| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mei Huang, Masakuni Horiguchi, Anna R Felix, Herbert Y Meltze. 5-HT1A and 5-HT7 receptors contribute to lurasidone-induced dopamine efflux. Neuroreport. vol 23. issue 7. 2012-08-02. PMID:22415605. |
these findings suggest that the effects of lurasidone on the prefrontal cortex and hippocampus, da efflux are dependent, at least partially, on its 5-ht1a agonist and 5-ht7 antagonist properties and may contribute to its efficacy to reverse the effects of subchronic phencyclidine treatment and improve schizophrenia. |
2012-08-02 |
2023-08-12 |
rat |
| Louise Harvey, Patricia Boks. A stereological comparison of GAD67 and reelin expression in the hippocampal stratum oriens of offspring from two mouse models of maternal inflammation during pregnancy. Neuropharmacology. vol 62. issue 4. 2012-07-27. PMID:22178614. |
altered expression of glutamic acid decarboxylase (gad67) and reelin in the hippocampus has been reported in post-mortem studies of people with schizophrenia or autism. |
2012-07-27 |
2023-08-12 |
mouse |
| Fulvia Adriano, Carlo Caltagirone, Gianfranco Spallett. Hippocampal volume reduction in first-episode and chronic schizophrenia: a review and meta-analysis. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 18. issue 2. 2012-07-26. PMID:21531988. |
hippocampal volume reduction in first-episode and chronic schizophrenia: a review and meta-analysis. |
2012-07-26 |
2023-08-12 |
human |
| Fulvia Adriano, Carlo Caltagirone, Gianfranco Spallett. Hippocampal volume reduction in first-episode and chronic schizophrenia: a review and meta-analysis. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 18. issue 2. 2012-07-26. PMID:21531988. |
in this review and meta-analysis, the authors aim to clarify whether a reduction in hippocampal volume characterizes patients with schizophrenia by considering illness phase (chronic and first episode) and hippocampus side separately. |
2012-07-26 |
2023-08-12 |
human |
| Fulvia Adriano, Carlo Caltagirone, Gianfranco Spallett. Hippocampal volume reduction in first-episode and chronic schizophrenia: a review and meta-analysis. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 18. issue 2. 2012-07-26. PMID:21531988. |
they made a detailed literature search for studies reporting physical volumetric hippocampal measures of patients with schizophrenia and healthy control (hc) participants and found 44 studies that were eligible for meta-analysis. |
2012-07-26 |
2023-08-12 |
human |
| Fulvia Adriano, Carlo Caltagirone, Gianfranco Spallett. Hippocampal volume reduction in first-episode and chronic schizophrenia: a review and meta-analysis. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 18. issue 2. 2012-07-26. PMID:21531988. |
this review and meta-analysis raises the question about whether hippocampal volume reduction in schizophrenia is of neurodevelopmental origin. |
2012-07-26 |
2023-08-12 |
human |
| András Szamosi, Oguz Kelemen, Szabolcs Kér. Hippocampal volume and the AKT signaling system in first-episode schizophrenia. Journal of psychiatric research. vol 46. issue 3. 2012-07-23. PMID:22209534. |
hippocampal volume and the akt signaling system in first-episode schizophrenia. |
2012-07-23 |
2023-08-12 |
Not clear |
| András Szamosi, Oguz Kelemen, Szabolcs Kér. Hippocampal volume and the AKT signaling system in first-episode schizophrenia. Journal of psychiatric research. vol 46. issue 3. 2012-07-23. PMID:22209534. |
the aim of this study was to investigate the relationship between nrg1--induced akt phosphorylation and hippocampal volume in schizophrenia. |
2012-07-23 |
2023-08-12 |
Not clear |
| Barbara Gisabella, Vadim Y Bolshakov, Francine M Bene. Kainate receptor-mediated modulation of hippocampal fast spiking interneurons in a rat model of schizophrenia. PloS one. vol 7. issue 3. 2012-07-23. PMID:22396770. |
kainate receptor-mediated modulation of hippocampal fast spiking interneurons in a rat model of schizophrenia. |
2012-07-23 |
2023-08-12 |
human |
| Barbara Gisabella, Vadim Y Bolshakov, Francine M Bene. Kainate receptor-mediated modulation of hippocampal fast spiking interneurons in a rat model of schizophrenia. PloS one. vol 7. issue 3. 2012-07-23. PMID:22396770. |
kainate receptor (kar) subunits are believed to be involved in abnormal gabaergic neurotransmission in the hippocampus (hipp) in schizophrenia (sz) and bipolar disorder. |
2012-07-23 |
2023-08-12 |
human |
| P Panther, S Nullmeier, H Dobrowolny, H Schwegler, R Wol. CPB-K mice a mouse model of schizophrenia? Differences in dopaminergic, serotonergic and behavioral markers compared to BALB/cJ mice. Behavioural brain research. vol 230. issue 1. 2012-07-23. PMID:22454846. |
our results can be summarized as follows: compared to balb/cj, cpb-k mice showed:(1) significantly reduced traveling distance and number of contacts in social interaction test, (2) differences in the number of serotonin transporter-immunoreactive neurons and volume of raphe nuclei and a lower serotonergic fiber density in the ventral and dorsal hippocampal subfields ca1 and ca3, (3) no alterations of dopaminergic markers like neuron number, neuron density and volume in subregions of substantia nigra and ventral tegmental area, but a significantly higher dopaminergic fiber density in the dorsal hippocampus, the ventral hippocampus of ca1 and gyrus dentatus, (4) no significant differences in serotonergic and dopaminergic fiber densities in the amygdala.based on our results and previous studies, cpb-k mice compared to balb/cj may serve as an important model to understand the interaction of the serotonergic and dopaminergic system and their impact on sensorimotor gating and cognitive function as related to neuropsychiatric disorders like schizophrenia. |
2012-07-23 |
2023-08-12 |
mouse |
| William S Stone, Xiaolu Hs. Declarative memory deficits and schizophrenia: problems and prospects. Neurobiology of learning and memory. vol 96. issue 4. 2012-07-19. PMID:21527348. |
the second part focuses on structural and functional abnormalities in the hippocampus, both in people with schizophrenia and in animal studies that model relevant features of the illness. |
2012-07-19 |
2023-08-12 |
Not clear |
| William S Stone, Xiaolu Hs. Declarative memory deficits and schizophrenia: problems and prospects. Neurobiology of learning and memory. vol 96. issue 4. 2012-07-19. PMID:21527348. |
the likelihood that poor glucose regulation/availability contribute to declarative memory deficits and hippocampal abnormalities is considered, along with the possibility that schizophrenia and poor glucose regulation share common etiologic elements, and with clinical implications of this perspective for enhancing declarative memory. |
2012-07-19 |
2023-08-12 |
Not clear |
| Sònia Darbra, Laura Mòdol, Marc Pallarè. Allopregnanolone infused into the dorsal (CA1) hippocampus increases prepulse inhibition of startle response in Wistar rats. Psychoneuroendocrinology. vol 37. issue 4. 2012-07-16. PMID:21871738. |
the hippocampus is a brain structure that has traditionally been associated with the pathophysiology and neuropathology of schizophrenia. |
2012-07-16 |
2023-08-12 |
rat |
| Erik Keimpema, Alex Straiker, Ken Mackie, Tibor Harkany, Jens Hjerling-Leffle. Sticking out of the crowd: the molecular identity and development of cholecystokinin-containing basket cells. The Journal of physiology. vol 590. issue 4. 2012-06-26. PMID:22219340. |
though only present in limited numbers, the impaired development of basket cells can result in changes in the hippocampal circuitry leading to neurological disorders, such as schizophrenia. |
2012-06-26 |
2023-08-12 |
Not clear |
| Desiree D Dickerson, Aleisha M Restieaux, David K Bilke. Clozapine administration ameliorates disrupted long-range synchrony in a neurodevelopmental animal model of schizophrenia. Schizophrenia research. vol 135. issue 1-3. 2012-06-26. PMID:22260963. |
we investigated whether acute clozapine treatment might function therapeutically by ameliorating the deficit in theta frequency coherence between the prefrontal cortex and the hippocampus that is induced in rats exposed to maternal immune activation (mia)--a risk-factor for schizophrenia. |
2012-06-26 |
2023-08-12 |
rat |
| Mark S Moehle, Richard F Luduena, Vahram Haroutunian, James H Meador-Woodruff, Robert E McCullumsmit. Regional differences in expression of β-tubulin isoforms in schizophrenia. Schizophrenia research. vol 135. issue 1-3. 2012-06-26. PMID:22264600. |
we found that βi-tubulin protein expression was decreased in the anterior cingulate cortex and increased in the dorsolateral prefrontal cortex, but not changed in superior temporal gyrus or hippocampus in schizophrenia. |
2012-06-26 |
2023-08-12 |
human |
| David R Watson, Feng Bai, Suzanne L Barrett, Aidan Turkington, Teresa M Rushe, Ciaran C Mulholland, Stephen J Coope. Structural changes in the hippocampus and amygdala at first episode of psychosis. Brain imaging and behavior. vol 6. issue 1. 2012-06-12. PMID:22045236. |
hippocampus and amygdala changes have been implicated in the pathophysiology and symptomatology of both schizophrenia (scz) and bipolar disorder (bd). |
2012-06-12 |
2023-08-12 |
Not clear |
| David R Watson, Feng Bai, Suzanne L Barrett, Aidan Turkington, Teresa M Rushe, Ciaran C Mulholland, Stephen J Coope. Structural changes in the hippocampus and amygdala at first episode of psychosis. Brain imaging and behavior. vol 6. issue 1. 2012-06-12. PMID:22045236. |
this investigation examined the associations between hippocampus and amygdala volumes and symptom dimensions in schizophrenia and bipolar disorder patients after their first episode of psychosis. |
2012-06-12 |
2023-08-12 |
Not clear |
| Charlie A Davidson, Noriomi Kuroki, Jorge L Alvarado, Margaret A Niznikiewicz, Robert W McCarley, James J Levit. An MRI study of septi pellucidi in relation to hippocampus volume and fornix integrity in schizophrenia. Schizophrenia research. vol 134. issue 2-3. 2012-06-04. PMID:22177349. |
an mri study of septi pellucidi in relation to hippocampus volume and fornix integrity in schizophrenia. |
2012-06-04 |
2023-08-12 |
Not clear |