| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Charlie A Davidson, Noriomi Kuroki, Jorge L Alvarado, Margaret A Niznikiewicz, Robert W McCarley, James J Levit. An MRI study of septi pellucidi in relation to hippocampus volume and fornix integrity in schizophrenia. Schizophrenia research. vol 134. issue 2-3. 2012-06-04. PMID:22177349. |
the cross-sectional study examined structural and diffusion-tensor mr measures, including hippocampus and fornix, in chronic schizophrenia (sz) at one time-point. |
2012-06-04 |
2023-08-12 |
Not clear |
| Darrick T Balu, Gregory C Carlson, Konrad Talbot, Hala Kazi, Tiffany E Hill-Smith, Rachel M Easton, Morris J Birnbaum, Irwin Luck. Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function. Hippocampus. vol 22. issue 2. 2012-05-14. PMID:21049487. |
akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function. |
2012-05-14 |
2023-08-12 |
mouse |
| Darrick T Balu, Gregory C Carlson, Konrad Talbot, Hala Kazi, Tiffany E Hill-Smith, Rachel M Easton, Morris J Birnbaum, Irwin Luck. Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function. Hippocampus. vol 22. issue 2. 2012-05-14. PMID:21049487. |
to establish a closer connection between akt1 and hippocampal function, mice with a selective deletion of akt1 (akt1(-/-) mice) were examined for physiological and behavioral outcomes dependent on the hippocampus and associated with schizophrenia. |
2012-05-14 |
2023-08-12 |
mouse |
| Darrick T Balu, Gregory C Carlson, Konrad Talbot, Hala Kazi, Tiffany E Hill-Smith, Rachel M Easton, Morris J Birnbaum, Irwin Luck. Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function. Hippocampus. vol 22. issue 2. 2012-05-14. PMID:21049487. |
postmortem tissue samples from patients with schizophrenia showed significant reductions of phosphorylated akt levels in hilar neurons of the dentate gyrus, the neurogenic zone of the hippocampus. |
2012-05-14 |
2023-08-12 |
mouse |
| Darrick T Balu, Gregory C Carlson, Konrad Talbot, Hala Kazi, Tiffany E Hill-Smith, Rachel M Easton, Morris J Birnbaum, Irwin Luck. Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function. Hippocampus. vol 22. issue 2. 2012-05-14. PMID:21049487. |
taken together, these results implicate the akt1 isoform in regulating hippocampal neuroplasticity and cognition and in contributing to the etiology of schizophrenia. |
2012-05-14 |
2023-08-12 |
mouse |
| Guillaume Ducharme, Germaine C Lowe, Romain Goutagny, Sylvain William. Early alterations in hippocampal circuitry and theta rhythm generation in a mouse model of prenatal infection: implications for schizophrenia. PloS one. vol 7. issue 1. 2012-05-14. PMID:22238649. |
early alterations in hippocampal circuitry and theta rhythm generation in a mouse model of prenatal infection: implications for schizophrenia. |
2012-05-14 |
2023-08-12 |
mouse |
| Kathryn M Gill, Daniel J Lodge, James M Cook, Shamim Aras, Anthony A Grac. A novel α5GABA(A)R-positive allosteric modulator reverses hyperactivation of the dopamine system in the MAM model of schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 9. 2012-05-08. PMID:21562483. |
we have shown previously that aberrant hippocampal (hpc) output underlies the dopamine (da) dysfunction observed in the methylazoxymethanol acetate (mam) developmental model of schizophrenia in the rodent. |
2012-05-08 |
2023-08-12 |
rat |
| Rodrigo S Sestito, Lucas B Trindade, Rodrigo G de Souza, Lucila N Kerbauy, Melina M Iyomasa, Maria L N M Ros. Effect of isolation rearing on the expression of AMPA glutamate receptors in the hippocampal formation. Journal of psychopharmacology (Oxford, England). vol 25. issue 12. 2012-04-26. PMID:20952455. |
the results suggest that isolation rearing from weaning induces changes on the expression of ampa glutamate receptors in the hippocampus similar to those reported for postmortem human brains with schizophrenia. |
2012-04-26 |
2023-08-12 |
human |
| Gaga Kochlamazashvili, Olena Bukalo, Oleg Senkov, Benedikt Salmen, Rita Gerardy-Schahn, Andreas K Engel, Melitta Schachner, Alexander Dityate. Restoration of synaptic plasticity and learning in young and aged NCAM-deficient mice by enhancing neurotransmission mediated by GluN2A-containing NMDA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 7. 2012-04-23. PMID:22396402. |
deficits in psa and/or ncam expression cause impairments in hippocampal long-term potentiation and depression (ltp and ltd) and are associated with schizophrenia and aging. |
2012-04-23 |
2023-08-12 |
mouse |
| Eva Hradetzky, Thomas M Sanderson, Tsz M Tsang, John L Sherwood, Stephen M Fitzjohn, Viktor Lakics, Nadia Malik, Stephanie Schoeffmann, Michael J O'Neill, Tammy Mk Cheng, Laura W Harris, Hassan Rahmoune, Paul C Guest, Emanuele Sher, Graham L Collingridge, Elaine Holmes, Mark D Tricklebank, Sabine Bah. The methylazoxymethanol acetate (MAM-E17) rat model: molecular and functional effects in the hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 2. 2012-04-17. PMID:21956444. |
in this study, we investigated the molecular phenotype of adult mam rats by focusing on the frontal cortex and hippocampal areas, as these are known to be affected in schizophrenia. |
2012-04-17 |
2023-08-12 |
rat |
| Eva Hradetzky, Thomas M Sanderson, Tsz M Tsang, John L Sherwood, Stephen M Fitzjohn, Viktor Lakics, Nadia Malik, Stephanie Schoeffmann, Michael J O'Neill, Tammy Mk Cheng, Laura W Harris, Hassan Rahmoune, Paul C Guest, Emanuele Sher, Graham L Collingridge, Elaine Holmes, Mark D Tricklebank, Sabine Bah. The methylazoxymethanol acetate (MAM-E17) rat model: molecular and functional effects in the hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 2. 2012-04-17. PMID:21956444. |
proteomic and metabonomic analyses showed that the mam treatment on e17 resulted primarily in deficits in hippocampal glutamatergic neurotransmission, as seen in some schizophrenia patients. |
2012-04-17 |
2023-08-12 |
rat |
| Eva Hradetzky, Thomas M Sanderson, Tsz M Tsang, John L Sherwood, Stephen M Fitzjohn, Viktor Lakics, Nadia Malik, Stephanie Schoeffmann, Michael J O'Neill, Tammy Mk Cheng, Laura W Harris, Hassan Rahmoune, Paul C Guest, Emanuele Sher, Graham L Collingridge, Elaine Holmes, Mark D Tricklebank, Sabine Bah. The methylazoxymethanol acetate (MAM-E17) rat model: molecular and functional effects in the hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 2. 2012-04-17. PMID:21956444. |
thus, this study provides the first molecular evidence, combined with functional validation, that the mam-e17 rat model reproduces hippocampal deficits relevant to the pathology of schizophrenia. |
2012-04-17 |
2023-08-12 |
rat |
| Patricio O'Donnel. Cortical disinhibition in the neonatal ventral hippocampal lesion model of schizophrenia: new vistas on possible therapeutic approaches. Pharmacology & therapeutics. vol 133. issue 1. 2012-04-10. PMID:21839776. |
cortical disinhibition in the neonatal ventral hippocampal lesion model of schizophrenia: new vistas on possible therapeutic approaches. |
2012-04-10 |
2023-08-12 |
rat |
| Patricio O'Donnel. Cortical disinhibition in the neonatal ventral hippocampal lesion model of schizophrenia: new vistas on possible therapeutic approaches. Pharmacology & therapeutics. vol 133. issue 1. 2012-04-10. PMID:21839776. |
the neonatal ventral hippocampal lesion (nvhl) model of schizophrenia has been extensively used in many laboratories over the past couple of decades. |
2012-04-10 |
2023-08-12 |
rat |
| Rubén Antonio Vázquez-Roque, Brenda Ramos, Carolina Tecuatl, Ismael Juárez, Anthony Adame, Fidel de la Cruz, Sergio Zamudio, Raúl Mena, Edward Rockenstein, Eliezer Masliah, Gonzalo Flore. Chronic administration of the neurotrophic agent cerebrolysin ameliorates the behavioral and morphological changes induced by neonatal ventral hippocampus lesion in a rat model of schizophrenia. Journal of neuroscience research. vol 90. issue 1. 2012-03-13. PMID:21932359. |
chronic administration of the neurotrophic agent cerebrolysin ameliorates the behavioral and morphological changes induced by neonatal ventral hippocampus lesion in a rat model of schizophrenia. |
2012-03-13 |
2023-08-12 |
rat |
| S T Pohlack, F Nees, M Ruttorf, S H Witt, V Nieratschker, M Rietschel, H Flo. Risk variant for schizophrenia in the neurogranin gene impacts on hippocampus activation during contextual fear conditioning. Molecular psychiatry. vol 16. issue 11. 2012-03-05. PMID:21647148. |
risk variant for schizophrenia in the neurogranin gene impacts on hippocampus activation during contextual fear conditioning. |
2012-03-05 |
2023-08-12 |
Not clear |
| Vina M Goghari, Angus W Macdonald, Scott R Sponhei. Temporal lobe structures and facial emotion recognition in schizophrenia patients and nonpsychotic relatives. Schizophrenia bulletin. vol 37. issue 6. 2012-02-23. PMID:20484523. |
several temporal lobe regions (fusiform, superior temporal, middle temporal, amygdala, and hippocampus) previously associated with face recognition in normative samples and found to be abnormal in schizophrenia were evaluated using volumetric analyses. |
2012-02-23 |
2023-08-12 |
human |
| Vina M Goghari, Angus W Macdonald, Scott R Sponhei. Temporal lobe structures and facial emotion recognition in schizophrenia patients and nonpsychotic relatives. Schizophrenia bulletin. vol 37. issue 6. 2012-02-23. PMID:20484523. |
schizophrenia patients additionally exhibited smaller hippocampal and middle temporal volumes. |
2012-02-23 |
2023-08-12 |
human |
| Lina Orikabe, Hidenori Yamasue, Hideyuki Inoue, Yoichiro Takayanagi, Yuriko Mozue, Yasuhiko Sudo, Tatsuji Ishii, Masanari Itokawa, Michio Suzuki, Masayoshi Kurachi, Yuji Okazaki, Kiyoto Kasa. Reduced amygdala and hippocampal volumes in patients with methamphetamine psychosis. Schizophrenia research. vol 132. issue 2-3. 2012-02-09. PMID:21784619. |
the prominent volume reduction in amygdala rather than that in hippocampus could be relatively specific characteristics of methamphetamine psychosis, since previous studies have shown significant volume reductions less frequently in amygdala than in hippocampus of the other psychosis such as schizophrenia. |
2012-02-09 |
2023-08-12 |
human |
| Michael W Salter, Graham M Pitche. Dysregulated Src upregulation of NMDA receptor activity: a common link in chronic pain and schizophrenia. The FEBS journal. vol 279. issue 1. 2012-01-31. PMID:21985289. |
on the other hand, in the hippocampus and prefrontal cortex, the physiological upregulation of nmda receptors by src is blocked by neuregulin 1-erbb4 signaling, a pathway that is genetically implicated in the positive symptoms of schizophrenia. |
2012-01-31 |
2023-08-12 |
Not clear |