| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emanuele Pilato, Andrea Dell'Amore, Luca Botta, Giorgio Arpesell. Combined heart and liver transplantation for familial amyloidotic neuropathy. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. vol 32. issue 1. 2007-10-02. PMID:17449267. |
familial amyloidotic polyneuropathy (fap) is an inherited disease characterized by an abnormal systemic deposition of a mutant protein called transthyretin (ttr) with elective involvement of the peripheral nervous system, but often determining cardiac, gastrointestinal, and urinary tract dysfunction. |
2007-10-02 |
2023-08-12 |
Not clear |
| Shizuyo Koide-Yoshida, Takeshi Niki, Mitsuharu Ueda, Shingo Himeno, Takahiro Taira, Sanae M M Iguchi-Ariga, Yukio Ando, Hiroyoshi Arig. DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy. International journal of molecular medicine. vol 19. issue 6. 2007-09-14. PMID:17487420. |
dj-1 has a protease-like structure and transthyretin (ttr), a protein causing familial amyloidotic polyneuropathy (fap), was identified as a substrate for dj-1 protease in this study. |
2007-09-14 |
2023-08-12 |
Not clear |
| Xu Hou, Marie-Isabel Aguilar, David H Smal. Transthyretin and familial amyloidotic polyneuropathy. Recent progress in understanding the molecular mechanism of neurodegeneration. The FEBS journal. vol 274. issue 7. 2007-07-31. PMID:17381508. |
familial amyloidotic polyneuropathy (fap) is an inherited autosomal dominant disease that is commonly caused by accumulation of deposits of transthyretin (ttr) amyloid around peripheral nerves. |
2007-07-31 |
2023-08-12 |
Not clear |
| Kyotaro Uotani, Akihiro Kawata, Masahiro Nagao, Toshio Mizutani, Hideaki Hayash. Trigger finger as an initial manifestation of familial amyloid polyneuropathy in a patient with Ile107Val TTR. Internal medicine (Tokyo, Japan). vol 46. issue 8. 2007-06-14. PMID:17443043. |
trigger finger as an initial manifestation of familial amyloid polyneuropathy in a patient with ile107val ttr. |
2007-06-14 |
2023-08-12 |
Not clear |
| Xu Hou, Helena C Parkington, Harold A Coleman, Adam Mechler, Lisandra L Martin, Marie-Isabel Aguilar, David H Smal. Transthyretin oligomers induce calcium influx via voltage-gated calcium channels. Journal of neurochemistry. vol 100. issue 2. 2007-03-06. PMID:17076759. |
the deposition of transthyretin (ttr) amyloid in the pns is a major pathological feature of familial amyloidotic polyneuropathy. |
2007-03-06 |
2023-08-12 |
human |
| M Yazaki, S Mitsuhashi, T Tokuda, F Kametani, Y-I Takei, J Koyama, A Kawamorita, H Kanno, S-I Iked. Progressive wild-type transthyretin deposition after liver transplantation preferentially occurs onto myocardium in FAP patients. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. vol 7. issue 1. 2007-03-05. PMID:17061984. |
to elucidate whether progressive wild-type transthyretin (ttr) deposition can actually occur after liver transplantation (lt), amyloid fibrils were investigated in two familial amyloid polyneuropathy patients with ttr val30leu variant, who died 1 year after lt. amyloid fibrils were extracted from cardiac muscles, sciatic nerves and kidney, which were investigated by the immunoprecipitation-mass spectrometry method and liquid chromatography-ion trap mass spectrometry analysis. |
2007-03-05 |
2023-08-12 |
Not clear |
| Kana Tojo, Yoshiki Sekijima, Jeffery W Kelly, Shu-ichi Iked. Diflunisal stabilizes familial amyloid polyneuropathy-associated transthyretin variant tetramers in serum against dissociation required for amyloidogenesis. Neuroscience research. vol 56. issue 4. 2007-01-17. PMID:17028027. |
transthyretin (ttr) tetramer dissociation, misfolding and misassembly are required for the process of amyloid fibril formation associated with familial amyloid polyneuropathy (fap). |
2007-01-17 |
2023-08-12 |
human |
| Pedro Filipe Teixeira, Filipe Cerca, Sofia D Santos, Maria João Saraiv. Endoplasmic reticulum stress associated with extracellular aggregates. Evidence from transthyretin deposition in familial amyloid polyneuropathy. The Journal of biological chemistry. vol 281. issue 31. 2006-10-16. PMID:16751191. |
the hallmark of familial amyloid polyneuropathy (fap) is the presence of extracellular deposits of transthyretin (ttr) aggregates and amyloid fibers in several tissues, particularly in the peripheral nervous system. |
2006-10-16 |
2023-08-12 |
Not clear |
| Mitsuharu Ueda, Yukio And. [Application to transthyretin analysis]. Rinsho byori. The Japanese journal of clinical pathology. vol 54. issue 6. 2006-09-15. PMID:16872010. |
transthyretin (ttr) is the precursor protein of familial amyloidotic polyneuropathy (fap) and senile systemic amyloidosis (ssa). |
2006-09-15 |
2023-08-12 |
Not clear |
| Anna Mazzeo, Antonio Toscano, Maria L Stromillo, Marco Battaglini, Corrado Messina, Antonio Federico, Giuseppe Vita, Nicola De Stefan. Diffuse metabolic changes in the brain of patients with familial amyloid polyneuropathy. A proton MRSI study. Journal of the neurological sciences. vol 246. issue 1-2. 2006-08-10. PMID:16530227. |
to assess brain metabolic abnormalities in patients with familial amyloid polyneuropathy (fap) due to the transthyretin (ttr) gene mutations. |
2006-08-10 |
2023-08-12 |
Not clear |
| Filipe Almeida Monteiro, Isabel Cardoso, Mónica Mendes Sousa, Maria João Saraiv. In vitro inhibition of transthyretin aggregate-induced cytotoxicity by full and peptide derived forms of the soluble receptor for advanced glycation end products (RAGE). FEBS letters. vol 580. issue 14. 2006-07-27. PMID:16716307. |
familial amyloidotic polyneuropathy is a neurodegenerative disorder characterized by systemic extracellular deposition of transthyretin (ttr) amyloid fibrils. |
2006-07-27 |
2023-08-12 |
mouse |
| Eurico Morais-de-Sá, Ricardo Miguel Neto-Silva, Pedro J B Pereira, Maria J Saraiva, Ana M Dama. The binding of 2,4-dinitrophenol to wild-type and amyloidogenic transthyretin. Acta crystallographica. Section D, Biological crystallography. vol 62. issue Pt 5. 2006-07-05. PMID:16627944. |
systemic deposition of transthyretin (ttr) amyloid fibrils is always observed in familial amyloidotic polyneuropathy, senile systemic amyloidosis and familial amyloidotic cardiomyopathy patients. |
2006-07-05 |
2023-08-12 |
human |
| Paola Rimessi, Pietro Spitali, Yukio Ando, Vincenzo Mazzaferro, Francesca Pastorelli, Carlo Alberto Tassinari, Elisa Calzolari, Fabrizio Salvi, Alessandra Ferlin. Transthyretin RNA profiling in livers from transplanted patients affected by familial amyloidotic polyneuropathy, and identification of a dual transcription start point. Liver international : official journal of the International Association for the Study of the Liver. vol 26. issue 2. 2006-06-15. PMID:16448460. |
mutations in the transthyretin (ttr) gene cause familial amyloidotic polyneuropathy (fap), an autosomal dominant peripheral neuropathy, often associated with cardiomyopathy. |
2006-06-15 |
2023-08-12 |
human |
| Antonino Biroccio, Piero Del Boccio, Marta Panella, Sergio Bernardini, Carmine Di Ilio, Domenico Gambi, Paolo Stanzione, Paolo Sacchetta, Giorgio Bernardi, Alessandro Martorana, Giorgio Federici, Alessandro Stefani, Andrea Urban. Differential post-translational modifications of transthyretin in Alzheimer's disease: a study of the cerebral spinal fluid. Proteomics. vol 6. issue 7. 2006-06-13. PMID:16552785. |
ttr can bind to the beta-amyloid peptide and a number of familial amyloidosis diseases (familial amyloid polyneuropathy) have been associated with its allele variants. |
2006-06-13 |
2023-08-12 |
mouse |
| Manuel E Zeledon R, Yukio Ando, Katsuhiro Asonuma, Masaaki Nakamura, Xuguo Sun, Mitsuharu Ueda, Junko Fujii, Yukihiro Inomat. Effect of tacrolimus and partial hepatectomy on transthyretin metabolism in rats. Transplant international : official journal of the European Society for Organ Transplantation. vol 19. issue 3. 2006-05-25. PMID:16441773. |
liver transplantation, which serves as treatment of familial amyloidotic polyneuropathy (fap), and domino liver transplantation, which utilizes resected livers from patients with fap for treatment of liver diseases, may induce changes in transthyretin (ttr), a pathogenic fap-related protein. |
2006-05-25 |
2023-08-12 |
rat |
| F A Monteiro, M M Sousa, I Cardoso, J Barbas do Amaral, A Guimarães, M J Saraiv. Activation of ERK1/2 MAP kinases in familial amyloidotic polyneuropathy. Journal of neurochemistry. vol 97. issue 1. 2006-05-18. PMID:16515552. |
familial amyloidotic polyneuropathy (fap) is a neurodegenerative disorder characterized by the extracellular deposition of transthyretin (ttr), especially in the pns. |
2006-05-18 |
2023-08-12 |
mouse |
| Nora S Green, Ted R Foss, Jeffery W Kell. Genistein, a natural product from soy, is a potent inhibitor of transthyretin amyloidosis. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 41. 2006-04-20. PMID:16195386. |
the misfolding of transthyretin (ttr), including rate-limiting tetramer dissociation and partial monomer denaturation, is sufficient for ttr misassembly into amyloid and other abnormal quaternary structures associated with three amyloid diseases: senile systemic amyloidosis, familial amyloid polyneuropathy, and familial amyloid cardiomyopathy. |
2006-04-20 |
2023-08-12 |
Not clear |
| Nora S Green, Ted R Foss, Jeffery W Kell. Genistein, a natural product from soy, is a potent inhibitor of transthyretin amyloidosis. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 41. 2006-04-20. PMID:16195386. |
genistein also inhibits the amyloidogenesis of the most common familial amyloid polyneuropathy and familial amyloid cardiomyopathy mutations in ttr: v30m and v122i, respectively. |
2006-04-20 |
2023-08-12 |
Not clear |
| Hisayasu Terazaki, Yukio Ando, Rui Fernandes, Ken-ichi Yamamura, Shuichiro Maeda, Maria J Saraiv. Immunization in familial amyloidotic polyneuropathy: counteracting deposition by immunization with a Y78F TTR mutant. Laboratory investigation; a journal of technical methods and pathology. vol 86. issue 1. 2006-03-28. PMID:16357867. |
immunization in familial amyloidotic polyneuropathy: counteracting deposition by immunization with a y78f ttr mutant. |
2006-03-28 |
2023-08-12 |
mouse |
| Hisayasu Terazaki, Yukio Ando, Rui Fernandes, Ken-ichi Yamamura, Shuichiro Maeda, Maria J Saraiv. Immunization in familial amyloidotic polyneuropathy: counteracting deposition by immunization with a Y78F TTR mutant. Laboratory investigation; a journal of technical methods and pathology. vol 86. issue 1. 2006-03-28. PMID:16357867. |
the mechanism of amyloid formation in familial amyloidotic polyneuropathy (fap), a hereditary disorder associated with mutant transthyretin (ttr), is still unknown. |
2006-03-28 |
2023-08-12 |
mouse |