| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui Li, Yu Zhang, Li Cao, Ran Xiong, Bei Zhang, Li Wu, Zongbo Zhao, Sheng-Di Che. Curcumin could reduce the monomer of TTR with Tyr114Cys mutation via autophagy in cell model of familial amyloid polyneuropathy. Drug design, development and therapy. vol 8. 2015-08-13. PMID:25382970. |
curcumin could reduce the monomer of ttr with tyr114cys mutation via autophagy in cell model of familial amyloid polyneuropathy. |
2015-08-13 |
2023-08-13 |
Not clear |
| Hui Li, Yu Zhang, Li Cao, Ran Xiong, Bei Zhang, Li Wu, Zongbo Zhao, Sheng-Di Che. Curcumin could reduce the monomer of TTR with Tyr114Cys mutation via autophagy in cell model of familial amyloid polyneuropathy. Drug design, development and therapy. vol 8. 2015-08-13. PMID:25382970. |
transthyretin (ttr) familial amyloid polyneuropathy (fap) is an autosomal dominant inherited neurodegenerative disorder caused by various mutations in the transthyretin gene. |
2015-08-13 |
2023-08-13 |
Not clear |
| A R Batista, D Gianni, M Ventosa, A V Coelho, M R Almeida, M Sena-Esteves, M J Saraiv. Gene therapy approach to FAP: in vivo influence of T119M in TTR deposition in a transgenic V30M mouse model. Gene therapy. vol 21. issue 12. 2015-07-27. PMID:25273354. |
familial amyloidotic polyneuropathy (fap) is a neurodegenerative disorder characterized by extracellular deposition of amyloid fibrils composed by mutated transthyretin (ttr) mainly in the peripheral nervous system. |
2015-07-27 |
2023-08-13 |
mouse |
| Marta Vieira, Maria João Saraiv. Transthyretin: a multifaceted protein. Biomolecular concepts. vol 5. issue 1. 2015-07-13. PMID:25372741. |
ttr aggregates are responsible for many amyloidosis such as familial amyloidotic polyneuropathy and cardiomyopathy. |
2015-07-13 |
2023-08-13 |
Not clear |
| Takayuki Anno, Taishi Higashi, Yuya Hayashi, Keiichi Motoyama, Hirofumi Jono, Yukio Ando, Hidetoshi Arim. Potential use of glucuronylglucosyl-β-cyclodextrin/dendrimer conjugate (G2) as a siRNA carrier for the treatment of familial amyloidotic polyneuropathy. Journal of drug targeting. vol 22. issue 10. 2015-07-06. PMID:25051178. |
in the present study, to investigate the potentials of gug-β-cde (g2) as a sirna carrier, we evaluated the rnai effect of its complex with sirna against transthyretin (ttr) mrna (sittr) for the treatment of familial amyloidotic polyneuropathy (fap). |
2015-07-06 |
2023-08-13 |
mouse |
| Ryoichi Takahashi, Kenjiro Ono, Shutaro Shibata, Keiko Nakamura, Junji Komatsu, Yoshihisa Ikeda, Tokuhei Ikeda, Miharu Samuraki, Kenji Sakai, Kazuo Iwasa, Daiki Kayano, Masahito Yamad. Efficacy of diflunisal on autonomic dysfunction of late-onset familial amyloid polyneuropathy (TTR Val30Met) in a Japanese endemic area. Journal of the neurological sciences. vol 345. issue 1-2. 2015-05-28. PMID:25060417. |
efficacy of diflunisal on autonomic dysfunction of late-onset familial amyloid polyneuropathy (ttr val30met) in a japanese endemic area. |
2015-05-28 |
2023-08-13 |
Not clear |
| Lesley J Scot. Tafamidis: a review of its use in familial amyloid polyneuropathy. Drugs. vol 74. issue 12. 2015-05-25. PMID:25022953. |
oral tafamidis (vyndaqel(®)) is indicated in the eu for the treatment of transthyretin (ttr) amyloidosis in adult patients with early stage symptomatic polyneuropathy to delay peripheral neurologic impairment and, in argentina, japan and mexico, for delaying the peripheral neurological impairment of ttr familial amyloid polyneuropathy (ttr-fap). |
2015-05-25 |
2023-08-13 |
Not clear |
| N Suanprasert, J L Berk, M D Benson, P J B Dyck, C J Klein, J A Gollob, B R Bettencourt, V Karsten, P J Dyc. Retrospective study of a TTR FAP cohort to modify NIS+7 for therapeutic trials. Journal of the neurological sciences. vol 344. issue 1-2. 2015-05-11. PMID:25012480. |
protein stabilization and oligonucleotide therapies are being tested in transthyretin amyloid polyneuropathy (ttr fap) trials. |
2015-05-11 |
2023-08-13 |
Not clear |
| N Suanprasert, J L Berk, M D Benson, P J B Dyck, C J Klein, J A Gollob, B R Bettencourt, V Karsten, P J Dyc. Retrospective study of a TTR FAP cohort to modify NIS+7 for therapeutic trials. Journal of the neurological sciences. vol 344. issue 1-2. 2015-05-11. PMID:25012480. |
our data confirms that ttr fap usually is a sensorimotor polyneuropathy with autonomic features which usually is symmetric, length dependent, lower limb predominant and progressive. |
2015-05-11 |
2023-08-13 |
Not clear |
| Katherine Ruzhansky, Jacqueline Scoon, Louis H Weimer, Mathew S Maurer, John L Berk, Thomas H Brannaga. Discordant phenotype in monozygotic female twins with Lys35Thr TTR familial amyloidotic polyneuropathy. Journal of clinical neuromuscular disease. vol 16. issue 1. 2015-05-11. PMID:25137508. |
discordant phenotype in monozygotic female twins with lys35thr ttr familial amyloidotic polyneuropathy. |
2015-05-11 |
2023-08-13 |
Not clear |
| Nádia Pereira Gonçalves, Maria Teixeira-Coelho, Maria João Saraiv. Protective role of anakinra against transthyretin-mediated axonal loss and cell death in a mouse model of familial amyloidotic polyneuropathy. Journal of neuropathology and experimental neurology. vol 74. issue 3. 2015-04-17. PMID:25668561. |
familial amyloidotic polyneuropathy (fap) is characterized by a length-dependent axonal loss in the peripheral nervous system that results from deposition of extracellular prefibrillar transthyretin (ttr) and amyloid fibrils. |
2015-04-17 |
2023-08-13 |
mouse |
| Takeshi Yokoyama, Yuto Kosaka, Mineyuki Mizuguch. Inhibitory activities of propolis and its promising component, caffeic acid phenethyl ester, against amyloidogenesis of human transthyretin. Journal of medicinal chemistry. vol 57. issue 21. 2015-03-03. PMID:25314129. |
transthyretin (ttr) is a homotetrameric serum protein associated with amyloidoses such as familial amyloid polyneuropathy and senile systemic amyloidosis. |
2015-03-03 |
2023-08-13 |
human |
| D Adam. [Review of the recent literature on peripheral neuropathies: therapeutic advances]. Revue neurologique. vol 169. issue 12. 2015-02-19. PMID:24262610. |
in familial amyloidotic polyneuropathy, a multicentric controlled study against placebo with tafamidis, an akinetic stabilizer of transthyretin (ttr) 20mg/d, in early stage of val30metttr showed efficiency in the evaluable group and led to marketing authorization by the ema in stage 1 to slow the progression of the neuropathy. |
2015-02-19 |
2023-08-12 |
Not clear |
| Ricardo Sant'Anna, Carolina Braga, Nathalia Varejão, Karinne M Pimenta, Ricardo Graña-Montes, Aline Alves, Juliana Cortines, Yraima Cordeiro, Salvador Ventura, Debora Fogue. The importance of a gatekeeper residue on the aggregation of transthyretin: implications for transthyretin-related amyloidoses. The Journal of biological chemistry. vol 289. issue 41. 2015-02-06. PMID:25086037. |
wild type transthyretin (ttr) is responsible for senile systemic amyloidosis, and more than 100 mutations in the ttr gene are involved in familial amyloid polyneuropathy. |
2015-02-06 |
2023-08-13 |
human |
| Takahiro Kawaji, Toshihiro Inoue, Ryuhei Hara, Daisuke Eiki, Yukio Ando, Hidenobu Tanihar. Long-term outcomes and complications of trabeculectomy for secondary glaucoma in patients with familial amyloidotic polyneuropathy. PloS one. vol 9. issue 5. 2015-01-12. PMID:24802803. |
secondary glaucoma is a serious complication in patients with transthyretin (ttr)-related familial amyloidotic polyneuropathy (fap). |
2015-01-12 |
2023-08-13 |
Not clear |
| Nelson Ferreira, Alda Pereira-Henriques, Aida Attar, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan, Luís Gales, Maria João Saraiva, Maria Rosário Almeid. Molecular tweezers targeting transthyretin amyloidosis. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 11. issue 2. 2014-12-16. PMID:24459092. |
to determine whether clr01 was effective in vivo, we tested the compound in mice expressing ttr v30m, a model of familial amyloidotic polyneuropathy, which recapitulates the main pathological features of the human disease. |
2014-12-16 |
2023-08-12 |
mouse |
| Monichan Phay, Veronika Blinder, Sallie Macy, Michael J Greene, Daniel C Wooliver, Wen Liu, Antoni Planas, Dominic M Walsh, Lawreen H Connors, Stanley R Primmer, Stephanie A Planque, Sudhir Paul, Brian O'Nuallai. Transthyretin aggregate-specific antibodies recognize cryptic epitopes on patient-derived amyloid fibrils. Rejuvenation research. vol 17. issue 2. 2014-12-03. PMID:24164623. |
notably, in the presence of normal human sera, three of the four mabs, 2t5c9, 2g9c, and t1f11, retained low nm binding to ttr amyloid fibrils derived from two patients with familial amyloidotic polyneuropathy (fap). |
2014-12-03 |
2023-08-12 |
human |
| Inmaculada Conejos-Sánchez, Isabel Cardoso, Maria J Saraiva, María J Vicen. Targeting a rare amyloidotic disease through rationally designed polymer conjugates. Journal of controlled release : official journal of the Controlled Release Society. vol 178. 2014-11-13. PMID:24486260. |
discovered in 2006 a rage-based peptide sequence capable of preventing transthyretin (ttr) aggregate-induced cytotoxicity, hallmark of initial stages of an inherited rare amyloidosis known as familial amyloidotic polyneuropathy (fap). |
2014-11-13 |
2023-08-12 |
Not clear |
| Giuseppe Granata, Marco Luigetti, Daniele Coraci, Alessandra Del Grande, Angela Romano, Giulia Bisogni, Placido Bramanti, Paolo Maria Rossini, Mario Sabatelli, Luca Padu. Ultrasound evaluation in transthyretin-related amyloid neuropathy. Muscle & nerve. vol 50. issue 3. 2014-10-06. PMID:24395461. |
familial amyloid polyneuropathy is a rare condition caused by mutations of the transthyretin gene (ttr). |
2014-10-06 |
2023-08-12 |
Not clear |
| Taro Yamashit. [Familial amyloid polyneuropathy: liver transplantation as first-line therapy]. Brain and nerve = Shinkei kenkyu no shinpo. vol 66. issue 7. 2014-10-06. PMID:24998821. |
liver transplantation is the only potentially curative treatment currently available for transthyretin familial amyloid polyneuropathy (ttr-fap) since transplantation results in the disappearance of amyloidogenic ttr, synthesized by the original liver, from plasma. |
2014-10-06 |
2023-08-13 |
Not clear |