huber, Michael L Alosco, Jesse Mez, Yorghos Tripodis, Raymond Nicks, Douglas I Katz, Brigid Dwyer, Daniel H Daneshvar, Brett Martin, Joseph Palmisano, Lee E Goldstein, John F Crary, Christopher Nowinski, Robert C Cantu, Neil W Kowall, Robert A Stern, Ivana Delalle, Ann C McKee, Thor D Stei. Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE. Acta neuropathologica. vol 147. issue 1. 2024-02-26. PMID:38407651. |
other comorbid tauopathies likely contributed in part to these differences: when cases with concurrent alzheimer dementia or frontal temporal lobar degeneration with tau pathology were excluded, differences were largely retained, but only remained significant for faq (p = 0.042), meta-cognition index t score (p = 0.014) and age of parkinsonian motor symptom onset (p = 0.046). |
2024-02-26 |
2024-02-28 |
human |
| Luca Pinzi, Christian Conze, Nicolo Bisi, Gabriele Dalla Torre, Ahmed Soliman, Nanci Monteiro-Abreu, Nataliya I Trushina, Andrea Krusenbaum, Maryam Khodaei Dolouei, Andrea Hellwig, Michael S Christodoulou, Daniele Passarella, Lidia Bakota, Giulio Rastelli, Roland Brand. Quantitative live cell imaging of a tauopathy model enables the identification of a polypharmacological drug candidate that restores physiological microtubule interaction. Nature communications. vol 15. issue 1. 2024-02-23. PMID:38396035. |
tauopathies such as alzheimer's disease are characterized by aggregation and increased phosphorylation of the microtubule-associated protein tau. |
2024-02-23 |
2024-02-26 |
human |
| Abrar Younas, Neelam Younas, Muhammad Javed Iqbal, Isidre Ferrer, Inga Zer. Comparative interactome mapping of Tau-protein in classical and rapidly progressive Alzheimer's disease identifies subtype-specific pathways. Neuropathology and applied neurobiology. vol 50. issue 1. 2024-02-20. PMID:38374702. |
tau is a key player in alzheimer's disease (ad) and other tauopathies. |
2024-02-20 |
2024-02-22 |
Not clear |
| Christian Ferschmann, Konstantin Messerschmidt, Johannes Gnörich, Henryk Barthel, Ken Marek, Carla Palleis, Sabrina Katzdobler, Anna Stockbauer, Urban Fietzek, Anika Finze, Gloria Biechele, Jost-Julian Rumpf, Dorothee Saur, Matthias L Schroeter, Michael Rullmann, Leonie Beyer, Florian Eckenweber, Stephan Wall, Andreas Schildan, Marianne Patt, Andrew Stephens, Joseph Classen, Peter Bartenstein, John Seibyl, Nicolai Franzmeier, Johannes Levin, Günter U Höglinger, Osama Sabri, Matthias Brendel, Maximilian Scheifel. Tau accumulation is associated with dopamine deficiency in vivo in four-repeat tauopathies. European journal of nuclear medicine and molecular imaging. 2024-02-17. PMID:38366196. |
tau accumulation is associated with dopamine deficiency in vivo in four-repeat tauopathies. |
2024-02-17 |
2024-02-19 |
Not clear |
| Christian Ferschmann, Konstantin Messerschmidt, Johannes Gnörich, Henryk Barthel, Ken Marek, Carla Palleis, Sabrina Katzdobler, Anna Stockbauer, Urban Fietzek, Anika Finze, Gloria Biechele, Jost-Julian Rumpf, Dorothee Saur, Matthias L Schroeter, Michael Rullmann, Leonie Beyer, Florian Eckenweber, Stephan Wall, Andreas Schildan, Marianne Patt, Andrew Stephens, Joseph Classen, Peter Bartenstein, John Seibyl, Nicolai Franzmeier, Johannes Levin, Günter U Höglinger, Osama Sabri, Matthias Brendel, Maximilian Scheifel. Tau accumulation is associated with dopamine deficiency in vivo in four-repeat tauopathies. European journal of nuclear medicine and molecular imaging. 2024-02-17. PMID:38366196. |
we hypothesized that severe tau burden in brain regions involved in direct or indirect pathways of the basal ganglia correlate with more severe striatal dopamine deficiency in four-repeat (4r) tauopathies. |
2024-02-17 |
2024-02-19 |
Not clear |
| Mohammed M Alhadidy, Nicholas M Kanaa. Biochemical approaches to assess the impact of post-translational modifications on pathogenic tau conformations using recombinant protein. Biochemical Society transactions. 2024-02-13. PMID:38348781. |
tau protein is associated with many neurodegenerative disorders known as tauopathies. |
2024-02-13 |
2024-02-15 |
Not clear |
| Pranesh Padmanabhan, Andrew Kneynsberg, Esteban Cruz, Adam Briner, Jürgen Göt. Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells. Molecular brain. vol 17. issue 1. 2024-02-12. PMID:38347594. |
the most studied of these modifications is phosphorylation, which affects tau's aggregation and loss- and gain-of-functions, including the interaction with microtubules, in alzheimer's disease and primary tauopathies. |
2024-02-12 |
2024-02-15 |
Not clear |
| Jingfen Su, Yue Xiao, Linyu Wei, Huiyang Lei, Fei Sun, Weixia Wang, Jun Yin, Rui Xiong, Shihong Li, Pei Zhang, Ying Zhou, Xiaochuan Wang, Jie Zheng, Jian-Zhi Wan. Generation of tau dephosphorylation-targeting chimeras for the treatment of Alzheimer's disease and related tauopathies. Science bulletin. 2024-02-10. PMID:38341350. |
generation of tau dephosphorylation-targeting chimeras for the treatment of alzheimer's disease and related tauopathies. |
2024-02-10 |
2024-02-14 |
mouse |
| Jingfen Su, Yue Xiao, Linyu Wei, Huiyang Lei, Fei Sun, Weixia Wang, Jun Yin, Rui Xiong, Shihong Li, Pei Zhang, Ying Zhou, Xiaochuan Wang, Jie Zheng, Jian-Zhi Wan. Generation of tau dephosphorylation-targeting chimeras for the treatment of Alzheimer's disease and related tauopathies. Science bulletin. 2024-02-10. PMID:38341350. |
abnormal hyperphosphorylation and accumulation of tau protein play a pivotal role in neurodegeneration in alzheimer's disease (ad) and many other tauopathies. |
2024-02-10 |
2024-02-14 |
mouse |
| Jingfen Su, Yue Xiao, Linyu Wei, Huiyang Lei, Fei Sun, Weixia Wang, Jun Yin, Rui Xiong, Shihong Li, Pei Zhang, Ying Zhou, Xiaochuan Wang, Jie Zheng, Jian-Zhi Wan. Generation of tau dephosphorylation-targeting chimeras for the treatment of Alzheimer's disease and related tauopathies. Science bulletin. 2024-02-10. PMID:38341350. |
these results suggested deptacs as targeted modulators of tau phosphorylation, which hold therapeutic potential for ad and other tauopathies. |
2024-02-10 |
2024-02-14 |
mouse |
| Chan Chen, Ramhari Kumbhar, Hu Wang, Xiuli Yang, Kundlik Gadhave, Cyrus Rastegar, Yasuyoshi Kimura, Adam Behensky, Sumasri Kotha, Grace Kuo, Sruthi Katakam, Deok Jeong, Liang Wang, Anthony Wang, Rong Chen, Shu Zhang, Lingtao Jin, Creg J Workman, Dario A A Vignali, Olga Pletinkova, Hongpeng Jia, Weiyi Peng, David W Nauen, Philip C Wong, Javier Redding-Ochoa, Juan C Troncoso, Mingyao Ying, Valina L Dawson, Ted M Dawson, Xiaobo Ma. Lymphocyte-Activation Gene 3 Facilitates Pathological Tau Neuron-to-Neuron Transmission. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-02-08. PMID:38327094. |
these results identify neuronal lag3 as a receptor of pathologic tau in the brain，and for ad and related tauopathies, a therapeutic target. |
2024-02-08 |
2024-02-10 |
mouse |
| Mohammad Reza Ashrafi-Kooshk, Fatemeh Norouzi, Ashkan Zare Karizak, Shahin Ahmadian, Ali Akabar Moosavi-Movahedi, Gholamhossein Riaz. Crosstalk between tau protein autoproteolysis and amyloid fibril formation. International journal of biological macromolecules. 2024-02-07. PMID:38325678. |
thus, targeting proteolysis of tau would be beneficial for the development of therapeutics for alzheimer's disease and related tauopathies. |
2024-02-07 |
2024-02-10 |
Not clear |
| Carolina Lucía Facal, Iván Fernández Bessone, Javier Andrés Muñiz, A Ezequiel Pereyra, Olivia Pedroncini, Indiana Páez-Paz, Ramiro Clerici-Delville, Cayetana Arnaiz, Leandro Urrutia, Germán Falasco, Carla Verónica Argañaraz, Trinidad Saez, Antonia Marin-Burgin, Mariano Soiza-Reilly, Tomás Falzone, María Elena Aval. Tau reduction with artificial microRNAs modulates neuronal physiology and improves tauopathy phenotypes in mice. Molecular therapy : the journal of the American Society of Gene Therapy. 2024-02-04. PMID:38310353. |
abnormal tau accumulation is the hallmark of several neurodegenerative diseases, named tauopathies. |
2024-02-04 |
2024-02-06 |
mouse |
| Frederike C Oertel, Daniel Casillas, Yann Cobigo, Shivany Condor Montes, Hilary W Heuer, Makenna Chapman, Alexandra Beaudry-Richard, Henriette Reinsberg, Ahmed Abdelhak, Christian Cordano, Bradley F Boeve, Bradford C Dickerson, Murray Grossman, Edward Huey, David J Irwin, Irene Litvan, Alexander Pantelyat, M Carmela Tartaglia, Lawren Vandevrede, Adam Boxer, Ari J Gree. Scientific commentary on: "Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer's disease and primary tauopathies". Acta neuropathologica. vol 147. issue 1. 2024-02-03. PMID:38308717. |
scientific commentary on: "phosphorylated tau in the retina correlates with tau pathology in the brain in alzheimer's disease and primary tauopathies". |
2024-02-03 |
2024-02-06 |
Not clear |
| Nikolaos Louros, Martin Wilkinson, Grigoria Tsaka, Meine Ramakers, Chiara Morelli, Teresa Garcia, Rodrigo Gallardo, Sam D'Haeyer, Vera Goossens, Dominique Audenaert, Dietmar Rudolf Thal, Ian R Mackenzie, Rosa Rademakers, Neil A Ranson, Sheena E Radford, Frederic Rousseau, Joost Schymkowit. Local structural preferences in shaping tau amyloid polymorphism. Nature communications. vol 15. issue 1. 2024-02-03. PMID:38310108. |
tauopathies encompass a group of neurodegenerative disorders characterised by diverse tau amyloid fibril structures. |
2024-02-03 |
2024-02-06 |
Not clear |
| Nikolaos Louros, Martin Wilkinson, Grigoria Tsaka, Meine Ramakers, Chiara Morelli, Teresa Garcia, Rodrigo Gallardo, Sam D'Haeyer, Vera Goossens, Dominique Audenaert, Dietmar Rudolf Thal, Ian R Mackenzie, Rosa Rademakers, Neil A Ranson, Sheena E Radford, Frederic Rousseau, Joost Schymkowit. Local structural preferences in shaping tau amyloid polymorphism. Nature communications. vol 15. issue 1. 2024-02-03. PMID:38310108. |
furthermore, in-cell experiments revealed that pam4 deletion hampers the cellular seeding efficiency of tau aggregates extracted from alzheimer's disease, corticobasal degeneration, and progressive supranuclear palsy patients, underscoring pam4's pivotal role in these tauopathies. |
2024-02-03 |
2024-02-06 |
Not clear |
| Maria do Socorro do Nascimento Amorim, Álefe Roger Silva França, Ralph Santos-Oliveira, Jonas Rodrigues Sanches, Thamys Marinho Melo, Bruno Araújo Serra Pinto, Leandro R S Barbosa, Luciana Magalhães Rebelo Alenca. Atomic Force Microscopy Applied to the Study of Tauopathies. ACS chemical neuroscience. 2024-02-02. PMID:38305187. |
tauopathies are neurodegenerative diseases featured by aggregation of phosphorylated tau protein inside neurons, leading to functional loss and progressive neurotoxicity. |
2024-02-02 |
2024-02-04 |
Not clear |
| Grant Kauwe, Kristeen A Pareja-Navarro, Lei Yao, Jackson H Chen, Ivy Wong, Rowan Saloner, Helen Cifuentes, Alissa L Nana, Samah Shah, Yaqiao Li, David Le, Salvatore Spina, Lea T Grinberg, William W Seeley, Joel H Kramer, Todd C Sacktor, Birgit Schilling, Li Gan, Kaitlin B Casaletto, Tara E Trac. KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss. The Journal of clinical investigation. vol 134. issue 3. 2024-02-01. PMID:38299587. |
synaptic plasticity is obstructed by pathogenic tau in the brain, representing a key mechanism that underlies memory loss in alzheimer's disease (ad) and related tauopathies. |
2024-02-01 |
2024-02-03 |
mouse |
| Maxwell Eisenbaum, Andrew Pearson, Camila Ortiz, Milica Koprivica, Arianna Cembran, Michael Mullan, Fiona Crawford, Joseph Ojo, Corbin Bachmeie. Repetitive head trauma and apoE4 induce chronic cerebrovascular alterations that impair tau elimination from the brain. Experimental neurology. 2024-02-01. PMID:38301863. |
repetitive mild traumatic brain injuries (r-mtbi) sustained in the military or contact sports have been associated with the accumulation of extracellular tau in the brain, which may contribute to the pathogenesis of neurodegenerative tauopathies. |
2024-02-01 |
2024-02-04 |
mouse |
| Courtney Lane-Donovan, Adam L Boxe. Disentangling tau: One protein, many therapeutic approaches. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2024-01-26. PMID:38278659. |
the tauopathies encompass over 20 adult neurodegenerative diseases and are characterized by the dysfunction and accumulation of insoluble tau protein. |
2024-01-26 |
2024-01-29 |
Not clear |