| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel Blasi, Gemma Arsequell, Gregori Valencia, Joan Nieto, Antoni Planas, Marta Pinto, Nuria B Centeno, Cele Abad-Zapatero, Jordi Quintan. Retrospective Mapping of SAR Data for TTR Protein in Chemico-Biological Space Using Ligand Efficiency Indices as a Guide to Drug Discovery Strategies. Molecular informatics. vol 30. issue 2-3. 2016-07-30. PMID:27466770. |
we have previously reported the design and synthesis of ligands that stabilize transthyretin protein (ttr) in order to obtain therapeutically active compounds for familial amyloid polyneuropathy (fap). |
2016-07-30 |
2023-08-13 |
Not clear |
| Laura Pont, Fernando Benavente, Marta Vilaseca, Estela Giménez, Victoria Sanz-Nebo. Characterisation of serum transthyretin by electrospray ionisation-ion mobility mass spectrometry: Application to familial amyloidotic polyneuropathy type I (FAP-I). Talanta. vol 144. 2016-07-26. PMID:26452950. |
transthyretin (ttr) is a homotetrameric protein which is known to misfold and aggregate causing different types of amyloidosis, such as familial amyloidotic polyneuropathy type i (fap-i). |
2016-07-26 |
2023-08-13 |
Not clear |
| Christoph Niemietz, Gursimran Chandhok, Hartmut Schmid. Therapeutic Oligonucleotides Targeting Liver Disease: TTR Amyloidosis. Molecules (Basel, Switzerland). vol 20. issue 10. 2016-06-27. PMID:26437390. |
mutations of the gene encoding transthyretin (ttr), expressed in vast amounts by the liver, result in a complex degenerative disease, termed familial amyloid polyneuropathy (fap). |
2016-06-27 |
2023-08-13 |
Not clear |
| Teresa Coelho, Giampaolo Merlini, Christine E Bulawa, James A Fleming, Daniel P Judge, Jeffery W Kelly, Mathew S Maurer, Violaine Planté-Bordeneuve, Richard Labaudinière, Rajiv Mundayat, Steve Riley, Ilise Lombardo, Pedro Huerta. Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transthyretin Amyloidosis. Neurology and therapy. vol 5. issue 1. 2016-06-24. PMID:26894299. |
tafamidis is the first pharmacotherapy approved to slow the progression of peripheral neurologic impairment in ttr familial amyloid polyneuropathy. |
2016-06-24 |
2023-08-13 |
Not clear |
| Hsing-Jung Lai, Ya-Wen Chiang, Chih-Chao Yang, Sung-Tsang Hsieh, Chi-Chao Chao, Ming-Jen Lee, Chung-Chin Ku. The Temporal Profiles of Changes in Nerve Excitability Indices in Familial Amyloid Polyneuropathy. PloS one. vol 10. issue 11. 2016-06-10. PMID:26529114. |
familial amyloid polyneuropathy (fap) caused by a mutation in transthyretin (ttr) gene is an autosomal dominant inherited disorder. |
2016-06-10 |
2023-08-13 |
Not clear |
| Can Ebru Bekircan-Kurt, Nalan Güneş, Arda Yılmaz, Sevim Erdem-Özdamar, Ersin Ta. Three Turkish families with different transthyretin mutations. Neuromuscular disorders : NMD. vol 25. issue 9. 2016-05-09. PMID:26115788. |
transthyretin (ttr)-related hereditary amyloidosis, also called familial amyloid polyneuropathy (fap), is a rare autosomal dominant systemic disorder that presents with progressive axonal sensory, autonomic and/or motor neuropathies. |
2016-05-09 |
2023-08-13 |
Not clear |
| Yoshiki Sekijima, Kana Tojo, Hiroshi Morita, Jun Koyama, Shu-ichi Iked. Safety and efficacy of long-term diflunisal administration in hereditary transthyretin (ATTR) amyloidosis. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 22. issue 2. 2016-04-25. PMID:26017328. |
a recent 2-year randomized controlled trial indicated that the transthyretin (ttr) tetramer stabilizer, diflunisal, inhibits polyneuropathy progression and preserves quality of life in hereditary attr amyloidosis. |
2016-04-25 |
2023-08-13 |
Not clear |
| Irina Iakovleva, Afshan Begum, Malgorzata Pokrzywa, Malin Walfridsson, A Elisabeth Sauer-Eriksson, Anders Olofsso. The flavonoid luteolin, but not luteolin-7-O-glucoside, prevents a transthyretin mediated toxic response. PloS one. vol 10. issue 5. 2016-04-01. PMID:26020516. |
transthyretin (ttr) is a homotetrameric plasma protein with amyloidogenic properties that has been linked to the development of familial amyloidotic polyneuropathy (fap), familial amyloidotic cardiomyopathy, and senile systemic amyloidosis. |
2016-04-01 |
2023-08-13 |
drosophila_melanogaster |
| Laura Pont, Fernando Benavente, José Barbosa, Victoria Sanz-Nebo. Analysis of transthyretin in human serum by capillary zone electrophoresis electrospray ionization time-of-flight mass spectrometry. Application to familial amyloidotic polyneuropathy type I. Electrophoresis. vol 36. issue 11-12. 2016-03-15. PMID:25820240. |
application to familial amyloidotic polyneuropathy type i. transthyretin (ttr) is known to misfold and aggregate, causing different types of amyloidosis. |
2016-03-15 |
2023-08-13 |
human |
| Laura Pont, Fernando Benavente, José Barbosa, Victoria Sanz-Nebo. Analysis of transthyretin in human serum by capillary zone electrophoresis electrospray ionization time-of-flight mass spectrometry. Application to familial amyloidotic polyneuropathy type I. Electrophoresis. vol 36. issue 11-12. 2016-03-15. PMID:25820240. |
familial amyloidotic polyneuropathy type i (fap-i), which is the most common hereditary systemic amyloidosis, is associated with a ttr variant that presents a single amino acid substitution of valine for methionine at position 30 (met 30). |
2016-03-15 |
2023-08-13 |
human |
| Karen J Klamerus, Eric Watsky, Robert Moller, Ronnie Wang, Steve Rile. The effect of tafamidis on the QTc interval in healthy subjects. British journal of clinical pharmacology. vol 79. issue 6. 2016-02-22. PMID:25546001. |
the transthyretin (ttr) stabilizer, tafamidis, has demonstrated efficacy and safety in the treatment of ttr familial amyloid polyneuropathy (20 mg day(-1) ). |
2016-02-22 |
2023-08-13 |
human |
| Victor H Jimenez-Zepeda, Nizar J Bahlis, Janet Gilbertson, Nigel Rendell, Riccardo Porcari, Helen J Lachmann, Julian D Gillmore, Philip N Hawkins, Dorota M Rowczeni. A novel transthyretin variant p.H110D (H90D) as a cause of familial amyloid polyneuropathy in a large Irish kindred. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 22. issue 1. 2015-12-31. PMID:25430583. |
we report here a large irish family with familial amyloid polyneuropathy (fap), consisting of multiple affected generations, caused by a novel ttr mutation; p.h110d (h90d). |
2015-12-31 |
2023-08-13 |
Not clear |
| João Melo Beirão, Jorge Malheiro, Carolina Lemos, Eduarda Matos, Idalina Beirão, Paulo Pinho-Costa, Paulo Torre. Impact of liver transplantation on the natural history of oculopathy in Portuguese patients with transthyretin (V30M) amyloidosis. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 22. issue 1. 2015-12-31. PMID:25475560. |
evaluation of the impact of liver transplantation in the natural history of ocular disorders in familial amyloidotic polyneuropathy (fap) amyloidosis ttr v30m related (attr v30m) patients. |
2015-12-31 |
2023-08-13 |
Not clear |
| Tiago Q Faria, Zaida L Almeida, Pedro F Cruz, Catarina S H Jesus, Pedro Castanheira, Rui M M Brit. A look into amyloid formation by transthyretin: aggregation pathway and a novel kinetic model. Physical chemistry chemical physics : PCCP. vol 17. issue 11. 2015-11-25. PMID:25694367. |
transthyretin (ttr) is a homotetrameric protein implicated in several amyloidoses like senile systemic amyloidosis (ssa), familial amyloid polyneuropathy (fap), familial amyloid cardiomyopathy (fac), and the rare central nervous system selective amyloidosis (cnsa). |
2015-11-25 |
2023-08-13 |
human |
| Chih-Hao Chen, Chiung-Wei Huang, Ming-Jen Le. A case of familial amyloidotic polyneuropathy with a rare Phe33Leu mutation in the TTR gene. Journal of the Formosan Medical Association = Taiwan yi zhi. vol 113. issue 8. 2015-11-23. PMID:25037766. |
a case of familial amyloidotic polyneuropathy with a rare phe33leu mutation in the ttr gene. |
2015-11-23 |
2023-08-13 |
Not clear |
| Yoshiki Sekijim. Transthyretin (ATTR) amyloidosis: clinical spectrum, molecular pathogenesis and disease-modifying treatments. Journal of neurology, neurosurgery, and psychiatry. vol 86. issue 9. 2015-11-09. PMID:25604431. |
ttr protein destabilised by ttr gene mutation is prone to dissociate from its native tetramer to monomer, and to then misfold and aggregate into amyloid fibrils, resulting in autosomal dominant hereditary amyloidosis, including familial amyloid polyneuropathy, familial amyloid cardiomyopathy and familial leptomeningeal amyloidosis. |
2015-11-09 |
2023-08-13 |
Not clear |
| Susanna Nencetti, Armando Rossello, Elisabetta Orlandin. Tafamidis (Vyndaqel): a light for FAP patients. ChemMedChem. vol 8. issue 10. 2015-10-26. PMID:24000164. |
tafamidis acts in a similar way to the natural hormone t4, prevents ttr amyloid fibril formation, and offers a potential alternative to liver transplantation for the treatment of patients with ttr familial amyloid polyneuropathies (ttr-fap). |
2015-10-26 |
2023-08-12 |
Not clear |
| Anne Schänzer, Christoph Kimmich, Christoph Röcken, Thomas Haverkamp, Isabell Weidner, Till Acker, Heidrun H Kräme. A woman with a rare p.Glu74Gly transthyretin mutation presenting exclusively with a rapidly progressive neuropathy: a case report. Journal of medical case reports. vol 8. 2015-09-24. PMID:25471118. |
familial amyloid polyneuropathy is a rare autosomal dominant disorder caused by mutations in the transthyretin gene, ttr. |
2015-09-24 |
2023-08-13 |
Not clear |
| Inmaculada Conejos-Sánchez, Isabel Cardoso, Marta Oteo-Vives, Eduardo Romero-Sanz, Alison Paul, Amparo Ruiz Sauri, Miguel A Morcillo, Maria J Saraiva, María J Vicen. Polymer-doxycycline conjugates as fibril disrupters: an approach towards the treatment of a rare amyloidotic disease. Journal of controlled release : official journal of the Controlled Release Society. vol 198. 2015-09-22. PMID:25481444. |
in the most common familial amyloid polyneuropathy (fap), transthyretin (ttr) displays this role primarily affecting the peripheral nervous system (pns). |
2015-09-22 |
2023-08-13 |
Not clear |
| Tatsufumi Murakami, Kazunori Sango, Kazuhiko Watabe, Naoko Niimi, Shizuka Takaku, Zhenghua Li, Ken-ichi Yamamura, Yoshihide Sunad. Schwann cells contribute to neurodegeneration in transthyretin amyloidosis. Journal of neurochemistry. vol 134. issue 1. 2015-09-09. PMID:25693163. |
familial amyloidotic polyneuropathy (fap) is one of the transthyretin (ttr) amyloidoses characterized by extracellular amyloid deposits and peripheral nerve involvement. |
2015-09-09 |
2023-08-13 |
mouse |