| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Rui Rodrigues, Carlos J V Simões, Cândida G Silva, Rui M M Brit. Potentially amyloidogenic conformational intermediates populate the unfolding landscape of transthyretin: insights from molecular dynamics simulations. Protein science : a publication of the Protein Society. vol 19. issue 2. 2010-03-15. PMID:19937650. |
transthyretin (ttr), a homotetrameric plasma protein, is known to be the causative agent of amyloid pathologies such as fap (familial amyloid polyneuropathy), fac (familial amyloid cardiomiopathy) and ssa (senile systemic amyloidosis). |
2010-03-15 |
2023-08-12 |
Not clear |
| R Niemczyk, J Brydak-Godowska, D Kecik, T Wagner, P Lewandowski, M Kecik, D Zygier, U Ołdakowska-Jedyna. Vitreous amyloidosis in two sisters as the indication of transthyretin-related familial form of systemic amyloidosis among liver transplantation candidates. Transplantation proceedings. vol 41. issue 8. 2010-03-01. PMID:19857683. |
vitreous amyloidosis, a rare condition characteristic of the familial form of systemic amyloidosis with polyneuropathy, is caused by a mutation in the transthyretin (ttr) gene. |
2010-03-01 |
2023-08-12 |
Not clear |
| Yohei Misumi, Yukio Ando, Mitsuharu Ueda, Konen Obayashi, Hirofumi Jono, Yu Su, Taro Yamashita, Makoto Uchin. Chain reaction of amyloid fibril formation with induction of basement membrane in familial amyloidotic polyneuropathy. The Journal of pathology. vol 219. issue 4. 2010-02-22. PMID:19790249. |
familial amyloidotic polyneuropathy (fap) is characterized by extracellular deposition of amyloid fibrils caused by a point mutation in the transthyretin (ttr) gene. |
2010-02-22 |
2023-08-12 |
Not clear |
| Nelson Ferreira, Isabel Cardoso, Maria Rosário Domingues, Rui Vitorino, Margarida Bastos, Guangyue Bai, Maria João Saraiva, Maria Rosário Almeid. Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity. FEBS letters. vol 583. issue 22. 2010-01-15. PMID:19861125. |
these findings together with the low toxicity of the compound raise the possibility of using egcg in a therapeutic approach for familial amyloidotic polyneuropathy, the most frequent form of hereditary ttr amyloidosis. |
2010-01-15 |
2023-08-12 |
Not clear |
| Carolina Estima Fleming, Ana Filipa Nunes, Mónica Mendes Sous. Transthyretin: more than meets the eye. Progress in neurobiology. vol 89. issue 3. 2010-01-12. PMID:19665514. |
when mutated, ttr is also well-described as the cause of familial amyloid polyneuropathy, a neurodegenerative lethal disorder characterized by systemic deposition of ttr amyloid fibrils, particularly in the peripheral nervous system. |
2010-01-12 |
2023-08-12 |
Not clear |
| A Bersano, R Del Bo, E Ballabio, C Cinnante, S Lanfranconi, G P Comi, P Baron, N Bresolin, L Candelis. Transthyretin Asn90 variant: amyloidogenic or non-amyloidogenic role. Journal of the neurological sciences. vol 284. issue 1-2. 2009-12-15. PMID:19428025. |
although ttr mutations were mostly associated with familial amyloid polyneuropathy (fap), these molecular variants were also found in patients with recurrent stroke, subarachnoidal bleeding and radiological findings of cerebral, cerebellar, cortical-subcortical infarctions and hemosiderosis. |
2009-12-15 |
2023-08-12 |
human |
| Efthimios Dardiotis, Pantelitsa Koutsou, Eleni Zamba-Papanicolaou, Ilia Vonta, Marilena Hadjivassiliou, Georgios Hadjigeorgiou, Marios Cariolou, Kyproula Christodoulou, Theodoros Kyriakide. Complement C1Q polymorphisms modulate onset in familial amyloidotic polyneuropathy TTR Val30Met. Journal of the neurological sciences. vol 284. issue 1-2. 2009-12-15. PMID:19493541. |
complement c1q polymorphisms modulate onset in familial amyloidotic polyneuropathy ttr val30met. |
2009-12-15 |
2023-08-12 |
Not clear |
| Efthimios Dardiotis, Pantelitsa Koutsou, Eleni Zamba-Papanicolaou, Ilia Vonta, Marilena Hadjivassiliou, Georgios Hadjigeorgiou, Marios Cariolou, Kyproula Christodoulou, Theodoros Kyriakide. Complement C1Q polymorphisms modulate onset in familial amyloidotic polyneuropathy TTR Val30Met. Journal of the neurological sciences. vol 284. issue 1-2. 2009-12-15. PMID:19493541. |
familial amyloidotic polyneuropathy (fap) ttr val30met is a lethal autosomal dominant sensorimotor and autonomic neuropathy due to a substitution of methionine for valine at position 30 of the transthyretin (ttr) gene. |
2009-12-15 |
2023-08-12 |
Not clear |
| Cláudia Vaz, Maura Couto, Cátia Duarte, Maria João Salvador, Luís Inês, Armando Malcat. [An unusual case of generalized pain: paramyloidosis simulating fibromyalgia]. Acta reumatologica portuguesa. vol 34. issue 2B. 2009-11-30. PMID:19727056. |
the search for ttr met 30 was positive, confirming the diagnosis of familial amyloidotic polyneuropathy. |
2009-11-30 |
2023-08-12 |
Not clear |
| Carolina E Fleming, Fernando Milhazes Mar, Filipa Franquinho, Mónica M Sous. Chapter 17: Transthyretin: an enhancer of nerve regeneration. International review of neurobiology. vol 87. 2009-10-06. PMID:19682646. |
under pathological conditions, various ttr mutations are related to familial amyloid polyneuropathy (fap), a neurodegenerative disorder characterized by deposition of ttr amyloid fibrils, particularly in the peripheral nervous system (pns), leading to axonal loss and neuronal death. |
2009-10-06 |
2023-08-12 |
Not clear |
| Ko-Woon Lee, Dong-Hoon Lee, Hosun Son, Yoon-Sook Kim, Jae-Yong Park, Gu-Seob Roh, Hyun-Joon Kim, Sang-Soo Kang, Gyeong-Jae Cho, Wan-Sung Cho. Clusterin regulates transthyretin amyloidosis. Biochemical and biophysical research communications. vol 388. issue 2. 2009-09-21. PMID:19664600. |
transthyretin (ttr) is a human disease-associated amyloidogenic protein that has been implicated in senile systemic amyloidosis (ssa) and familial amyloidotic polyneuropathy (fap). |
2009-09-21 |
2023-08-12 |
human |
| Gladys Pérez, María Cristina Romero, Pedro Trigo, Javier Lendoire, Oscar Imventarza, Alcira Ness. [Diagnosis of familial amyloid polyneuropathy type I in Argentina]. Medicina. vol 68. issue 4. 2009-07-24. PMID:18786882. |
familial amyloid polyneuropathy (fap) is an autosomal dominant inherited disease, characterized by systemic deposition of amyloid fibrils in various tissues, especially in peripheral nerves, being a variant of transthyretin (ttr) the principal component of amyloid fibrils. |
2009-07-24 |
2023-08-12 |
Not clear |
| Gladys Pérez, María Cristina Romero, Pedro Trigo, Javier Lendoire, Oscar Imventarza, Alcira Ness. [Diagnosis of familial amyloid polyneuropathy type I in Argentina]. Medicina. vol 68. issue 4. 2009-07-24. PMID:18786882. |
among many mutations that have been found in the ttr gene, the variant with a single amino acid substitution of methionine for valine at position 30 (ttr val30met) is the responsible of the portuguese-type familial amyloidotic polyneuropathy (fap type i). |
2009-07-24 |
2023-08-12 |
Not clear |
| M A C Saporta, C Zaros, M W Cruz, C André, M Misrahi, C Bonaïti-Pellié, V Planté-Bordeneuv. Penetrance estimation of TTR familial amyloid polyneuropathy (type I) in Brazilian families. European journal of neurology. vol 16. issue 3. 2009-07-09. PMID:19364362. |
penetrance estimation of ttr familial amyloid polyneuropathy (type i) in brazilian families. |
2009-07-09 |
2023-08-12 |
Not clear |
| M A C Saporta, C Zaros, M W Cruz, C André, M Misrahi, C Bonaïti-Pellié, V Planté-Bordeneuv. Penetrance estimation of TTR familial amyloid polyneuropathy (type I) in Brazilian families. European journal of neurology. vol 16. issue 3. 2009-07-09. PMID:19364362. |
familial amyloid polyneuropathy (fap) type i is a severe autosomal dominant inherited neuropathy associated with mutations in the transthyretin (ttr) gene. |
2009-07-09 |
2023-08-12 |
Not clear |
| Noboru Hanyu, Toshio Shimizu, Kazuyoshi Yamauchi, Nobuo Okumura, Hiroya Hidak. Characterization of cysteine and homocysteine bound to human serum transthyretin. Clinica chimica acta; international journal of clinical chemistry. vol 403. issue 1-2. 2009-07-06. PMID:19361464. |
cysteine-bound transthyretin (ttr) in serum is believed to be associated with deposition of amyloid in familial amyloidotic polyneuropathy (fap). |
2009-07-06 |
2023-08-12 |
human |
| Yukio And. [Transthyretin: it's miracle function and pathogenesis]. Rinsho byori. The Japanese journal of clinical pathology. vol 57. issue 3. 2009-06-25. PMID:19363993. |
since ttr is a highly amyloidogenic protein because it contains a beta-sheet structure, it becomes a precursor protein in familial amyloidotic polyneuropathy(fap). |
2009-06-25 |
2023-08-12 |
Not clear |
| Mitsuharu Ueda, Yohei Misumi, Mineyuki Mizuguchi, Masaaki Nakamura, Taro Yamashita, Yoshiki Sekijima, Kazutoshi Ota, Satoru Shinriki, Hirofumi Jono, Shu-ichi Ikeda, Ole B Suhr, Yukio And. SELDI-TOF mass spectrometry evaluation of variant transthyretins for diagnosis and pathogenesis of familial amyloidotic polyneuropathy. Clinical chemistry. vol 55. issue 6. 2009-06-19. PMID:19372189. |
mass spectrometric analyses are valuable for detection of transthyretin (ttr) variants, which cause familial amyloidotic polyneuropathy (fap). |
2009-06-19 |
2023-08-12 |
Not clear |
| Xuguo Sun, Mitsuharu Ueda, Taro Yamashita, Masaaki Nakamura, Joakim Bergström, Manuel E Zeledon Ramirez, Miyo Okajima, Shogo Misumi, Shozo Shoji, Yoshihiro Motomiya, Yukio And. Lipid droplets are present in amyloid deposits in familial amyloidotic polyneuropathy and dialysis related amyloidosis. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 13. issue 1. 2009-06-02. PMID:16690496. |
it has been well documented that transthyretin (ttr) shows an affinity for lipoproteins and amyloid is deposited around adipocytes in patients with familial amyloidotic polyneuropathy (fap). |
2009-06-02 |
2023-08-12 |
Not clear |
| Mitsuharu Ueda, Yukio Ando, Katsuki Haraoka, Shoichi Katsuragi, Yasuhiro Terasaki, Mineharu Sugimoto, Xuguo Sun, Makoto Uchin. Aging and transthyretin-related amyloidosis: pathologic examinations in pulmonary amyloidosis. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 13. issue 1. 2009-06-02. PMID:16690497. |
although aging is closely related with the onset of senile systemic amyloidosis (ssa) caused by wild-type transthyretin (ttr), the effect of aging on amyloid formation has remained unclear in familial amyloidotic polyneuropathy (fap), caused by variant- and wild-type ttr. |
2009-06-02 |
2023-08-12 |
Not clear |