| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bárbara Macedo, Joana Magalhães, Ana Rita Batista, Maria João Saraiv. Carvedilol treatment reduces transthyretin deposition in a familial amyloidotic polyneuropathy mouse model. Pharmacological research. vol 62. issue 6. 2011-03-11. PMID:20692343. |
we hypothesised a possible therapeutical application of carvedilol in familial amyloidotic polyneuropathy (fap), a neurodegenerative disease caused by deposition of transthyretin (ttr) amyloid fibrils. |
2011-03-11 |
2023-08-12 |
mouse |
| Syoichiro Kono, Yasuhiro Manabe, Tomotaka Tanaka, Daiki Fujii, Yasuko Sakai, Hisashi Narai, Nobuhiko Omori, Mitsuharu Ueda, Yukio Ando, Koji Ab. A case of familial amyloid polyneuropathy due to Phe33Val TTR with vitreous involvement as the initial manifestation. Internal medicine (Tokyo, Japan). vol 49. issue 12. 2011-03-08. PMID:20558946. |
a case of familial amyloid polyneuropathy due to phe33val ttr with vitreous involvement as the initial manifestation. |
2011-03-08 |
2023-08-12 |
Not clear |
| Syoichiro Kono, Yasuhiro Manabe, Tomotaka Tanaka, Daiki Fujii, Yasuko Sakai, Hisashi Narai, Nobuhiko Omori, Mitsuharu Ueda, Yukio Ando, Koji Ab. A case of familial amyloid polyneuropathy due to Phe33Val TTR with vitreous involvement as the initial manifestation. Internal medicine (Tokyo, Japan). vol 49. issue 12. 2011-03-08. PMID:20558946. |
we report a 61-year-old japanese woman with transthyretin (ttr) val33-related familial amyloid polyneuropathy (fap). |
2011-03-08 |
2023-08-12 |
Not clear |
| Carlos J V Simões, Trishna Mukherjee, Rui M M Brito, Richard M Jackso. Toward the discovery of functional transthyretin amyloid inhibitors: application of virtual screening methods. Journal of chemical information and modeling. vol 50. issue 10. 2011-02-14. PMID:20883031. |
inhibition of amyloid fibril formation by stabilization of the native form of the protein transthyretin (ttr) is a viable approach for the treatment of familial amyloid polyneuropathy that has been gaining momentum in the field of amyloid research. |
2011-02-14 |
2023-08-12 |
Not clear |
| Joana Magalhães, Sofia Duque Santos, Maria João Saraiv. αB-crystallin (HspB5) in familial amyloidotic polyneuropathy. International journal of experimental pathology. vol 91. issue 6. 2011-01-28. PMID:20804537. |
in familial amyloidotic polyneuropathy (fap), a neurodegenerative disorder characterized by extracellular deposition of mutated transthyretin (ttr), activation of heat shock factor 1 -hsf1- by extracellular ttr deposition has been shown as well as induction of the expression of heat shock proteins, hsp27 and hsp70. |
2011-01-28 |
2023-08-12 |
mouse |
| Avik Banerjee, Hridoy R Bairagya, Bishnu P Mukhopadhyay, Tapas K Nandi, Asim K Ber. Structural insight to mutated Y116S transthyretin by molecular dynamics simulation. Indian journal of biochemistry & biophysics. vol 47. issue 4. 2011-01-24. PMID:21174946. |
familial amyloidotic polyneuropathy (fap) is strictly associated with point mutations of transthyretin (ttr) protein. |
2011-01-24 |
2023-08-12 |
Not clear |
| Sung-Tsang Hsie. Pathology and functional diagnosis of small-fiber painful neuropathy. Acta neurologica Taiwanica. vol 19. issue 2. 2010-11-16. PMID:20714957. |
one major etiology of small-fiber sensory neuropathy is familial amyloid polyneuropathy caused by mutations of transthyretin (ttr). |
2010-11-16 |
2023-08-12 |
Not clear |
| Tatsufumi Murakami, Yutaka Ohsawa, Li Zhenghua, Ken-Ichi Yamamura, Yoshihide Sunad. The transthyretin gene is expressed in Schwann cells of peripheral nerves. Brain research. vol 1348. 2010-11-09. PMID:20547140. |
the majority of familial amyloidotic polyneuropathy cases are caused by a mutant ttr gene. |
2010-11-09 |
2023-08-12 |
mouse |
| Bernard Bonaïti, Malin Olsson, Urban Hellman, Ole Suhr, Catherine Bonaïti-Pellié, Violaine Planté-Bordeneuv. TTR familial amyloid polyneuropathy: does a mitochondrial polymorphism entirely explain the parent-of-origin difference in penetrance? European journal of human genetics : EJHG. vol 18. issue 8. 2010-11-01. PMID:20234390. |
ttr familial amyloid polyneuropathy: does a mitochondrial polymorphism entirely explain the parent-of-origin difference in penetrance? |
2010-11-01 |
2023-08-12 |
Not clear |
| N C-C Yang, M-J Lee, C-C Chao, Y-T Chuang, W-M Lin, M-F Chang, P-C Hsieh, H-W Kan, Y-H Lin, C-C Yang, M-J Chiu, H-H Liou, S-T Hsie. Clinical presentations and skin denervation in amyloid neuropathy due to transthyretin Ala97Ser. Neurology. vol 75. issue 6. 2010-10-22. PMID:20697105. |
familial amyloid polyneuropathy (fap) due to amyloidogenic transthyretin (ttr) is often associated with impairment of thermonociceptive functions. |
2010-10-22 |
2023-08-12 |
Not clear |
| Jiali Du, Regina M Murph. Characterization of the interaction of β-amyloid with transthyretin monomers and tetramers. Biochemistry. vol 49. issue 38. 2010-10-22. PMID:20795734. |
wild-type (wt) ttr amyloid deposits are linked to senile systemic amyloidosis, a common disease of aging, while several ttr mutants are linked to familial amyloid polyneuropathy. |
2010-10-22 |
2023-08-12 |
mouse |
| Malin Olsson, Nina Norgren, Konen Obayashi, Violaine Plante-Bordeneuve, Ole B Suhr, Kristina Cederquist, Jenni Jonasso. A possible role for miRNA silencing in disease phenotype variation in Swedish transthyretin V30M carriers. BMC medical genetics. vol 11. 2010-10-12. PMID:20840742. |
familial amyloidosis with polyneuropathy (fap) is an autosomal dominant disease caused by transthyretin (ttr) mutations, of which v30m (ttr c.148g > a, p.val50met, "val30met") is the most common. |
2010-10-12 |
2023-08-12 |
Not clear |
| Isabel Cardoso, Diana Martins, Tania Ribeiro, Giampaolo Merlini, Maria João Saraiv. Synergy of combined doxycycline/TUDCA treatment in lowering Transthyretin deposition and associated biomarkers: studies in FAP mouse models. Journal of translational medicine. vol 8. 2010-10-05. PMID:20673327. |
familial amyloidotic polyneuropathy (fap) is a disorder characterized by the extracellular deposition of fibrillar transthyretin (ttr) amyloid, with a special involvement of the peripheral nerve. |
2010-10-05 |
2023-08-12 |
mouse |
| Márcia A Liz, Fernando M Mar, Filipa Franquinho, Mónica M Sous. Aboard transthyretin: From transport to cleavage. IUBMB life. vol 62. issue 6. 2010-09-13. PMID:20503435. |
mutated ttr leads to familial amyloid polyneuropathy, a neurodegenerative disorder characterized by ttr amyloid deposition particularly in peripheral nerves. |
2010-09-13 |
2023-08-12 |
Not clear |
| Erez Podoly, Geula Hanin, Hermona Sore. Alanine-to-threonine substitutions and amyloid diseases: butyrylcholinesterase as a case study. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20060816. |
other examples are, parkinson's disease (pd), where a53t alpha-synuclein occurs in lewy bodies and familial amyloid polyneuropathy (fap), where an a25t substitution appears in transthyretin (ttr). |
2010-09-01 |
2023-08-12 |
Not clear |
| Masanori Miyata, Takashi Sato, Miyuki Kugimiya, Misato Sho, Teruya Nakamura, Shinji Ikemizu, Mami Chirifu, Mineyuki Mizuguchi, Yuko Nabeshima, Yoshiaki Suwa, Hiroshi Morioka, Takao Arimori, Mary Ann Suico, Tsuyoshi Shuto, Yasuhiro Sako, Mamiko Momohara, Tomoaki Koga, Saori Morino-Koga, Yuriko Yamagata, Hirofumi Ka. The crystal structure of the green tea polyphenol (-)-epigallocatechin gallate-transthyretin complex reveals a novel binding site distinct from the thyroxine binding site. Biochemistry. vol 49. issue 29. 2010-08-23. PMID:20565072. |
familial amyloid polyneuropathy (fap) is a hereditary disease caused by a point mutation of the human plasma protein, transthyretin (ttr), which binds and transports thyroxine (t(4)). |
2010-08-23 |
2023-08-12 |
human |
| Joel Buxbaum, Intissar Anan, Ole Suh. Serum transthyretin levels in Swedish TTR V30M carriers. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 17. issue 2. 2010-08-09. PMID:20462367. |
serum transthyretin (ttr) levels have been reported to be reduced in portuguese and japanese patients with ttr v30m familial amyloidotic polyneuropathy and pre-symptomatic carriers of the allele as well as in the carriers of a number of other mutant ttrs. |
2010-08-09 |
2023-08-12 |
Not clear |
| Toyofumi Nakanishi, Masanori Yoshioka, Kazuyoshi Moriuchi, Daisuke Yamamoto, Motomu Tsuji, Takayuki Takub. S-sulfonation of transthyretin is an important trigger step in the formation of transthyretin-related amyloid fibril. Biochimica et biophysica acta. vol 1804. issue 7. 2010-07-22. PMID:20388560. |
senile systemic amyloidosis and familial amyloid polyneuropathy are caused by oxidative deposition of conformationally altered transthyretin (ttr). |
2010-07-22 |
2023-08-12 |
Not clear |
| C Vital, A Lagueny, P Mercie, J-F Viallard, J-P Delabrousse-Mayoux, A Vita. Usefulness of combined nerve and muscle biopsy in the diagnosis of amyloid neuropathy--a study of 6 new cases. Clinical neuropathology. vol 29. issue 2. 2010-05-21. PMID:20175953. |
most cases of familial amyloid polyneuropathy are identified by molecular genetic analysis of the transthyretin (ttr) gene. |
2010-05-21 |
2023-08-12 |
Not clear |
| Kana Tojo, Ayako Tsuchiya-Suzuki, Yoshiki Sekijima, Hiroshi Morita, Naoko Sumita, Shu-Ichi Iked. Upper limb neuropathy such as carpal tunnel syndrome as an initial manifestation of ATTR Val30Met familial amyloid polyneuropathy. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 17. issue 1. 2010-05-04. PMID:20132088. |
in both patients systemic ttr amyloidosis consisting of polyneuropathy affecting both upper and lower limbs and/or autonomic dysfunction gradually appeared after surgery for cts. |
2010-05-04 |
2023-08-12 |
Not clear |