| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sathiya Sekar, Entesar Omran, Venkat Gopalakrishnan, John G Howland, Terrance P Snutch, Changiz Taghibiglo. Elevated sterol regulatory elementary binding protein 1 and GluA2 levels in the hippocampal nuclear fraction of Genetic Absence Epilepsy Rats from Strasbourg. Epilepsy research. vol 136. 2018-05-07. PMID:28719803. |
studies in animal models and human tissues show that nuclear translocation of sterol regulatory element binding protein 1 (srebp1) and glutamate a2 subunit (glua2) of cell-surface ampa receptor (ampar) trigger neuronal excitotoxicity-induced apoptosis in stroke. |
2018-05-07 |
2023-08-13 |
human |
| Kobar Akhoundzadeh, Abedin Vakili, Hamid Reza Sameni, Abbas Ali Vafaei, Ali Rashidy-Pour, Manouchehr Safari, Razieh Mohammadkhan. Effects of the combined treatment of bone marrow stromal cells with mild exercise and thyroid hormone on brain damage and apoptosis in a mouse focal cerebral ischemia model. Metabolic brain disease. vol 32. issue 4. 2018-04-23. PMID:28547077. |
more likely, these effects mediate via enchaining generation of new neuronal cells and the attenuation of apoptosis in ischemia stroke in young mice. |
2018-04-23 |
2023-08-13 |
mouse |
| Rosita Stanzione, Franca Bianchi, Maria Cotugno, Simona Marchitti, Maurizio Forte, Carla Busceti, Larisa Ryskalin, Francesco Fornai, Massimo Volpe, Speranza Rubatt. A Decrease of Brain MicroRNA-122 Level Is an Early Marker of Cerebrovascular Disease in the Stroke-Prone Spontaneously Hypertensive Rat. Oxidative medicine and cellular longevity. vol 2017. 2018-04-17. PMID:28751928. |
at this time, levels of markers of oxidative stress and inflammation, as well as of endothelial integrity and function, apoptosis and necrosis were differently modulated in the brains of jd-fed shrsp as compared to shrsr, pointing to a significant activation of all deleterious mechanisms underlying subsequent stroke development in shrsp. |
2018-04-17 |
2023-08-13 |
human |
| Seyed Esmaeil Khoshnam, William Winlow, Maryam Farzaneh, Yaghoob Farbood, Hadi Fathi Moghadda. Pathogenic mechanisms following ischemic stroke. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 38. issue 7. 2018-04-12. PMID:28417216. |
brain injury following stroke results from a complex series of pathophysiological events including excitotoxicity, oxidative and nitrative stress, inflammation, and apoptosis. |
2018-04-12 |
2023-08-13 |
Not clear |
| Ying Xing, Si-Dong Yang, Fang Dong, Man-Man Wang, Ya-Shuo Feng, Feng Zhan. The beneficial role of early exercise training following stroke and possible mechanisms. Life sciences. vol 198. 2018-04-09. PMID:29452165. |
the conclusion is that the voluntary exercise is better in promoting the functional recovery following stroke compared to forced exercise; too early initiated exercise might play a harmful role following stroke, while early initiated exercise might exert benefits after stroke; mild and moderate intensity exercise training could generate better neuroprotection in comparison with high intensity exercise training; early excise training could regulate the process of brain edema, cell apoptosis, oxidative damage, stem cells and other mechanisms in order to exert neuroprotection for brain. |
2018-04-09 |
2023-08-13 |
Not clear |
| Sasan Andalib, Afshin A Divani, Tanja M Michel, Poul F Høilund-Carlsen, Manouchehr S Vafaee, Albert Gjedd. Pandora's Box: mitochondrial defects in ischaemic heart disease and stroke. Expert reviews in molecular medicine. vol 19. 2018-04-06. PMID:28376937. |
not only can mitochondrial reactive oxygen species give rise to ischaemic heart disease and stroke by production of oxidised low-density lipoprotein and induction of apoptosis, but the impact on pericytes contributes directly to the pathogenesis. |
2018-04-06 |
2023-08-13 |
Not clear |
| Fang Chen, Huimin Li, Guoguo Zhu, Xiaojuan Chen, Zhongzhi Tan. Sodium tanshinone IIA sulfonate improves inflammation, aortic endothelial cell apoptosis, disseminated intravascular coagulation and multiple organ damage in a rat heat stroke model. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28498471. |
sodium tanshinone iia sulfonate improves inflammation, aortic endothelial cell apoptosis, disseminated intravascular coagulation and multiple organ damage in a rat heat stroke model. |
2018-03-26 |
2023-08-13 |
rat |
| Fang Chen, Huimin Li, Guoguo Zhu, Xiaojuan Chen, Zhongzhi Tan. Sodium tanshinone IIA sulfonate improves inflammation, aortic endothelial cell apoptosis, disseminated intravascular coagulation and multiple organ damage in a rat heat stroke model. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28498471. |
the aim of the present study was to investigate the effects of sodium tanshinone iia sulfonate (sts) on inflammatory responses, aortic endothelial cell apoptosis, disseminated intravascular coagulation (dic) and multiple organ damage in an animal model of classic heat stroke (chs). |
2018-03-26 |
2023-08-13 |
rat |
| Yu-Long Ma, Li-Xia Zhang, Guang-Lin Liu, Yanhong Fan, Ye Peng, Wu-Gang Ho. N-Myc Downstream-Regulated Gene 2 (Ndrg2) Is Involved in Ischemia-Hypoxia-Induced Astrocyte Apoptosis: a Novel Target for Stroke Therapy. Molecular neurobiology. vol 54. issue 5. 2018-03-09. PMID:27154863. |
n-myc downstream-regulated gene 2 (ndrg2) is involved in ischemia-hypoxia-induced astrocyte apoptosis: a novel target for stroke therapy. |
2018-03-09 |
2023-08-13 |
Not clear |
| Serdar Altinay, Murat Cabalar, Cihan Isler, Funda Yildirim, Duygu S Celik, Oguzhan Zengi, Abdurrahim Tas, Ahmet Gulcubu. Is Chronic Curcumin Supplementation Neuroprotective Against Ischemia for Antioxidant Activity, Neurological Deficit, or Neuronal Apoptosis in an Experimental Stroke Model? Turkish neurosurgery. vol 27. issue 4. 2018-02-19. PMID:27593816. |
is chronic curcumin supplementation neuroprotective against ischemia for antioxidant activity, neurological deficit, or neuronal apoptosis in an experimental stroke model? |
2018-02-19 |
2023-08-13 |
rat |
| Pingping Yu, Li Wang, Fanren Tang, Li Zeng, Luling Zhou, Xiaosong Song, Wei Jia, Jixiang Chen, Qin Yan. Resveratrol Pretreatment Decreases Ischemic Injury and Improves Neurological Function Via Sonic Hedgehog Signaling After Stroke in Rats. Molecular neurobiology. vol 54. issue 1. 2018-02-09. PMID:26738852. |
we observed that resveratrol pretreatment significantly improved neurological function, decreased infarct volume, enhanced vitality, and reduced apoptosis of neurons in vivo and vitro after stroke. |
2018-02-09 |
2023-08-13 |
rat |
| Paloma Patiño, Esther Parada, Victor Farré-Alins, Simone Molz, Ramón Cacabelos, José Marco-Contelles, Manuela G López, Carla I Tasca, Eva Ramos, Alejandro Romero, Javier Ege. Melatonin protects against oxygen and glucose deprivation by decreasing extracellular glutamate and Nox-derived ROS in rat hippocampal slices. Neurotoxicology. vol 57. 2017-11-21. PMID:27620136. |
therapeutic interventions on pathological processes involved in the ischemic cascade, such as oxidative stress, neuroinflammation, excitotoxicity and/or apoptosis, are of urgent need for stroke treatment. |
2017-11-21 |
2023-08-13 |
rat |
| Seema Yousuf, Fahim Atif, Iqbal Sayeed, Jun Wang, Donald G Stei. Neuroprotection by progesterone after transient cerebral ischemia in stroke-prone spontaneously hypertensive rats. Hormones and behavior. vol 84. 2017-10-03. PMID:27283379. |
we conclude that, despite hypertensive comorbidity, p4 improves functional outcomes and attenuates stroke infarct in hypertensive rats by reducing superoxide anion expression and by decreasing inflammation and neuronal apoptosis. |
2017-10-03 |
2023-08-13 |
rat |
| Ariane Ethur Flores, Eduardo Tanuri Pascotini, Aline Kegler, Patricia Gabbi, Guilherme Vargas Bochi, Fernanda Barbisan, Thiago Duarte, Ana Lucia Cervi Prado, Marta M M F Duarte, Ivana B M da Cruz, Rafael Noal Moresco, Adair Roberto Soares Santos, Guilherme Bresciani, Luiz Fernando Freire Royes, Michele Rechia Figher. ALA16VAL-MnSOD gene polymorphism and stroke: Association with dyslipidemia and glucose levels. Gene. vol 627. 2017-08-07. PMID:28552711. |
stroke risk has been associated to the progression of carotid plaques due to high glucose levels and lipid accumulation, which are greatly associated to cerebral injury, brain oxidative stress, and apoptosis. |
2017-08-07 |
2023-08-13 |
Not clear |
| Dana O Kravchick, Anna Karpova, Matous Hrdinka, Jeffrey Lopez-Rojas, Sanda Iacobas, Abigail U Carbonell, Dumitru A Iacobas, Michael R Kreutz, Bryen A Jorda. Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity. The EMBO journal. vol 35. issue 17. 2017-06-29. PMID:27458189. |
elevated c-jun levels result in apoptosis and are evident in neurodegenerative disorders such as alzheimer's disease and dementia and after global cerebral insults including stroke and epilepsy. |
2017-06-29 |
2023-08-13 |
Not clear |
| Han Shan, Yaqi Bian, Zhaoma Shu, Linxia Zhang, Jialei Zhu, Jianhua Ding, Ming Lu, Ming Xiao, Gang H. Fluoxetine protects against IL-1β-induced neuronal apoptosis via downregulation of p53. Neuropharmacology. vol 107. 2017-06-21. PMID:26976669. |
collectively, our findings have revealed that fluoxetine protects against il-1β-induced neuronal apoptosis via p38-p53 dependent pathway, which give us an insight into the potential of fluoxetine in terms of opening up novel therapeutic avenues for neurological diseases including stroke. |
2017-06-21 |
2023-08-13 |
mouse |
| Fatemeh Forouzanfar, Hossein Hosseinzadeh, Alireza Ebrahimzadeh Bideskan, Hamid R Sadeghni. Aqueous and Ethanolic Extracts of Boswellia serrata Protect Against Focal Cerebral Ischemia and Reperfusion Injury in Rats. Phytotherapy research : PTR. vol 30. issue 12. 2017-03-30. PMID:27515127. |
b. serrata and akba significantly improved neurological deficit and reduced brain infarction, neuronal cell loss and apoptosis and also attenuated lipid peroxidation while increasing glutathione content and superoxide dismutase activity in the cerebral cortex following a stroke. |
2017-03-30 |
2023-08-13 |
rat |
| Jin-Jing Zhao, Jin-Qing Song, Shu-Yi Pan, Kai Wan. Treatment with Isorhamnetin Protects the Brain Against Ischemic Injury in Mice. Neurochemical research. vol 41. issue 8. 2017-03-03. PMID:27161367. |
it was found that treatment of experimental stroke mice with isorhamnetin reduced infarct volume and caspase-3 activity (a biomarker of apoptosis), and improved neurological function recovery. |
2017-03-03 |
2023-08-13 |
mouse |
| Zeinab Vahidinia, Nasim Alipour, Mohammad Ali Atlasi, Homayoun Naderian, Cordian Beyer, Abolfazl Azami Tame. Gonadal steroids block the calpain-1-dependent intrinsic pathway of apoptosis in an experimental rat stroke model. Neurological research. vol 39. issue 1. 2017-01-17. PMID:27832728. |
gonadal steroids block the calpain-1-dependent intrinsic pathway of apoptosis in an experimental rat stroke model. |
2017-01-17 |
2023-08-13 |
rat |
| Shihoko Kimura-Ohba, Yi Yan. Oxidative DNA Damage Mediated by Intranuclear MMP Activity Is Associated with Neuronal Apoptosis in Ischemic Stroke. Oxidative medicine and cellular longevity. vol 2016. 2016-12-13. PMID:26925194. |
in particular, we highlighted the roles of intranuclear mmps in oxidative dna damage, neuronal apoptosis, and neuroinflammation at an early stage of stroke insult. |
2016-12-13 |
2023-08-13 |
Not clear |