| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Hammarström, F Schneider, J W Kell. Trans-suppression of misfolding in an amyloid disease. Science (New York, N.Y.). vol 293. issue 5539. 2001-10-11. PMID:11577236. |
the val30 --> met30 (v30m) ttr mutation is the most prevalent cause of familial amyloid polyneuropathy in heterozygotes, whereas a thr119 --> met119 (t119m) mutation on the second ttr allele protects v30m carriers from disease. |
2001-10-11 |
2023-08-12 |
human |
| J Figueras, M Munar-Qués, D Parés, J Torras, J Fabregat, A Rafecas, E Ramos, C Lama, E Jaurriet. [Sequential liver transplantation: description of the first three patients in Spain]. Medicina clinica. vol 116. issue 10. 2001-08-09. PMID:11333672. |
the liver from a patient with familial amyloidotic polyneuropathy(fap) is used to another patient aged more than 60 with hepatic disease generally cancer, because fap livers are anatomically and functionally normal except for the synthesis of the systemic ttr variant which only could generate fap in the recipient after more than 8 years. |
2001-08-09 |
2023-08-12 |
Not clear |
| M J Saraiv. Transthyretin amyloidosis: a tale of weak interactions. FEBS letters. vol 498. issue 2-3. 2001-07-12. PMID:11412857. |
ttr is the main constituent of amyloid that deposits preferentially in peripheral nerve giving rise to familial amyloid polyneuropathy (fap), or in the heart leading to familial amyloid cardiomyopathy. |
2001-07-12 |
2023-08-12 |
Not clear |
| H E Purkey, M I Dorrell, J W Kell. Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 10. 2001-06-14. PMID:11344299. |
transthyretin (ttr) tetramer dissociation and misfolding facilitate assembly into amyloid fibrils that putatively cause senile systemic amyloidosis and familial amyloid polyneuropathy. |
2001-06-14 |
2023-08-12 |
human |
| P Ramirez, P De Mingo, F Andreu, M Munar, Q Hernández, V Munítiz, R Robles, F Sanchez-Bueno, P Parrill. Long-term results of liver transplantation in four siblings from the same family with familial amyloidotic polyneuropathy type I TTR Ala-71. Transplant international : official journal of the European Society for Organ Transplantation. vol 13 Suppl 1. 2001-05-31. PMID:11111990. |
long-term results of liver transplantation in four siblings from the same family with familial amyloidotic polyneuropathy type i ttr ala-71. |
2001-05-31 |
2023-08-12 |
Not clear |
| M H Teng, J Y Yin, R Vidal, J Ghiso, A Kumar, R Rabenou, A Shah, D R Jacobson, C Tagoe, G Gallo, J Buxbau. Amyloid and nonfibrillar deposits in mice transgenic for wild-type human transthyretin: a possible model for senile systemic amyloidosis. Laboratory investigation; a journal of technical methods and pathology. vol 81. issue 3. 2001-05-03. PMID:11310831. |
the human serum protein transthyretin (ttr) is highly fibrillogenic in vitro and is the fibril precursor in both autosomal dominant (familial amyloidotic polyneuropathy [fap] and familial amyloidotic cardiomyopathy [fac]) and sporadic (senile systemic amyloidosis [ssa]) forms of human cardiac amyloidosis. |
2001-05-03 |
2023-08-12 |
mouse |
| K Tanaka, T Yamada, Y Ohyagi, H Asahara, I Horiuchi, J Kir. Suppression of transthyretin expression by ribozymes: a possible therapy for familial amyloidotic polyneuropathy. Journal of the neurological sciences. vol 183. issue 1. 2001-04-12. PMID:11166799. |
familial amyloidotic polyneuropathy type 1 (fap) is an autosomal-dominantly inherited disorder with systemic deposition of a variant transthyretin (ttr). |
2001-04-12 |
2023-08-12 |
Not clear |
| M Munar-Qués, L Salva-Ladaria, P Mulet-Perera, M Solé, F R López-Andreu, M J Saraiv. Vitreous amyloidosis after liver transplantation in patients with familial amyloid polyneuropathy: ocular synthesis of mutant transthyretin. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 7. issue 4. 2001-03-08. PMID:11132095. |
vitreous amyloidosis has been reported in patients with familial amyloidotic polyneuropathy (fap) who are carriers of different mutant transthyretins (ttr). |
2001-03-08 |
2023-08-12 |
human |
| V L Shnyrov, E Villar, G G Zhadan, J M Sanchez-Ruiz, A Quintas, M J Saraiva, R M Brit. Comparative calorimetric study of non-amyloidogenic and amyloidogenic variants of the homotetrameric protein transthyretin. Biophysical chemistry. vol 88. issue 1-3. 2001-03-08. PMID:11152276. |
familial amyloidotic polyneuropathy (fap) is an autosomal dominant hereditary type of amyloidosis involving amino acid substitutions in transthyretin (ttr). |
2001-03-08 |
2023-08-12 |
Not clear |
| S Araki, S Y. Pathology of familial amyloidotic polyneuropathy with TTR met 30 in Kumamoto, Japan. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 20 Suppl. 2001-02-22. PMID:11037187. |
pathology of familial amyloidotic polyneuropathy with ttr met 30 in kumamoto, japan. |
2001-02-22 |
2023-08-12 |
mouse |
| S Araki, S Y. Pathology of familial amyloidotic polyneuropathy with TTR met 30 in Kumamoto, Japan. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 20 Suppl. 2001-02-22. PMID:11037187. |
seventeen autopsy and 12 sural nerve biopsy cases of familial amyloidotic polyneuropathy (fap) with transthyretin (ttr) met 30 were examined clinicopathologically. |
2001-02-22 |
2023-08-12 |
mouse |
| E B Haagsma, H Scheffer, K Altland, A E De Jager, B P Hazenber. Transthyretin Val71Ala mutation in a Dutch family with familial amyloidotic polyneuropathy. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 7. issue 3. 2001-02-08. PMID:11019863. |
this is the third reported family with this mutation, causing at the protein level an unstable ttr monomer and at the clinical level progressive wasting, polyneuropathy, autonomic dysfunction and vitreous opacities. |
2001-02-08 |
2023-08-12 |
Not clear |
| M J Carvalho, L Lobato, A Ventura, I Beirão, G Rocha, R Seca, H P Miranda, F Silvestre, M C Pereira, S Guimarãe. Remission of proteinuria following liver transplantation for familial amyloid polyneuropathy TTR met30. Transplantation proceedings. vol 32. issue 8. 2001-01-26. PMID:11134752. |
remission of proteinuria following liver transplantation for familial amyloid polyneuropathy ttr met30. |
2001-01-26 |
2023-08-12 |
Not clear |
| C Redondo, A M Damas, A Olofsson, E Lundgren, M J Saraiv. Search for intermediate structures in transthyretin fibrillogenesis: soluble tetrameric Tyr78Phe TTR expresses a specific epitope present only in amyloid fibrils. Journal of molecular biology. vol 304. issue 3. 2000-12-28. PMID:11090287. |
familial amyloidotic polyneuropathy (fap) is caused by the assembly of ttr into an insoluble beta-sheet. |
2000-12-28 |
2023-08-12 |
Not clear |
| M Santos, L Dias, P Esperanç. [The importance of TTR met 30 in the diagnosis of familial amyloidotic polyneuropathy in the absence of a positive family history]. Revista de neurologia. vol 30. issue 10. 2000-09-20. PMID:10919188. |
[the importance of ttr met 30 in the diagnosis of familial amyloidotic polyneuropathy in the absence of a positive family history]. |
2000-09-20 |
2023-08-12 |
Not clear |
| M Santos, L Dias, P Esperanç. [The importance of TTR met 30 in the diagnosis of familial amyloidotic polyneuropathy in the absence of a positive family history]. Revista de neurologia. vol 30. issue 10. 2000-09-20. PMID:10919188. |
familial amyloidotic polyneuropathy type i is an hereditary autosomal dominant disease, characterized by having a mutant transthyretin (ttr met 30). |
2000-09-20 |
2023-08-12 |
Not clear |
| K Misu, N Hattori, Y Ando, S Ikeda, G Sobu. Anticipation in early- but not late-onset familial amyloid polyneuropathy (TTR met 30) in Japan. Neurology. vol 55. issue 3. 2000-08-21. PMID:10932290. |
anticipation in early- but not late-onset familial amyloid polyneuropathy (ttr met 30) in japan. |
2000-08-21 |
2023-08-12 |
Not clear |
| M Nakamura, K Hamidi Asl, M D Benso. A novel variant of transthyretin (Glu89Lys) associated with familial amyloidotic polyneuropathy. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 7. issue 1. 2000-08-08. PMID:10842705. |
we detected a point mutation in the transthyretin (ttr) gene associated with familial amyloidotic polyneuropathy (fap) in a 57-year old male presenting with sensorimotor polyneuropathy, severe autonomic dysfunction and cardiomyopathy using a non-isotopic rnase cleavage assay (nirca). |
2000-08-08 |
2023-08-12 |
Not clear |
| D Adams, D Samuel, C Goulon-Goeau, M Nakazato, P M Costa, C Feray, V Planté, B Ducot, P Ichai, C Lacroix, S Metral, H Bismuth, G Sai. The course and prognostic factors of familial amyloid polyneuropathy after liver transplantation. Brain : a journal of neurology. vol 123 ( Pt 7). 2000-08-07. PMID:10869060. |
familial amyloid polyneuropathy (fap) associated with mutations of the transthyretin (ttr) gene is the most common type of fap, a devastating disease causing death within 10 years after the first symptoms. |
2000-08-07 |
2023-08-12 |
Not clear |
| M M Sousa, S D Yan, D Stern, M J Saraiv. Interaction of the receptor for advanced glycation end products (RAGE) with transthyretin triggers nuclear transcription factor kB (NF-kB) activation. Laboratory investigation; a journal of technical methods and pathology. vol 80. issue 7. 2000-08-01. PMID:10908156. |
mutated transthyretin (ttr) fibrils are associated with the pathology of familial amyloidotic polyneuropathy (fap), in which extracellular amyloid deposits lead to degeneration of cells and tissues, in particular neurons of the peripheral nerve. |
2000-08-01 |
2023-08-12 |
Not clear |