| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yasin Asadi, Fazel Gorjipour, Sedigheh Behrouzifar, Abedin Vakil. Irisin Peptide Protects Brain Against Ischemic Injury Through Reducing Apoptosis and Enhancing BDNF in a Rodent Model of Stroke. Neurochemical research. vol 43. issue 8. 2019-04-01. PMID:29882126. |
the present study aimed to assess the effects of recombinant irisin on the infarct size, neurological outcomes, blood-brain barrier (bbb) permeability, apoptosis and brain-derived neurotrophic factor (bdnf) expression in a mouse model of stroke. |
2019-04-01 |
2023-08-13 |
mouse |
| Yasin Asadi, Fazel Gorjipour, Sedigheh Behrouzifar, Abedin Vakil. Irisin Peptide Protects Brain Against Ischemic Injury Through Reducing Apoptosis and Enhancing BDNF in a Rodent Model of Stroke. Neurochemical research. vol 43. issue 8. 2019-04-01. PMID:29882126. |
the present study indicated that irisin attenuates brain damage via reducing apoptosis and increasing bdnf protein of brain cortex in the experimental model of stroke in mice. |
2019-04-01 |
2023-08-13 |
mouse |
| Huinan Zhang, Jun Wang, Jing Huang, Tingyu Shi, Xue Ma, Xiaoxing Luo, Xia Li, Mingkai L. Inhibiting Jumoji domain containing protein 3 (JMJD3) prevent neuronal apoptosis from stroke. Experimental neurology. vol 308. 2019-02-19. PMID:30028997. |
inhibiting jumoji domain containing protein 3 (jmjd3) prevent neuronal apoptosis from stroke. |
2019-02-19 |
2023-08-13 |
Not clear |
| Youngchul Kim, Young Seo Kim, Hyun Young Kim, Min-Young Noh, Ji Young Kim, Young-Jun Lee, Jeongmin Kim, Jiseon Park, Seung Hyun Ki. Early Treatment with Poly(ADP-Ribose) Polymerase-1 Inhibitor (JPI-289) Reduces Infarct Volume and Improves Long-Term Behavior in an Animal Model of Ischemic Stroke. Molecular neurobiology. vol 55. issue 9. 2019-02-04. PMID:29383691. |
in patients with stroke and neurodegenerative diseases, overactivation of poly(adp-ribose) polymerase-1 (parp-1) causes harmful effects by inducing apoptosis, necrosis, neuroinflammation, and immune dysregulation. |
2019-02-04 |
2023-08-13 |
Not clear |
| Guangwen Li, Kahlilia C Morris-Blanco, Mary S Lopez, Tuo Yang, Haiping Zhao, Raghu Vemuganti, Yumin Lu. Impact of microRNAs on ischemic stroke: From pre- to post-disease. Progress in neurobiology. vol 163-164. 2018-12-11. PMID:28842356. |
in this review, we compile mirnas that have been reported to regulate various stroke risk factors and pre-disease mechanisms, including hypertension, atherosclerosis, and diabetes, followed by an in-depth analysis of mirnas in ischemic stroke pathogenesis, such as excitotoxicity, oxidative stress, inflammation, apoptosis, angiogenesis and neurogenesis. |
2018-12-11 |
2023-08-13 |
Not clear |
| Hengli Zhao, Yujie Chen, Hua Fen. P2X7 Receptor-Associated Programmed Cell Death in the Pathophysiology of Hemorrhagic Stroke. Current neuropharmacology. vol 16. issue 9. 2018-11-26. PMID:29766811. |
recently, programmed cell death, such as apoptosis, autophagy, necroptosis, pyroptosis, and ferroptosis, has been demonstrated to play crucial roles in the pathophysiology of stroke. |
2018-11-26 |
2023-08-13 |
Not clear |
| Jing Fan, Ted M Dawson, Valina L Dawso. Cell Death Mechanisms of Neurodegeneration. Advances in neurobiology. vol 15. 2018-11-01. PMID:28674991. |
besides apoptosis, necroptosis, and autophagy, an important form of death termed parthanatos plays a prominent role in stroke and several neurodegenerative diseases, which is due to parp-1 overactivation, par accumulation, nuclear translocation of the mitochondria protein aif, and large-scale dna cleavage. |
2018-11-01 |
2023-08-13 |
Not clear |
| Beatrice Ballarin, Michael Tymiansk. Discovery and development of NA-1 for the treatment of acute ischemic stroke. Acta pharmacologica Sinica. vol 39. issue 5. 2018-10-10. PMID:29565039. |
stroke creates a complex interplay of multiple signaing pathways including excitotoxicity, ionic imbalance, inflammation, oxidative stress and apoptosis. |
2018-10-10 |
2023-08-13 |
Not clear |
| Ida R Marlet, Joakim N E Ölmestig, Tina Vilsbøll, Jørgen Rungby, Christina Kruus. Neuroprotective Mechanisms of Glucagon-like Peptide-1-based Therapies in Ischaemic Stroke: A Systematic Review based on Pre-Clinical Studies. Basic & clinical pharmacology & toxicology. vol 122. issue 6. 2018-09-27. PMID:29411931. |
both glp-1ras and dpp-4is significantly affected inflammation, oxidative stress and apoptosis in animal stroke models; however, data from clinical trials only report therapeutic efficacy for glp-1ras. |
2018-09-27 |
2023-08-13 |
Not clear |
| Jun Wei, Chongling Sun, Chang Liu, Qimei Zhan. Effects of Rat Anti-mouse Interleukin-6 Receptor Antibody on the Recovery of Cognitive Function in Stroke Mice. Cellular and molecular neurobiology. vol 38. issue 2. 2018-08-27. PMID:28488007. |
furthermore, mr16-1 promoted the expression of bcl-2 and inhibited the expression of bax in stroke mice, which revealed the inhibitory effect of mr16-1 on neuronal apoptosis. |
2018-08-27 |
2023-08-13 |
mouse |
| Jun Wei, Chongling Sun, Chang Liu, Qimei Zhan. Effects of Rat Anti-mouse Interleukin-6 Receptor Antibody on the Recovery of Cognitive Function in Stroke Mice. Cellular and molecular neurobiology. vol 38. issue 2. 2018-08-27. PMID:28488007. |
mr16-1 ameliorated cognitive dysfunction and apoptosis in stroke mice, involving the inhibition of inflammatory response and pro-apoptotic bax, and the up-regulation of anti-apoptotic bcl-2. |
2018-08-27 |
2023-08-13 |
mouse |
| Ziying Wang, Zhuanli Zhou, Xinbing Wei, Mingwei Wang, Bi-Ou Wang, Yanan Zhang, Xiaoting He, Yu Sun, Xiaojie Wang, Mingcheng Sun, Yan Zhang, Xiaowei Gong, Fan Y. Therapeutic Potential of Novel Twin Compounds Containing Tetramethylpyrazine and Carnitine Substructures in Experimental Ischemic Stroke. Oxidative medicine and cellular longevity. vol 2017. 2018-08-13. PMID:29387294. |
although studies have seen dramatic advances in the understanding of the pathogenesis of stroke such as oxidative stress, inflammation, excitotoxicity, calcium overload and apoptosis, the delivery of stroke therapies is still a great challenge. |
2018-08-13 |
2023-08-13 |
rat |
| Pratibha Singh, Priti Talwa. Exploring putative inhibitors of Death Associated Protein Kinase 1 (DAPK1) via targeting Gly-Glu-Leu (GEL) and Pro-Glu-Asn (PEN) substrate recognition motifs. Journal of molecular graphics & modelling. vol 77. 2018-07-24. PMID:28858643. |
it is this dapk1-nr2b interaction that arbitrates the pathological processes like apoptosis, necrosis, and autophagy of neuronal cells observed in stroke injury, hence we aimed to inhibit this vital interaction to prevent neuronal damage. |
2018-07-24 |
2023-08-13 |
Not clear |
| Zhiyi Xie, Budbazar Enkhjargal, Lingyun Wu, Keren Zhou, Chengmei Sun, Xin Hu, Vadim Gospodarev, Jiping Tang, Chao You, John H Zhan. Exendin-4 attenuates neuronal death via GLP-1R/PI3K/Akt pathway in early brain injury after subarachnoid hemorrhage in rats. Neuropharmacology. vol 128. 2018-07-13. PMID:28986282. |
in conclusion, the neuroprotective effect of ex-4 in ebi after sah was mediated by attenuation of neuronal apoptosis via glp-1r/pi3k/akt signaling pathway, therefore ex-4 should be further investigated as a potential therapeutic agent in stroke patients. |
2018-07-13 |
2023-08-13 |
rat |
| Cheng-Fu Chang, Jing-Huei Lai, John Chung-Che Wu, Nigel H Greig, Robert E Becker, Yu Luo, Yen-Hua Chen, Shuo-Jhen Kang, Yung-Hsiao Chiang, Kai-Yun Che. (-)-Phenserine inhibits neuronal apoptosis following ischemia/reperfusion injury. Brain research. vol 1677. 2018-06-11. PMID:28963051. |
acetylcholinesterase (ache) is upregulated and allied with inflammation and apoptosis after stroke. |
2018-06-11 |
2023-08-13 |
rat |
| Cheng-Fu Chang, Jing-Huei Lai, John Chung-Che Wu, Nigel H Greig, Robert E Becker, Yu Luo, Yen-Hua Chen, Shuo-Jhen Kang, Yung-Hsiao Chiang, Kai-Yun Che. (-)-Phenserine inhibits neuronal apoptosis following ischemia/reperfusion injury. Brain research. vol 1677. 2018-06-11. PMID:28963051. |
these actions mitigated neuronal apoptosis in the stroke penumbra, and decreased matrix metallopeptidase-9 (mmp-9) expression. |
2018-06-11 |
2023-08-13 |
rat |
| Yingshi Ji, Xin Yan, Yang Hu, Huan Xue, Jianfeng Sun, Huaqiu Chen, Jiayu Zhang, Liping Wang, Baigong Xue, Li Su. DhHP‑6 attenuates cerebral ischemia‑reperfusion injury in rats through the inhibition of apoptosis. Molecular medicine reports. vol 16. issue 5. 2018-06-06. PMID:28944912. |
the infarct volume, brain edema, brain apoptosis and neurological function were evaluated 24 h following stroke. |
2018-06-06 |
2023-08-13 |
rat |
| Peter Kraft, Rebecca Schleicher, Marcus Olbrich, Michael K Schuhmann, Kelly Daryll Blanz, Frederic Emschermann, Sonja Ebenhoech, Christopher Starz, Ingo Hilgendorf, Sven G Meuth, Frank Edlich, Christoph Kleinschnitz, Harald F Lange. Platelet derived FasL contributes to apoptosis in stroke. Thrombosis and haemostasis. vol 116. issue 5. 2018-06-04. PMID:27608763. |
platelet derived fasl contributes to apoptosis in stroke. |
2018-06-04 |
2023-08-13 |
Not clear |
| Jong Youl Kim, Nuri Kim, Jong Eun Lee, Midori A Yenar. Hypothermia Identifies Dynamin as a Potential Therapeutic Target in Experimental Stroke. Therapeutic hypothermia and temperature management. vol 7. issue 3. 2018-05-29. PMID:28665255. |
hypothermia has been shown to improve outcome in numerous stroke models, and this protection is associated with reduced apoptosis and fas expression. |
2018-05-29 |
2023-08-13 |
mouse |
| Dong-Quan Kou, Yan-Ling Jiang, Jia-Hua Qin, Yin-Hui Huan. Magnolol attenuates the inflammation and apoptosis through the activation of SIRT1 in experimental stroke rats. Pharmacological reports : PR. vol 69. issue 4. 2018-05-09. PMID:28527875. |
magnolol attenuates the inflammation and apoptosis through the activation of sirt1 in experimental stroke rats. |
2018-05-09 |
2023-08-13 |
rat |