| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Yamashita, K Deguchi, K Sawamoto, H Okano, T Kamiya, K Ab. Neuroprotection and neurosupplementation in ischaemic brain. Biochemical Society transactions. vol 34. issue Pt 6. 2007-02-13. PMID:17073809. |
possible strategies for treating ischaemic stroke include: (i) neuroprotection (preventing damaged neurons from undergoing apoptosis in the acute phase of cerebral ischaemia), and (ii) neurosupplementation (the repair of broken neuronal networks with newly born neurons in the chronic phase of cerebral ischaemia). |
2007-02-13 |
2023-08-12 |
mouse |
| Mohammad Allahtavakoli, Alireza P Shabanzadeh, Seyed Shahabeddin Sadr, Mohsen Parviz, Bijan Djahanguir. Rosiglitazone, a peroxisome proliferator-activated receptor-gamma ligand, reduces infarction volume and neurological deficits in an embolic model of stroke. Clinical and experimental pharmacology & physiology. vol 33. issue 11. 2007-02-01. PMID:17042914. |
stroke is accompanied by a robust inflammatory response, glutamate-mediated excitotoxicity, release of reactive oxygen species and apoptosis. |
2007-02-01 |
2023-08-12 |
rat |
| N Mitsios, J Gaffney, P Kumar, J Krupinski, S Kumar, M Slevi. Pathophysiology of acute ischaemic stroke: an analysis of common signalling mechanisms and identification of new molecular targets. Pathobiology : journal of immunopathology, molecular and cellular biology. vol 73. issue 4. 2007-01-04. PMID:17119345. |
the objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, especially the role of cell signalling in excitotoxicity, inflammation, apoptosis, neuroprotection and angiogenesis, and highlight potential novel targets for drug discovery. |
2007-01-04 |
2023-08-12 |
Not clear |
| Francis G Blankenberg, Judy Kalinyak, Liping Liu, Maya Koike, Danye Cheng, Michael L Goris, Allan Green, Jean-Luc Vanderheyden, David C Tong, Midori Anne Yenar. 99mTc-HYNIC-annexin V SPECT imaging of acute stroke and its response to neuroprotective therapy with anti-Fas ligand antibody. European journal of nuclear medicine and molecular imaging. vol 33. issue 5. 2006-10-24. PMID:16477433. |
the first aim of the study was to determine whether (99m)tc-hynic-annexin v, a marker of cellular stress and apoptosis, can detect ischemic injury in patients with acute stroke. |
2006-10-24 |
2023-08-12 |
Not clear |
| Mordechai Lorberboym, Francis G Blankenberg, Menahem Sadeh, Yair Lamp. In vivo imaging of apoptosis in patients with acute stroke: correlation with blood-brain barrier permeability. Brain research. vol 1103. issue 1. 2006-09-28. PMID:16806116. |
in vivo imaging of apoptosis in patients with acute stroke: correlation with blood-brain barrier permeability. |
2006-09-28 |
2023-08-12 |
Not clear |
| b' B Andersson, B Bjelke, E Sykov\\xc3\\xa. Temporal profile of ultrastructural changes in cortical neurones after a compression lesion. Physiological research. vol 55. issue 3. 2006-09-22. PMID:16083307.' |
we studied the occurrence of apoptosis and secondary delayed cell death at various time points in the penumbra zone, which is the target for therapeutic intervention after stroke. |
2006-09-22 |
2023-08-12 |
rat |
| Heng Zhao, Robert M Sapolsky, Gary K Steinber. Interrupting reperfusion as a stroke therapy: ischemic postconditioning reduces infarct size after focal ischemia in rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 26. issue 9. 2006-09-20. PMID:16736038. |
in addition, postconditioning blocked terminal deoxynucleotidyl transferase-mediated uridine 5'-triphosphate-biotin nick end labeling-positive staining, a marker of apoptosis, in the penumbra 2 days after stroke. |
2006-09-20 |
2023-08-12 |
rat |
| Meng Mao, Yimin Hua, Xiangning Jiang, Lihua Li, Li Zhang, Dezhi M. Expression of tumor necrosis factor alpha and neuronal apoptosis in the developing rat brain after neonatal stroke. Neuroscience letters. vol 403. issue 3. 2006-09-01. PMID:16797840. |
expression of tumor necrosis factor alpha and neuronal apoptosis in the developing rat brain after neonatal stroke. |
2006-09-01 |
2023-08-12 |
rat |
| Meng Mao, Yimin Hua, Xiangning Jiang, Lihua Li, Li Zhang, Dezhi M. Expression of tumor necrosis factor alpha and neuronal apoptosis in the developing rat brain after neonatal stroke. Neuroscience letters. vol 403. issue 3. 2006-09-01. PMID:16797840. |
our findings suggest that tnfalpha expression increases after neonatal stroke and is associated with neuronal apoptosis after transient focal cerebral ischemia. |
2006-09-01 |
2023-08-12 |
rat |
| André Schrattenholz, Vukic Soski. NMDA receptors are not alone: dynamic regulation of NMDA receptor structure and function by neuregulins and transient cholesterol-rich membrane domains leads to disease-specific nuances of glutamate-signalling. Current topics in medicinal chemistry. vol 6. issue 7. 2006-08-01. PMID:16719808. |
nmda receptors are thought to be responsible for excitotoxicity and subsequent downstream events like neuroinflammation and apoptosis and thus have been implicated in many important human pathologies, ranging from amyotrophic lateral sclerosis, alzheimer's and parkinson' disease, depression, epilepsy, trauma and stroke to schizophrenia. |
2006-08-01 |
2023-08-12 |
human |
| Rui Lan Zhang, Zheng Gang Zhang, Mei Lu, Ying Wang, James J Yang, Michael Chop. Reduction of the cell cycle length by decreasing G1 phase and cell cycle reentry expand neuronal progenitor cells in the subventricular zone of adult rat after stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 26. issue 6. 2006-07-18. PMID:16251885. |
few terminal deoxynucleotidyl transferase-mediated biotinylated utp nick end labeling-positive cells were detected in the svz cells of nonstroke and stroke groups, suggesting that the majority of dividing cells in the svz do not undergo apoptosis. |
2006-07-18 |
2023-08-12 |
rat |
| Halina Offner, Sandhya Subramanian, Susan M Parker, Chunhe Wang, Michael E Afentoulis, Anne Lewis, Arthur A Vandenbark, Patricia D Hur. Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages. Journal of immunology (Baltimore, Md. : 1950). vol 176. issue 11. 2006-07-13. PMID:16709809. |
moreover, our results demonstrate that stroke leads to splenic atrophy characterized by a reduction in organ size, a drastic loss of splenocyte numbers, and induction of annexin v+ and tunel+ cells within the spleen that are in the late stages of apoptosis. |
2006-07-13 |
2023-08-12 |
Not clear |
| Pär Thored, Andreas Arvidsson, Emanuele Cacci, Henrik Ahlenius, Therése Kallur, Vladimer Darsalia, Christine T Ekdahl, Zaal Kokaia, Olle Lindval. Persistent production of neurons from adult brain stem cells during recovery after stroke. Stem cells (Dayton, Ohio). vol 24. issue 3. 2006-06-08. PMID:16210404. |
neuroblasts formed early or late after stroke either differentiate into mature neurons, which survive for several months, or die through caspase-mediated apoptosis. |
2006-06-08 |
2023-08-12 |
rat |
| Chun-Fang Xia, Hang Yin, Yu-Yu Yao, Cesar V Borlongan, Lee Chao, Julie Cha. Kallikrein protects against ischemic stroke by inhibiting apoptosis and inflammation and promoting angiogenesis and neurogenesis. Human gene therapy. vol 17. issue 2. 2006-03-10. PMID:16454654. |
these results indicate that delayed systemic administration of the kallikrein gene after onset of stroke protects against ischemic brain injury by inhibiting apoptosis and inflammation and by promoting angiogenesis and neurogenesis. |
2006-03-10 |
2023-08-12 |
human |
| Alexei Degterev, Zhihong Huang, Michael Boyce, Yaqiao Li, Prakash Jagtap, Noboru Mizushima, Gregory D Cuny, Timothy J Mitchison, Michael A Moskowitz, Junying Yua. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nature chemical biology. vol 1. issue 2. 2006-02-09. PMID:16408008. |
we demonstrated that necroptosis contributes to delayed mouse ischemic brain injury in vivo through a mechanism distinct from that of apoptosis and offers a new therapeutic target for stroke with an extended window for neuroprotection. |
2006-02-09 |
2023-08-12 |
mouse |
| Tiina Sairanen, Marja-Liisa Karjalainen-Lindsberg, Anders Paetau, Petra Ijäs, Perttu J Lindsber. Apoptosis dominant in the periinfarct area of human ischaemic stroke--a possible target of antiapoptotic treatments. Brain : a journal of neurology. vol 129. issue Pt 1. 2006-01-25. PMID:16272167. |
apoptosis dominant in the periinfarct area of human ischaemic stroke--a possible target of antiapoptotic treatments. |
2006-01-25 |
2023-08-12 |
human |
| Tiina Sairanen, Marja-Liisa Karjalainen-Lindsberg, Anders Paetau, Petra Ijäs, Perttu J Lindsber. Apoptosis dominant in the periinfarct area of human ischaemic stroke--a possible target of antiapoptotic treatments. Brain : a journal of neurology. vol 129. issue Pt 1. 2006-01-25. PMID:16272167. |
the objective of the study was to determine whether apoptosis occurs in human ischaemic stroke and to describe its topographical distribution. |
2006-01-25 |
2023-08-12 |
human |
| Baolu Zha. Natural antioxidants for neurodegenerative diseases. Molecular neurobiology. vol 31. issue 1-3. 2006-01-24. PMID:15953828. |
the author reviews the studies on the preventing effects of natural antioxidants, such as vitamins e and c, flavonoids, and polyphenols on neurodegenerative diseases, especially summarizing the results on the protective effect of ginkgo biloba extract on neuron cells, preventing effects of green tea polyphenols on apoptosis of pc12 cells (parkison's disease model), preventing effects of genestien on amyloid-beta-induced apoptosis of hippocampal neuronal cells (alzhemer's disease model), and preventing effect of crataegus flavonoids on ischemic-reperfusion damage to the brain of the mongolian gerbil (stroke model) in the laboratory. |
2006-01-24 |
2023-08-12 |
Not clear |
| Martin Holcí. Targeting endogenous inhibitors of apoptosis for treatment of cancer, stroke and multiple sclerosis. Expert opinion on therapeutic targets. vol 8. issue 3. 2006-01-16. PMID:15161430. |
targeting endogenous inhibitors of apoptosis for treatment of cancer, stroke and multiple sclerosis. |
2006-01-16 |
2023-08-12 |
human |
| Vladimir P Skulache. How to clean the dirtiest place in the cell: cationic antioxidants as intramitochondrial ROS scavengers. IUBMB life. vol 57. issue 4-5. 2005-09-16. PMID:16036614. |
these effects indicate that mitoq and similar compounds may be promising in treatment of heart attack, stroke and other diseases accompanied by massive apoptosis in the injured tissue. |
2005-09-16 |
2023-08-12 |
Not clear |