| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seyed Mojtaba Hosseini, Nastaran Samimi, Mohammad Farahmandnia, Benafshe Shakibajahromi, Fatemeh Sabet Sarvestani, Mahsa Sani, Masoomeh Mohamadpou. The Preventive Effects of Neural Stem Cells and Mesenchymal Stem Cells Intra-ventricular Injection on Brain Stroke in Rats. North American journal of medical sciences. vol 7. issue 9. 2015-11-25. PMID:26605202. |
inflammation of cns plays an important role in stroke pathogenesis, in addition, apoptosis and neural death could be the other reasons of poor neurological out come after stroke. |
2015-11-25 |
2023-08-13 |
rat |
| H L Qu, M Zhao, S S Zhao, T Xiao, C G Song, Y P Cao, J Jolkkonen, C S Zha. Forced limb-use enhanced neurogenesis and behavioral recovery after stroke in the aged rats. Neuroscience. vol 286. 2015-09-14. PMID:25463522. |
furthermore, forced limb-use suppressed apoptosis and improved the motor functions after stroke in the aged rats. |
2015-09-14 |
2023-08-13 |
rat |
| Valérie Jolivel, Sébastien Arthaud, Béatrice Botia, Christophe Portal, Bruno Delest, Guillaume Clavé, Jérôme Leprince, Anthony Romieu, Pierre-Yves Renard, Omar Touzani, Heidi Ligeret, Pauline Noack, Marc Massonneau, Alain Fournier, Hubert Vaudry, David Vaudr. Biochemical characterization of a Caspase-3 far-red fluorescent probe for non-invasive optical imaging of neuronal apoptosis. Journal of molecular neuroscience : MN. vol 54. issue 3. 2015-07-14. PMID:24865411. |
apoptosis is a regulated process, leading to cell death, which is involved in several pathologies including neurodegenerative diseases and stroke. |
2015-07-14 |
2023-08-13 |
Not clear |
| Mohammed Abdelsaid, Roshini Prakash, Weiguo Li, Maha Coucha, Sherif Hafez, Maribeth H Johnson, Susan C Fagan, Adviye Ergu. Metformin treatment in the period after stroke prevents nitrative stress and restores angiogenic signaling in the brain in diabetes. Diabetes. vol 64. issue 5. 2015-06-29. PMID:25524911. |
our results provide evidence that i/r-induced peroxynitrite inhibits survival, induces apoptosis, and promotes peroxynitrite as a novel therapeutic target for the improvement of reparative angiogenesis after stroke in diabetes. |
2015-06-29 |
2023-08-13 |
rat |
| Sevda Gheibi, Nahid Aboutaleb, Mehdi Khaksari, Hamid Kalalian-Moghaddam, Abedin Vakili, Yasin Asadi, Fatemeh Zare Mehrjerdi, Azam Gheib. Hydrogen sulfide protects the brain against ischemic reperfusion injury in a transient model of focal cerebral ischemia. Journal of molecular neuroscience : MN. vol 54. issue 2. 2015-05-28. PMID:24643521. |
in addition, nahs at doses of 1 and 5 mg reduced brain edema (p < 0.05) and inhibited apoptosis by decreasing positive tunel cells (p < 0.001).the present study shows that treatment with h(2)s reduces brain injuries and postischemic cerebral edema in a dose-dependent manner likely through the blocking programmed cell death.we propose that h(2)s might be a promising therapeutic target for stroke, although more researches are necessary to take into account the potential therapeutic effects of h(2)s in stroke patients. |
2015-05-28 |
2023-08-12 |
Not clear |
| Takashi D Y Kozai, Xia Li, Lance M Bodily, Ellen M Caparosa, Georgios A Zenonos, Diane L Carlisle, Robert M Friedlander, X Tracy Cu. Effects of caspase-1 knockout on chronic neural recording quality and longevity: insight into cellular and molecular mechanisms of the reactive tissue response. Biomaterials. vol 35. issue 36. 2015-05-20. PMID:25176060. |
caspase-1 knockout (ko) mice are resistant to apoptosis and these mice have preserved neurologic function by reducing ischemia-induced brain injury in stroke models. |
2015-05-20 |
2023-08-13 |
mouse |
| Gagandip K Poone, Henrik Hasseldam, Nina Munkholm, Rune S Rasmussen, Nina V Grønberg, Flemming F Johanse. The Hypothermic Influence on CHOP and Ero1-α in an Endoplasmic Reticulum Stress Model of Cerebral Ischemia. Brain sciences. vol 5. issue 2. 2015-05-20. PMID:25989620. |
hypothermia attenuated the expression of chop, supporting that hypothermia suppress endoplasmic reticulum stress induced apoptosis in stroke. |
2015-05-20 |
2023-08-13 |
rat |
| Keisuke Mishiro, Takahiko Imai, Sou Sugitani, Akira Kitashoji, Yukiya Suzuki, Toshinori Takagi, Huayue Chen, Yasunori Oumi, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Har. Diabetes mellitus aggravates hemorrhagic transformation after ischemic stroke via mitochondrial defects leading to endothelial apoptosis. PloS one. vol 9. issue 8. 2015-05-12. PMID:25133692. |
in conclusion, chronic hyperglycemia aggravated hemorrhagic transformation after stroke through mitochondrial dysfunction and morphological alteration, partially via mmp-9 activation, leading to caspase-dependent apoptosis of endothelial cells of diabetic mice. |
2015-05-12 |
2023-08-13 |
mouse |
| Jingxiao Zhang, Yan Li, Xuetong Chen, Yanqiu Pan, Shuwei Zhang, Yonghua Wan. Systems pharmacology dissection of multi-scale mechanisms of action for herbal medicines in stroke treatment and prevention. PloS one. vol 9. issue 8. 2015-04-24. PMID:25093322. |
our systematic analysis results display that, in these anti-stroke herbal medicines, 168 out of 1285 constituents with the favorable pharmacokinetic profiles might be implicated in stroke therapy, and the systematic use of these compounds probably acts through multiple mechanisms to synergistically benefit patients with stroke, which can roughly be classified as preventing ischemic inflammatory response, scavenging free radicals and inhibiting neuronal apoptosis against ischemic cerebral damage, as well as exhibiting lipid-lowering, anti-diabetic, anti-thrombotic and antiplatelet effects to decrease recurrent strokes. |
2015-04-24 |
2023-08-13 |
Not clear |
| Nadine Jaenisch, Anke Popp, Madlen Guenther, Juliane Schnabel, Otto W Witte, Christiane Frah. Pro-apoptotic function of GABA-related transcripts following stroke. Neurobiology of disease. vol 70. 2015-04-21. PMID:24983209. |
staurosporine-mediated cell death led to cleaved caspase-3 activation, a key regulator of apoptosis following stroke. |
2015-04-21 |
2023-08-13 |
mouse |
| Li Li, Zhengtao Gu, Zhifeng Liu, Lei S. [The effect of reactive oxygen species regulation of expression of Bcl-2 and Bax in apoptosis of human umbilical vein endothelial cell induced by heat stress]. Zhonghua wei zhong bing ji jiu yi xue. vol 26. issue 7. 2015-04-08. PMID:25027422. |
to observe the effect of heat stress-induced reactive oxygen species (ros) burst on the regulation of expression of bcl-2 and bax in human umbilical vein endothelial cell (huvec) apoptosis induced by heat stress, and explore the pathogenesis of vascular endothelial damage caused by severe heat stroke. |
2015-04-08 |
2023-08-13 |
human |
| Li-Jun Xu, Yi-Bing Ouyang, Xiaoxing Xiong, Creed M Stary, Rona G Giffar. Post-stroke treatment with miR-181 antagomir reduces injury and improves long-term behavioral recovery in mice after focal cerebral ischemia. Experimental neurology. vol 264. 2015-03-30. PMID:25433215. |
targets affected by mir-181a antagomir administered after stroke onset include bcl2 and x-linked inhibitor of apoptosis protein (xiap). |
2015-03-30 |
2023-08-13 |
mouse |
| Saema Ansar, Eva Chatzikonstantinou, Rushani Thiagarajah, Laurent Tritschler, Marc Fatar, Michael G Hennerici, Stephen Meair. Pro-inflammatory mediators and apoptosis correlate to rt-PA response in a novel mouse model of thromboembolic stroke. PloS one. vol 9. issue 1. 2015-01-23. PMID:24465746. |
pro-inflammatory mediators and apoptosis correlate to rt-pa response in a novel mouse model of thromboembolic stroke. |
2015-01-23 |
2023-08-12 |
mouse |
| Eric Bradley, Xiaying Zhao, Rebecca Wang, Darrell Brann, Erhard Bieberich, Guanghu Wan. Low dose Hsp90 inhibitor 17AAG protects neural progenitor cells from ischemia induced death. Journal of cell communication and signaling. vol 8. issue 4. 2014-12-30. PMID:25280831. |
this is an important question for regenerative medicine to treat stroke since other types of cell death such as necrosis are also prominent in the stroke brain apart from apoptosis. |
2014-12-30 |
2023-08-13 |
Not clear |
| Michele Longoni Calió, Darci Sousa Marinho, Gui Mi Ko, Renata Rodrigues Ribeiro, Adriana Ferraz Carbonel, Lila Missae Oyama, Milene Ormanji, Tatiana Pinoti Guirao, Pedro Luiz Calió, Luciana Aparecida Reis, Manuel de Jesus Simões, Telma Lisbôa-Nascimento, Alice Teixeira Ferreira, Clélia Rejane Antônio Bertoncin. Transplantation of bone marrow mesenchymal stem cells decreases oxidative stress, apoptosis, and hippocampal damage in brain of a spontaneous stroke model. Free radical biology & medicine. vol 70. 2014-12-09. PMID:24525001. |
transplantation of bone marrow mesenchymal stem cells decreases oxidative stress, apoptosis, and hippocampal damage in brain of a spontaneous stroke model. |
2014-12-09 |
2023-08-12 |
rat |
| Yi Yang, Xiangjian Zhang, Haiying Cui, Cong Zhang, Chunhua Zhu, Litao L. Apelin-13 protects the brain against ischemia/reperfusion injury through activating PI3K/Akt and ERK1/2 signaling pathways. Neuroscience letters. vol 568. 2014-12-09. PMID:24686182. |
neurological function, infarct volume, brain edema and apoptosis were measured at 24h after stroke. |
2014-12-09 |
2023-08-12 |
mouse |
| Tatsurou Yagami, Yasuhiro Yamamoto, Hiromi Kom. The role of secretory phospholipase A₂ in the central nervous system and neurological diseases. Molecular neurobiology. vol 49. issue 2. 2014-11-21. PMID:24113843. |
the common pathology (e.g., neuronal apoptosis) of alzheimer's disease and stroke coexists in the mixed dementia, suggesting common pathogenic mechanisms of the two neurological diseases. |
2014-11-21 |
2023-08-12 |
rat |
| Niyathi Hegde Shah, Elias Aizenma. Voltage-gated potassium channels at the crossroads of neuronal function, ischemic tolerance, and neurodegeneration. Translational stroke research. vol 5. issue 1. 2014-10-27. PMID:24323720. |
injury-mediated increased k(+) efflux through kv2.1 channels promotes neuronal apoptosis, contributing to widespread neuronal loss in neurodegenerative disorders such as alzheimer's disease and stroke. |
2014-10-27 |
2023-08-12 |
human |
| Wenying Fan, Yiqin Dai, Haochen Xu, Ximin Zhu, Ping Cai, Lixiang Wang, Chungang Sun, Changlong Hu, Ping Zheng, Bing-Qiao Zha. Caspase-3 modulates regenerative response after stroke. Stem cells (Dayton, Ohio). vol 32. issue 2. 2014-09-19. PMID:23939807. |
here, we show that cleaved caspase-3 was increased in newborn neuronal precursor cells (npcs) in the subventricular zone (svz) and the dentate gyrus during the period of stroke recovery, with no evidence of apoptosis. |
2014-09-19 |
2023-08-12 |
mouse |
| Mei Xiang, Lang Wang, Sen Guo, Yan-Yun Lu, Hao Lei, Ding-Sheng Jiang, Yan Zhang, Yi Liu, Yan Zhou, Xiao-Dong Zhang, Hongliang L. Interferon regulatory factor 8 protects against cerebral ischaemic-reperfusion injury. Journal of neurochemistry. vol 129. issue 6. 2014-08-26. PMID:24528256. |
the irf8 knockout mice exhibited aggravated apoptosis, inflammation and oxidative injury in the ischaemic brain, eventually leading to poorer stroke outcomes, whereas neuron-specific irf8 transgenic mice showed a marked inhibition of apoptosis and improved stroke outcomes. |
2014-08-26 |
2023-08-12 |
mouse |