| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Fonseca, N Cardim, H Morais, T Ferreira, A T Pereira, M L Luís, A S Luís, F Ceia, J M Correi. [Diastolic dysfunction and left ventricular hypertrophy in familial amyloidotic polyneuropathy: a cause-effect relationship?]. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology. vol 19. issue 4. 2000-07-19. PMID:10874844. |
ttr met30 familial amyloidotic polyneuropathy of the portuguese type (fap) is an incapacitating and lethal hereditary disorder that affects predominantly young adults of both genders. |
2000-07-19 |
2023-08-12 |
Not clear |
| J A Palha, D Ballinari, N Amboldi, I Cardoso, R Fernandes, V Bellotti, G Merlini, M J Saraiv. 4'-Iodo-4'-deoxydoxorubicin disrupts the fibrillar structure of transthyretin amyloid. The American journal of pathology. vol 156. issue 6. 2000-06-28. PMID:10854215. |
some forms of polyneuropathy, vitreopathy, and cardiomyopathy are caused by the deposition of normal and/or mutant ttr molecules in the form of amyloid fibrils. |
2000-06-28 |
2023-08-12 |
Not clear |
| J A Palha, D Ballinari, N Amboldi, I Cardoso, R Fernandes, V Bellotti, G Merlini, M J Saraiv. 4'-Iodo-4'-deoxydoxorubicin disrupts the fibrillar structure of transthyretin amyloid. The American journal of pathology. vol 156. issue 6. 2000-06-28. PMID:10854215. |
familial amyloidotic polyneuropathy is the most common form of ttr amyloidosis related to the v30m variant. |
2000-06-28 |
2023-08-12 |
Not clear |
| J A Palha, D Ballinari, N Amboldi, I Cardoso, R Fernandes, V Bellotti, G Merlini, M J Saraiv. 4'-Iodo-4'-deoxydoxorubicin disrupts the fibrillar structure of transthyretin amyloid. The American journal of pathology. vol 156. issue 6. 2000-06-28. PMID:10854215. |
we report that 1) i-dox co-localizes with amyloid deposits in tissue sections of patients with familial amyloidotic polyneuropathy; 2) i-dox strongly interacts with ttr amyloid fibrils and presents two binding sites with k(d) of 1.5 x 10(-11) mol/l and 5.6 x 10(-10) mol/l, respectively; and 3) i-dox disrupts the fibrillar structure of ttr amyloid into amorphous material, as assessed by electron microscopy but does not solubilize the fibrils as confirmed by filter assays. |
2000-06-28 |
2023-08-12 |
Not clear |
| M R Almeida, I L Alves, H Terazaki, Y Ando, M J Saraiv. Comparative studies of two transthyretin variants with protective effects on familial amyloidotic polyneuropathy: TTR R104H and TTR T119M. Biochemical and biophysical research communications. vol 270. issue 3. 2000-05-22. PMID:10772944. |
comparative studies of two transthyretin variants with protective effects on familial amyloidotic polyneuropathy: ttr r104h and ttr t119m. |
2000-05-22 |
2023-08-12 |
Not clear |
| M R Almeida, I L Alves, H Terazaki, Y Ando, M J Saraiv. Comparative studies of two transthyretin variants with protective effects on familial amyloidotic polyneuropathy: TTR R104H and TTR T119M. Biochemical and biophysical research communications. vol 270. issue 3. 2000-05-22. PMID:10772944. |
recently, a new nonpathogenic transthyretin (ttr) variant-ttr r104h (ttr h104)-has been described in heterozygotic and compound heterozygotic individuals from a japanese family with familial amyloidotic polyneuropathy (fap). |
2000-05-22 |
2023-08-12 |
Not clear |
| T Klabunde, H M Petrassi, V B Oza, P Raman, J W Kelly, J C Sacchettin. Rational design of potent human transthyretin amyloid disease inhibitors. Nature structural biology. vol 7. issue 4. 2000-05-02. PMID:10742177. |
the human amyloid disorders, familial amyloid polyneuropathy, familial amyloid cardiomyopathy and senile systemic amyloidosis, are caused by insoluble transthyretin (ttr) fibrils, which deposit in the peripheral nerves and heart tissue. |
2000-05-02 |
2023-08-12 |
human |
| T Yamashita, Y Ando, O Bernt Suhr, M Nakamura, N Sakashita, P I Ohlsson, H Terazaki, K Obayashi, M Uchino, M And. A new diagnostic procedure to detect unknown transthyretin (TTR) mutations in familial amyloidotic polyneuropathy (FAP). Journal of the neurological sciences. vol 173. issue 2. 2000-04-24. PMID:10675660. |
a new diagnostic procedure to detect unknown transthyretin (ttr) mutations in familial amyloidotic polyneuropathy (fap). |
2000-04-24 |
2023-08-12 |
Not clear |
| J C Lendoire, P Trigo, H Aziz, M C Romero, O Inventarza, Y Ando, K Tashima, P I Ohlsson, K Cederquist, G Holmgren, O B Suh. Variant transthyretin (TTR) amyloidosis in Argentina. Detection of the trait by electrospray ionization mass spectrometry of lyophilized TTR immunoprecipitate. Scandinavian journal of clinical and laboratory investigation. vol 59. issue 8. 2000-03-09. PMID:10691052. |
lyophilized anti-ttr-antibody precipitates stored at room temperature for 1 week exhibited only minor differences compared with plasma samples stored at -70 degrees c. in a new argentinian study on familial amyloidotic polyneuropathy, the variant ttr was quickly identified and typed by esi-ms. to facilitate transportation, dry-frozen samples can be used and the quality of the spectra is similar to that of samples stored at -70 degrees c. |
2000-03-09 |
2023-08-12 |
human |
| C Solaro, A Schenone, A Di Sapio, L Pradotto, G L Mancardi, A Primavera, A Maur. An Italian family with Ala-47 transthyretin mutation associated with cardiomyopathy and polyneuropathy. Neuromuscular disorders : NMD. vol 10. issue 1. 2000-03-07. PMID:10677864. |
we describe two italian first cousins with familial amyloidotic polyneuropathy associated with transthyretin variant consisting of the substitution of alanine for glycine at codon 47 (ttr ala-47), from a family with a history of cardiac failure. |
2000-03-07 |
2023-08-12 |
Not clear |
| M Kishikawa, T Nakanishi, A Miyazaki, M Hatanaka, A Shimizu, S Tamoto, N Ohsawa, H Hayashi, M Kana. A new nonamyloid transthyretin variant, G101S, detected by electrospray ionization/mass spectrometry. Mutations in brief no. 201. Online. Human mutation. vol 12. issue 5. 2000-02-07. PMID:10671063. |
familial amyloidotic polyneuropathy is caused by transthyretin (ttr) variants. |
2000-02-07 |
2023-08-12 |
Not clear |
| N Tachibana, T Tokuda, K Yoshida, T Taketomi, M Nakazato, Y F Li, Y Masuda, S Iked. Usefulness of MALDI/TOF mass spectrometry of immunoprecipitated serum variant transthyretin in the diagnosis of familial amyloid polyneuropathy. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 6. issue 4. 2000-01-19. PMID:10611950. |
a matrix-assisted laser desorption ionization/time-of-flight (maldi/tof) mass spectrometry (ms) system was used to detect variant transthyretin (ttr) in immunoprecipitated serum ttr molecules obtained from 6 patients with familial amyloid polyneuropathy (fap) who were already proven not to have attr val30met. |
2000-01-19 |
2023-08-12 |
Not clear |
| S A Palácios, P L Bittencourt, E L Cançado, A Q Farias, P C Massarollo, S Mies, J Kalil, A C Goldber. Familial amyloidotic polyneuropathy type 1 in Brazil is associated with the transthyretin Val30Met variant. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 6. issue 4. 2000-01-19. PMID:10611951. |
familial amyloidotic polyneuropathy type 1 (fap1) is an inherited systemic amyloidosis that is secondary to the deposition of transthyretin (ttr) variants in peripheral nerves and in certain visceral organs. |
2000-01-19 |
2023-08-12 |
human |
| D R Booth, J D Gillmore, M R Persey, S E Booth, K D Cafferty, G A Tennent, S Madhoo, S W Cochrane, T C Whitehead, G Pasvol, P N Hawkin. Transthyretin Ile73Val is associated with familial amyloidotic polyneuropathy in a Bangladeshi family. Mutations in brief no. 158. Online. Human mutation. vol 12. issue 2. 2000-01-18. PMID:10694917. |
we report a novel mutation of the transthyretin (ttr) coding for ttr ile73val which is associated with familial amylodotic polyneuropathy (fap) in a bangladeshi family. |
2000-01-18 |
2023-08-12 |
Not clear |
| A M Misrahi, V Plante, T Lalu, L Serre, D Adams, D C Lacroix, G Saï. New transthyretin variants SER 91 and SER 116 associated with familial amyloidotic polyneuropathy. Mutations in brief no. 151. Online. Human mutation. vol 12. issue 1. 2000-01-05. PMID:10627135. |
mutations of the transthyretin (ttr) gene are associated with familial amyloidotic polyneuropathy (fap). |
2000-01-05 |
2023-08-12 |
Not clear |
| K Altland, P Winte. Potential treatment of transthyretin-type amyloidoses by sulfite. Neurogenetics. vol 2. issue 3. 1999-12-10. PMID:10541593. |
familial amyloidotic polyneuropathy (fap) and senile systemic amyloidosis (ssa) are characterized by systemic extracellular deposition of insoluble transthyretin (ttr) fibrils. |
1999-12-10 |
2023-08-12 |
Not clear |
| H Terazaki, Y Ando, S Misumi, M Nakamura, E Ando, N Matsunaga, S Shoji, M Okuyama, H Ideta, K Nakagawa, T Ishizaki, M Ando, M J Saraiv. A novel compound heterozygote (FAP ATTR Arg104His/ATTR Val30Met) with high serum transthyretin (TTR) and retinol binding protein (RBP) levels. Biochemical and biophysical research communications. vol 264. issue 2. 1999-12-07. PMID:10529370. |
we report here a new compound heterozygote in the ttr gene with familial amyloidotic polyneuropathy (fap). |
1999-12-07 |
2023-08-12 |
human |
| K i Misu, N Hattori, M Nagamatsu, S i Ikeda, Y Ando, M Nakazato, Y i Takei, N Hanyu, Y Usui, F Tanaka, T Harada, A Inukai, Y Hashizume, G Sobu. Late-onset familial amyloid polyneuropathy type I (transthyretin Met30-associated familial amyloid polyneuropathy) unrelated to endemic focus in Japan. Clinicopathological and genetic features. Brain : a journal of neurology. vol 122 ( Pt 10). 1999-11-05. PMID:10506096. |
clinicopathological and genetic features were assessed on 35 japanese families affected by late-onset familial amyloid polyneuropathy type i (transthyretin met30-associated familial amyloid polyneuropathy, fap ttr met30) whose siblings were unrelated to endemic japanese foci. |
1999-11-05 |
2023-08-12 |
Not clear |
| K Altland, P Winter, M K Sauerbor. Electrically neutral microheterogeneity of human plasma transthyretin (prealbumin) detected by isoelectric focusing in urea gradients. Electrophoresis. vol 20. issue 7. 1999-10-20. PMID:10424456. |
mutants of the human plasma transthyretin (ttr, prealbumin) have attracted interest due to their rather frequent association with the autosomal dominant disease familial amyloidotic polyneuropathy (fap). |
1999-10-20 |
2023-08-12 |
human |
| P Ramírez, P De Mingo, F Andreu, M Munar, Q Hernández, V Munitiz, A Rios, J A Pons, M Miras, R Robles, F Sánchez-Bueno, P Parrill. Long-term results of liver transplantation in four siblings from the same family with familial amyloidotic polyneuropathy type I TTR ALA-71. Transplantation proceedings. vol 31. issue 6. 1999-10-14. PMID:10500684. |
long-term results of liver transplantation in four siblings from the same family with familial amyloidotic polyneuropathy type i ttr ala-71. |
1999-10-14 |
2023-08-12 |
Not clear |