| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianfeng Li, Wenyan Li, Jialin Su, Weimin Liu, Bella T Altura, Burton M Altur. Hydrogen peroxide induces apoptosis in cerebral vascular smooth muscle cells: possible relation to neurodegenerative diseases and strokes. Brain research bulletin. vol 62. issue 2. 2004-02-06. PMID:14638383. |
apoptosis has been suggested to play an important role in neurodegenerative diseases, traumatic brain injury and strokes. |
2004-02-06 |
2023-08-12 |
Not clear |
| Jianfeng Li, Wenyan Li, Jialin Su, Weimin Liu, Bella T Altura, Burton M Altur. Hydrogen peroxide induces apoptosis in cerebral vascular smooth muscle cells: possible relation to neurodegenerative diseases and strokes. Brain research bulletin. vol 62. issue 2. 2004-02-06. PMID:14638383. |
the present new data suggest that apoptosis in cerebral vsmcs, induced by ros, such as h2o2, could play important roles in neruodegenerative processes, traumatic brain injury and strokes. |
2004-02-06 |
2023-08-12 |
Not clear |
| Chia-Yi Kuan, Alan J Whitmarsh, Derek D Yang, Guanghong Liao, Aryn J Schloemer, Chen Dong, Jue Bao, Kenneth J Banasiak, Gabriel G Haddad, Richard A Flavell, Roger J Davis, Pasko Raki. A critical role of neural-specific JNK3 for ischemic apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 25. 2004-01-23. PMID:14657393. |
the downstream mechanism of jnk3-mediated apoptosis may include the induction of bim and fas and the mitochondrial release of cytochrome c. these results suggest that jnk3 is a potential target for neuroprotection therapies in stroke. |
2004-01-23 |
2023-08-12 |
mouse |
| Jianfeng Li, Jialin Su, Wenyan Li, Weimin Liu, Bella T Altura, Burton M Altur. Peroxynitrite induces apoptosis in canine cerebral vascular muscle cells: possible relation to neurodegenerative diseases and strokes. Neuroscience letters. vol 350. issue 3. 2003-11-10. PMID:14550922. |
peroxynitrite induces apoptosis in canine cerebral vascular muscle cells: possible relation to neurodegenerative diseases and strokes. |
2003-11-10 |
2023-08-12 |
Not clear |
| Jianfeng Li, Jialin Su, Wenyan Li, Weimin Liu, Bella T Altura, Burton M Altur. Peroxynitrite induces apoptosis in canine cerebral vascular muscle cells: possible relation to neurodegenerative diseases and strokes. Neuroscience letters. vol 350. issue 3. 2003-11-10. PMID:14550922. |
apoptosis) play important roles in neurodegeneration and stroke. |
2003-11-10 |
2023-08-12 |
Not clear |
| Jianfeng Li, Jialin Su, Wenyan Li, Weimin Liu, Bella T Altura, Burton M Altur. Peroxynitrite induces apoptosis in canine cerebral vascular muscle cells: possible relation to neurodegenerative diseases and strokes. Neuroscience letters. vol 350. issue 3. 2003-11-10. PMID:14550922. |
although the precise mechanisms by which peroxynitrite induces apoptosis need to be further investigated, the present findings could be used to suggest that onoo- formation in the brain may play important roles in neurodegenerative processes and strokes via detrimental actions on cerebral microvessels and blood flow. |
2003-11-10 |
2023-08-12 |
Not clear |
| Fabian Docagne, Carine Ali, Sylvain Lesne, Olivier Nicole, Eric T MacKenzie, Alain Buisson, Denis Vivie. [Does transforming growth factor-beta (TGF-beta) act as a neuroprotective agent in cerebral ischemia?]. Journal de la Societe de biologie. vol 197. issue 2. 2003-10-23. PMID:12910629. |
necrosis and apoptosis are the two fundamental hallmarks of neuronal death in stroke. |
2003-10-23 |
2023-08-12 |
Not clear |
| Jieli Chen, Yi Li, Mark Katakowski, Xiaoguang Chen, Lei Wang, Dunyue Lu, Mei Lu, Subhash C Gautam, Michael Chop. Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat. Journal of neuroscience research. vol 73. issue 6. 2003-10-14. PMID:12949903. |
intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat. |
2003-10-14 |
2023-08-12 |
rat |
| Jieli Chen, Yi Li, Mark Katakowski, Xiaoguang Chen, Lei Wang, Dunyue Lu, Mei Lu, Subhash C Gautam, Michael Chop. Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat. Journal of neuroscience research. vol 73. issue 6. 2003-10-14. PMID:12949903. |
the present study investigates the induction of neurogenesis, reduction of apoptosis, and promotion of basic fibroblast growth factor (bfgf) expression as possible mechanisms by which treatment of stroke with bone marrow stromal cells (mscs) improves neurological functional recovery. |
2003-10-14 |
2023-08-12 |
rat |
| Jieli Chen, Yi Li, Mark Katakowski, Xiaoguang Chen, Lei Wang, Dunyue Lu, Mei Lu, Subhash C Gautam, Michael Chop. Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat. Journal of neuroscience research. vol 73. issue 6. 2003-10-14. PMID:12949903. |
here we demonstrate that intravenously administered male mscs increase bfgf expression, reduce apoptosis, promote endogenous cellular proliferation, and improve functional recovery after stroke in female rats. |
2003-10-14 |
2023-08-12 |
rat |
| Nancy J Linford, Daniel M Dors. 17beta-Estradiol and the phytoestrogen genistein attenuate neuronal apoptosis induced by the endoplasmic reticulum calcium-ATPase inhibitor thapsigargin. Steroids. vol 67. issue 13-14. 2003-09-22. PMID:12441188. |
the importance of apoptosis in the brain has been recognized with regard to organization of the developing brain as well as degeneration in response to disease or stroke; however, the effects of estrogenic compounds on neuronal apoptosis have not been thoroughly examined. |
2003-09-22 |
2023-08-12 |
Not clear |
| V I Skvortsova, S A Limborskaia, P A Slominskiĭ, L V Gubskiĭ, E A Kol'tsova, I M Shetova, N A Shamalov, T I Tupitsina, I A Platonov. [Association between Bam HI RFLP p53 gene polymorphism and brain infarction volume in patients with atherothrombotic ischemic stroke]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. issue Suppl 8. 2003-09-17. PMID:12830514. |
a significant association between p53 bam hi polymorphism and infarction volume in patients with carotid atherothrombotic stroke confirms an important role of apoptosis in ischemic brain lesions formation that demands temporary antiapoptotic influence on patients with stroke. |
2003-09-17 |
2023-08-12 |
Not clear |
| Russell J Reiter, Rosa M Sainz, Silvia Lopez-Burillo, Juan C Mayo, Lucien C Manchester, Dun Xian Ta. Melatonin ameliorates neurologic damage and neurophysiologic deficits in experimental models of stroke. Annals of the New York Academy of Sciences. vol 993. 2003-08-25. PMID:12853293. |
the exogenous administration of melatonin in these experimental stroke models reduced infarct volume, lowered the frequency of apoptosis, increased the number of surviving neurons, reduced reactive gliosis, lowered the oxidation of neural lipids and oxidatively damaged dna, induced bcl-2 gene expression (the activity of which improves cell survival), upregulated excision repair cross-complementing factor 6 (an essential gene for preferential dna excision repair), restrained poly(adp ribose) synthetase (which depletes cellular nad resulting in the loss of atp) activity, and improved neurophysiologic outcomes. |
2003-08-25 |
2023-08-12 |
rat |
| Joseph W Eichenbaum, Paul H Pevsner, Gabriel Pivawer, George M Kleinman, Luis Chiriboga, Arnold Stern, Ari Rosenbach, Kathryn Iannuzzi, Douglas C Mille. A murine photochemical stroke model with histologic correlates of apoptotic and nonapoptotic mechanisms. Journal of pharmacological and toxicological methods. vol 47. issue 2. 2003-06-19. PMID:12459144. |
the neuronal cell death that occurs after ischemia-induced cerebral infarction (stroke) contains elements of apoptosis and necrosis, an intermediary form of the two, and a distinct excitotoxic process. |
2003-06-19 |
2023-08-12 |
mouse |
| Jung-Chul Seo, Sang-Won Han, Chang-Sik Yin, Hyung-Kyun Koh, Chang-Hwan Kim, Ee-Hwa Kim, Kang-Hyun Leem, Hyang-Sook Lee, Hi-Joon Park, Soon-Ae Kim, Bong-Keun Choe, Hee-Jae Lee, Sung-Vin Yim, Chang-Ju Kim, Joo-Ho Chun. Evaluation of a Apo-1/Fas promoter polymorphism in Korean stroke patients. Experimental & molecular medicine. vol 34. issue 4. 2003-04-11. PMID:12515395. |
apoptosis has been implicated in the pathogenesis of neurodegenerative diseases such as stroke and alzheimer's disease. |
2003-04-11 |
2023-08-12 |
Not clear |
| Jung-Chul Seo, Sang-Won Han, Chang-Sik Yin, Hyung-Kyun Koh, Chang-Hwan Kim, Ee-Hwa Kim, Kang-Hyun Leem, Hyang-Sook Lee, Hi-Joon Park, Soon-Ae Kim, Bong-Keun Choe, Hee-Jae Lee, Sung-Vin Yim, Chang-Ju Kim, Joo-Ho Chun. Evaluation of a Apo-1/Fas promoter polymorphism in Korean stroke patients. Experimental & molecular medicine. vol 34. issue 4. 2003-04-11. PMID:12515395. |
apo-1/fas gene is one of the mediators of apoptosis in stroke. |
2003-04-11 |
2023-08-12 |
Not clear |
| Nadia El-Guendy, Vivek M Rangneka. Apoptosis by Par-4 in cancer and neurodegenerative diseases. Experimental cell research. vol 283. issue 1. 2003-03-12. PMID:12565819. |
cells that are resistant to apoptosis by par-4 alone, however, are greatly sensitized by par-4 to the action of other pro-apoptotic insults such as growth factor withdrawal, tumor necrosis factor, ionizing radiation, intracellular calcium elevation, or those involved in neurodegenerative diseases such as alzheimer's, parkinson's, huntington's, and stroke. |
2003-03-12 |
2023-08-12 |
Not clear |
| Jun Yang, Lori K Klaidman, Mei Ling Chang, Seyha Kem, Taku Sugawara, Pak Chan, James D Adam. Nicotinamide therapy protects against both necrosis and apoptosis in a stroke model. Pharmacology, biochemistry, and behavior. vol 73. issue 4. 2003-03-04. PMID:12213537. |
nicotinamide therapy protects against both necrosis and apoptosis in a stroke model. |
2003-03-04 |
2023-08-12 |
Not clear |
| Q Yuan, R Li, H Yang, G Zhan. [Effects of reperfusion on neuronal changes and macrophagic response after transient focal ischemia--reperfusion of brain in rats]. Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao. vol 30. issue 2. 2003-01-14. PMID:12212045. |
the results indicate that, firstly, it is important to prevent the neuronal apoptosis and reduce the volume of infarct in stroke patients; secondly, irreversible neuronal lesions simultaneously stimulate microglial activation and the presence of extrinsic macrophages from meninges was earlier than the appearance of the macrophages from parenchyma blood-monocytes. |
2003-01-14 |
2023-08-12 |
rat |
| XiaoLei Hu, Inga-Maj Johansson, Thomas Brännström, Tommy Olsson, Per Weste. Long-lasting neuronal apoptotic cell death in regions with severe ischemia after photothrombotic ring stroke in rats. Acta neuropathologica. vol 104. issue 5. 2002-12-23. PMID:12410394. |
this study explored the temporal and spatial pattern of apoptosis and necrosis in a novel photothrombotic ring stroke model with or without spontaneous reperfusion. |
2002-12-23 |
2023-08-12 |
rat |