| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emily N J Ord, Rachel Shirley, John D McClure, Christopher McCabe, Eric J Kremer, I Mhairi Macrae, Lorraine M Wor. Combined antiapoptotic and antioxidant approach to acute neuroprotection for stroke in hypertensive rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 33. issue 8. 2013-10-22. PMID:23632970. |
combined ngb overexpression with jnk inhibition reduced hypoxia/reoxygenation-induced oxidative stress and apoptosis in cultured neurons and reduced infarct and improved neurologic outcome more than single therapy after in vivo experimental stroke in hypertensive rats. |
2013-10-22 |
2023-08-12 |
rat |
| Colin R Lenihan, Cormac T Taylo. The impact of hypoxia on cell death pathways. Biochemical Society transactions. vol 41. issue 2. 2013-09-04. PMID:23514172. |
hypoxia is a frequently encountered feature of the cellular microenvironment in a number of pathophysiological processes in which programmed cell death (apoptosis) affects disease progression including, but not limited to, cancer, chronic inflammation, myocardial infarction, stroke and ischaemic acute kidney injury. |
2013-09-04 |
2023-08-12 |
Not clear |
| Nsikan Akpan, Carol M Tro. Caspase inhibitors: prospective therapies for stroke. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 19. issue 2. 2013-08-30. PMID:22645109. |
cysteine-aspartic proteases (caspases) are key mediators of apoptosis and neurodegeneration in stroke. |
2013-08-30 |
2023-08-12 |
Not clear |
| S-J Liao, Q Gong, X-R Chen, L-X Ye, Q Ding, J-S Zeng, J Y. Netrin-1 rescues neuron loss by attenuating secondary apoptosis in ipsilateral thalamic nucleus following focal cerebral infarction in hypertensive rats. Neuroscience. vol 231. 2013-07-25. PMID:23232257. |
taken together, the present study indicates that exogenous netrin-1 could rescue neuron loss by attenuating secondary apoptosis in the ipsilateral vpn after focal cerebral infarction, possibly via its receptor unc5h2, suggesting that relative insufficiency of endogenous netrin-1 be an underlying mechanism of secondary injury in the vpn post stroke. |
2013-07-25 |
2023-08-12 |
rat |
| Yuqing Zhang, Gail D Stevenson, Christy Barber, Lars R Furenlid, Harrison H Barrett, James M Woolfenden, Ming Zhao, Zhonglin Li. Imaging of rat cerebral ischemia-reperfusion injury using(99m)Tc-labeled duramycin. Nuclear medicine and biology. vol 40. issue 1. 2013-05-21. PMID:23123139. |
prompt identification of necrosis and apoptosis in the infarct core and penumbra region is critical in acute stroke for delineating the underlying ischemic/reperfusion molecular pathologic events and defining therapeutic alternatives. |
2013-05-21 |
2023-08-12 |
rat |
| Yulin Ma, Tara Lovekamp-Swan, Woube Bekele, Akiko Dohi, Derek A Schreihofe. Hypoxia-inducible factor and vascular endothelial growth factor are targets of dietary soy during acute stroke in female rats. Endocrinology. vol 154. issue 4. 2013-05-06. PMID:23456363. |
similar to estrogens, dietary soy significantly reduced cerebral edema and vascular apoptosis 24 hours after stroke. |
2013-05-06 |
2023-08-12 |
rat |
| Pengyue Zhang, Yuling Zhang, Jie Zhang, Yi Wu, Jie Jia, Junfa Wu, Yongshan H. Early Exercise Protects against Cerebral Ischemic Injury through Inhibiting Neuron Apoptosis in Cortex in Rats. International journal of molecular sciences. vol 14. issue 3. 2013-03-19. PMID:23502470. |
apoptosis plays a critical role after stroke. |
2013-03-19 |
2023-08-12 |
rat |
| Pengyue Zhang, Yuling Zhang, Jie Zhang, Yi Wu, Jie Jia, Junfa Wu, Yongshan H. Early Exercise Protects against Cerebral Ischemic Injury through Inhibiting Neuron Apoptosis in Cortex in Rats. International journal of molecular sciences. vol 14. issue 3. 2013-03-19. PMID:23502470. |
however, it is unclear whether early exercise inhibits apoptosis after stroke. |
2013-03-19 |
2023-08-12 |
rat |
| Na Zhu, Hongyan Li, Ming Han, Lin Guo, Liqun Chen, Yang Yun, Zhen Guo, Guangke Li, Nan San. Environmental nitrogen dioxide (NO2) exposure influences development and progression of ischemic stroke. Toxicology letters. vol 214. issue 2. 2013-03-18. PMID:22960396. |
based on this, we set up stroke rat model and exposed them to no(2) at the same concentration for one week, and found that no(2) exposure time-dependently delayed neurological structure and function recovery of mcao (middle cerebral artery occlusion) rat, and worsened pathological injuries and apoptosis induced by mcao operation. |
2013-03-18 |
2023-08-12 |
rat |
| Tine Zgavc, An-Gaëlle Ceulemans, Said Hachimi-Idrissi, Ron Kooijman, Sophie Sarre, Yvette Michott. The neuroprotective effect of post ischemic brief mild hypothermic treatment correlates with apoptosis, but not with gliosis in endothelin-1 treated rats. BMC neuroscience. vol 13. 2013-03-08. PMID:22920191. |
in this sub-acute phase following stroke induction, the effects of the hypothermic treatment on apoptosis, phagocytosis and astrogliosis were assessed as well. |
2013-03-08 |
2023-08-12 |
rat |
| Christian Hölsche. Potential role of glucagon-like peptide-1 (GLP-1) in neuroprotection. CNS drugs. vol 26. issue 10. 2013-02-14. PMID:22938097. |
in pre-clinical studies, glp-1 and longer-lasting protease-resistant analogues cross the blood-brain barrier, protect memory formation (ad) or motor activity (pd), protect synapses and synaptic functions, enhance neurogenesis, reduce apoptosis, protect neurons from oxidative stress, and reduce plaque formation and the chronic inflammation response in the brains of mouse models of ad, pd, amyotrophic lateral sclerosis, stroke and other degenerative diseases. |
2013-02-14 |
2023-08-12 |
mouse |
| Claudia A McCarthy, Antony Vinh, Brad R S Broughton, Christopher G Sobey, Jennifer K Callaway, Robert E Widdo. Angiotensin II type 2 receptor stimulation initiated after stroke causes neuroprotection in conscious rats. Hypertension (Dallas, Tex. : 1979). vol 60. issue 6. 2013-02-07. PMID:23090772. |
furthermore, we have demonstrated that at(2)r stimulation after stroke increased neuronal survival, decreased apoptosis, and caused an increase in the number of activated microglia in the core region of damage. |
2013-02-07 |
2023-08-12 |
rat |
| George E Barreto, Robin E White, Lijun Xu, Curtis J Palm, Rona G Giffar. Effects of heat shock protein 72 (Hsp72) on evolution of astrocyte activation following stroke in the mouse. Experimental neurology. vol 238. issue 2. 2013-01-21. PMID:22940431. |
after stroke both genotypes exhibited changes in genes related to apoptosis, inflammation, and stress, with more downregulated genes in hsp72tg and more inflammation-related genes increased in wt mice. |
2013-01-21 |
2023-08-12 |
mouse |
| Benjamin J White, Sami Tarabishy, Venugopal Reddy Venna, Bharti Manwani, Sharon Benashski, Louise D McCullough, Jun L. Protection from cerebral ischemia by inhibition of TGFβ-activated kinase. Experimental neurology. vol 237. issue 1. 2012-11-05. PMID:22683931. |
transforming growth factor-β-activated kinase (tak1) is a member of the mitogen-activated protein kinase family that plays important roles in apoptosis and inflammatory signaling, both of which are critical components of stroke pathology. |
2012-11-05 |
2023-08-12 |
Not clear |
| M D Linni. Role of apoptosis in acute neurodegenerative disorders. Restorative neurology and neuroscience. vol 9. issue 4. 2012-10-02. PMID:21551910. |
several recent studies suggest that a suicide-like phenomena similar to apoptosis or programmed cell death also contributes to the loss of neurons in stroke. |
2012-10-02 |
2023-08-12 |
mouse |
| M D Linni. Role of apoptosis in acute neurodegenerative disorders. Restorative neurology and neuroscience. vol 9. issue 4. 2012-10-02. PMID:21551910. |
the evidence implicating apoptosis in stroke can be divided into three categories; biochemical, molecular and pharmacological. |
2012-10-02 |
2023-08-12 |
mouse |
| M D Linni. Role of apoptosis in acute neurodegenerative disorders. Restorative neurology and neuroscience. vol 9. issue 4. 2012-10-02. PMID:21551910. |
in conclusion, the observation that an apoptotic-like process contributes to stroke may have important therapeutic implications since therapies that inhibit apoptosis improve outcome in experimental stroke. |
2012-10-02 |
2023-08-12 |
mouse |
| Hyun-Kyung Park, Dae Jean J. Polymorphisms of integrin, alpha 6 contribute to the development and neurologic symptoms of intracerebral hemorrhage in korean population. Journal of Korean Neurosurgical Society. vol 50. issue 4. 2012-08-23. PMID:22200009. |
the extracellular matrix (ecm) and cell adhesion molecules play crucial roles in angiogenesis, apoptosis, thrombosis, and inflammation, and also contribute to the pathogenesis of stroke. |
2012-08-23 |
2023-08-12 |
Not clear |
| Shunsuke Koga, Shunsuke Kojima, Takashi Kishimoto, Satoshi Kuwabara, Atsushi Yamaguch. Over-expression of map kinase phosphatase-1 (MKP-1) suppresses neuronal death through regulating JNK signaling in hypoxia/re-oxygenation. Brain research. vol 1436. 2012-06-29. PMID:22197701. |
a pivotal role of c-jun n-terminal kinase (jnk) on neuronal apoptosis has been demonstrated in a rodent stroke model. |
2012-06-29 |
2023-08-12 |
rat |
| Alexander Kunz, Ulrich Dirnagl, Philipp Mergenthale. Acute pathophysiological processes after ischaemic and traumatic brain injury. Best practice & research. Clinical anaesthesiology. vol 24. issue 4. 2012-06-04. PMID:21619862. |
main attention will be on pathophysiological events initiated after ischaemic stroke including excitotoxicity, oxidative/nitrosative stress, peri-infarct depolarizations, apoptosis and inflammation. |
2012-06-04 |
2023-08-12 |
Not clear |