| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kazuaki Taguchi, Hirofumi Jono, Tomoe Kugimiya-Taguchi, Saori Nagao, Yu Su, Keishi Yamasaki, Mineyuki Mizuguchi, Toru Maruyama, Yukio Ando, Masaki Otagir. Effect of albumin on transthyretin and amyloidogenic transthyretin Val30Met disposition and tissue deposition in familial amyloidotic polyneuropathy. Life sciences. vol 93. issue 25-26. 2014-01-30. PMID:24211615. |
transthyretin (ttr)-related familial amyloidotic polyneuropathy (fap) is characterized by the systemic accumulation of amyloid fibrils caused by amyloidogenic. |
2014-01-30 |
2023-08-12 |
Not clear |
| Jean-Pascal Lefaucheur, Sophie Ng Wing Tin, Philippe Kerschen, Thibaud Damy, Violaine Planté-Bordeneuv. Neurophysiological markers of small fibre neuropathy in TTR-FAP mutation carriers. Journal of neurology. vol 260. issue 6. 2014-01-15. PMID:23306657. |
individuals carrying the amyloidogenic transthyretin (ttr) mutation are predisposed to develop familial amyloid polyneuropathy (fap). |
2014-01-15 |
2023-08-12 |
Not clear |
| Ming-Feng Liao, Hong-Shiu Chan. A novel variant mutation of transthyretin Ile73Val-related amyloidotic polyneuropathy in Taiwanese. Acta neurologica Taiwanica. vol 22. issue 2. 2014-01-14. PMID:24030042. |
we reported here the first patient of amyloidotic polyneuropathy with ile73val ttr mutation in taiwan. |
2014-01-14 |
2023-08-12 |
Not clear |
| K A Landers, R H Mortimer, K Richar. Transthyretin and the human placenta. Placenta. vol 34. issue 7. 2014-01-06. PMID:23664144. |
ttr derived amyloid is associated with diseases such as senile systemic amyloidosis, familial amyloid polyneuropathy and familial amyloid cardiomyopathy. |
2014-01-06 |
2023-08-12 |
human |
| Raquel J Nunes, Paula de Oliveira, Ana Lages, Jörg D Becker, Paulo Marcelino, Eduardo Barroso, Rui Perdigoto, Jeffery W Kelly, Alexandre Quintas, Susana Constantino Rosa Santo. Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells. The Journal of biological chemistry. vol 288. issue 44. 2013-12-31. PMID:24030829. |
familial amyloidotic polyneuropathy (fap) has a high prevalence in portugal, and the most common form of hereditary amyloidosis is caused by an amyloidogenic variant of transthyretin (ttr) with a substitution of methionine for valine at position 30 (v30m). |
2013-12-31 |
2023-08-12 |
Not clear |
| Anabela C Teixeira, Maria J Saraiv. Presence of N-glycosylated transthyretin in plasma of V30M carriers in familial amyloidotic polyneuropathy: an escape from ERAD. Journal of cellular and molecular medicine. vol 17. issue 3. 2013-11-19. PMID:23387326. |
familial amyloid polyneuropathy (fap) is an autosomal dominant disease characterized by deposition of amyloid related to the presence of mutations in the transthyretin (ttr) gene. |
2013-11-19 |
2023-08-12 |
mouse |
| Adam Castaño, Stephen Helmke, Julissa Alvarez, Susan Delisle, Mathew S Maure. Diflunisal for ATTR cardiac amyloidosis. Congestive heart failure (Greenwich, Conn.). vol 18. issue 6. 2013-11-14. PMID:22747647. |
it is one of two small molecules assessed in animal safety studies and human clinical trials of ttr polyneuropathy. |
2013-11-14 |
2023-08-12 |
human |
| Ana Paula Barreiros, Peter R Galle, Gerd Ott. Familial amyloid polyneuropathy. Digestive diseases (Basel, Switzerland). vol 31. issue 1. 2013-10-25. PMID:23797140. |
familial amyloid polyneuropathy (fap; also known as familiar amyloidosis and hereditary amyloidosis) is an autosomal dominant inherited disease due to mutations of the transthyretin (ttr) gene coding for the corresponding protein, consisting of 127 amino acids. |
2013-10-25 |
2023-08-12 |
Not clear |
| Neil P Grimster, Stephen Connelly, Aleksandra Baranczak, Jiajia Dong, Larissa B Krasnova, K Barry Sharpless, Evan T Powers, Ian A Wilson, Jeffery W Kell. Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate. Journal of the American Chemical Society. vol 135. issue 15. 2013-10-21. PMID:23350654. |
when bound in the thyroxine binding site, most of the aryl sulfonyl fluorides react rapidly and chemoselectively with the pka-perturbed k15 residue, kinetically stabilizing ttr and thus preventing amyloid fibril formation, known to cause polyneuropathy. |
2013-10-21 |
2023-08-12 |
Not clear |
| Yohei Misumi, Yukio Ando, Nádia P Gonçalves, Maria J Saraiv. Fibroblasts endocytose and degrade transthyretin aggregates in transthyretin-related amyloidosis. Laboratory investigation; a journal of technical methods and pathology. vol 93. issue 8. 2013-10-18. PMID:23817086. |
mutations in the ttr gene cause an autosomal dominant form of the disease-familial amyloidotic polyneuropathy (fap). |
2013-10-18 |
2023-08-12 |
mouse |
| Feng Zhang, Cheng Hu, Yang Dong, Ming-Shen Lin, Jingyao Liu, Xinmei Jiang, Yubin Ge, Yingjie Gu. The impact of V30A mutation on transthyretin protein structural stability and cytotoxicity against neuroblastoma cells. Archives of biochemistry and biophysics. vol 535. issue 2. 2013-08-16. PMID:23523753. |
single point mutations in the transthyretin (ttr) gene may cause a hereditary neurodegenerative disease termed familial amyloidotic polyneuropathy (fap) due to accelerated deposition of amyloid fibrils, resulting in peripheral and autonomic nervous system dysfunction. |
2013-08-16 |
2023-08-12 |
human |
| Jean-Michel Vallat, Benoît Funalot, Frédéric Faugeras, Laurent Mag. [Familial amyloidotic polyneuropathies]. Bulletin de l'Academie nationale de medecine. vol 196. issue 7. 2013-07-17. PMID:23815017. |
genetic testing for ttr gene mutations should be performed in case of progressive length-dependent axonal polyneuropathy predominantly involving small nerve fibers. |
2013-07-17 |
2023-08-12 |
Not clear |
| David Adams, Cécile Cauquil, Marie Théaudi. [Familial amyloid polyneuropathies: therapeutic issues]. Bulletin de l'Academie nationale de medecine. vol 196. issue 7. 2013-07-17. PMID:23815018. |
tafamidis (vyndaqel(r), pfizer), a novel stabilizer of tetrameric ttr, has shown short-term effectiveness in slowing the progression of peripheral neuropathy in very early stages of met30 ttr-fap this drug should thus be proposed for stage 1 symptomatic polyneuropathy. |
2013-07-17 |
2023-08-12 |
Not clear |
| Ernst Hun. Familial amyloidotic polyneuropathy: current and emerging treatment options for transthyretin-mediated amyloidosis. The application of clinical genetics. vol 5. 2013-06-19. PMID:23776379. |
transthyretin familial amyloid polyneuropathy (ttr-fap) is a fatal clinical disorder characterized by extracellular deposition of abnormal fibrils derived from misfolded, normally soluble transthyretin (ttr) molecules. |
2013-06-19 |
2023-08-12 |
Not clear |
| Jing-Yao Liu, Xin-Mei Jiang, Min Zhang, Ying-Jie Gu. Analysis of mitochondrial haplogroups associated with TTR Val30Ala familial amyloidotic polyneuropathy in Chinese patients. The International journal of neuroscience. vol 122. issue 12. 2013-05-07. PMID:22784244. |
analysis of mitochondrial haplogroups associated with ttr val30ala familial amyloidotic polyneuropathy in chinese patients. |
2013-05-07 |
2023-08-12 |
Not clear |
| Jing-Yao Liu, Xin-Mei Jiang, Min Zhang, Ying-Jie Gu. Analysis of mitochondrial haplogroups associated with TTR Val30Ala familial amyloidotic polyneuropathy in Chinese patients. The International journal of neuroscience. vol 122. issue 12. 2013-05-07. PMID:22784244. |
extracellular deposition of abnormal transthyretin (ttr) amyloid fibrils leads to familial amyloidotic polyneuropathy (fap), an inherited autsomal dominant disease. |
2013-05-07 |
2023-08-12 |
Not clear |
| Alejandra González-Duarte, Karla Cárdenas Soto, Deborah Martínez-Baños, Jazmin Arteaga-Vazquez, Fausto Barrera, Mauricio Berenguer-Sanchez, Carlos Cantu-Brito, Guillermo García-Ramos, Bruno Estañol Vida. Familial amyloidosis with polyneuropathy associated with TTR Ser50Arg mutation. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 19. issue 4. 2013-04-09. PMID:22928869. |
familial amyloidosis with polyneuropathy associated with ttr ser50arg mutation. |
2013-04-09 |
2023-08-12 |
Not clear |
| Yanfang Liang, Moriam O Ore, Sylvie Morin, Derek J Wilso. Specific disruption of transthyretin(105-115) fibrilization using "stabilizing" inhibitors of transthyretin amyloidogenesis. Biochemistry. vol 51. issue 16. 2013-04-03. PMID:22482799. |
transthyretin (ttr) is a cerebrospinal fluid and serum protein that undergoes ordered aggregation (amyloidogenesis) in familial amyloidotic polyneuropathy (fap) and senile systemic amyloidosis (ssa). |
2013-04-03 |
2023-08-12 |
Not clear |
| Ricardo O Sant'anna, Carolina A Braga, Igor Polikarpov, Salvador Ventura, Luis Mauricio T R Lima, Debora Fogue. Inhibition of human transthyretin aggregation by non-steroidal anti-inflammatory compounds: a structural and thermodynamic analysis. International journal of molecular sciences. vol 14. issue 3. 2013-03-08. PMID:23466880. |
transthyretin (ttr) is a homotetrameric protein that circulates in plasma and cerebral spinal fluid (csf) whose aggregation into amyloid fibrils has been associated with at least two different amyloid diseases: senile systemic amyloidosis (ssa) and familial amyloid polyneuropathy (fap). |
2013-03-08 |
2023-08-12 |
human |
| Nelson Ferreira, Sónia A O Santos, Maria Rosário M Domingues, Maria João Saraiva, Maria Rosário Almeid. Dietary curcumin counteracts extracellular transthyretin deposition: insights on the mechanism of amyloid inhibition. Biochimica et biophysica acta. vol 1832. issue 1. 2013-03-04. PMID:23069388. |
in the present study, we aim to assess the effect of curcumin on ttr amyloidogenesis in vivo, using a well characterized mouse model for familial amyloidotic polyneuropathy (fap). |
2013-03-04 |
2023-08-12 |
mouse |