| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lidia Ciccone, Susanna Nencetti, Armando Rossello, Enrico Adriano Stura, Elisabetta Orlandin. Synthesis and structural analysis of halogen substituted fibril formation inhibitors of Human Transthyretin (TTR). Journal of enzyme inhibition and medicinal chemistry. vol 31. issue sup1. 2017-02-22. PMID:27067161. |
transthyretin (ttr), a β-sheet-rich tetrameric protein, in equilibrium with an unstable amyloidogenic monomeric form is responsible for extracellular deposition of amyloid fibrils, is associated with the onset of neurodegenerative diseases, such as senile systemic amyloidosis, familial amyloid polyneuropathy and familial amyloid cardiomyopathy. |
2017-02-22 |
2023-08-13 |
human |
| Elizabeth J Ackermann, Shuling Guo, Merrill D Benson, Sheri Booten, Sue Freier, Steven G Hughes, Tae-Won Kim, T Jesse Kwoh, John Matson, Dan Norris, Rosie Yu, Andy Watt, Brett P Moni. Suppressing transthyretin production in mice, monkeys and humans using 2nd-Generation antisense oligonucleotides. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 23. issue 3. 2017-01-10. PMID:27355239. |
transthyretin amyloidosis (attr amyloidosis) is a rare disease that results from the deposition of misfolded transthyretin (ttr) protein from the plasma into tissues as amyloid fibrils, leading to polyneuropathy and cardiomyopathy. |
2017-01-10 |
2023-08-13 |
mouse |
| Paula Gonçalves, Helena Martins, Susete Costelha, Luis F Maia, Maria Joao Saraiv. Efficiency of silencing RNA for removal of transthyretin V30M in a TTR leptomeningeal animal model. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 23. issue 4. 2017-01-10. PMID:27884058. |
familial amyloid polyneuropathy (fap) with leptomeningeal involvement has been described in 9% of transthyretin (ttr) mutations and in valine for methionine at position 30 (v30m) patients. |
2017-01-10 |
2023-08-13 |
mouse |
| Manuela Leri, Daniele Nosi, Antonino Natalello, Riccardo Porcari, Matteo Ramazzotti, Fabrizio Chiti, Vittorio Bellotti, Silvia Maria Doglia, Massimo Stefani, Monica Bucciantin. The polyphenol Oleuropein aglycone hinders the growth of toxic transthyretin amyloid assemblies. The Journal of nutritional biochemistry. vol 30. 2017-01-09. PMID:27012632. |
transthyretin (ttr) is involved in a subset of familial or sporadic amyloid diseases including senile systemic amyloidosis (ssa), familial amyloid polyneuropathy and cardiomyopathy (fap/fac) for which no effective therapy has been found yet. |
2017-01-09 |
2023-08-13 |
Not clear |
| Susana Lêdo, Ângela Leite, Teresa Souto, Maria A Dinis, Jorge Sequeiro. Mid- and long-term anxiety levels associated with presymptomatic testing of Huntington's disease, Machado-Joseph disease, and familial amyloid polyneuropathy. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). vol 38. issue 2. 2016-12-14. PMID:26870910. |
to study anxiety as a variable of the mid- and long-term psychological impact of pre-symptomatic testing for three autosomal dominant late-onset disorders - huntington's disease (hd), machado-joseph disease (mjd) and familial amyloid polyneuropathy (fap) ttr v30m - in a portuguese sample. |
2016-12-14 |
2023-08-13 |
Not clear |
| Kosuke Okumura, Taro Yamashita, Teruaki Masuda, Yohei Misumi, Akihiko Ueda, Mitsuharu Ueda, Konen Obayashi, Hirofumi Jono, Satoshi Yamashita, Yukihiro Inomata, Yukio And. Long-term outcome of patients with hereditary transthyretin V30M amyloidosis with polyneuropathy after liver transplantation. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 23. issue 1. 2016-12-13. PMID:26763274. |
liver transplantation halts production of mutated transthyretin (ttr), and thus it is an accepted treatment, with improved survival, in patients with hereditary (familial) amyloidosis with polyneuropathy (fap). |
2016-12-13 |
2023-08-13 |
Not clear |
| Yukio Ando, Yoshiki Sekijima, Konen Obayashi, Taro Yamashita, Mitsuharu Ueda, Yohei Misumi, Hiroshi Morita, Katsuyuki Machii, Makoto Ohta, Ami Takata, Shû-Ichi Iked. Effects of tafamidis treatment on transthyretin (TTR) stabilization, efficacy, and safety in Japanese patients with familial amyloid polyneuropathy (TTR-FAP) with Val30Met and non-Val30Met: A phase III, open-label study. Journal of the neurological sciences. vol 362. 2016-12-13. PMID:26944161. |
effects of tafamidis treatment on transthyretin (ttr) stabilization, efficacy, and safety in japanese patients with familial amyloid polyneuropathy (ttr-fap) with val30met and non-val30met: a phase iii, open-label study. |
2016-12-13 |
2023-08-13 |
Not clear |
| Yukio Ando, Yoshiki Sekijima, Konen Obayashi, Taro Yamashita, Mitsuharu Ueda, Yohei Misumi, Hiroshi Morita, Katsuyuki Machii, Makoto Ohta, Ami Takata, Shû-Ichi Iked. Effects of tafamidis treatment on transthyretin (TTR) stabilization, efficacy, and safety in Japanese patients with familial amyloid polyneuropathy (TTR-FAP) with Val30Met and non-Val30Met: A phase III, open-label study. Journal of the neurological sciences. vol 362. 2016-12-13. PMID:26944161. |
the efficacy and safety of tafamidis in transthyretin (ttr) familial amyloid polyneuropathy (ttr-fap) were evaluated in this open-label study. |
2016-12-13 |
2023-08-13 |
Not clear |
| Philip N Hawkins, Yukio Ando, Angela Dispenzeri, Alejandra Gonzalez-Duarte, David Adams, Ole B Suh. Evolving landscape in the management of transthyretin amyloidosis. Annals of medicine. vol 47. issue 8. 2016-10-12. PMID:26611723. |
the ttr stabilizers tafamidis and diflunisal slow disease progression in some patients with attr amyloidosis with polyneuropathy, and the postulated synergistic effect of doxycycline and tauroursodeoxycholic acid on dissolution of amyloid is under investigation. |
2016-10-12 |
2023-08-13 |
Not clear |
| Ângela Leite, Maria Alzira P Dinis, Jorge Sequeiros, Constança Paú. Subjects At-Risk for Genetic Diseases in Portugal: Illness Representations. Journal of genetic counseling. vol 25. issue 1. 2016-09-29. PMID:25986962. |
this study investigates illness representations of subjects at-risk for 3 autosomal dominant late-onset disorders: familial amyloid polyneuropathy (fap) ttr v30m, huntington's disease (hd) and machado-joseph disease (mjd), comparing them with the illness representations of subjects at-risk for hemochromatosis (hh). |
2016-09-29 |
2023-08-13 |
human |
| Takeshi Yokoyama, Shun Takaki, Keisuke Chosa, Takashi Sato, Mary Ann Suico, Yuriko Teranishi, Tsuyoshi Shuto, Mineyuki Mizuguchi, Hirofumi Ka. Structural stabilization of transthyretin by a new compound, 6-benzoyl-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione. Journal of pharmacological sciences. vol 129. issue 4. 2016-09-26. PMID:26639444. |
familial amyloid polyneuropathy (fap) is a genetic, adult-onset, neurodegenerative disorder caused by amyloid formation of transthyretin (ttr), a thyroxine-binding protein. |
2016-09-26 |
2023-08-13 |
Not clear |
| Irina Iakovleva, Afshan Begum, Kristoffer Brännström, Alexandra Wijsekera, Lina Nilsson, Jin Zhang, Patrik L Andersson, A Elisabeth Sauer-Eriksson, Anders Olofsso. Tetrabromobisphenol A Is an Efficient Stabilizer of the Transthyretin Tetramer. PloS one. vol 11. issue 4. 2016-08-29. PMID:27093678. |
amyloid formation of the human plasma protein transthyretin (ttr) is associated with several human disorders, including familial amyloidotic polyneuropathy (fap) and senile systemic amyloidosis. |
2016-08-29 |
2023-08-13 |
human |
| David Adams, Cecile Cauquil, Céline Labeyrie, Guillemette Beaudonnet, Vincent Algalarrondo, Marie Théaudi. TTR kinetic stabilizers and TTR gene silencing: a new era in therapy for familial amyloidotic polyneuropathies. Expert opinion on pharmacotherapy. vol 17. issue 6. 2016-08-25. PMID:26800456. |
ttr kinetic stabilizers and ttr gene silencing: a new era in therapy for familial amyloidotic polyneuropathies. |
2016-08-25 |
2023-08-13 |
Not clear |
| David Adams, Cecile Cauquil, Céline Labeyrie, Guillemette Beaudonnet, Vincent Algalarrondo, Marie Théaudi. TTR kinetic stabilizers and TTR gene silencing: a new era in therapy for familial amyloidotic polyneuropathies. Expert opinion on pharmacotherapy. vol 17. issue 6. 2016-08-25. PMID:26800456. |
transthyretin familial amyloid polyneuropathy (ttr-fap) is a rare disease with autosomal dominant transmission due to a point mutation of the ttr gene. |
2016-08-25 |
2023-08-13 |
Not clear |
| David Adams, Cecile Cauquil, Céline Labeyrie, Guillemette Beaudonnet, Vincent Algalarrondo, Marie Théaudi. TTR kinetic stabilizers and TTR gene silencing: a new era in therapy for familial amyloidotic polyneuropathies. Expert opinion on pharmacotherapy. vol 17. issue 6. 2016-08-25. PMID:26800456. |
by removing the main source of systemic mutant ttr, liver transplantation (lt) has become the reference therapy of this severe and fatal polyneuropathy of adult-onset, stopping disease progression in subgroup of patients. |
2016-08-25 |
2023-08-13 |
Not clear |
| Lina Nilsson, Andreas Larsson, Afshan Begum, Irina Iakovleva, Marcus Carlsson, Kristoffer Brännström, A Elisabeth Sauer-Eriksson, Anders Olofsso. Modifications of the 7-Hydroxyl Group of the Transthyretin Ligand Luteolin Provide Mechanistic Insights into Its Binding Properties and High Plasma Specificity. PloS one. vol 11. issue 4. 2016-08-22. PMID:27050398. |
amyloid formation of the plasma protein transthyretin (ttr) has been linked to familial amyloid polyneuropathy and senile systemic amyloidosis. |
2016-08-22 |
2023-08-13 |
human |
| Yukio And. [Amyloidosis and neurological disorders: Treatable amyloidosis]. Rinsho shinkeigaku = Clinical neurology. vol 55. issue 11. 2016-08-11. PMID:26458571. |
in addition to these amyloidosis, in transthyretin (ttr) related familial amyloidotic polyneuropathy (fap), liver transplantation, tertial structure stabilizing drugs, and gene silencing drugs have been developing now. |
2016-08-11 |
2023-08-13 |
Not clear |
| Tsuneaki Yoshinaga, Masahide Yazaki, Yoshiki Sekijima, Fuyuki Kametani, Kana Miyashita, Naomi Hachiya, Tomohiro Tanaka, Norihiro Kokudo, Keiichi Higuchi, Shu-Ichi Iked. The pathological and biochemical identification of possible seed-lesions of transmitted transthyretin amyloidosis after domino liver transplantation. The journal of pathology. Clinical research. vol 2. issue 2. 2016-08-08. PMID:27499917. |
the most serious issue in domino liver transplantation (dlt) using liver grafts from patients with transthyretin (ttr)-related familial amyloid polyneuropathy (fap) is the development of iatrogenic transmitted amyloidosis (de novo amyloidosis) in dlt-recipients. |
2016-08-08 |
2023-08-13 |
Not clear |
| Sophie Ng Wing Tin, Violaine Planté-Bordeneuve, Hayet Salhi, Colette Goujon, Thibaud Damy, Jean-Pascal Lefaucheu. Characterization of Pain in Familial Amyloid Polyneuropathy. The journal of pain. vol 16. issue 11. 2016-08-03. PMID:26291275. |
familial amyloid polyneuropathy (fap) caused by transthyretin (ttr) mutation is a small-fiber predominant polyneuropathy, exposing patients with ttr-fap to development of neuropathic pain. |
2016-08-03 |
2023-08-13 |
Not clear |
| Marta Vilà-Rico, Núria Colomé-Calls, Luna Martín-Castel, Marina Gay, Sebastián Azorín, Marta Vilaseca, Antoni Planas, Francesc Canal. Quantitative analysis of post-translational modifications in human serum transthyretin associated with familial amyloidotic polyneuropathy by targeted LC-MS and intact protein MS. Journal of proteomics. vol 127. issue Pt B. 2016-08-01. PMID:25910794. |
quantitative analysis of post-translational modifications in human serum transthyretin associated with familial amyloidotic polyneuropathy by targeted lc-ms and intact protein ms. transthyretin (ttr) is an amyloidogenic tetrameric protein, present in human plasma, associated with several familial amyloidoses. |
2016-08-01 |
2023-08-13 |
human |