| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David A Bateman, Robert Tycko, Reed B Wickne. Experimentally derived structural constraints for amyloid fibrils of wild-type transthyretin. Biophysical journal. vol 101. issue 10. 2012-03-20. PMID:22098747. |
ttr mutants lead to familial amyloidotic polyneuropathy and familial amyloid cardiomyopathy, with an earlier age of onset. |
2012-03-20 |
2023-08-12 |
Not clear |
| David A Bateman, Robert Tycko, Reed B Wickne. Experimentally derived structural constraints for amyloid fibrils of wild-type transthyretin. Biophysical journal. vol 101. issue 10. 2012-03-20. PMID:22098747. |
studies of amyloid fibrils of familial amyloidotic polyneuropathy mutant ttr suggest a structure similar to the native state with only a simple opening of a β-strand-loop-strand region exposing the two main β-sheets of the protein for fibril elongation. |
2012-03-20 |
2023-08-12 |
Not clear |
| Jing-Yao Liu, Ying-Jie Guo, Chun-Kui Zhou, Yu-Qin Ye, Jun-Qiang Feng, Fei Yin, Xin-Mei Jian. Clinical and histopathological features of familial amyloidotic polyneuropathy with transthyretin Val30Ala in a Chinese family. Journal of the neurological sciences. vol 304. issue 1-2. 2012-03-06. PMID:21397913. |
familial amyloidotic polyneuropathy (fap) is characterized by extracellular deposition of amyloid fibrils caused by a point mutation in the transthyretin (ttr) gene. |
2012-03-06 |
2023-08-12 |
Not clear |
| Gonçalo da Costa, Ricardo A Gomes, Ana Guerreiro, Élia Mateus, Estela Monteiro, Eduardo Barroso, Ana V Coelho, Ana Ponces Freire, Carlos Cordeir. Beyond genetic factors in familial amyloidotic polyneuropathy: protein glycation and the loss of fibrinogen's chaperone activity. PloS one. vol 6. issue 10. 2012-02-24. PMID:22053176. |
familial amyloidotic polyneuropathy (fap) is a systemic conformational disease characterized by extracellular amyloid fibril formation from plasma transthyretin (ttr). |
2012-02-24 |
2023-08-12 |
Not clear |
| Joana Magalhães, Maria João Saraiv. Clusterin overexpression and its possible protective role in transthyretin deposition in familial amyloidotic polyneuropathy. Journal of neuropathology and experimental neurology. vol 70. issue 12. 2012-02-10. PMID:22082661. |
we investigated the localization and potential functions of clusterin in familial amyloidotic polyneuropathy (fap), a neurodegenerative disorder characterized by extracellular deposition of mutant transthyretin (ttr) in the peripheral nervous system. |
2012-02-10 |
2023-08-12 |
mouse |
| Violaine Planté-Bordeneuve, Gerard Sai. Familial amyloid polyneuropathy. The Lancet. Neurology. vol 10. issue 12. 2012-01-16. PMID:22094129. |
ttr fap typically causes a nerve length-dependent polyneuropathy that starts in the feet with loss of temperature and pain sensations, along with life-threatening autonomic dysfunction leading to cachexia and death within 10 years on average. |
2012-01-16 |
2023-08-12 |
Not clear |
| Takuya Yamamoto, Kei Muto, Masato Komiyama, Jérôme Canivet, Junichiro Yamaguchi, Kenichiro Itam. Nickel-catalyzed C-H arylation of azoles with haloarenes: scope, mechanism, and applications to the synthesis of bioactive molecules. Chemistry (Weinheim an der Bergstrasse, Germany). vol 17. issue 36. 2011-12-28. PMID:21744407. |
this newly developed methodology has been successfully applied to the syntheses of febuxostat (a xanthine oxidase inhibitor that is effective for the treatment of gout and hyperuricemia), tafamidis (effective for the treatment of ttr amyloid polyneuropathy), and texaline (a natural product having antitubercular activity). |
2011-12-28 |
2023-08-12 |
Not clear |
| Sung-Tsang Hsie. Amyloid neuropathy with transthyretin mutations: overview and unique Ala97Ser in Taiwan. Acta neurologica Taiwanica. vol 20. issue 2. 2011-12-27. PMID:21739396. |
our studies indicated that the mutation of ttr at ala97ser (ttr ala97ser) was a new mutation only reported in ethnic taiwanese, and this mutation accounted for the most frequent etiology of adult-onset pan-modality (involving motor, sensory, and autonomic components of peripheral nerves) polyneuropathy with the pathology of axonal degeneration type. |
2011-12-27 |
2023-08-12 |
Not clear |
| L Lobato, I Beirão, R Seca, H Pessegueiro, M J Rocha, J Queiroz, M Gomes, A C Henriques, M Teixeira, R Almeid. Combined liver-kidney transplantation in familial amyloidotic polyneuropathy TTR V30M: nephrological assessment. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 18 Suppl 1. 2011-11-15. PMID:21838483. |
combined liver-kidney transplantation in familial amyloidotic polyneuropathy ttr v30m: nephrological assessment. |
2011-11-15 |
2023-08-12 |
Not clear |
| Tomoe Kugimiya, Hirofumi Jono, Shiori Saito, Toru Maruyama, Daisuke Kadowaki, Yohei Misumi, Yoshinobu Hoshii, Masayoshi Tasaki, Yu Su, Mitsuharu Ueda, Konen Obayashi, Makoto Shono, Masaki Otagiri, Yukio And. Loss of functional albumin triggers acceleration of transthyretin amyloid fibril formation in familial amyloidotic polyneuropathy. Laboratory investigation; a journal of technical methods and pathology. vol 91. issue 8. 2011-09-23. PMID:21537325. |
transthyretin (ttr)-related familial amyloidotic polyneuropathy (fap) is characterized by systemic accumulation of amyloid fibrils caused by a point mutation in the ttr gene. |
2011-09-23 |
2023-08-12 |
human |
| Hirofumi Jono, Takayuki Anno, Keiichi Motoyama, Yohei Misumi, Masayoshi Tasaki, Toshinori Oshima, Yoshimasa Mori, Mineyuki Mizuguchi, Mitsuharu Ueda, Makoto Shono, Konen Obayashi, Hidetoshi Arima, Yukio And. Cyclodextrin, a novel therapeutic tool for suppressing amyloidogenic transthyretin misfolding in transthyretin-related amyloidosis. The Biochemical journal. vol 437. issue 1. 2011-08-30. PMID:21668413. |
ttr (transthyretin), a β-sheet-rich protein, is the precursor protein of familial amyloidotic polyneuropathy and senile systemic amyloidosis. |
2011-08-30 |
2023-08-12 |
human |
| Haruki Koike, Rina Hashimoto, Minoru Tomita, Yuichi Kawagashira, Masahiro Iijima, Fumiaki Tanaka, Gen Sobu. Diagnosis of sporadic transthyretin Val30Met familial amyloid polyneuropathy: a practical analysis. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 18. issue 2. 2011-08-22. PMID:21463231. |
transthyretin (ttr) val30met-associated familial amyloid polyneuropathy (fap attr val30met) is the most common form of fap and is now prevalent in areas other than those seen within conventional endemic foci. |
2011-08-22 |
2023-08-12 |
Not clear |
| Robert J Gasperini, Xu Hou, Helena Parkington, Harry Coleman, David W Klaver, Adele J Vincent, Lisa C Foa, David H Smal. TRPM8 and Nav1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons. Molecular neurodegeneration. vol 6. issue 1. 2011-07-14. PMID:21375738. |
familial amyloidotic polyneuropathy (fap) is a peripheral neuropathy caused by the extracellular accumulation and deposition of insoluble transthyretin (ttr) aggregates. |
2011-07-14 |
2023-08-12 |
Not clear |
| Taro Yamashita, Yukio Ando, Makoto Uchin. [Familial amyloid polyneuropathy]. Brain and nerve = Shinkei kenkyu no shinpo. vol 63. issue 6. 2011-07-08. PMID:21613661. |
familial amyloid polyneuropathy (fap), a fatal disorder inherited in an autosomal dominant fashion, is characterized by systemic accumulation of polymerized transthyretin (ttr) in the peripheral nerves and systemic organs. |
2011-07-08 |
2023-08-12 |
Not clear |
| Malgorzata Pokrzywa, Ingrid Dacklin, Monika Vestling, Dan Hultmark, Erik Lundgren, Rafael Canter. Uptake of aggregating transthyretin by fat body in a Drosophila model for TTR-associated amyloidosis. PloS one. vol 5. issue 12. 2011-07-05. PMID:21179560. |
a functional link has been established between the severe neurodegenerative disorder familial amyloidotic polyneuropathy and the enhanced propensity of the plasma protein transthyretin (ttr) to form aggregates in patients with single point mutations in the ttr gene. |
2011-07-05 |
2023-08-12 |
human |
| A Rocha, L Lobato, H Silva, I Beirão, J Santos, H Pessegueiro, R Almeida, A Cabrit. Characterization of end-stage renal disease after liver transplantation in transthyretin amyloidosis (ATTR V30M). Transplantation proceedings. vol 43. issue 1. 2011-05-31. PMID:21335185. |
transthyretin (ttr) amyloidosis, an autosomal-dominant disease, is characterized by peripheral and autonomic neuropathy--familial amyloidotic polyneuropathy (fap). |
2011-05-31 |
2023-08-12 |
human |
| Gonçalo da Costa, Ana Guerreiro, Catarina F Correia, Ricardo J Gomes, António Freire, Estela Monteiro, Eduardo Barroso, Ana V Coelho, Tiago F Outeiro, Ana Ponces Freire, Carlos Cordeir. A non-invasive method based on saliva to characterize transthyretin in familial amyloidotic polyneuropathy patients using FT-ICR high-resolution MS. Proteomics. Clinical applications. vol 4. issue 6-7. 2011-05-06. PMID:21179887. |
a non-invasive method based on saliva to characterize transthyretin in familial amyloidotic polyneuropathy patients using ft-icr high-resolution ms. to identify, characterize and perform a relative quantification of human transthyretin (ttr) variants in human saliva. |
2011-05-06 |
2023-08-12 |
human |
| Masato Asahina, Yuichi Akaogi, Sonoko Misawa, Kazuaki Kanai, Yukio Ando, Ryuji Sakakibara, Kimihito Arai, Takamichi Hattori, Satoshi Kuwabar. Sensorimotor manifestations without autonomic symptoms in two siblings with TTR Val107 familial amyloid polyneuropathy. Clinical neurology and neurosurgery. vol 113. issue 2. 2011-05-04. PMID:20943310. |
sensorimotor manifestations without autonomic symptoms in two siblings with ttr val107 familial amyloid polyneuropathy. |
2011-05-04 |
2023-08-12 |
Not clear |
| Shukuro Araki, Yukio And. Transthyretin-related familial amyloidotic polyneuropathy-Progress in Kumamoto, Japan (1967-2010)-. Proceedings of the Japan Academy. Series B, Physical and biological sciences. vol 86. issue 7. 2011-04-18. PMID:20689228. |
the authors reviewed contribution of kumamoto university group to the progress of the studies on transthyretin (ttr)-related familial amyloidotic polyneuropathy (ttr-related fap) for 42 years (from 1967 to 2009). |
2011-04-18 |
2023-08-12 |
Not clear |
| Laura Lladó, Carme Baliellas, Carlos Casasnovas, Isidre Ferrer, Joan Fabregat, Emilio Ramos, Jose Castellote, Jaume Torras, Xavier Xiol, Antoni Rafeca. Risk of transmission of systemic transthyretin amyloidosis after domino liver transplantation. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. vol 16. issue 12. 2011-03-31. PMID:21117248. |
recent reports of the transmission of systemic transthyretin (ttr) amyloidosis after domino liver transplantation (dlt) using grafts from patients with familial amyloid polyneuropathy (fap) have raised concerns about the procedure. |
2011-03-31 |
2023-08-12 |
Not clear |