| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kevin Pounot, Clara Piersson, Andrew K Goring, Frédéric Rosu, Valérie Gabelica, Martin Weik, Songi Han, Yann Ficho. Mutations in Tau Protein Promote Aggregation by Favoring Extended Conformations. JACS Au. vol 4. issue 1. 2024-01-26. PMID:38274251. |
amyloid aggregation of the intrinsically disordered protein (idp) tau is involved in several diseases, called tauopathies. |
2024-01-26 |
2024-01-28 |
Not clear |
| Kevin Pounot, Clara Piersson, Andrew K Goring, Frédéric Rosu, Valérie Gabelica, Martin Weik, Songi Han, Yann Ficho. Mutations in Tau Protein Promote Aggregation by Favoring Extended Conformations. JACS Au. vol 4. issue 1. 2024-01-26. PMID:38274251. |
some tauopathies can be inherited due to mutations in the gene encoding tau, which might favor the formation of tau amyloid fibrils. |
2024-01-26 |
2024-01-28 |
Not clear |
| Karthikeyan Selvarasu, Abhay Kumar Singh, Avinash Dakshinamoorthy, Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Moorthi Radhakrishnan, Supriti Patnaik, Jian-Dong Huang, Leonard L Williams, Sanjib Senapati, Siva Sundara Kumar Durairaja. Interaction of Tau with Kinesin-1: Effect of Kinesin-1 Heavy Chain Elimination on Autophagy-Mediated Mutant Tau Degradation. Biomedicines. vol 12. issue 1. 2024-01-26. PMID:38275365. |
natively unfolded tau has a low propensity to form aggregates, but in tauopathies, such as alzheimer's disease (ad), tau aggregates into paired helical filaments (phfs) and neurofibrillary tangles (nfts). |
2024-01-26 |
2024-01-28 |
mouse |
| Huahua Shi, Yan Zha. Modulation of Tau Pathology in Alzheimer's Disease by Dietary Bioactive Compounds. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38255905. |
the abnormal intracellular accumulation of tau aggregates is a major characteristic of brains from patients with alzheimer's disease (ad) and other tauopathies. |
2024-01-23 |
2024-01-25 |
Not clear |
| Eduardo Pena, Rocio San Martin-Salamanca, Samia El Alam, Karen Flores, Karem Arriaz. Tau Protein Alterations Induced by Hypobaric Hypoxia Exposure. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38255962. |
tauopathies are a group of neurodegenerative diseases whose central feature is dysfunction of the microtubule-associated protein tau (mapt). |
2024-01-23 |
2024-01-25 |
Not clear |
| Chloé Jacquemin, Nicolas Villain, Rita Azevedo, Susana Boluda, Etienne A Thévenot, François Fenaille, Foudil Lamari, François Beche. Evaluation of SP3 for antibody-free quantification of tau in CSF mimic and brain by mass spectrometry. European journal of mass spectrometry (Chichester, England). 2024-01-23. PMID:38258392. |
tubulin-associated unit (tau) has an important role in the pathogenesis and the diagnosis of alzheimer's disease (ad) and other tauopathies. |
2024-01-23 |
2024-01-25 |
human |
| Ling Wu, Stephanie Arvai, Shih-Hsiu J Wang, Andy J Liu, Bin X. Differential diagnosis of mild cognitive impairment of Alzheimer's disease by Simoa p-tau181 measurements with matching plasma and CSF. Frontiers in molecular neuroscience. vol 16. 2024-01-23. PMID:38260807. |
misfolded phosphorylated tau aggregates (p-tau) are present in multiple neurodegenerative diseases known as "tauopathies", with the most common being ad. |
2024-01-23 |
2024-01-25 |
human |
| Chong Peng, Wei Wei, Huitu Zhang, Ying Wang, Baogen Chang, Wenping Zhao, Longgang Jia, Li Li, Fuping Lu, Fufeng Li. Heterologous expression and fibrillary characterization of the microtubule-binding domain of tau associated with tauopathies. Molecular biology reports. vol 51. issue 1. 2024-01-23. PMID:38261107. |
heterologous expression and fibrillary characterization of the microtubule-binding domain of tau associated with tauopathies. |
2024-01-23 |
2024-01-25 |
Not clear |
| Samantha P Martin, Beth A Leeman-Markowsk. Proposed mechanisms of tau: relationships to traumatic brain injury, Alzheimer's disease, and epilepsy. Frontiers in neurology. vol 14. 2024-01-22. PMID:38249745. |
although tau is typically present intracellularly, in tauopathies, phosphorylated (p-) and hyper-phosphorylated (hp-) tau are released extracellularly, the latter leading to decreased neuronal stability and neurofibrillary tangles (nfts). |
2024-01-22 |
2024-01-24 |
Not clear |
| Brianne B Rogers, Ashlyn G Anderson, Shelby N Lauzon, M Natalie Davis, Rebecca M Hauser, Sydney C Roberts, Ivan Rodriguez-Nunez, Katie Trausch-Lowther, Erin A Barinaga, Paige I Hall, Matthew T Knuesel, Jared W Taylor, Mark Mackiewicz, Brian S Roberts, Sara J Cooper, Lindsay F Rizzardi, Richard M Myers, J Nicholas Cochra. Neuronal MAPT expression is mediated by long-range interactions with cis-regulatory elements. American journal of human genetics. 2024-01-17. PMID:38232730. |
tauopathies are a group of neurodegenerative diseases defined by abnormal aggregates of tau, a microtubule-associated protein encoded by mapt. |
2024-01-17 |
2024-01-20 |
human |
| Geoffrey Canet, Emma Rocaboy, Francis Laliberté, Emmanuelle Boscher, Isabelle Guisle, Sofia Diego-Diaz, Parissa Fereydouni-Forouzandeh, Robert A Whittington, Sébastien S Hébert, Vincent Pernet, Emmanuel Plane. Temperature-induced Artifacts in Tau Phosphorylation: Implications for Reliable Alzheimer's Disease Research. Experimental neurobiology. vol 32. issue 6. 2024-01-10. PMID:38196137. |
in preclinical research on alzheimer's disease and related tauopathies, tau phosphorylation analysis is routinely employed in both cellular and animal models. |
2024-01-10 |
2024-01-13 |
mouse |
| Morrie Lam, Szu-Yu Kuo, Surya Reis, Jason E Gestwicki, M Catarina Silva, Stephen J Haggart. Cholesterol Dysregulation Drives Seed-Dependent Tau Aggregation in Patient Stem Cell-Derived Models of Tauopathy. bioRxiv : the preprint server for biology. 2024-01-03. PMID:38168389. |
tauopathies are a class of neurodegenerative diseases characterized by the progressive misfolding and accumulation of pathological tau protein in focal regions of the brain, leading to insidious neurodegeneration. |
2024-01-03 |
2024-01-06 |
Not clear |
| Calina Glynn, Joshua E Chun, Cameron C Donahue, Monica J S Nadler, Zhanyun Fan, Bradley T Hyma. Reconstitution of the Alzheimer's Disease Tau Core Structure from Recombinant Tau Biochemistry. 2023-12-28. PMID:38154792. |
reconstitution of the alzheimer's disease tau core structure from recombinant tau the protein tau misfolds into disease-specific fibrillar structures in more than 20 neurodegenerative diseases collectively referred to as tauopathies. |
2023-12-28 |
2023-12-31 |
Not clear |
| Indalo Domene-Serrano, Raquel Cuadros, Felix Hernandez, Jesus Avila, Ismael Santa-Mari. Tridimensional Structural Analysis of Tau Isoforms Generated by Intronic Retention. Journal of Alzheimer's disease reports. vol 7. issue 1. 2023-12-25. PMID:38143771. |
tauopathies are a subset of neurodegenerative diseases characterized by abnormal tau inclusions. |
2023-12-25 |
2023-12-27 |
human |
| Indalo Domene-Serrano, Raquel Cuadros, Felix Hernandez, Jesus Avila, Ismael Santa-Mari. Tridimensional Structural Analysis of Tau Isoforms Generated by Intronic Retention. Journal of Alzheimer's disease reports. vol 7. issue 1. 2023-12-25. PMID:38143771. |
our preliminary data suggests this newly discovered w-tau isoform might prevent aberrant aggregation of other tau isoforms but is significantly downregulated in tauopathies such as alzheimer's disease. |
2023-12-25 |
2023-12-27 |
human |
| Nicha Puangmalai, Nemil Bhatt, Alice Bittar, Cynthia Jerez, Nikita Shchankin, Rakez Kaye. Traumatic brain injury derived pathological tau polymorphs induce the distinct propagation pattern and neuroinflammatory response in wild type mice. Progress in neurobiology. 2023-12-22. PMID:38135105. |
the misfolding and aggregation of the tau protein into neurofibrillary tangles constitutes a central feature of tauopathies. |
2023-12-22 |
2023-12-25 |
mouse |
| Vivian Hook, Sonia Podvin, Charles Mosier, Ben Boyarko, Laura Seyffert, Haley Stringer, Robert A Rissma. Emerging evidence for dysregulated proteome cargoes of tau-propagating extracellular vesicles driven by familial mutations of tau and presenilin. Extracellular vesicles and circulating nucleic acids. vol 4. issue 4. 2023-12-21. PMID:38125374. |
tau accumulates in alzheimer's disease (ad), frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17), chronic traumatic encephalopathy (cte), progressive supranuclear palsy, and related tauopathies. |
2023-12-21 |
2023-12-23 |
human |
| Vivian Hook, Sonia Podvin, Charles Mosier, Ben Boyarko, Laura Seyffert, Haley Stringer, Robert A Rissma. Emerging evidence for dysregulated proteome cargoes of tau-propagating extracellular vesicles driven by familial mutations of tau and presenilin. Extracellular vesicles and circulating nucleic acids. vol 4. issue 4. 2023-12-21. PMID:38125374. |
recent findings show that evs generated by neurons expressing familial mutations of tauopathies of ftdp-17 (p301l and v337m) (mtau) and presenilin (a246e) (mps1) in ad induce tau propagation and accumulation after injection into rodent brain. |
2023-12-21 |
2023-12-23 |
human |
| Vivian Hook, Sonia Podvin, Charles Mosier, Ben Boyarko, Laura Seyffert, Haley Stringer, Robert A Rissma. Emerging evidence for dysregulated proteome cargoes of tau-propagating extracellular vesicles driven by familial mutations of tau and presenilin. Extracellular vesicles and circulating nucleic acids. vol 4. issue 4. 2023-12-21. PMID:38125374. |
furthermore, elucidation of ev cargo components that mediate tau propagation will have potential as biomarkers and therapeutic strategies to ameliorate dementia of tauopathies. |
2023-12-21 |
2023-12-23 |
human |
| Khalid Iqba. Tau and Alzheimer's disease: Past, present and future. Cytoskeleton (Hoboken, N.J.). 2023-12-21. PMID:38126608. |
tau pathology, which without fail is made up of the aggregated hyperphosphorylated state of the protein, is also the hallmark lesion of a family of around 20 related neurodegenerative diseases, called tauopathies. |
2023-12-21 |
2023-12-23 |
human |