| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| XiaoLei Hu, Inga-Maj Johansson, Thomas Brännström, Tommy Olsson, Per Weste. Long-lasting neuronal apoptotic cell death in regions with severe ischemia after photothrombotic ring stroke in rats. Acta neuropathologica. vol 104. issue 5. 2002-12-23. PMID:12410394. |
therefore, apoptosis may be an important contributor to neuronal cell death in brain regions with severely reduced blood flow after thrombo-embolic stroke. |
2002-12-23 |
2023-08-12 |
rat |
| H Loppnow, E Westphal, R Buchhorn, A Wessel, K Werda. Interleukin-1 and related proteins in cardiovascular disease in adults and children. Shock (Augusta, Ga.). vol 16 Suppl 1. 2002-06-17. PMID:11770030. |
it has been suggested that cytokines and apoptosis are involved in pathogenesis of cardiovascular diseases such as atherosclerosis, chronic heart failure, myocarditis, cardiomyopathy, or stroke. |
2002-06-17 |
2023-08-12 |
Not clear |
| A C DeVries, H D Joh, O Bernard, K Hattori, P D Hurn, R J Traystman, N J Alkaye. Social stress exacerbates stroke outcome by suppressing Bcl-2 expression. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 20. 2001-12-04. PMID:11553785. |
the bcl-2 protooncogene promotes cell survival and protects against apoptosis and cellular necrosis in numerous neurodegenerative disorders, including stroke. |
2001-12-04 |
2023-08-12 |
mouse |
| Y Morita-Fujimura, M Fujimura, T Yoshimoto, P H Cha. Superoxide during reperfusion contributes to caspase-8 expression and apoptosis after transient focal stroke. Stroke. vol 32. issue 10. 2001-11-01. PMID:11588326. |
superoxide during reperfusion contributes to caspase-8 expression and apoptosis after transient focal stroke. |
2001-11-01 |
2023-08-12 |
mouse |
| P J Crack, J M Taylor, N J Flentjar, J de Haan, P Hertzog, R C Iannello, I Kol. Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury. Journal of neurochemistry. vol 78. issue 6. 2001-10-25. PMID:11579147. |
this is the first known report of such a dramatic increase, both temporally and in level of apoptosis in a mouse stroke model. |
2001-10-25 |
2023-08-12 |
mouse |
| S H Ahmed, A Y Shaikh, Z Shaikh, C Y Hs. What animal models have taught us about the treatment of acute stroke and brain protection. Current atherosclerosis reports. vol 2. issue 2. 2001-07-26. PMID:11122741. |
the major achievements made in the past 2 decades applying animal stroke models include 1) the identification of the mediator role of excitotoxin and oxygen free radicals in ischemic brain injury; 2) the confirmation of apoptosis as a major mechanism of ischemic cell death; 3) the characterization of postischemic gene expression; 4) the delineation of postischemic inflammatory reaction; 5) the application of transgenic mice to confirm the roles of purported mediators in ischemic brain injury; 6) development of novel magnetic resonance imaging sequences for early noninvasive detection of ischemic brain lesions; and, 7) the development of novel therapeutic strategies based on preclinical findings derived from animal stroke models. |
2001-07-26 |
2023-08-12 |
mouse |
| D C Harrison, R P Davis, B C Bond, C A Campbell, M F James, A A Parsons, K L Philpot. Caspase mRNA expression in a rat model of focal cerebral ischemia. Brain research. Molecular brain research. vol 89. issue 1-2. 2001-07-12. PMID:11311984. |
proteins of the caspase family are involved in the signalling pathway that ultimately leads to programmed cell death (apoptosis), which has been reported to occur in some experimental models of stroke. |
2001-07-12 |
2023-08-12 |
rat |
| C Culmsee, Y Zhu, J Krieglstein, M P Mattso. Evidence for the involvement of Par-4 in ischemic neuron cell death. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 21. issue 4. 2001-05-17. PMID:11323519. |
after a stroke many neurons in the ischemic brain tissue die by a process called apoptosis, a form of cell death that may be preventable. |
2001-05-17 |
2023-08-12 |
mouse |
| J P MacManus, A M Bucha. Apoptosis after experimental stroke: fact or fashion? Journal of neurotrauma. vol 17. issue 10. 2001-03-01. PMID:11063056. |
apoptosis after experimental stroke: fact or fashion? |
2001-03-01 |
2023-08-12 |
Not clear |
| J P MacManus, A M Bucha. Apoptosis after experimental stroke: fact or fashion? Journal of neurotrauma. vol 17. issue 10. 2001-03-01. PMID:11063056. |
this review examines the appearance of hallmarks of apoptosis following experimental stroke. |
2001-03-01 |
2023-08-12 |
Not clear |
| M P Mattson, C Culmsee, Z F Y. Apoptotic and antiapoptotic mechanisms in stroke. Cell and tissue research. vol 301. issue 1. 2000-12-07. PMID:10928290. |
recent findings also implicate apoptosis in neuronal degeneration after ischemic brain injury in animal models of stroke. |
2000-12-07 |
2023-08-12 |
Not clear |
| S Chatterje. Neutral sphingomyelinase: past, present and future. Chemistry and physics of lipids. vol 102. issue 1-2. 2000-09-29. PMID:11001563. |
since plaque stability is an integral aspect of atherosclerosis management, activation of n-smase and subsequent apoptosis may be vital events in the onset of plaque rupture, stroke and heart failure. |
2000-09-29 |
2023-08-12 |
human |
| M Yepes, M Sandkvist, M K Wong, T A Coleman, E Smith, S L Cohan, D A Lawrenc. Neuroserpin reduces cerebral infarct volume and protects neurons from ischemia-induced apoptosis. Blood. vol 96. issue 2. 2000-08-17. PMID:10887120. |
thus, neuroserpin may be a naturally occurring neuroprotective proteinase inhibitor, whose therapeutic administration decreases stroke volume most likely by inhibiting proteinase activity and subsequent apoptosis associated with focal cerebral ischemia/reperfusion. |
2000-08-17 |
2023-08-12 |
rat |
| Y Z Zhu, G N Chimon, Y C Zhu, Q Lu, B Li, H Z Hu, E H Yap, H S Lee, P T Won. Expression of angiotensin II AT2 receptor in the acute phase of stroke in rats. Neuroreport. vol 11. issue 6. 2000-07-17. PMID:10817589. |
this demonstrated up-regulation of at2 receptor may be involved in the apoptosis of tissue repair after stroke. |
2000-07-17 |
2023-08-12 |
rat |
| E Tarkowski, A Ringqvist, L Rosengren, C Jensen, S Ekholm, A Wennmal. Intrathecal release of nitric oxide and its relation to final brain damage in patients with stroke. Cerebrovascular diseases (Basel, Switzerland). vol 10. issue 3. 2000-06-30. PMID:10773646. |
76, p < 0.05) to bcl-2, a protein downregulating neuronal apoptosis, in the late stage of the stroke. |
2000-06-30 |
2023-08-12 |
Not clear |
| M P Mattson, F M LaFerla, S L Chan, M A Leissring, P N Shepel, J D Geige. Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders. Trends in neurosciences. vol 23. issue 5. 2000-06-21. PMID:10782128. |
alterations in ca2+ homeostasis in er contribute to neuronal apoptosis and excitotoxicity, and are being linked to the pathogenesis of several different neurodegenerative disorders, including alzheimer's disease and stroke. |
2000-06-21 |
2023-08-12 |
Not clear |
| G S Robertson, S J Crocker, D W Nicholson, J B Schul. Neuroprotection by the inhibition of apoptosis. Brain pathology (Zurich, Switzerland). vol 10. issue 2. 2000-06-06. PMID:10764048. |
indeed, peptide-based caspase inhibitors prevent neuronal loss in animal models of head injury and stroke suggesting that these compounds may be the forerunners of non-peptide small molecules that halt apoptosis processes implicated in these neurodegenerative disorders. |
2000-06-06 |
2023-08-12 |
mouse |
| M Minami, K L Jin, W Li, T Nagayama, D C Henshall, R P Simo. Bcl-w expression is increased in brain regions affected by focal cerebral ischemia in the rat. Neuroscience letters. vol 279. issue 3. 2000-03-17. PMID:10688062. |
proteins of the bcl-2 family are important regulators of apoptosis in many tissues of the embryo and adult and may play a role in cell death following stroke. |
2000-03-17 |
2023-08-12 |
rat |
| Z Song, H Stelle. Death by design: mechanism and control of apoptosis. Trends in cell biology. vol 9. issue 12. 2000-02-29. PMID:10611682. |
active cellular suicide by apoptosis plays important roles in animal development, tissue homeostasis and a wide variety of diseases, including cancer, aids, stroke and many neurodegenerative disorders. |
2000-02-29 |
2023-08-12 |
caenorhabditis_elegans |
| G Famular. The puzzle of neuronal death and life: is mannitol the right drug for the treatment of brain oedema associated with ischaemic stroke? European journal of emergency medicine : official journal of the European Society for Emergency Medicine. vol 6. issue 4. 2000-02-15. PMID:10646927. |
this could have important clinical implications as apoptosis is involved in the more gradual loss of neurons in the penumbra zone surrounding the core of ischaemic stroke where neurons die immediately from oxygen starvation. |
2000-02-15 |
2023-08-12 |
human |