| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mei Xiang, Lang Wang, Sen Guo, Yan-Yun Lu, Hao Lei, Ding-Sheng Jiang, Yan Zhang, Yi Liu, Yan Zhou, Xiao-Dong Zhang, Hongliang L. Interferon regulatory factor 8 protects against cerebral ischaemic-reperfusion injury. Journal of neurochemistry. vol 129. issue 6. 2014-08-26. PMID:24528256. |
these data indicate that irf8 is strongly protective in ischaemic stroke by regulating neuronal apoptosis, the inflammatory response and oxidative stress. |
2014-08-26 |
2023-08-12 |
mouse |
| Desislava Doycheva, Gary Shih, Hank Chen, Richard Applegate, John H Zhang, Jiping Tan. Granulocyte-colony stimulating factor in combination with stem cell factor confers greater neuroprotection after hypoxic-ischemic brain damage in the neonatal rats than a solitary treatment. Translational stroke research. vol 4. issue 2. 2014-08-18. PMID:23565130. |
granulocyte-colony stimulating factor (g-csf) has been shown to have neuroprotective activity via inhibition of apoptosis and inflammation in various stroke models. |
2014-08-18 |
2023-08-12 |
rat |
| Ozge Cevik, Zelal Adiguzel, Ahmet Tarik Baykal, Goksel Somay, Azize Sene. The apoptotic actions of platelets in acute ischemic stroke. Molecular biology reports. vol 40. issue 12. 2014-07-02. PMID:24057255. |
the data of this work suggests that inflammation may have a role in platelet apoptosis in stroke which may suggest a new aspect of the role of inflammation in the development of acute ischemic stroke. |
2014-07-02 |
2023-08-12 |
human |
| Teresa García-Berrocoso, Dolors Giralt, Alejandro Bustamante, Victor Llombart, Marta Rubiera, Anna Penalba, Cristina Boada, Marc Espadaler, Carlos Molina, Joan Montane. Role of beta-defensin 2 and interleukin-4 receptor as stroke outcome biomarkers. Journal of neurochemistry. vol 129. issue 3. 2014-06-04. PMID:24386991. |
ten representative candidates, mainly cytokines and chemokines, were assayed for replication in individual baseline plasma samples from 80 new stroke patients: β-defensin2, mip-3b, plasminogen activator inhibitor 1 active, β-cell-attracting chemokine 1, exodus-2, interleukin-4 receptor (il-4r), il-12p40, leukemia inhibitor factor, mip-1b, and tumor necrosis factor-related weak inducer of apoptosis. |
2014-06-04 |
2023-08-12 |
Not clear |
| Xiaokun Geng, Sweena Parmar, Xuemei Li, Changya Peng, Xunming Ji, Tia Chakraborty, William A Li, Huishan Du, Xiaomu Tan, Feng Ling, Murali Guthikonda, José A Rafols, Yuchuan Din. Reduced apoptosis by combining normobaric oxygenation with ethanol in transient ischemic stroke. Brain research. vol 1531. 2014-04-10. PMID:23920008. |
the present study evaluated the effect of nbo on ischemia-induced apoptosis and assessed the potential for improved outcomes by combining nbo administration with another neuroprotective agent, ethanol, in a rat stroke model. |
2014-04-10 |
2023-08-12 |
rat |
| Da-Jeong Chang, Seung-Hun Oh, Nayeon Lee, Chunggab Choi, Iksoo Jeon, Hyun Sook Kim, Dong Ah Shin, Seo Eun Lee, Daehong Kim, Jihwan Son. Contralaterally transplanted human embryonic stem cell-derived neural precursor cells (ENStem-A) migrate and improve brain functions in stroke-damaged rats. Experimental & molecular medicine. vol 45. 2014-03-20. PMID:24232252. |
interestingly, we found that the extent of gliosis (glial fibrillary acidic protein-positive cells) and apoptosis (tunel-positive cells) were significantly decreased in the cell-transplanted group, suggesting that hesc-npcs have a positive role in reducing glia scar formation and cell death after stroke. |
2014-03-20 |
2023-08-12 |
human |
| Juhyun Song, Kyoung Joo Cho, So Yeong Cheon, Sa-Hyun Kim, Kyung Ah Park, Won Taek Lee, Jong Eun Le. Apoptosis signal-regulating kinase 1 (ASK1) is linked to neural stem cell differentiation after ischemic brain injury. Experimental & molecular medicine. vol 45. 2014-03-20. PMID:24357833. |
apoptosis signal-regulating kinase 1 (ask1) is preferentially activated by oxidative stress and inflammation, which is the fundamental pathology of brain damage in stroke. |
2014-03-20 |
2023-08-12 |
Not clear |
| Lingzhi Sun, Weiduan Zhuang, Xiangqing Xu, Jun Yang, Jing Teng, Fengxia Zhan. The effect of injection of EGb 761 into the lateral ventricle on hippocampal cell apoptosis and stem cell stimulation in situ of the ischemic/reperfusion rat model. Neuroscience letters. vol 555. 2014-01-31. PMID:24036465. |
this study reports the therapeutic potential of egb 761 in stroke animals, which could be related to the attenuation of apoptosis and enhancement of neurogenesis. |
2014-01-31 |
2023-08-12 |
rat |
| Sung-Chun Tang, Shin-Joe Yeh, Yu-I Li, Yu-Chi Wang, Sang-Ha Baik, Tomislav Santro, Alexander Widiapradja, Silvia Manzanero, Christopher G Sobey, Dong-Gyu Jo, Thiruma V Arumugam, Jiann-Shing Jen. Evidence for a detrimental role of TLR8 in ischemic stroke. Experimental neurology. vol 250. 2014-01-30. PMID:24196452. |
here we provide the first evidence that tlr8 activation plays a detrimental role in stroke outcome by promoting neuronal apoptosis and t cell-mediated post-stroke inflammation. |
2014-01-30 |
2023-08-12 |
Not clear |
| S P Sergeeva, P F Litvickiy, M M Gultyaev, A A Savin, I D Breslavic. [To the Fas-induced neurons apoptosis mechanisms in stroke pathogenesis]. Patologicheskaia fiziologiia i eksperimental'naia terapiia. issue 3. 2014-01-02. PMID:24340612. |
[to the fas-induced neurons apoptosis mechanisms in stroke pathogenesis]. |
2014-01-02 |
2023-08-12 |
Not clear |
| S P Sergeeva, P F Litvickiy, M M Gultyaev, A A Savin, I D Breslavic. [To the Fas-induced neurons apoptosis mechanisms in stroke pathogenesis]. Patologicheskaia fiziologiia i eksperimental'naia terapiia. issue 3. 2014-01-02. PMID:24340612. |
the goal of the present study was to investigate the plasma levels of proteins regulating fas-induced apoptosis in acute stroke and to relate ones to brain damage and clinical features. |
2014-01-02 |
2023-08-12 |
Not clear |
| S P Sergeeva, P F Litvickiy, M M Gultyaev, A A Savin, I D Breslavic. [To the Fas-induced neurons apoptosis mechanisms in stroke pathogenesis]. Patologicheskaia fiziologiia i eksperimental'naia terapiia. issue 3. 2014-01-02. PMID:24340612. |
it is summarized, that fas-induced apoptosis play significant role in stroke pathogenesis. |
2014-01-02 |
2023-08-12 |
Not clear |
| S P Sergeeva, P F Litvickiy, M M Gultyaev, A A Savin, I D Breslavic. [To the Fas-induced neurons apoptosis mechanisms in stroke pathogenesis]. Patologicheskaia fiziologiia i eksperimental'naia terapiia. issue 3. 2014-01-02. PMID:24340612. |
fas induced apoptosis mechanisms seems to be perspective target for search new therapy stroke patients. |
2014-01-02 |
2023-08-12 |
Not clear |
| Xiao-Guang Wang, Jing Tao, Ming-Ming Ma, Yong-Bo Tang, Jia-Guo Zhou, Yong-Yuan Gua. Tyrosine 284 phosphorylation is required for ClC-3 chloride channel activation in vascular smooth muscle cells. Cardiovascular research. vol 98. issue 3. 2013-12-31. PMID:23536605. |
the clc-3 chloride channel (and current, icl,clc-3) plays an important role in cell volume regulation, proliferation, and apoptosis in vascular smooth muscle cells, and is a potential target for prevention of vascular remodelling and stroke. |
2013-12-31 |
2023-08-12 |
Not clear |
| Lili Cui, Huiling Qu, Ting Xiao, Mei Zhao, Jukka Jolkkonen, Chuansheng Zha. Stromal cell-derived factor-1 and its receptor CXCR4 in adult neurogenesis after cerebral ischemia. Restorative neurology and neuroscience. vol 31. issue 3. 2013-12-03. PMID:23482064. |
however, the majority of the neuroblasts produced after stroke undergo apoptosis and only a few differentiate and survive in the long-term. |
2013-12-03 |
2023-08-12 |
Not clear |
| Peter Kraft, Tobias Schwarz, Eva Göb, Nadine Heydenreich, Marc Brede, Sven G Meuth, Christoph Kleinschnit. The phosphodiesterase-4 inhibitor rolipram protects from ischemic stroke in mice by reducing blood-brain-barrier damage, inflammation and thrombosis. Experimental neurology. vol 247. 2013-11-26. PMID:23570902. |
finally, rolipram exerted antithrombotic effects upon stroke and fewer neurons in the rolipram group underwent apoptosis. |
2013-11-26 |
2023-08-12 |
mouse |
| Ya-ping Zhang, Hao Zhang, Dayue Darrel Dua. Chloride channels in stroke. Acta pharmacologica Sinica. vol 34. issue 1. 2013-11-18. PMID:23103617. |
vascular remodeling of cerebral arterioles, including proliferation, migration, and apoptosis of vascular smooth muscle cells (vsmcs), is the major cause of changes in the cross-sectional area and diameter of the arteries and sudden interruption of blood flow or hemorrhage in the brain, ie, stroke. |
2013-11-18 |
2023-08-12 |
Not clear |
| Mayur V Jain, Anna M Paczulla, Thomas Klonisch, Florence N Dimgba, Sahana B Rao, Karin Roberg, Frank Schweizer, Claudia Lengerke, Padideh Davoodpour, Vivek R Palicharla, Subbareddy Maddika, Marek Ło. Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development. Journal of cellular and molecular medicine. vol 17. issue 1. 2013-11-13. PMID:23301705. |
the rapid accumulation of knowledge on apoptosis regulation in the 1990s was followed by the development of several experimental anticancer- and anti-ischaemia (stroke or myocardial infarction) drugs. |
2013-11-13 |
2023-08-12 |
Not clear |
| Mark A Eckert, Quynh Vu, Kate Xie, Jingxia Yu, Wenbin Liao, Steven C Cramer, Weian Zha. Evidence for high translational potential of mesenchymal stromal cell therapy to improve recovery from ischemic stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 33. issue 9. 2013-11-01. PMID:23756689. |
mesenchymal stromal cells may aid in reducing the long-term impact of stroke via multiple mechanisms that include induction of angiogenesis, promotion of neurogenesis, prevention of apoptosis, and immunomodulation. |
2013-11-01 |
2023-08-12 |
human |
| Prisca Boisguerin, Jean-Michel Giorgi, Stéphanie Barrère-Lemair. CPP-conjugated anti-apoptotic peptides as therapeutic tools of ischemia-reperfusion injuries. Current pharmaceutical design. vol 19. issue 16. 2013-10-28. PMID:23140457. |
more importantly, similar peptidic strategies and tools are likely to be adaptable to many other situations in which cells have to be protected from apoptosis such as stroke or organ transplantation. |
2013-10-28 |
2023-08-12 |
Not clear |