| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Raghu Pullakhandam, P N B S Srinivas, Madhavan K Nair, G Bhanuprakash Redd. Binding and stabilization of transthyretin by curcumin. Archives of biochemistry and biophysics. vol 485. issue 2. 2009-05-28. PMID:19268650. |
biophysical evidences suggest that transthyretin (ttr) tetramer dissociation to the monomeric intermediate and subsequent polymerization leads to amyloid fibril formation, which is implicated in the pathogenesis of familial amyloid polyneuropathy (fap) and senile systemic amyloidosis (ssa). |
2009-05-28 |
2023-08-12 |
Not clear |
| Seiko Susuki, Takashi Sato, Masanori Miyata, Mamiko Momohara, Mary Ann Suico, Tsuyoshi Shuto, Yukio Ando, Hirofumi Ka. The Endoplasmic Reticulum-associated Degradation of Transthyretin Variants Is Negatively Regulated by BiP in Mammalian Cells. The Journal of biological chemistry. vol 284. issue 13. 2009-05-26. PMID:19188365. |
amyloid fibril formation of mutant transthyretin (ttr) that causes familial amyloid polyneuropathy occurs in the extracellular space. |
2009-05-26 |
2023-08-12 |
Not clear |
| M Olsson, U Hellman, V Planté-Bordeneuve, J Jonasson, K Lång, O B Suh. Mitochondrial haplogroup is associated with the phenotype of familial amyloidosis with polyneuropathy in Swedish and French patients. Clinical genetics. vol 75. issue 2. 2009-04-16. PMID:19018796. |
familial amyloidotic polyneuropathy (fap) is a monogenic disease caused by mutations in the transthyretin (ttr) gene. |
2009-04-16 |
2023-08-12 |
Not clear |
| Carolina E Fleming, Fernando Milhazes Mar, Filipa Franquinho, Maria J Saraiva, Mónica M Sous. Transthyretin internalization by sensory neurons is megalin mediated and necessary for its neuritogenic activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 10. 2009-04-10. PMID:19279259. |
mutated transthyretin (ttr) causes familial amyloid polyneuropathy, a neurodegenerative disorder characterized by ttr deposition in the peripheral nervous system (pns). |
2009-04-10 |
2023-08-12 |
mouse |
| Carolina E Fleming, Fernando Milhazes Mar, Filipa Franquinho, Maria J Saraiva, Mónica M Sous. Transthyretin internalization by sensory neurons is megalin mediated and necessary for its neuritogenic activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 10. 2009-04-10. PMID:19279259. |
additionally, ttr presence in the nerve, as is here shown, may underlie its preferential deposition in the pns of familial amyloid polyneuropathy patients. |
2009-04-10 |
2023-08-12 |
mouse |
| Takamura Nagasaka, Shinji Togashi, Harue Watanabe, Haruyasu Iida, Kaori Nagasaka, Yuki Nakamura, Michiaki Miwa, Fumikazu Kobayashi, Kazumasa Shindo, Zenji Shiozaw. Clinical and histopathological features of progressive-type familial amyloidotic polyneuropathy with TTR Lys54. Journal of the neurological sciences. vol 276. issue 1-2. 2009-03-17. PMID:18930252. |
clinical and histopathological features of progressive-type familial amyloidotic polyneuropathy with ttr lys54. |
2009-03-17 |
2023-08-12 |
Not clear |
| Fernando L Palhano, Larissa P Leme, Roberta G Busnardo, Debora Fogue. Trapping the monomer of a non-amyloidogenic variant of transthyretin: exploring its possible use as a therapeutic strategy against transthyretin amyloidogenic diseases. The Journal of biological chemistry. vol 284. issue 3. 2009-03-12. PMID:18984591. |
familial amyloidotic polyneuropathy is a hereditary form of ttr amyloidosis that is associated with one among 80 different variants of ttr. |
2009-03-12 |
2023-08-12 |
human |
| Haruki Koike, Yuichi Kawagashira, Masahiro Iijima, Masahiko Yamamoto, Naoki Hattori, Fumiaki Tanaka, Masaaki Hirayama, Yukio Ando, Shu-ichi Ikeda, Gen Sobu. Electrophysiological features of late-onset transthyretin Met30 familial amyloid polyneuropathy unrelated to endemic foci. Journal of neurology. vol 255. issue 10. 2009-02-26. PMID:18821042. |
through the development of gene diagnostic techniques, late-onset transthyretin met30-associated familial amyloid polyneuropathy (fap ttr met30) has been shown to be more prevalent than is generally believed. |
2009-02-26 |
2023-08-12 |
Not clear |
| Yoshiki Sekijima, Jeffery W Kelly, Shu-ichi Iked. Pathogenesis of and therapeutic strategies to ameliorate the transthyretin amyloidoses. Current pharmaceutical design. vol 14. issue 30. 2009-02-09. PMID:19075702. |
rate-limiting tetramer dissociation and rapid monomer misfolding and misassembly of variant ttr results in familial amyloid polyneuropathy (fap), familial amyloid cardiomyopathy (fac), or familial central nervous system amyloidosis. |
2009-02-09 |
2023-08-12 |
Not clear |
| Yohei Misumi, Mitsuharu Ueda, Hiromi Fujimori, Satoru Shinriki, Wei Meng, Jaemi Kim, Shiori Saito, Konen Obayashi, Makoto Uchino, Yukio And. Transthyretin forms amyloid fibrils at physiological pH with ultrasonication. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 15. issue 4. 2009-01-28. PMID:19065294. |
in transthyretin (ttr)-related amyloidosis, wild-type ttr (wt-ttr), as well as mutated ttrs play important roles in the pathogenesis of senile systemic amyloidosis and familial amyloidotic polyneuropathy. |
2009-01-28 |
2023-08-12 |
Not clear |
| M Lindhagen-Persson, M Vestling, N Reixach, A Olofsso. Formation of cytotoxic transthyretin is not dependent on inter-molecular disulphide bridges commonly found within the amyloid form. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 15. issue 4. 2009-01-28. PMID:19065295. |
familial amyloidotic polyneuropathy (fap) is linked to destabilising point mutations in the human plasma protein transthyretin (ttr). |
2009-01-28 |
2023-08-12 |
mouse |
| Joel Buxbaum, James Koziol, Lawreen H Connor. Serum transthyretin levels in senile systemic amyloidosis: effects of age, gender and ethnicity. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 15. issue 4. 2009-01-28. PMID:19065297. |
serum transthyretin (ttr) levels are reduced in familial amyloidotic polyneuropathy (fap). |
2009-01-28 |
2023-08-12 |
Not clear |
| Miguel Munar-Ques, Jacinto Martinez-Nadal, Jose Juan Torres-Rovira, Manel Sole, Jose Maria Zabay-Becerril, Juana Maria Mulet-Ferre. Finding of vascular amyloid TTR in inferior nasal concha in a patient with FAP TTRVal30Met. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 15. issue 4. 2009-01-28. PMID:19065300. |
we report the case of a female patient with familial amyloid polyneuropathy (fap) who demonstrated ttr amyloid deposition in the inferior nasal conchal vessels. |
2009-01-28 |
2023-08-12 |
Not clear |
| Mónica Mendes Sousa, Maria João Saraiv. Transthyretin is not expressed by dorsal root ganglia cells. Experimental neurology. vol 214. issue 2. 2009-01-07. PMID:18835560. |
several mutations in transthyretin (ttr) are related to familial amyloidotic polyneuropathy (fap), a neurodegenerative disorder caused by extracellular deposition of ttr fibrils, particularly in the peripheral nervous system (pns). |
2009-01-07 |
2023-08-12 |
mouse |
| I Gonçalves, C H Alves, T Quintela, G Baltazar, S Socorro, M J Saraiva, R Abreu, C R A Santo. Transthyretin is up-regulated by sex hormones in mice liver. Molecular and cellular biochemistry. vol 317. issue 1-2. 2008-12-16. PMID:18568387. |
misfolding and aggregation of mutated and wild-type transthyretin (ttr) can cause familial amyloid polyneuropathy (fap) and senile systemic amyloidosis (ssa), respectively. |
2008-12-16 |
2023-08-12 |
mouse |
| Thomas Rudolph, Martin Wilhelm Kurz, Elisabeth Farb. Late-onset familial amyloid polyneuropathy (FAP) Val30Met without family history. Clinical medicine & research. vol 6. issue 2. 2008-12-09. PMID:18606975. |
familial amyloid polyneuropathy (fap) is rare and most commonly caused by the val30met mutation of the transthyretin (ttr) gene. |
2008-12-09 |
2023-08-12 |
Not clear |
| Urban Hellman, Flora Alarcon, Hans-Erik Lundgren, Ole B Suhr, Catherine Bonaiti-Pellié, Violaine Planté-Bordeneuv. Heterogeneity of penetrance in familial amyloid polyneuropathy, ATTR Val30Met, in the Swedish population. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 15. issue 3. 2008-11-18. PMID:18925456. |
transthyretin (ttr) familial amyloid polyneuropathies (fap) are autosomal dominant devastating afflictions. |
2008-11-18 |
2023-08-12 |
Not clear |
| Idalina Beirão, Luísa Lobato, Luciana Moreira, Paulo Mp Costa, Isabel Fonseca, António Cabrita, Graça Port. Long-term treatment of anemia with recombinant human erythropoietin in familial amyloidosis TTR V30M. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 15. issue 3. 2008-11-18. PMID:18925459. |
familial amyloidosis or familial amyloid polyneuropathy (fap) ttr v30m is a hereditary disease presented, in most cases, as a sensorimotor and autonomic neuropathy. |
2008-11-18 |
2023-08-12 |
human |
| Richard L Julius, M Frederick Hawthorn. Amyloid disease prevention by transthyretin native state complexation with carborane derivatives lacking cyclooxygenase inhibition. Drug news & perspectives. vol 21. issue 5. 2008-10-23. PMID:18596990. |
in humans, the t119m-ttr variant has been shown to be protective against familial amyloid polyneuropathy, a ttr amyloid disease, through kinetic stabilization of the unliganded tetrameric structure. |
2008-10-23 |
2023-08-12 |
human |
| I Cardoso, M Brito, M J Saraiv. Extracellular matrix markers for disease progression and follow-up of therapies in familial amyloid polyneuropathy V30M TTR-related. Disease markers. vol 25. issue 1. 2008-10-17. PMID:18776590. |
familial amyloidotic polyneuropathy (fap) is a disorder characterized by the extracellular deposition of fibrillar transthyretin (ttr) amyloid, with a special involvement of the peripheral nerve. |
2008-10-17 |
2023-08-12 |
mouse |