| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mustafa Kırça, Akın Yeşilkay. Methylglyoxal stimulates endoplasmic reticulum stress in vascular smooth muscle cells. Journal of receptor and signal transduction research. 2021-04-26. PMID:33896363. |
supposing that er stress is not mitigated, this table might be finalized in cell apoptosis, plaque rupture, and stroke. |
2021-04-26 |
2023-08-13 |
rat |
| Paweł Łukasik, Michał Załuski, Izabela Gutowsk. Cyclin-Dependent Kinases (CDK) and Their Role in Diseases Development-Review. International journal of molecular sciences. vol 22. issue 6. 2021-04-23. PMID:33805800. |
deregulation of any of the stages of the cell cycle or transcription leads to apoptosis but, if uncorrected, can result in a series of diseases, such as cancer, neurodegenerative diseases (alzheimer's or parkinson's disease), and stroke. |
2021-04-23 |
2023-08-13 |
Not clear |
| Weifeng Shan, Huifeng Ge, Bingquan Chen, Linger Huang, Shaojun Zhu, Yanfeng Zho. Upregulation of miR-499a-5p Decreases Cerebral Ischemia/Reperfusion Injury by Targeting PDCD4. Cellular and molecular neurobiology. 2021-04-10. PMID:33837492. |
we further found that mir-499a-5p overexpression decreased infarct volumes and cell apoptosis in the in vivo i/r stroke model using ttc and tunel staining. |
2021-04-10 |
2023-08-13 |
rat |
| Chul Jung, Mi Hee Kim, Ye Yeong Kim, Ji Ae Kim, Eun Jae Ko, Seung Hak Lee, Dae Yul Ki. Determining the Optimal Administration Conditions under Which MIF Exerts Neuroprotective Effects by Inducing BDNF Expression and Inhibiting Apoptosis in an In Vitro Stroke Model. Brain sciences. vol 11. issue 2. 2021-03-16. PMID:33672416. |
determining the optimal administration conditions under which mif exerts neuroprotective effects by inducing bdnf expression and inhibiting apoptosis in an in vitro stroke model. |
2021-03-16 |
2023-08-13 |
human |
| Xiaolin Wu, Lijin Lin, Juan-Juan Qin, Lifen Wang, Hao Wang, Yichun Zou, Xueyong Zhu, Ying Hong, Yan Zhang, Ye Liu, Can Xin, Shuangxiang Xu, Shengda Ye, Jianjian Zhang, Zhongwei Xiong, Lihua Zhu, Hongliang Li, Jincao Chen, Zhi-Gang Sh. CARD3 Promotes Cerebral Ischemia-Reperfusion Injury Via Activation of TAK1. Journal of the American Heart Association. vol 9. issue 9. 2021-03-10. PMID:32349637. |
although card3 (caspase activation and recruitment domain 3) protein is an important factor involved in regulating immunity, inflammation, lipid metabolism, and apoptosis, its role in cerebral stroke is currently unknown. |
2021-03-10 |
2023-08-13 |
mouse |
| Qian Xie, Rong Ma, Xiaoqing Guo, Hai Chen, Jian Wan. Benzoinum from Styrax tonkinensis (Pierre) Craib ex Hart exerts a NVU protective effect by inhibiting cell apoptosis in cerebral ischaemia rats. Journal of ethnopharmacology. vol 265. 2021-02-26. PMID:32891816. |
benzoinum has also proven to have diverse pharmacological activity, but the neuroprotection mechanism of apoptosis in ischaemic stroke was not determined. |
2021-02-26 |
2023-08-13 |
rat |
| Xia Liu, Qi Le. TRIM62 knockout protects against cerebral ischemic injury in mice by suppressing NLRP3-regulated neuroinflammation. Biochemical and biophysical research communications. vol 529. issue 2. 2021-02-10. PMID:32703402. |
the trim62 knockout (ko) mice exhibited alleviated apoptosis and neuroinflammation in the ischemic brain, eventually attenuating the stroke outcomes. |
2021-02-10 |
2023-08-13 |
mouse |
| Junna He, Xiangjian Zhan. miR-668 inhibitor attenuates mitochondrial membrane potential and protects against neuronal apoptosis in cerebral ischemic stroke. Folia neuropathologica. vol 58. issue 1. 2021-02-04. PMID:32337954. |
these observations suggested that inhibition of mir-668 reduces neuronal apoptosis by ameliorating the expression of caspase 3, bax and bcl-2 protein in i/r stroke rats. |
2021-02-04 |
2023-08-13 |
rat |
| Junna He, Xiangjian Zhan. miR-668 inhibitor attenuates mitochondrial membrane potential and protects against neuronal apoptosis in cerebral ischemic stroke. Folia neuropathologica. vol 58. issue 1. 2021-02-04. PMID:32337954. |
in conclusion, the results of the present study indicated that inhibition of mir-668 prevented neuronal apoptosis in cerebral i/r-induced stroke by modulating mitochondrial function and regulating nlrp3 signalling. |
2021-02-04 |
2023-08-13 |
rat |
| Natasha Ting Lee, Carly Selan, Joanne S J Chia, Sharelle A Sturgeon, David K Wright, Akram Zamani, Melrine Pereira, Harshal H Nandurkar, Maithili Sashindranat. Characterization of a novel model of global forebrain ischaemia-reperfusion injury in mice and comparison with focal ischaemic and haemorrhagic stroke. Scientific reports. vol 10. issue 1. 2021-01-19. PMID:33097782. |
secondary injury mechanisms after any stroke are similar, and encompass inflammation, endothelial dysfunction, blood-brain barrier (bbb) damage and apoptosis. |
2021-01-19 |
2023-08-13 |
mouse |
| Agustín Sánchez-Temprano, José Luis Relova, Jesús P Camiña, Yolanda Pazo. Concurrent Akt, ERK1/2 and AMPK Activation by Obestatin Inhibits Apoptotic Signaling Cascades on Nutrient-Deprived PC12 Cells. Cellular and molecular neurobiology. 2021-01-05. PMID:33400083. |
targeting apoptosis in the ischemic penumbra is a rational therapeutic approach for restricting cerebral infarct volume after clinical stroke. |
2021-01-05 |
2023-08-13 |
Not clear |
| Lijing Li, Penghua Cui, Huimin Ge, Yanjing Shi, Xiaoguang Wu, Zhang Fan R. miR-188-5p inhibits apoptosis of neuronal cells during oxygen-glucose deprivation (OGD)-induced stroke by suppressing PTEN. Experimental and molecular pathology. vol 116. 2020-12-15. PMID:32745469. |
mir-188-5p inhibits apoptosis of neuronal cells during oxygen-glucose deprivation (ogd)-induced stroke by suppressing pten. |
2020-12-15 |
2023-08-13 |
human |
| Anwen Shao, Danfeng Lin, Lingling Wang, Sheng Tu, Cameron Lenahan, Jianmin Zhan. Oxidative Stress at the Crossroads of Aging, Stroke and Depression. Aging and disease. vol 11. issue 6. 2020-12-07. PMID:33269106. |
this review summarizes the mechanisms of os and os-mediated pathological processes, such as inflammation, apoptosis, and the microbial-gut-brain axis in stroke and depression. |
2020-12-07 |
2023-08-13 |
Not clear |
| Jun Li, Tao Tao, Jian Xu, Zhi Liu, Zhehua Zou, Minglu Ji. HIF‑1α attenuates neuronal apoptosis by upregulating EPO expression following cerebral ischemia‑reperfusion injury in a rat MCAO model. International journal of molecular medicine. vol 45. issue 4. 2020-11-30. PMID:32124933. |
in the present study, the potential for hif‑1α to inhibit neuronal apoptosis through upregulating erythropoietin (epo) was investigated in a transient middle cerebral artery occlusion (tmcao) rat stroke model. |
2020-11-30 |
2023-08-13 |
rat |
| Lihong Nan, Qingqing Xie, Zheming Chen, Yuqin Zhang, Yaping Chen, Huang Li, Wenfang Lai, Yan Chen, Mei Huan. Involvement of PARP-1/AIF Signaling Pathway in Protective Effects of Gualou Guizhi Decoction Against Ischemia-Reperfusion Injury-Induced Apoptosis. Neurochemical research. vol 45. issue 2. 2020-11-17. PMID:31792665. |
poly(adp-ribose) (par) polymerase-1 (parp-1)/apoptosis-inducing factor (aif) signaling pathway-mediated apoptosis is one of the non-caspase-dependent cell death programs that are widely present in neurological diseases such as stroke. |
2020-11-17 |
2023-08-13 |
rat |
| S V Demyanenko, V A Dzreyan, M A Neginskaya, A B Uzdensk. Expression of Histone Deacetylases HDAC1 and HDAC2 and Their Role in Apoptosis in the Penumbra Induced by Photothrombotic Stroke. Molecular neurobiology. vol 57. issue 1. 2020-10-07. PMID:31493239. |
expression of histone deacetylases hdac1 and hdac2 and their role in apoptosis in the penumbra induced by photothrombotic stroke. |
2020-10-07 |
2023-08-13 |
rat |
| Jamary Oliveira-Filh. Stroke and brain atrophy in chronic Chagas disease patients: A new theory proposition. Dementia & neuropsychologia. vol 3. issue 1. 2020-10-01. PMID:29213605. |
chronic inflammation directed against t. cruzi may act as a trigger for endothelial damage, platelet activation, acceleration of atherosclerosis and apoptosis, all of which lead to stroke and brain atrophy. |
2020-10-01 |
2023-08-13 |
Not clear |
| Rajeev Gupta, Subhendu Ghos. Putative roles of mitochondrial Voltage-Dependent Anion Channel, Bcl-2 family proteins and c-Jun N-terminal Kinases in ischemic stroke associated apoptosis. Biochimie open. vol 4. 2020-10-01. PMID:29450141. |
it has been found that inhibiting apoptosis in the peripheral ischemic neurons could be very effective in the prevention of stroke progression. |
2020-10-01 |
2023-08-13 |
Not clear |
| Rajeev Gupta, Subhendu Ghos. Putative roles of mitochondrial Voltage-Dependent Anion Channel, Bcl-2 family proteins and c-Jun N-terminal Kinases in ischemic stroke associated apoptosis. Biochimie open. vol 4. 2020-10-01. PMID:29450141. |
during stroke associated apoptosis, cytosolic c-jun n-terminal kinases (jnks) and bcl-2 family proteins translocate towards mitochondria and promote cytochrome |
2020-10-01 |
2023-08-13 |
Not clear |
| Olena Y Glushakova, Andriy A Glushakov, Dayanjan S Wijesinghe, Alex B Valadka, Ronald L Hayes, Alexander V Glushako. Prospective clinical biomarkers of caspase-mediated apoptosis associated with neuronal and neurovascular damage following stroke and other severe brain injuries: Implications for chronic neurodegeneration. Brain circulation. vol 3. issue 2. 2020-10-01. PMID:30276309. |
prospective clinical biomarkers of caspase-mediated apoptosis associated with neuronal and neurovascular damage following stroke and other severe brain injuries: implications for chronic neurodegeneration. |
2020-10-01 |
2023-08-13 |
Not clear |