| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haruki Koike, Ken-ichiro Misu, Shu-ichi Ikeda, Yukio Ando, Masamitsu Nakazato, Eiko Ando, Masahiko Yamamoto, Naoki Hattori, Gen Sobu. Type I (transthyretin Met30) familial amyloid polyneuropathy in Japan: early- vs late-onset form. Archives of neurology. vol 59. issue 11. 2002-12-16. PMID:12433265. |
type i (transthyretin met30) familial amyloid polyneuropathy (fap ttr met30) occurs in 2 endemic foci in japan. |
2002-12-16 |
2023-08-12 |
Not clear |
| Therese Eneqvist, Anders Olofsson, Yukio Ando, Taihei Miyakawa, Shoichi Katsuragi, Jana Jass, Erik Lundgren, A Elisabeth Sauer-Eriksso. Disulfide-bond formation in the transthyretin mutant Y114C prevents amyloid fibril formation in vivo and in vitro. Biochemistry. vol 41. issue 44. 2002-12-13. PMID:12403615. |
the y114c mutation in human transthyretin (ttr) is associated with a particular form of familial amyloidotic polyneuropathy. |
2002-12-13 |
2023-08-12 |
human |
| Mamede de Carvalho, Isabel Conceição, Carla Bentes, M L Sales Luí. Long-term quantitative evaluation of liver transplantation in familial amyloid polyneuropathy (Portuguese V30M). Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 9. issue 2. 2002-12-09. PMID:12440485. |
familial amyloid polyneuropathy (fap) is associated with massive endoneurial and extracellular deposition of amyloid, which isformed from a mutated transthyretin (ttr) protein. |
2002-12-09 |
2023-08-12 |
Not clear |
| Mónica Mendes Sousa, Rui Fernandes, Joana Almeida Palha, Ana Taboada, Paulo Vieira, Maria João Saraiv. Evidence for early cytotoxic aggregates in transgenic mice for human transthyretin Leu55Pro. The American journal of pathology. vol 161. issue 5. 2002-11-22. PMID:12414539. |
familial amyloidotic polyneuropathy (fap) is a lethal autosomal dominant disorder characterized by systemic extracellular deposition of transthyretin (ttr) amyloid fibrils. |
2002-11-22 |
2023-08-12 |
mouse |
| Nobuhiro Kotani, Takeshi Hattori, Shingo Yamagata, Takahiko Tokuda, Akira Shirasawa, Shuhei Yamaguchi, Shotai Kobayashi, Shu-ichi Iked. Transthyretin Thr60Ala Appalachian-type mutation in a Japanese family with familial amyloidotic polyneuropathy. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 9. issue 1. 2002-10-30. PMID:12000195. |
a japanese case with familial amyloidotic polyneuropathy (fap) associated with the transthyretin mutation thr60ala (appalachian-type mutation) is described this is the first reported case of a non-caucasian harboring this type of ttr mutation. |
2002-10-30 |
2023-08-12 |
Not clear |
| Akira Shimizu, Toyofumi Nakanishi, Masahiko Kishikawa, Ayako Miyazak. Detection and identification of protein variants and adducts in blood and tissues: an application of soft ionization mass spectrometry to clinical diagnosis. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 776. issue 1. 2002-10-01. PMID:12127321. |
most of the variant ttr causes amyloidotic polyneuropathy. |
2002-10-01 |
2023-08-12 |
Not clear |
| Dianna Quan, Jeffrey A Cohe. Clinical variant of familial amyloid polyneuropathy. Muscle & nerve. vol 26. issue 3. 2002-09-26. PMID:12210373. |
we describe a patient with a tyr77 ttr gene mutation who presented with sensorimotor polyneuropathy but no other systemic symptoms of amyloidosis. |
2002-09-26 |
2023-08-12 |
Not clear |
| Kai Liu, Jeffery W Kelly, David E Wemme. Native state hydrogen exchange study of suppressor and pathogenic variants of transthyretin. Journal of molecular biology. vol 320. issue 4. 2002-08-27. PMID:12095258. |
herein three human ttr single amino acid variant homotetramers including two familial amyloidotic polyneuropathy (fap) causing variants (v30m and l55p), and a suppressor variant t119m (known to protect v30m carriers from disease by trans-suppression) were investigated in a residue-specific fashion by monitoring (2)h-(1)h exchange employing nmr spectroscopy. |
2002-08-27 |
2023-08-12 |
human |
| Y Sekijima, T Tokuda, F Kametani, K Tanaka, K Maruyama, S Iked. Serum transthyretin monomer in patients with familial amyloid polyneuropathy. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 8. issue 4. 2002-08-12. PMID:11791618. |
although dissociation of the transthyretin (ttr) tetramer is suspected of being the first step in amyloid fibril formation in hereditary ttr amyloidosis, including familial amyloid polyneuropathy (fap), the ttr monomer has never been examined in vivo. |
2002-08-12 |
2023-08-12 |
Not clear |
| Tara Nath Niraula, Katsuki Haraoka, Yukio Ando, Hua Li, Hiroaki Yamada, Kazuyuki Akasak. Decreased thermodynamic stability as a crucial factor for familial amyloidotic polyneuropathy. Journal of molecular biology. vol 320. issue 2. 2002-08-09. PMID:12079390. |
a single mutation in the wild-type transthyretin (wt ttr) such as v30m causes a familial amyloidotic polyneuropathy disease. |
2002-08-09 |
2023-08-12 |
Not clear |
| Tara Nath Niraula, Katsuki Haraoka, Yukio Ando, Hua Li, Hiroaki Yamada, Kazuyuki Akasak. Decreased thermodynamic stability as a crucial factor for familial amyloidotic polyneuropathy. Journal of molecular biology. vol 320. issue 2. 2002-08-09. PMID:12079390. |
significant reduction of thermodynamic stability of wt ttr by mutation could be a crucial factor for familial amyloidotic polyneuropathy. |
2002-08-09 |
2023-08-12 |
Not clear |
| Kazunori Nanri, Hiroya Utsumi, Masahito Yamada, Yoshifumi Takata, Atsushi Matsumura, Kazusa Kougo, Shigeo Sekine, Daisaku Ogawa, Mitsuyasu Toyod. Transthyretin Val 107 in a Japanese patient with familial amyloid polyneuropathy. Journal of the neurological sciences. vol 198. issue 1-2. 2002-07-31. PMID:12039669. |
a 70-year-old japanese man with amyloid polyneuropathy associated with a val 107 transthyretin (ttr) mutation is reported. |
2002-07-31 |
2023-08-12 |
Not clear |
| I Cardoso, C S Goldsbury, S A Müller, V Olivieri, S Wirtz, A M Damas, U Aebi, M J Saraiv. Transthyretin fibrillogenesis entails the assembly of monomers: a molecular model for in vitro assembled transthyretin amyloid-like fibrils. Journal of molecular biology. vol 317. issue 5. 2002-05-15. PMID:11955017. |
extracellular accumulation of transthyretin (ttr) variants in the form of fibrillar amyloid deposits is the pathological hallmark of familial amyloidotic polyneuropathy (fap). |
2002-05-15 |
2023-08-12 |
Not clear |
| P Raghu, G Bhanuprakash Reddy, B Sivakuma. Inhibition of transthyretin amyloid fibril formation by 2,4-dinitrophenol through tetramer stabilization. Archives of biochemistry and biophysics. vol 400. issue 1. 2002-05-06. PMID:11913969. |
ttr amyloid fibril formation and deposition have been associated with several diseases like familial amyloid polyneuropathy and senile systemic amyloidosis. |
2002-05-06 |
2023-08-12 |
Not clear |
| Paulo Lisboa Bittencourt, Claudia Alves Couto, Alberto Queiroz Farias, Paulo Marchiori, Paulo Celso Bosco Massarollo, Sérgio Mie. Results of liver transplantation for familial amyloid polyneuropathy type I in Brazil. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. vol 8. issue 1. 2002-03-07. PMID:11799483. |
familial amyloid polyneuropathy type i (fap-i) is an inherited amyloidosis secondary to systemic deposition of amyloid fibrils containing mutant transthyretin (ttr) variants. |
2002-03-07 |
2023-08-12 |
Not clear |
| F Carvalho, M Sousa, S Fernandes, J Silva, M J Saraiva, A Barro. Preimplantation genetic diagnosis for familial amyloidotic polyneuropathy (FAP). Prenatal diagnosis. vol 21. issue 12. 2002-03-01. PMID:11746170. |
portuguese-type familial amyloidotic polyneuropathy (fap type i), is an autosomal dominant disease presenting an inherited mutation in the gene encoding the plasma protein transthyretin (ttr). |
2002-03-01 |
2023-08-12 |
Not clear |
| H Watanabe, K Misu, M Hirayama, N Hattori, T Yoshihara, M Doyu, G Sobu. Low cardiac 123I-MIBG uptake in late-onset familial amyloid polyneuropathy type I (TTR Met30). Journal of neurology. vol 248. issue 7. 2002-01-11. PMID:11518010. |
low cardiac 123i-mibg uptake in late-onset familial amyloid polyneuropathy type i (ttr met30). |
2002-01-11 |
2023-08-12 |
Not clear |
| M M Sousa, I Cardoso, R Fernandes, A Guimarães, M J Saraiv. Deposition of transthyretin in early stages of familial amyloidotic polyneuropathy: evidence for toxicity of nonfibrillar aggregates. The American journal of pathology. vol 159. issue 6. 2001-12-18. PMID:11733349. |
familial amyloidotic polyneuropathy (fap) is a neurodegenerative disorder characterized by extracellular deposition of transthyretin (ttr) amyloid fibrils, particularly in the peripheral nervous system. |
2001-12-18 |
2023-08-12 |
Not clear |
| C M Chung, L H Connors, M D Benson, M T Wals. Biophysical analysis of normal transthyretin: implications for fibril formation in senile systemic amyloidosis. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 8. issue 2. 2001-12-05. PMID:11409037. |
eighty-four variants of ttr have been identified and seventy-four are associated with familial amyloidotic polyneuropathy. |
2001-12-05 |
2023-08-12 |
Not clear |
| M M Sousa, S Du Yan, R Fernandes, A Guimaraes, D Stern, M J Saraiv. Familial amyloid polyneuropathy: receptor for advanced glycation end products-dependent triggering of neuronal inflammatory and apoptotic pathways. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 19. 2001-10-11. PMID:11567048. |
familial amyloid polyneuropathy (fap) is a neurodegenerative disorder associated with extracellular deposition of mutant transthyretin (ttr) amyloid fibrils, particularly in the peripheral nervous system. |
2001-10-11 |
2023-08-12 |
Not clear |