| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Har. [Involvement of caspase on apoptosis in ischemia-induced neuronal cell death: usefulness of caspase inhibitors for stroke therapy]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 113. issue 2. 1999-05-17. PMID:10205784. |
several lines of evidence suggest that apoptosis is also an important mechanism of cell death in adult brain in acute or chronic diseases such as stroke and alzheimer's disease. |
1999-05-17 |
2023-08-12 |
Not clear |
| R P Mason, P R Leeds, R F Jacob, C J Hough, K G Zhang, P E Mason, D M Chuan. Inhibition of excessive neuronal apoptosis by the calcium antagonist amlodipine and antioxidants in cerebellar granule cells. Journal of neurochemistry. vol 72. issue 4. 1999-04-13. PMID:10098848. |
neuronal cell death as a result of apoptosis is associated with cerebrovascular stroke and various neurodegenerative disorders. |
1999-04-13 |
2023-08-12 |
rat |
| R P Mason, P R Leeds, R F Jacob, C J Hough, K G Zhang, P E Mason, D M Chuan. Inhibition of excessive neuronal apoptosis by the calcium antagonist amlodipine and antioxidants in cerebellar granule cells. Journal of neurochemistry. vol 72. issue 4. 1999-04-13. PMID:10098848. |
agents such as amlodipine that block voltage-sensitive ca2+ channels and inhibit cellular oxidative stress may be effective in the treatment of cerebrovascular stroke and neurodegenerative diseases associated with excessive apoptosis. |
1999-04-13 |
2023-08-12 |
rat |
| E Tarkowski, L Rosengren, C Blomstrand, C Jensen, S Ekholm, A Tarkowsk. Intrathecal expression of proteins regulating apoptosis in acute stroke. Stroke. vol 30. issue 2. 1999-03-01. PMID:9933267. |
intrathecal expression of proteins regulating apoptosis in acute stroke. |
1999-03-01 |
2023-08-12 |
Not clear |
| E Tarkowski, L Rosengren, C Blomstrand, C Jensen, S Ekholm, A Tarkowsk. Intrathecal expression of proteins regulating apoptosis in acute stroke. Stroke. vol 30. issue 2. 1999-03-01. PMID:9933267. |
the aim of the present study was to investigate the intrathecal levels of proteins regulating apoptosis in acute stroke and to relate these levels to brain damage and to production of proinflammatory and anti-inflammatory cytokines. |
1999-03-01 |
2023-08-12 |
Not clear |
| M A Guglielmo, P T Chan, S Cortez, E G Stopa, P McMillan, C E Johanson, M Epstein, C E Doberstei. The temporal profile and morphologic features of neuronal death in human stroke resemble those observed in experimental forebrain ischemia: the potential role of apoptosis. Neurological research. vol 20. issue 4. 1998-08-20. PMID:9618690. |
the temporal profile and morphologic features of neuronal death in human stroke resemble those observed in experimental forebrain ischemia: the potential role of apoptosis. |
1998-08-20 |
2023-08-12 |
human |
| Y J Gen. Regulation of programmed cell death or apoptosis in atherosclerosis. Heart and vessels. vol Suppl 12. 1998-04-07. PMID:9476549. |
clarification of the molecular mechanism that regulates apoptosis may help design a new strategy for treatment of patients with atherosclerosis and its major complications, heart attack and stroke. |
1998-04-07 |
2023-08-12 |
human |
| Y Li, M Chopp, C Powers, N Jian. Apoptosis and protein expression after focal cerebral ischemia in rat. Brain research. vol 765. issue 2. 1997-11-13. PMID:9313903. |
the selective expression of proteins associated with dna damage, dna repair and cell cycle observed in morphologically intact cells, ischemic injured cells and apoptotic cells suggests a differential role for these proteins in cell survival and apoptosis after stroke. |
1997-11-13 |
2023-08-12 |
rat |
| G A MacGibbon, P A Lawlor, E S Sirimanne, M R Walton, B Connor, D Young, C Williams, P Gluckman, R L Faull, P Hughes, M Draguno. Bax expression in mammalian neurons undergoing apoptosis, and in Alzheimer's disease hippocampus. Brain research. vol 750. issue 1-2. 1997-06-17. PMID:9098548. |
to investigate the role of bax in nerve cell death in the rat brain we examined the level of bax expression in cells undergoing apoptosis, using a hypoxic-ischemic stroke model. |
1997-06-17 |
2023-08-12 |
rat |
| G A MacGibbon, P A Lawlor, E S Sirimanne, M R Walton, B Connor, D Young, C Williams, P Gluckman, R L Faull, P Hughes, M Draguno. Bax expression in mammalian neurons undergoing apoptosis, and in Alzheimer's disease hippocampus. Brain research. vol 750. issue 1-2. 1997-06-17. PMID:9098548. |
we found that bax was expressed at high levels in the nuclei of neurons in the hippocampus, cortex, cerebellum, and striatum on the control side, and that bax levels increased in hippocampal neurons undergoing apoptosis on the stroke side, and then declined (correlating with cell loss). |
1997-06-17 |
2023-08-12 |
rat |
| M Tagami, K Yamagata, Y Nara, H Fujino, A Kubota, F Numano, Y Yamor. Insulin-like growth factors prevent apoptosis in cortical neurons isolated from stroke-prone spontaneously hypertensive rats. Laboratory investigation; a journal of technical methods and pathology. vol 76. issue 5. 1997-06-17. PMID:9166279. |
for this purpose, we prepared cortical neurons from wky and shrsp (15 weeks of gestation) to test the genetic vulnerability involved in the pathogenesis of stroke as well as apoptosis of cortical neurons isolated from shrsp. |
1997-06-17 |
2023-08-12 |
rat |
| M Tagami, K Yamagata, Y Nara, H Fujino, A Kubota, F Numano, Y Yamor. Insulin-like growth factors prevent apoptosis in cortical neurons isolated from stroke-prone spontaneously hypertensive rats. Laboratory investigation; a journal of technical methods and pathology. vol 76. issue 5. 1997-06-17. PMID:9166279. |
the data thus indicate that genetic factors related to neuronal vulnerability to apoptosis are involved in the pathogenesis of stroke lesions in shrsp. |
1997-06-17 |
2023-08-12 |
rat |
| M Tagami, K Ikeda, Y Nara, H Fujino, A Kubota, F Numano, Y Yamor. Insulin-like growth factor-1 attenuates apoptosis in hippocampal neurons caused by cerebral ischemia and reperfusion in stroke-prone spontaneously hypertensive rats. Laboratory investigation; a journal of technical methods and pathology. vol 76. issue 5. 1997-06-17. PMID:9166280. |
we concluded that the genetic vulnerability to apoptosis in shrsp neurons was involved in the pathogenesis of stroke lesions and that this vulnerability was attenuated by the igf-1 pretreatment. |
1997-06-17 |
2023-08-12 |
rat |
| D W Cho. Ischemia-induced neuronal apoptosis. Current opinion in neurobiology. vol 6. issue 5. 1997-03-11. PMID:8937832. |
while many questions remain unanswered, the concept of ischemic apoptosis has raised exciting prospects of combining anti-apoptotic with anti-excitotoxic treatments to achieve heightened therapeutic benefits in the brains of patients traumatized by cardiac arrest or stroke. |
1997-03-11 |
2023-08-12 |
Not clear |
| D E Bredese. Genetic control of neural cell apoptosis. Perspectives on developmental neurobiology. vol 3. issue 2. 1996-12-16. PMID:8826528. |
neural apoptosis occurs not only in neural development, but also in pathophysiological states such as stroke and beta-amyloid peptide toxicity. |
1996-12-16 |
2023-08-12 |
Not clear |
| D L Vaux, G Häcke. Hypothesis: apoptosis caused by cytotoxins represents a defensive response that evolved to combat intracellular pathogens. Clinical and experimental pharmacology & physiology. vol 22. issue 11. 1996-04-09. PMID:8593745. |
for example, human cells may activate a suicide pathway in response to sub-lethal amounts of anoxia following a stroke or heart attack and so blocking apoptosis may be a useful therapy to limit tissue damage. |
1996-04-09 |
2023-08-12 |
human |
| E M Johnson, L J Greenlund, P T Akins, C Y Hs. Neuronal apoptosis: current understanding of molecular mechanisms and potential role in ischemic brain injury. Journal of neurotrauma. vol 12. issue 5. 1996-04-09. PMID:8594212. |
the second part of this article reviews recent studies in in vivo stroke models on the mechanism of cell death relevant to apoptosis after cerebral ischemia. |
1996-04-09 |
2023-08-12 |
Not clear |
| M D Linnik, J A Miller, J Sprinkle-Cavallo, P J Mason, F Y Thompson, L R Montgomery, K K Schroede. Apoptotic DNA fragmentation in the rat cerebral cortex induced by permanent middle cerebral artery occlusion. Brain research. Molecular brain research. vol 32. issue 1. 1996-01-11. PMID:7494449. |
this type of fragmentation is characteristic of programmed cell death or apoptosis and suggests that neuronal death in stroke may be more complex than simple necrotic death. |
1996-01-11 |
2023-08-12 |
rat |