| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yoshinori Okada, Harumi Sakai, Eri Kohiki, Etsuko Suga, Yoshiko Yanagisawa, Kazunori Tanaka, Shinji Hadano, Hitoshi Osuga, Joh-E Iked. A dopamine D4 receptor antagonist attenuates ischemia-induced neuronal cell damage via upregulation of neuronal apoptosis inhibitory protein. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 25. issue 7. 2005-07-27. PMID:15729293. |
neuronal apoptosis inhibitory protein (naip/birc1), the inhibitor of apoptosis protein (iap) family member, suppresses neuronal cell death induced by a variety of insults, including cell death from ischemia and stroke. |
2005-07-27 |
2023-08-12 |
Not clear |
| Mila Komitova, Li Ru Zhao, Gunilla Gidö, Barbro B Johansson, Peter Eriksso. Postischemic exercise attenuates whereas enriched environment has certain enhancing effects on lesion-induced subventricular zone activation in the adult rat. The European journal of neuroscience. vol 21. issue 9. 2005-07-14. PMID:15932598. |
lesion-induced proliferation of neural stem/progenitor cells and neuronal precursors was attenuated in stroke runners without any effects on apoptosis or neuronal migration in the forebrain. |
2005-07-14 |
2023-08-12 |
rat |
| Feng-Yan Sun, Xin Gu. Molecular and cellular mechanisms of neuroprotection by vascular endothelial growth factor. Journal of neuroscience research. vol 79. issue 1-2. 2005-03-18. PMID:15573409. |
the main neuroprotective mechanisms of vegf include: (1) modulation of the phosphatidylinositol 3'-kinase (pi3k)/akt/nuclear factor-kappab signaling pathway, inhibition of caspase-3 activity, and reduction of ischemic neuronal apoptosis; (2) inhibition of outward delayed rectifier potassium channel currents and increase of ischemia-induced tyrosine phosphorylation of kv1.2 potassium channel proteins via activation of the pi3k pathway; and (3) enhancement of proliferation and migration of neural progenitors in the subventricular zone and improvement of striatal neurogenesis and maturation of newborn neurons in adult rat brains after stroke. |
2005-03-18 |
2023-08-12 |
rat |
| Hai Wang, Ying-li Zhang, Xing-Chun Tang, Hua-Song Feng, Gang H. Targeting ischemic stroke with a novel opener of ATP-sensitive potassium channels in the brain. Molecular pharmacology. vol 66. issue 5. 2004-12-06. PMID:15304552. |
in different animal models of stroke as well as in cell cultures, iptakalim provided significant neuroprotection, not only in promoting behavioral recovery but also in protecting neurons against necrosis and apoptosis. |
2004-12-06 |
2023-08-12 |
Not clear |
| Chi-Hsiao Yeh, Yao-Chang Wang, Yi-Cheng Wu, Yu-Min Lin, Pyng Jing Li. Ischemic preconditioning or heat shock pretreatment ameliorates neuronal apoptosis following hypothermic circulatory arrest. The Journal of thoracic and cardiovascular surgery. vol 128. issue 2. 2004-10-26. PMID:15282456. |
stroke and/or neurologic injury can occur after prolonged hypothermic circulatory arrest, possibly due to apoptosis. |
2004-10-26 |
2023-08-12 |
Not clear |
| Jialin Su, Jianfeng Li, Wenyan Li, Bella T Altura, Burton M Altur. Cocaine induces apoptosis in cerebral vascular muscle cells: potential roles in strokes and brain damage. European journal of pharmacology. vol 482. issue 1-3. 2004-08-16. PMID:14660005. |
cocaine induces apoptosis in cerebral vascular muscle cells: potential roles in strokes and brain damage. |
2004-08-16 |
2023-08-12 |
Not clear |
| Jialin Su, Jianfeng Li, Wenyan Li, Bella T Altura, Burton M Altur. Cocaine induces apoptosis in cerebral vascular muscle cells: potential roles in strokes and brain damage. European journal of pharmacology. vol 482. issue 1-3. 2004-08-16. PMID:14660005. |
cocaine-induced apoptosis may thus play a major role in brain-microvascular damage, cerebral vascular toxicity and strokes. |
2004-08-16 |
2023-08-12 |
Not clear |
| Yi Wen, Otuonye Onyewuchi, Shaohua Yang, Ran Liu, James W Simpkin. Increased beta-secretase activity and expression in rats following transient cerebral ischemia. Brain research. vol 1009. issue 1-2. 2004-07-12. PMID:15120577. |
further, our results support the hypothesis that apoptosis and aberrant app processing are correlated events in ad brain, and suggest that inhibition of bace may have a therapeutic effect in the prevention of dementia after stroke recovery. |
2004-07-12 |
2023-08-12 |
rat |
| Taizen Nakase, Goran Söhl, Martin Theis, Klaus Willecke, Christian C G Nau. Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytes. The American journal of pathology. vol 164. issue 6. 2004-07-08. PMID:15161641. |
we have previously shown that heterozygous cx43 null mice subjected to middle cerebral artery occlusion exhibited significantly enhanced stroke volume and apoptosis compared to wild-type mice. |
2004-07-08 |
2023-08-12 |
mouse |
| Taizen Nakase, Goran Söhl, Martin Theis, Klaus Willecke, Christian C G Nau. Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytes. The American journal of pathology. vol 164. issue 6. 2004-07-08. PMID:15161641. |
cre(+) mice showed a significantly increased stroke volume and enhanced apoptosis, detected by terminal dutp nick-end labeling and caspase-3 immunostaining, compared to cre(-) mice. |
2004-07-08 |
2023-08-12 |
mouse |
| Taizen Nakase, Goran Söhl, Martin Theis, Klaus Willecke, Christian C G Nau. Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytes. The American journal of pathology. vol 164. issue 6. 2004-07-08. PMID:15161641. |
our results suggest that astrocytic gap junctions could be important for the regulation of neuronal apoptosis and the inflammatory response after stroke. |
2004-07-08 |
2023-08-12 |
mouse |
| Yi Wen, Shaohua Yang, Ran Liu, Anne Marie Brun-Zinkernagel, Peter Koulen, James W Simpkin. Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats. The Journal of biological chemistry. vol 279. issue 21. 2004-06-30. PMID:14982935. |
these results provide a neuropathological basis for the higher prevalence of dementia in stroke patients and support the hypothesis that apoptosis and aberrant mitosis are integrated pathological events in neurons that may play a critical role in the development of alzheimer's disease and other tauopathy-related neuropathology. |
2004-06-30 |
2023-08-12 |
rat |
| Heng Zhao, Midori A Yenari, Danye Cheng, Odmara L Barreto-Chang, Robert M Sapolsky, Gary K Steinber. Bcl-2 transfection via herpes simplex virus blocks apoptosis-inducing factor translocation after focal ischemia in the rat. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 24. issue 6. 2004-06-29. PMID:15181376. |
apoptosis plays a critical role in many neurologic diseases, including stroke. |
2004-06-29 |
2023-08-12 |
rat |
| Asla Pitkänen, Hana Kubov. Antiepileptic drugs in neuroprotection. Expert opinion on pharmacotherapy. vol 5. issue 4. 2004-05-26. PMID:15102563. |
for example, aeds protecting adult brain from stroke or se-induced injury can cause apoptosis in immature brain. |
2004-05-26 |
2023-08-12 |
Not clear |
| Baoqiang Guo, Shant Kumar, Chenggang Li, Mark Slevin, Pat Kuma. CD105 (endoglin), apoptosis, and stroke. Stroke. vol 35. issue 5. 2004-05-19. PMID:15060327. |
cd105 (endoglin), apoptosis, and stroke. |
2004-05-19 |
2023-08-12 |
Not clear |
| Sean P Cregan, Valina L Dawson, Ruth S Slac. Role of AIF in caspase-dependent and caspase-independent cell death. Oncogene. vol 23. issue 16. 2004-05-06. PMID:15077142. |
continued study of the mechanisms of apoptosis including caspase-independent death processes are likely to reveal novel therapeutic targets for the treatment of diverse human pathologies including cancer, neurodegenerative diseases and acute injuries such as stroke or myocardial infarction. |
2004-05-06 |
2023-08-12 |
human |
| Alain Buisson, Sylvain Lesne, Fabian Docagne, Carine Ali, Olivier Nicole, Eric T MacKenzie, Denis Vivie. Transforming growth factor-beta and ischemic brain injury. Cellular and molecular neurobiology. vol 23. issue 4-5. 2004-04-30. PMID:14514014. |
necrosis and apoptosis are the two fundamental hallmarks of neuronal death in stroke. |
2004-04-30 |
2023-08-12 |
Not clear |
| Allan S Wagman, Kirk W Johnson, Dirksen E Bussier. Discovery and development of GSK3 inhibitors for the treatment of type 2 diabetes. Current pharmaceutical design. vol 10. issue 10. 2004-04-30. PMID:15078145. |
gsk3's association with neuronal apoptosis and hyper-phosphorylation of tau make this kinase an attractive therapeutic target for neurodegenerative conditions such as head trauma, stroke and alzheimer's disease. |
2004-04-30 |
2023-08-12 |
Not clear |
| Wenyan Li, Jianfeng Li, Weiming Liu, Bella T Altura, Burton M Altur. Alcohol-induced apoptosis of canine cerebral vascular smooth muscle cells: role of extracellular and intracellular calcium ions. Neuroscience letters. vol 354. issue 3. 2004-03-08. PMID:14700736. |
from these new findings, we suggest that alcohol-induced apoptosis may contribute to alcohol-induced brain-vascular damage and stroke. |
2004-03-08 |
2023-08-12 |
Not clear |
| Jianfeng Li, Wenyan Li, Jialin Su, Weimin Liu, Bella T Altura, Burton M Altur. Hydrogen peroxide induces apoptosis in cerebral vascular smooth muscle cells: possible relation to neurodegenerative diseases and strokes. Brain research bulletin. vol 62. issue 2. 2004-02-06. PMID:14638383. |
hydrogen peroxide induces apoptosis in cerebral vascular smooth muscle cells: possible relation to neurodegenerative diseases and strokes. |
2004-02-06 |
2023-08-12 |
Not clear |