| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takashi Sato, Yukio Ando, Seiko Susuki, Fumi Mikami, Shinji Ikemizu, Masaaki Nakamura, Ole Suhr, Makoto Anraku, Toshiya Kai, Mary Ann Suico, Tsuyoshi Shuto, Mineyuki Mizuguchi, Yuriko Yamagata, Hirofumi Ka. Chromium(III) ion and thyroxine cooperate to stabilize the transthyretin tetramer and suppress in vitro amyloid fibril formation. FEBS letters. vol 580. issue 2. 2006-03-21. PMID:16386248. |
transthyretin (ttr) amyloid fibril formation, which is triggered by the dissociation of tetrameric ttr, appears to be the causative factor in familial amyloidotic polyneuropathy and senile systemic amyloidosis. |
2006-03-21 |
2023-08-12 |
Not clear |
| Ignacio Dolado, Joan Nieto, Maria João M Saraiva, Gemma Arsequell, Gregori Valencia, Antoni Plana. Kinetic assay for high-throughput screening of in vitro transthyretin amyloid fibrillogenesis inhibitors. Journal of combinatorial chemistry. vol 7. issue 2. 2006-02-08. PMID:15762752. |
stabilization of tetrameric transthyretin (ttr) by binding of small ligands is a current strategy aimed at inhibiting amyloid fibrillogenesis in transthyretin-associated pathologies, such as senile systemic amyloidosis (ssa) and familial amyloidotic polyneuropathy (fap). |
2006-02-08 |
2023-08-12 |
human |
| M R Almeida, L Gales, A M Damas, I Cardoso, M J Saraiv. Small transthyretin (TTR) ligands as possible therapeutic agents in TTR amyloidoses. Current drug targets. CNS and neurological disorders. vol 4. issue 5. 2006-01-23. PMID:16266291. |
in transthyretin (ttr) amyloidosis ttr variants deposit as amyloid fibrils giving origin, in most cases, to peripheral polyneuropathy, cardiomyopathy, carpal tunnel syndrome and/or amyloid deposition in the eye. |
2006-01-23 |
2023-08-12 |
Not clear |
| Takayuki Kurosawa, Shuichi Igarashi, Masatoyo Nishizawa, Osamu Onoder. Selective silencing of a mutant transthyretin allele by small interfering RNAs. Biochemical and biophysical research communications. vol 337. issue 3. 2005-12-15. PMID:16225852. |
familial amyloidotic polyneuropathy (fap) is a hereditary systemic amyloidosis caused by dominantly acting missense mutations in the gene encoding transthyretin (ttr). |
2005-12-15 |
2023-08-12 |
Not clear |
| Masaaki Nakamura, Yukio And. Applications of gene therapy for familial amyloidotic polyneuropathy. Expert opinion on biological therapy. vol 4. issue 10. 2005-12-13. PMID:15461573. |
familial amyloidotic polyneuropathy (fap), caused by mutated transthyretin (ttr), is the common form of hereditary generalised amyloidosis. |
2005-12-13 |
2023-08-12 |
Not clear |
| Yukio And. Liver transplantation and new therapeutic approaches for familial amyloidotic polyneuropathy (FAP). Medical molecular morphology. vol 38. issue 3. 2005-12-06. PMID:16170462. |
liver transplantation has been considered as a promising therapy to halt the progression of clinical symptoms in familial amyloidotic polyneuropathy (fap) because most transthyretin (ttr) is produced by the liver. |
2005-12-06 |
2023-08-12 |
mouse |
| Mónica Mendes Sousa, José Barbas do Amaral, António Guimarães, Maria João Saraiv. Up-regulation of the extracellular matrix remodeling genes, biglycan, neutrophil gelatinase-associated lipocalin, and matrix metalloproteinase-9 in familial amyloid polyneuropathy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 1. 2005-11-07. PMID:15536164. |
familial amyloid polyneuropathy (fap) is characterized by extracellular deposition of transthyretin (ttr) aggregates and amyloid fibrils, particularly in the peripheral nervous system (pns) and is accompanied with changes in connective tissue. |
2005-11-07 |
2023-08-12 |
Not clear |
| Takahiro Kawaji, Yukio Ando, Masaaki Nakamura, Keiichi Yamamoto, Eiko Ando, Akiomi Takano, Yasuya Inomata, Akira Hirata, Hidenobu Tanihar. Transthyretin synthesis in rabbit ciliary pigment epithelium. Experimental eye research. vol 81. issue 3. 2005-10-27. PMID:16129098. |
ocular symptoms of transthyretin (ttr)-related familial amyloidotic polyneuropathy (fap) suggest that ciliary pigment epithelium (cpe) may synthesize ttr and its ttr may lead to amyloid formation in addition to ttr from vessels and retinal pigment epithelium (rpe). |
2005-10-27 |
2023-08-12 |
rabbit |
| Mikael Lindgren, Karin Sörgjerd, Per Hammarströ. Detection and characterization of aggregates, prefibrillar amyloidogenic oligomers, and protofibrils using fluorescence spectroscopy. Biophysical journal. vol 88. issue 6. 2005-10-17. PMID:15764666. |
transthyretin (ttr) is a protein linked to a number of different amyloid diseases including senile systemic amyloidosis and familial amyloidotic polyneuropathy. |
2005-10-17 |
2023-08-12 |
Not clear |
| Yukio And. [Immunological and serological laboratory tests: transthyretin]. Rinsho byori. The Japanese journal of clinical pathology. vol 53. issue 6. 2005-09-13. PMID:16026084. |
however, ttr is also an anti-acute phase protein, and the concentration is influenced by various conditions, such as inflammation and infection, mutated forms of ttr are the precursor protein of familial amyloidotic polyneuropathy (fap). |
2005-09-13 |
2023-08-12 |
Not clear |
| F Salvi, F Pastorelli, R Plasmati, A Ferlini, G L Grazi, E Jovine, M Mascalchi, C A Tassinar. Early onset aggressive hereditary amyloidosis: report of an Italian family with TTR Arg47 mutation. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 26. issue 2. 2005-08-30. PMID:15995833. |
arg47 is a rare transthyretin-related (ttr) amyloidosis variant that is characterised by polyneuropathy and autonomic failure. |
2005-08-30 |
2023-08-12 |
Not clear |
| V M Almeida, P M Costa, P Moreira, J Gonçalves, J Brag. Birth of two healthy females after preimplantation genetic diagnosis for familial amyloid polyneuropathy. Reproductive biomedicine online. vol 10. issue 5. 2005-08-05. PMID:15949223. |
familial amyloid polyneuropathy (fap), portuguese type, is a late onset, high penetrance, autosomal dominant mendelian disorder caused by a v30m substitution in the transthyretin (ttr) protein. |
2005-08-05 |
2023-08-12 |
Not clear |
| Miguel L Soares, Teresa Coelho, Alda Sousa, Serge Batalov, Isabel Conceição, Maria L Sales-Luís, Marylyn D Ritchie, Scott M Williams, Caroline M Nievergelt, Nicholas J Schork, Maria João Saraiva, Joel N Buxbau. Susceptibility and modifier genes in Portuguese transthyretin V30M amyloid polyneuropathy: complexity in a single-gene disease. Human molecular genetics. vol 14. issue 4. 2005-07-12. PMID:15649951. |
familial amyloid polyneuropathy type i is an autosomal dominant disorder caused by mutations in the transthyretin (ttr) gene; however, carriers of the same mutation exhibit variability in penetrance and clinical expression. |
2005-07-12 |
2023-08-12 |
Not clear |
| Joakim Bergström, Asa Gustavsson, Ulf Hellman, Knut Sletten, Charles L Murphy, Deborah T Weiss, Alan Solomon, Bert-Ove Olofsson, Per Westermar. Amyloid deposits in transthyretin-derived amyloidosis: cleaved transthyretin is associated with distinct amyloid morphology. The Journal of pathology. vol 206. issue 2. 2005-07-05. PMID:15810051. |
the pathological fibrillar deposits found in the heart and other organs of patients with senile systemic amyloidosis (ssa) and swedish familial amyloidotic polyneuropathy (fap) contain wild-type (wt) and a mutant form of transthyretin (ttr), respectively. |
2005-07-05 |
2023-08-12 |
Not clear |
| Lan Wei, Hiroo Kawano, Xiaoying Fu, Dan Cui, Sadahiro Ito, Ken-ichi Yamamura, Tokuhiro Ishihara, Takahiko Tokuda, Keiichi Higuchi, Shuichiro Maed. Deposition of transthyretin amyloid is not accelerated by the same amyloid in vivo. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 11. issue 2. 2005-05-24. PMID:15478467. |
families with a variant transthyretin (ttr v30m)-associated familial amyloidotic polyneuropathy (fap) exhibit genetic anticipation, with ttr v30m-amyloid depositing at an earlier age in successive generations. |
2005-05-24 |
2023-08-12 |
mouse |
| Roberta Frigerio, Gian Maria Fabrizi, Moreno Ferrarini, Tiziana Cavallaro, Laura Brighina, Patrizia Santoro, Elio Agostoni, Guido Cavaletti, Nicolò Rizzuto, Carlo Ferrares. An unusual transthyretin gene missense mutation (TTR Phe33Val) linked to familial amyloidotic polyneuropathy. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 11. issue 2. 2005-05-24. PMID:15478468. |
an unusual transthyretin gene missense mutation (ttr phe33val) linked to familial amyloidotic polyneuropathy. |
2005-05-24 |
2023-08-12 |
Not clear |
| Roberta Frigerio, Gian Maria Fabrizi, Moreno Ferrarini, Tiziana Cavallaro, Laura Brighina, Patrizia Santoro, Elio Agostoni, Guido Cavaletti, Nicolò Rizzuto, Carlo Ferrares. An unusual transthyretin gene missense mutation (TTR Phe33Val) linked to familial amyloidotic polyneuropathy. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 11. issue 2. 2005-05-24. PMID:15478468. |
we report here the clinical and molecular characterization of a rare ttr missense mutation discovered in a young woman from macedonia, showing severe axonal sensory-motor polyneuropathy, restrictive cardiomyopathy and bilateral vitreous deposits. |
2005-05-24 |
2023-08-12 |
Not clear |
| Idalina Beirão, Luísa Lobato, Paulo M P Costa, Isabel Fonseca, Paula Mendes, Manuela Silva, Fernanda Bravo, António Cabrita, Graça Port. Kidney and anemia in familial amyloidosis type I. Kidney international. vol 66. issue 5. 2005-04-25. PMID:15496172. |
kidney and anemia in familial amyloidosis type i. familial amyloid polyneuropathy (fap) type i is caused by a mutated transthyretin (ttr v30m) and characterized by a sensorimotor and autonomic neuropathy. |
2005-04-25 |
2023-08-12 |
Not clear |
| Alexander L Schwarzman, Maria Tsiper, Henning Wente, Audrey Wang, Michael P Vitek, V Vasiliev, Dmitry Goldgabe. Amyloidogenic and anti-amyloidogenic properties of recombinant transthyretin variants. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 11. issue 1. 2005-03-10. PMID:15185492. |
most transthyretin (ttr) mutations lead to ttr amyloid depositions in patients with familial amyloidotic polyneuropathy and familial amyloidotic cardiomyopathy. |
2005-03-10 |
2023-08-12 |
Not clear |
| Elizabeth B Haagsma, Philip N Hawkins, Merrill D Benson, Helen J Lachmann, Alison Bybee, Bouke P Hazenber. Familial amyloidotic polyneuropathy with severe renal involvement in association with transthyretin Gly47Glu in Dutch, British and American-Finnish families. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 11. issue 1. 2005-03-10. PMID:15185498. |
familial amyloidotic polyneuropathy (fap) is an autosomal dominant disorder associated with more than 80 different transthyretin (ttr) mutations. |
2005-03-10 |
2023-08-12 |
Not clear |